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1. 发明授权

US06315413B1 Systems and methods for imaging corneal profiles 有权
标题翻译：角膜剖面成像系统和方法
公开(公告)号：US06315413B1
公开(公告)日：2001-11-13
申请号：US09565851
申请日：2000-05-05
申请人： John K. Shimmick , Stephen J. Hinkson , Charles R. Munnerlyn
发明人： John K. Shimmick , Stephen J. Hinkson , Charles R. Munnerlyn
IPC分类号： A61B310
CPC分类号： A61F9/008 , A61F9/00804 , A61F9/00817 , A61F2009/00844 , A61F2009/00846 , A61F2009/00872 , A61F2009/00882
摘要： Systems, methods and apparatus for generating images of portions of the patient's eye, such as the anterior surface of the cornea. The methods and apparatus of the present invention are particularly useful for directly imaging the profile of the ablated region of the cornea during or immediately following a laser ablation procedure, such as photorefractive keratometry (PRK), phototherapeutic keratectomy (PTK), laser in-situ keratomileusis (LASIK) or the like. These methods and apparatus allow the surgeon to precisely image the exterior edge of the eye to characterize the profile of ablated corneas and to determine the spatial variance of tissue ablation rates during the surgical procedures. Methods and apparatus are also provided for generating one or more images depicting the profile of the ablated region of the cornea. The profile is registered with a pre-ablation profile to provide feedback regarding the true ablation properties of the eye. This feedback permits the laser system to be programmed with a laser ablation algorithm based on the measured ablation properties of the eye.
摘要翻译：用于产生患者眼睛部分图像的系统，方法和装置，例如角膜的前表面。本发明的方法和装置特别可用于在激光消融过程期间或之后直接成像角膜的消融区域，例如光折射角膜曲率法（PRK），光治疗角膜切除术（PTK），原位激光角膜磨镶术（LASIK）等。这些方法和装置允许外科医生精确地成像眼睛的外部边缘以表征消融的角膜的轮廓并且确定外科手术过程中组织消融速率的空间方差。还提供了用于产生描绘角膜切除区域的轮廓的一个或多个图像的方法和装置。使用预消融轮廓记录轮廓以提供关于眼睛的真实消融性质的反馈。该反馈允许激光系统基于所测量的眼睛的消融性质用激光烧蚀算法进行编程。

2. 发明授权

US06605081B1 Systems and methods for imaging corneal profiles 有权
标题翻译：角膜剖面成像系统和方法
公开(公告)号：US06605081B1
公开(公告)日：2003-08-12
申请号：US09565774
申请日：2000-05-05
申请人： John K. Shimmick , Stephen J. Hinkson , Charles R. Munnerlyn
发明人： John K. Shimmick , Stephen J. Hinkson , Charles R. Munnerlyn
IPC分类号： A61F9007
CPC分类号： A61F9/008 , A61F9/00804 , A61F9/00817 , A61F2009/00844 , A61F2009/00846 , A61F2009/00872 , A61F2009/00882
摘要： Systems, methods and apparatus for generating images of portions of the patient's eye, such as the anterior surface of the cornea. The methods and apparatus of the present invention are particularly useful for directly imaging the profile of the ablated region of the cornea during or immediately following a laser ablation procedure, such as photorefractive keratometry (PRK), phototherapeutic keratectomy (PTK), laser in-situ keratomileusis (LASIK) or the like. These methods and apparatus allow the surgeon to precisely image the exterior edge of the eye to characterize the profile of ablated corneas and to determine the spatial variance of tissue ablation rates during the surgical procedures. Methods and apparatus are also provided for generating one or more images depicting the profile of the ablated region of the cornea. The profile is registered with a pre-ablation profile to provide feedback regarding the true ablation properties of the eye. This feedback permits the laser system to be programmed with a laser ablation algorithm based on the measured ablation properties of the eye.
摘要翻译：用于产生患者眼睛部分图像的系统，方法和装置，例如角膜的前表面。本发明的方法和装置特别可用于在激光消融过程期间或之后直接成像角膜的消融区域，例如光折射角膜曲率法（PRK），光治疗角膜切除术（PTK），原位激光角膜磨镶术（LASIK）等。这些方法和装置允许外科医生精确地成像眼睛的外部边缘以表征消融的角膜的轮廓并且确定外科手术过程中组织消融速率的空间方差。还提供了用于产生描绘角膜切除区域的轮廓的一个或多个图像的方法和装置。使用预消融轮廓记录轮廓以提供关于眼睛的真实消融性质的反馈。该反馈允许激光系统基于所测量的眼睛的消融性质用激光烧蚀算法进行编程。

3. 发明授权

US06520958B1 System and methods for imaging corneal profiles 有权
标题翻译：用于成像角膜剖面的系统和方法
公开(公告)号：US06520958B1
公开(公告)日：2003-02-18
申请号：US09565764
申请日：2000-05-05
申请人： John K. Shimmick , Stephen J. Hinkson , Charles R. Munnerlyn
发明人： John K. Shimmick , Stephen J. Hinkson , Charles R. Munnerlyn
IPC分类号： A61B1818
CPC分类号： A61F9/008 , A61F9/00804 , A61F9/00817 , A61F2009/00844 , A61F2009/00846 , A61F2009/00872 , A61F2009/00882
摘要： Systems, methods and apparatus for generating images of portions of the patient's eye, such as the anterior surface of the cornea. The methods and apparatus of the present invention are particularly useful for directly imaging the profile of the ablated region of the cornea during or immediately following a laser ablation procedure, such as photorefractive keratometry (PRK), phototherapeutic keratectomy (PTK), laser in-situ keratomileusis (LASIK) or the like. These methods and apparatus allow the surgeon to precisely image the exterior edge of the eye to characterize the profile of ablated corneas and to determine the spatial variance of tissue ablation rates during the surgical procedures. Methods and apparatus are also provided for generating one or more images depicting the profile of the ablated region of the cornea. The profile is registered with a pre-ablation profile to provide feedback regarding the true ablation properties of the eye. This feedback permits the laser system to be programmed with a laser ablation algorithm based on the measured ablation properties of the eye.
摘要翻译：用于产生患者眼睛部分图像的系统，方法和装置，例如角膜的前表面。本发明的方法和装置特别可用于在激光消融过程期间或之后直接成像角膜的消融区域，例如光折射角膜曲率法（PRK），光治疗角膜切除术（PTK），原位激光角膜磨镶术（LASIK）等。这些方法和装置允许外科医生精确地成像眼睛的外部边缘以表征消融的角膜的轮廓并且确定外科手术过程中组织消融速率的空间方差。还提供了用于产生描绘角膜切除区域的轮廓的一个或多个图像的方法和装置。使用预消融轮廓记录轮廓以提供关于眼睛的真实消融性质的反馈。该反馈允许激光系统基于所测量的眼睛的消融性质用激光烧蚀算法进行编程。

4. 发明授权

US06302876B1 Systems and methods for imaging corneal profiles 失效
公开(公告)号：US06302876B1
公开(公告)日：2001-10-16
申请号：US09083773
申请日：1998-05-22
申请人： John K. Shimmick , Stephen J. Hinkson , Charles R. Munnerlyn
发明人： John K. Shimmick , Stephen J. Hinkson , Charles R. Munnerlyn
IPC分类号： A61F901
CPC分类号： A61F9/008 , A61F9/00804 , A61F9/00817 , A61F2009/00844 , A61F2009/00846 , A61F2009/00872 , A61F2009/00882
摘要： Systems, methods and apparatus for generating images of portions of the patient's eye, such as the anterior surface of the cornea. The methods and apparatus of the present invention are particularly useful for directly imaging the profile of the ablated region of the cornea during or immediately following a laser ablation procedure, such as photorefractive keratometry (PRK), phototherapeutic keratectomy (PTK), laser in-situ keratomileusis (LASIK) or the like. These methods and apparatus allow the surgeon to precisely image the exterior edge of the eye to characterize the profile of ablated corneas and to determine the spatial variance of tissue ablation rates during the surgical procedures. Methods and apparatus are also provided for generating one or more images depicting the profile of the ablated region of the cornea. The profile is registered with a pre-ablation profile to provide feedback regarding the true ablation properties of the eye. This feedback permits the laser system to be programmed with a laser ablation algorithm based on the measured ablation properties of the eye.

5. 发明申请

US20110114743A1 AVOIDANCE OF BOUNCING AND SPLASHING IN DROPLET-BASED FLUID TRANSPORT 有权
标题翻译：在基于流体的液体运输中避免渗透和溢出
公开(公告)号：US20110114743A1
公开(公告)日：2011-05-19
申请号：US12944364
申请日：2010-11-11
申请人： Richard G. Stearns , Stephen J. Hinkson
发明人： Richard G. Stearns , Stephen J. Hinkson
IPC分类号： B05B5/025
CPC分类号： B05B5/005 , B01L3/0268 , B01L2300/0819 , B01L2300/0829 , B01L2400/027 , B01L2400/0415 , B01L2400/0436 , B01L2400/0487 , B05B17/06 , G01N35/1009 , G01N35/1074 , G01N2035/1034 , Y10T436/2575
摘要： A system for fluid transport is provided where a quantity of fluid is held in a reservoir. A droplet generator is employed to generate droplets from the fluid, for example a nozzle-based system or a nozzleless system such as an acoustic ejection system. A generated droplet has a trajectory whereby it arrives at a target. A circuit is used to modify one or more characteristics of the generated droplet in a way which increases the likelihood that the droplet will not splash or bounce when it arrives at the target. The circuit may in different embodiments control the speed of the droplet or the Weber number of the droplet. The circuit may create an electric field in an area of space where the droplet passes. The circuit may charge the droplet by causing it to contact ions.
摘要翻译：提供一种用于流体输送的系统，其中将一定量的流体保持在储存器中。液滴发生器用于从流体产生液滴，例如基于喷嘴的系统或无喷射系统，例如声弹射系统。产生的液滴具有到达目标的轨迹。电路用于以增加液滴在到达目标时不会飞溅或反弹的可能性的方式来修改产生的液滴的一个或多个特性。电路可以在不同的实施例中控制液滴的速度或微波的韦伯数。电路可以在液滴通过的空间区域中产生电场。该电路可通过使其与离子接触来对液滴进行充电。

6. 发明授权

US08389295B2 Avoidance of bouncing and splashing in droplet-based fluid transport 有权
标题翻译：避免弹跳和飞溅在基于液滴的流体输送
公开(公告)号：US08389295B2
公开(公告)日：2013-03-05
申请号：US12944364
申请日：2010-11-11
申请人： Richard G. Stearns , Stephen J. Hinkson
发明人： Richard G. Stearns , Stephen J. Hinkson
IPC分类号： G01N1/10
CPC分类号： B05B5/005 , B01L3/0268 , B01L2300/0819 , B01L2300/0829 , B01L2400/027 , B01L2400/0415 , B01L2400/0436 , B01L2400/0487 , B05B17/06 , G01N35/1009 , G01N35/1074 , G01N2035/1034 , Y10T436/2575
摘要： A system for fluid transport is provided where a quantity of fluid is held in a reservoir. A droplet generator is employed to generate droplets from the fluid, for example a nozzle-based system or a nozzleless system such as an acoustic ejection system. A generated droplet has a trajectory whereby it arrives at a target. A circuit is used to modify one or more characteristics of the generated droplet in a way which increases the likelihood that the droplet will not splash or bounce when it arrives at the target. The circuit may in different embodiments control the speed of the droplet or the Weber number of the droplet. The circuit may create an electric field in an area of space where the droplet passes. The circuit may charge the droplet by causing it to contact ions.
摘要翻译：提供一种用于流体输送的系统，其中将一定量的流体保持在储存器中。液滴发生器用于从流体产生液滴，例如基于喷嘴的系统或无喷射系统，例如声弹射系统。产生的液滴具有到达目标的轨迹。电路用于以增加液滴在到达目标时不会飞溅或反弹的可能性的方式来修改产生的液滴的一个或多个特性。电路可以在不同的实施例中控制液滴的速度或微波的韦伯数。电路可以在液滴通过的空间区域中产生电场。该电路可通过使其与离子接触来对液滴进行充电。

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