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1. 发明申请

US20140170122A1 ADULT STEM CELLS DERIVED FROM HUMAN SKIN DERMIS 审中-公开
标题翻译：从人类皮肤细胞衍生的成年干细胞
公开(公告)号：US20140170122A1
公开(公告)日：2014-06-19
申请号：US14240330
申请日：2012-08-24
申请人： Joong Hyun Shim , Seung Ha Yang , Tae Ryong Lee , Hak Hee Kang , Dong Wook Shin
发明人： Joong Hyun Shim , Seung Ha Yang , Tae Ryong Lee , Hak Hee Kang , Dong Wook Shin
IPC分类号： C12N5/0775 , A61K35/28
CPC分类号： C12N5/0668 , A61K35/28 , A61K35/32 , A61K35/35 , A61K35/36 , C12N5/0625 , C12N2533/54 , C12Q1/6881 , C12Q2600/158 , G01N33/74 , G01N2333/475 , G01N2333/485 , G01N2333/49 , G01N2333/50
摘要： Provided in the present invention are adult stem cells derived from human skin dermis, and a method for isolating same. Further provided in the present invention are osteoblastic cells and adipocytes differentiated from the adult stem cells derived from human skin dermis, and a differentiation method therefor. Further provided in the present invention is a composition for osteogenesis or lipogenesis containing the stem cells, osteoblastic cells, or adipocytes. The isolation method of the present invention enables the adult stem cells derived from human skin dermis to be obtained in an easy and simple manner at a high yield rate. Genes and growth factors which are specifically expressed in the adult stem cells derived from human skin dermis isolated using the method can be separated, identified, and used later.
摘要翻译：本发明中提供的是源自人皮肤真皮的成体干细胞及其分离方法。本发明还提供了从源于人皮肤真皮的成体干细胞分化的成骨细胞和脂肪细胞及其分化方法。本发明还提供了含有干细胞，成骨细胞或脂肪细胞的成骨或脂肪生成组合物。本发明的分离方法能够以高产率以容易且简单的方式获得源自人皮肤真皮的成体干细胞。在使用该方法分离的来自人皮肤真皮的成体干细胞中特异性表达的基因和生长因子可以被分离，鉴定和使用。

2. 发明授权

US07247378B2 UV-scattering inorganic/polymer composite particles and a method for preparing the same 有权
标题翻译：紫外线散射无机/聚合物复合颗粒及其制备方法
公开(公告)号：US07247378B2
公开(公告)日：2007-07-24
申请号：US10157987
申请日：2002-05-31
申请人： Jin Woong Kim , Jong Won Shim , Young Ha Lee , Han Kon Kim , Hak Hee Kang
发明人： Jin Woong Kim , Jong Won Shim , Young Ha Lee , Han Kon Kim , Hak Hee Kang
IPC分类号： B32B5/16 , B32B9/00
CPC分类号： C08L51/10 , C08F257/02 , C08F265/04 , C08F292/00 , C08L51/003 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998
摘要： There are provided inorganic/polymer composite particles having good UV-scattering efficiency and improved dispersion stability in organic formulation; and a method for preparing the same, which comprises the following steps of (1) dispersing hydrophobic-treated inorganic particles in monomer and then adding initiator thereto; (2) emulsifying the inorganic dispersion of step (1) in presence of surfactant and dispersion stabilizer; and (3) suspension polymerizing the inorganic/monomer emulsion of step (2), to give inorganic/polymer composite particles.
摘要翻译：提供了具有良好的UV散射效率和改善有机配方中分散稳定性的无机/聚合物复合颗粒; 及其制备方法，其包括以下步骤：（1）将疏水处理的无机颗粒分散在单体中，然后向其中加入引发剂; （2）在表面活性剂和分散稳定剂的存在下乳化步骤（1）的无机分散体; 和（3）将步骤（2）的无机/单体乳液悬浮聚合，得到无机/聚合物复合颗粒。

3. 发明申请

US20080268004A1 Stable Water-In-Oil-In-Water Multiple Emulsion System Produced By Hydrodynamic Dual Stabilization And A Method For Preparation Thereof 审中-公开
标题翻译：水动力双稳态产生的稳定的水包油水包油乳液系统及其制备方法
公开(公告)号：US20080268004A1
公开(公告)日：2008-10-30
申请号：US12019122
申请日：2008-01-24
申请人： Jin Woong Kim , Sung II Lee , Byung Guen Chae , Han Kon Kim , Hak Hee Kang , Ih Seop Chang
发明人： Jin Woong Kim , Sung II Lee , Byung Guen Chae , Han Kon Kim , Hak Hee Kang , Ih Seop Chang
IPC分类号： A61K9/113 , B01F17/00 , A61K8/06
CPC分类号： A61K8/42 , A61K8/066 , A61K8/4973 , A61K8/738 , A61Q19/00
摘要： The present invention relates to a water-in-oil-in-water multiple emulsion system and a method for preparation thereof, characterized by hydrodynamically stabilizing the multiple emulsion system by using hydrodynamic dual stabilization (HDS) technology. The HDS technology hydrophobizes water molecules in the internal aqueous phase by using a hydrogen bonding inhibitor and by improving the aggregating force between water molecules in the internal aqueous phase by using a water molecule aggregating agent.
摘要翻译：水包油包水复合乳液体系及其制备方法技术领域本发明涉及一种水包油包水型多重乳液体系及其制备方法，其特征在于通过使用流体力学双稳定化（HDS）技术对多重乳液体系进行流体动力学稳定化。 HDS技术通过使用氢键抑制剂和通过使用水分子聚集剂改善内部水相中的水分子之间的聚集力来疏水内部水相中的水分子。

4. 发明授权

US07041304B2 Thermotropic liquid crystal polymer microcapsules, a method for preparing the same, and cosmetic compositions containing the same 有权
公开(公告)号：US07041304B2
公开(公告)日：2006-05-09
申请号：US10207199
申请日：2002-07-30
申请人： Hee Kyung Ju , Jin Woong Kim , Sang Hoon Han , Ih Seop Chang , Han Kon Kim , Hak Hee Kang , Ok Sub Lee
发明人： Hee Kyung Ju , Jin Woong Kim , Sang Hoon Han , Ih Seop Chang , Han Kon Kim , Hak Hee Kang , Ok Sub Lee
IPC分类号： A61K9/14
CPC分类号： B01J13/16 , A61K8/0295 , A61K8/11 , A61K8/8147 , A61K2800/412 , A61Q1/06 , A61Q1/12 , A61Q19/00
摘要： There are provided thermotropic liquid crystal polymer microcapsules which can show behavior of liquid crystal as it is within polymer phase due to phase separation between liquid crystal and polymer, so to be incorporated into cosmetic composition as an additive for visual effect, and in loading active ingredients within liquid crystal, can improve the stability of the active ingredients in cosmetic base; and a method for preparing the same; and cosmetic compositions containing the same.

5. 发明授权

US06410752B1 Tocopherol derivatives and method for preparation thereof 有权
标题翻译：生育酚衍生物及其制备方法
公开(公告)号：US06410752B1
公开(公告)日：2002-06-25
申请号：US09756179
申请日：2001-01-09
申请人： Kil Joong Kim , Duck Hee Kim , Ho Sik Rho , Jae Won You , Chun Ja Nam , Jong Eoun Hong , Hak Hee Kang , Ih Seob Chang
发明人： Kil Joong Kim , Duck Hee Kim , Ho Sik Rho , Jae Won You , Chun Ja Nam , Jong Eoun Hong , Hak Hee Kang , Ih Seob Chang
IPC分类号： C07F906
CPC分类号： C07F9/65522 , A61K8/678 , A61Q19/08
摘要： An object of the present invention is to provide the tocopherol derivatives represented by the following formula (I), and their salts: Wherein, R1, R2 and R3 are H or methyl group, and at least one positions selected from group consisting of the R1, R2 and R3 positions are methyl group; and, A is CH2—CH(CH3)— or CH═C(CH3)— The other object of the present invention is to provide a method for preparing the above tocopherol derivatives. The tocopherol derivatives is prepared by reacting tocopherol with phosphorous oxychloride in an equivalent ratio of 1:1˜1.3, in presence of an organic base, in an organic solvent; reacting the tocopherol dichlorophosphate produced by the above reaction with 3-aminopropanol in presence of an organic base, in an organic solvent; and, hydrolyzing the above products. The tocopherol derivatives according to the present invention can be hydrolyzed by biological enzymes in a living body to produce tocopherol and 3-aminopropane phosphate. And they can induce physiological activities including recovery of injured skin, prevention from aging of bio-membrane, etc. Also, the tocopherol derivatives according to the present invention have improved stability, safety to skin and anti-oxidant effect superior to preceding tocopherol and its derivatives.
摘要翻译：本发明的目的是提供由下式（I）表示的生育酚衍生物及其盐：其中，R1，R2和R3为H或甲基，以及至少一个选自R1 R2和R3位是甲基; 并且A是CH 2 -CH（CH 3） - 或CH = C（CH 3） - 本发明的另一个目的是提供一种制备上述生育酚衍生物的方法。生育酚衍生物通过在有机碱存在下，在有机溶剂中使生育酚与磷酰氯以1：1〜1.3的当量比反应制备; 在有机溶剂中，通过上述反应生成的生育酚二氯磷酸与有机碱存在下的3-氨基丙醇反应; 并且水解上述产物。根据本发明的生育酚衍生物可以通过活体中的生物酶水解以产生生育酚和3-氨基丙烷磷酸酯。它们可以诱导生理活性，包括恢复受伤的皮肤，防止生物膜老化等。此外，根据本发明的生育酚衍生物具有改善的稳定性，对皮肤的安全性和优于前述生育酚的抗氧化作用及其衍生品

6. 发明授权

US5980917A Oil-in-water type cosmetic composition containing retinoids stabilized by a liquidcrystal 失效
标题翻译：油包水型化妆品组合物，其含有通过液晶稳定的维甲酸
公开(公告)号：US5980917A
公开(公告)日：1999-11-09
申请号：US956291
申请日：1997-10-23
申请人： Hak Hee Kang , Jun Chul Cho , Jung Su Kim , Ok Sob Lee
发明人： Hak Hee Kang , Jun Chul Cho , Jung Su Kim , Ok Sob Lee
IPC分类号： A61K8/30 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/33 , A61K8/34 , A61K8/37 , A61K8/39 , A61K8/41 , A61K8/63 , A61K8/67 , A61Q19/00 , A61K7/00
CPC分类号： A61K8/062 , A61K8/0295 , A61K8/06 , A61K8/39 , A61K8/671 , A61Q19/00 , Y10S514/938
摘要： Disclosed herein is an oil-in-water type cosmetic composition containing retinoids stabilized within a core of a liquidcrystal formed by a surfactant having a phase transition temperature of 45.degree. C. or higher and a bulky structure.
摘要翻译：本文公开了一种水包油型化妆品组合物，其含有稳定在由相转变温度为45℃以上的表面活性剂形成的液晶体的核心内的类维生素A和庞大的结构。

7. 发明申请

US20100015187A1 MACRO-SIZED LIPID CAPSULE EMULSION COMPOSITION AND COSMETIC COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译：大型脂肪乳胶组合物和含有其的化妆品组合物
公开(公告)号：US20100015187A1
公开(公告)日：2010-01-21
申请号：US12300251
申请日：2006-11-30
申请人： Chan Koo Kang , Hak Hee Kang , Chang Hoon Park , Sang Hoon Han
发明人： Chan Koo Kang , Hak Hee Kang , Chang Hoon Park , Sang Hoon Han
IPC分类号： A61K8/06 , A61Q5/00 , A61Q19/00
CPC分类号： A61K8/11 , A61K8/342 , A61K8/375 , A61K8/671 , A61K2800/52 , A61Q19/00 , A61Q19/08
摘要： An emulsion composition of the invention has macro-sized (0.01 to 5 mm) lipid capsule particles and it is for a skin cosmetic composition. An emulsion composition of the invention exhibits improved stability for its particle size by adjusting a size of the particle through a combination of liquid phase oil and integument lipid or lipoid material and encapsulating the liquid phase oil with the integument lipid. The emulsion composition of the invention has unique outward appearance and use feeling due to the macro-sized particles in it, also exhibits excellent skin safety and moisture persistence by containing no surfactant and maintains an activity of an oleophilic effective ingredient which is apt to be oxidized for a long time.
摘要翻译：本发明的乳剂组合物具有大尺寸（0.01〜5mm）的脂质胶囊颗粒，并且用于皮肤化妆品组合物。本发明的乳液组合物通过液相油和皮肤脂质或脂质物质的组合调节颗粒的尺寸并用液体脂质包封液相油来显示出其粒度的稳定性。本发明的乳液组合物由于其中的大尺寸颗粒而具有独特的外观和使用感，还通过不含表面活性剂而显示优异的皮肤安全性和水分持久性，并保持易于被氧化的亲油有效成分的活性需很长时间。

8. 发明授权

US06521662B2 Ceramide-like compounds having antioxidant property and a method for preparation thereof, and a cosmetic composition containing the same 有权
标题翻译：具有抗氧化性的神经酰胺类化合物及其制备方法，以及含有该化合物的化妆品组合物
公开(公告)号：US06521662B2
公开(公告)日：2003-02-18
申请号：US09764426
申请日：2001-01-19
申请人： Ho Sik Rho , Duck Hee Kim , Kil Joong Kim , Jae Won You , Hak Hee Kang , Ok Sub Lee , Jong Ho Park , Su Sun An , Eui Dong Son
发明人： Ho Sik Rho , Duck Hee Kim , Kil Joong Kim , Jae Won You , Hak Hee Kang , Ok Sub Lee , Jong Ho Park , Su Sun An , Eui Dong Son
IPC分类号： A61K31355
CPC分类号： C07F9/65522 , A61K8/68 , A61Q19/08 , C07D311/70
摘要： A ceramide-like compound having properties of the natural ceramides are represented by the following formula (I), and a method for producing the same , and a cosmetic composition containing the same as an active ingredient:
摘要翻译：具有天然神经酰胺性质的神经酰胺样化合物由下式（I）表示，及其制备方法和含有该活性成分的化妆品组合物：

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