专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07627381B2 Systems and methods for combined RF-induced hyperthermia and radioimmunotherapy 有权
标题翻译：用于组合RF诱导的高热和放射免疫治疗的系统和方法
公开(公告)号：US07627381B2
公开(公告)日：2009-12-01
申请号：US11050478
申请日：2005-02-03
申请人： John Kanzius , William Harry Steinbrink , Robert J. McDonald , Michael J. Keating
发明人： John Kanzius , William Harry Steinbrink , Robert J. McDonald , Michael J. Keating
IPC分类号： A61F2/00
CPC分类号： A61K41/0052 , A61N1/403 , A61N1/406 , A61N5/1001 , B82Y5/00
摘要： A combined radiotherapy and hyperthermia therapy is provided, including inducing hyperthermia in at least a portion of a target area—e.g., a tumor or a portion of a tumor or targeted cancerous cells—is provided. Biomolecules labeled with at least one radionuclide suitable for radiotherapy are provided and introduced into a patient; targeted RF absorption enhancers are provided and introduced into a patient; and a hyperthermia generating RF signal is directed via toward the target cells, thereby warming the radionuclide-labeled biomolecules and targeted RF absorption enhancers bound to target cells. The targeted RF absorption enhancers may, in a manner of speaking, add one or more RF absorption frequencies to cells in the target area, which will permit a hyperthermia generating RF signal at that frequency or frequencies to heat the targeted cells. Biomolecules labeled with at least one radionuclide suitable for radiotherapy may be used for both radiotherapy and as RF absorption enhancers for the hyperthermia generating RF signal.
摘要翻译：提供了联合放疗和高热疗法，包括在目标区域的至少一部分（例如肿瘤或部分肿瘤或靶向癌细胞）中诱导高热。提供用至少一种适用于放射治疗的放射性核素标记的生物分子并将其引入患者体内; 提供靶向RF吸收增强剂并将其引入患者体内; 并且通过朝向靶细胞引导产生高热的RF信号，从而加热与靶细胞结合的放射性核素标记的生物分子和靶向RF吸收增强剂。靶向RF吸收增强剂可以以说话的方式将一个或多个RF吸收频率添加到目标区域中的细胞，这将允许产生以该频率或频率的RF信号以加热靶细胞的热疗。用适合于放射治疗的至少一种放射性核素标记的生物分子可以用于放射治疗，也可以用作RF热吸收增强剂，用于产生高热的RF信号。

2. 外观设计

USD398431S Utility hand cart 失效
公开(公告)号：USD398431S
公开(公告)日：1998-09-15
申请号：US063820
申请日：1996-12-16
申请人： Robert J. McDonald
设计人： Robert J. McDonald

3. 发明授权

US5781504A Shallow water beamforming methodology for toroidal volume search sonar 失效
标题翻译：用于环形体积搜索声纳的浅水波束成形方法
公开(公告)号：US5781504A
公开(公告)日：1998-07-14
申请号：US869722
申请日：1997-06-05
申请人： Robert C. Manning , Robert J. McDonald , Jo Ellen Wilbur
发明人： Robert C. Manning , Robert J. McDonald , Jo Ellen Wilbur
IPC分类号： G01S7/527 , G01S15/04 , G01S15/42 , G01S15/89
CPC分类号： G01S15/42 , G01S15/04 , G01S7/527
摘要： An apparatus and method for beamforming for a toroidal volume search sonar.onar array vehicle motion is used to reduce reverberation by fixing beams geometrically in space to prevent beam contact, prior to a specified range, with the sea surface or sea bottom interfaces. Reverberation is further reduced by creating a composite beam from one scanned beam containing the target dominated by surface reverberation and another dominated by bottom reverberation. A correlation and averaging procedure is applied to the two scanned beams to further reduce the reverberation in the composite beam. To further reduce reverberation, the two beams selected for correlation and averaging processing are chosen such that the number of common elements associated with the two beams is a minimum within a given angular separation.
摘要翻译：用于环形体积搜索声纳的波束成形的装置和方法。声纳阵列车辆运动用于通过几何地将光束固定在空间中来减少混响，以防止在特定范围内与海面或海底界面的光束接触。通过从包含由表面混响主导的目标的一个扫描光束创建复合光束并且另一个由底部混响所支配的混响进一步减小混响。将相关和平均程序应用于两个扫描光束，以进一步减少复合光束中的混响。为了进一步减少混响，选择用于相关和平均处理的两个波束，使得与两个波束相关联的公共元件的数量在给定的角度间隔内是最小的。

4. 发明授权

US06445647B1 Wideband-to-narrowband conversion method and apparatus 失效
标题翻译：宽带到窄带的转换方法和装置
公开(公告)号：US06445647B1
公开(公告)日：2002-09-03
申请号：US09382717
申请日：1999-08-24
申请人： Robert J. McDonald , Joellen Wilbur
发明人： Robert J. McDonald , Joellen Wilbur
IPC分类号： G01S3801
CPC分类号： G10K11/346 , G01S7/527 , G01S7/53 , G01S15/102
摘要： A wideband-to-narrowband conversion method and apparatus performs the operational step of receiving an acoustic wideband signal, initially incident on an array of acoustic wideband transducers and subsequently digitized, and in response thereto generating a spatial Wigner bilinear kernel output signal, and the operational step of receiving and spatially bandpass filtering the spatial Wigner bilinear kernel output signal to remove a wideband low frequency portion as well as any unwanted noise therefrom and retain and output only a narrowband portion thereof.
摘要翻译：宽带到窄带转换方法和装置执行操作步骤，其接收最初入射到声学宽带换能器阵列上的声学宽带信号，随后数字化，并响应于此产生空间Wigner双线性内核输出信号，并且操作接收空间带通滤波空间Wigner双线性内核输出信号以去除宽带低频部分以及任何不需要的噪声的步骤，并仅保留和输出其窄带部分。

5. 发明授权

US5946272A Image conversion for a scanning toroidal volume search sonar 失效
标题翻译：扫描环形体积搜索声纳的图像转换
公开(公告)号：US5946272A
公开(公告)日：1999-08-31
申请号：US138053
申请日：1998-08-17
申请人： Robert J. McDonald , Jo Ellen Wilbur , Robert C. Manning , Lisa B. Tubridy
发明人： Robert J. McDonald , Jo Ellen Wilbur , Robert C. Manning , Lisa B. Tubridy
IPC分类号： G01S7/52 , G01S7/62 , G01S15/89
CPC分类号： G01S7/52003 , G01S7/6236
摘要： A method is provided to compress and display received data from a toroidalolume search sonar (TVSS) in terms of horizontal range. For any TVSS receive beam having a horizontal component projection that is equal to or greater than a selected horizontal range, the data values occurring at that selected horizontal range are averaged to form a compressed data value. Range dependent weight factors are applied during the averaging process so that the effects of surface and bottom reverberation do not bias the compressed data value. The compressed data value can then be displayed as a function of horizontal range for a series of sonar pings in order to provide a time history.
摘要翻译：提供了一种在水平范围内从环形体积搜索声纳（TVSS）压缩和显示接收数据的方法。对于具有等于或大于所选水平范围的水平分量投影的任何TVSS接收波束，在所选择的水平范围处出现的数据值被平均以形成压缩数据值。在平均过程中应用范围依赖的权重因子，使得表面和底部混响的影响不会偏压压缩的数据值。然后可以将压缩数据值显示为一系列声纳波的水平范围的函数，以便提供时间历程。

6. 发明授权

US5387864A Channel equalized DC squid flux-locked loop 失效
标题翻译：通道均衡DC鱿鱼通量锁定环
公开(公告)号：US5387864A
公开(公告)日：1995-02-07
申请号：US95557
申请日：1993-07-26
申请人： Meir Gershenson , Robert J. McDonald
发明人： Meir Gershenson , Robert J. McDonald
IPC分类号： G01R33/035 , H01L39/24
CPC分类号： G01R33/0356 , Y10S505/846
摘要： A DC superconductor quantum interference device (i.e. DC SQUID) is used in a flux-locked loop as a sensitive detector of magnetic flux. Prior art devices of this sort had a transfer function which was frequency-limited by the transfer function of impedance matching circuitry which is used to connect the DC SQUID with the first preamplifier, which amplifies the DC SQUID signal before it is applied to a detector circuit. The present invention corrects this frequency limitation by creating a compensating circuit having a transfer function which is the inverse of that of the impedance matching circuitry, and inserting it in the system after the first preamplifier and before the detector circuit.
摘要翻译：在磁通锁定环路中使用DC超导体量子干涉装置（即DC SQUID）作为磁通量的敏感检测器。这种现有技术的装置具有通过阻抗匹配电路的传递函数进行频率限制的传递函数，阻抗匹配电路用于将DC SQUID与第一前置放大器相连，该第一前置放大器在将DC SQUID信号施加到检测器电路之前放大。本发明通过产生具有与阻抗匹配电路的传递函数相反的传递函数并将其插入到第一前置放大器之后和检测器电路之前的系统中来校正该频率限制。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式