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1. 发明授权

US06402736B1 Apparatus and method for filtering intravascular fluids and for delivering diagnostic and therapeutic agents 失效
标题翻译：用于过滤血管内液体和递送诊断和治疗剂的装置和方法
公开(公告)号：US06402736B1
公开(公告)日：2002-06-11
申请号：US09558078
申请日：2000-04-25
申请人： Joe E. Brown , Matt D. Pursley
发明人： Joe E. Brown , Matt D. Pursley
IPC分类号： A61M2500
CPC分类号： A61M25/0017 , A61F2/88 , A61F2250/0067 , A61F2250/0098 , A61M25/0021 , A61M25/0041 , A61M25/0108 , A61M25/0662 , A61M2025/0057 , A61N2005/1021
摘要： An apparatus and method for filtering intravascular fluids and for delivering diagnostic and therapeutic agents intravascularly is disclosed in which the apparatus has a shape defined by a preset shape of a resilient fiber core. The resilient fiber core is covered by a soft polymer tubing or other polymer material to form a delivery apparatus that takes the shape of the resilient fiber core. Various shapes and structures are disclosed that infuse diagnostic and therapeutic agents through a lumen of the polymer tubing, that deliver the agents in the form of a soluble coating, that circulate or contain a preloaded charge of radioactive material for intravascular radiotherapy, and that deploy filtration devices intravascularly for removing particulate matter from body fluid. The resilient fiber core and soft polymer material permit the construction of a very small apparatus that can be removed easily following treatment. Various deployment systems are disclosed for deploying the filtering and delivery apparatuses into a vessel and for protecting against radiation exposure.
摘要翻译：公开了一种用于过滤血管内液体和用于输送血管内的诊断和治疗剂的装置和方法，其中该装置具有由弹性纤维芯的预设形状限定的形状。弹性纤维芯被软聚合物管或其它聚合物材料覆盖以形成呈弹性纤维芯形状的输送装置。公开了各种形状和结构，其通过聚合物管的内腔注入诊断和治疗剂，该内腔以可溶性涂层的形式递送试剂，其循环或容纳用于血管内放射治疗的放射性物质的预加载电荷，并且部署过滤用于从体液中去除颗粒物的血管内装置。弹性纤维芯和软质聚合物材料允许构造非常小的装置，其可以在处理后容易地除去。公开了用于将过滤和递送装置部署到容器中并用于防止辐射暴露的各种部署系统。

2. 发明授权

US6053900A Apparatus and method for delivering diagnostic and therapeutic agents intravascularly 有权
标题翻译：血管内递送诊断和治疗药物的装置和方法
公开(公告)号：US6053900A
公开(公告)日：2000-04-25
申请号：US168133
申请日：1998-10-07
申请人： Joe E. Brown , Matt D. Pursley
发明人： Joe E. Brown , Matt D. Pursley
IPC分类号： A61F2/00 , A61F2/06 , A61F2/88 , A61M25/00 , A61M25/01 , A61M25/06 , A61N5/10 , A61K9/22
CPC分类号： A61M25/0041 , A61M25/0017 , A61M25/0021 , A61F2/88 , A61F2250/0067 , A61F2250/0098 , A61M2025/0057 , A61M25/0108 , A61M25/0662 , A61N2005/1021
摘要： An apparatus and method for delivering diagnostic and therapeutic agents intravascularly in which the apparatus has a shape defined by a preset shape of a resilient fiber core. The resilient fiber core is covered by a soft polymer tubing or other polymer material to form a delivery apparatus that takes the shape of the resilient fiber core. Various shapes and structures are disclosed that infuse diagnostic and therapeutic agents through a lumen of the polymer tubing, that deliver the agents in the form of a soluble coating, and that circulate or contain a preloaded charge of radioactive material for intravascular radiotherapy. The resilient fiber core and soft polymer material permit the construction of a very small apparatus that can be removed easily following treatment. Various deployment systems are disclosed for deploying the delivery apparatuses into a vessel and for protecting against radiation exposure.
摘要翻译：用于递送血管内的诊断和治疗剂的装置和方法，其中该装置具有由弹性纤维芯的预设形状限定的形状。弹性纤维芯被软聚合物管或其它聚合物材料覆盖以形成呈弹性纤维芯形状的输送装置。公开了各种形状和结构，其通过聚合物管的管腔输注诊断和治疗剂，其以可溶性涂层的形式递送药剂，并且循环或容纳用于血管内放射治疗的放射性物质的预加载电荷。弹性纤维芯和软质聚合物材料允许构造非常小的装置，其可以在处理后容易地除去。公开了用于将输送装置部署到容器中并用于防止辐射暴露的各种部署系统。

3. 发明授权

US5603694A Infusion coil apparatus and method for delivering fluid-based agents intravascularly 失效
标题翻译：输液管线装置及血管内给药液的方法
公开(公告)号：US5603694A
公开(公告)日：1997-02-18
申请号：US602424
申请日：1996-02-16
申请人： Joe E. Brown , Matt D. Pursley
发明人： Joe E. Brown , Matt D. Pursley
IPC分类号： A61F2/00 , A61F2/06 , A61F2/88 , A61M25/00 , A61N5/10 , A61M31/00
CPC分类号： A61M25/0021 , A61M25/0041 , A61F2/88 , A61F2250/0067 , A61F2250/0098 , A61N2005/1021
摘要： An infusion coil apparatus and method for delivering fluid-based diagnostic and therapeutic agents intravascularly in which an infusion coil is placed in an artery or other vessel at a diseased location, and then fluid-based agents are delivered through the infusion coil to that specific location. The infusion coil apparatus includes a resilient fiber core enclosed in a soft, hollow polymer tubing. The resilient fiber core has a preshaped coil at one end that overcomes the susceptibility of the infusion coil to become uncoiled, while permitting a construction of the infusion coil having a very small diameter. The polymer tubing is radiopaque and has a soft surface for engaging the inside of a vessel. The infusion coil is deployed by a deployment device at a specific site in a vessel to be treated. Once at the delivery site, the deployment device ejects the infusion coil out of a delivery sheath into the vessel. The infusion coil is perforated so that fluid-based agents can be delivered through the infusion coil to the site adjacent the wall of the vessel. Variations in the shape of the coil and in the deployment devices are disclosed.
摘要翻译：一种输液线圈装置和方法，用于输送血液内流体的诊断和治疗剂，其中将输注线圈放置在患病位置的动脉或其他血管中，然后将基于流体的药剂通过输注线圈输送到该特定位置。输注线圈装置包括封装在柔软的中空聚合物管中的弹性纤维芯。弹性纤维芯在一端具有预成型线圈，其克服了输注线圈变得未卷曲的易感性，同时允许具有非常小直径的输注线圈的构造。聚合物管是不透射线的，并且具有用于接合容器内部的柔软表面。输注线圈由待处理的容器中的特定部位的展开装置展开。一旦在分娩地点，展开装置就将输液线圈从输送鞘排出到容器中。输注线圈是穿孔的，使得流体基剂可以通过输注线圈输送到邻近容器壁的位置。公开了线圈形状和展开装置的变化。

4. 发明授权

US5558737A Method of welding a tip to a catheter 失效
标题翻译：将尖端焊接到导管的方法
公开(公告)号：US5558737A
公开(公告)日：1996-09-24
申请号：US116349
申请日：1993-09-03
申请人： Joe E. Brown , Matt D. Pursley , D. Joe Clark
发明人： Joe E. Brown , Matt D. Pursley , D. Joe Clark
IPC分类号： A61M25/00 , A61M25/01 , B29C47/02 , B29C59/00 , B29C65/02
CPC分类号： A61M25/0012 , A61M25/0023 , A61M25/005 , B29C47/0016 , B29C47/0023 , B29C47/003 , B29C47/0033 , B29C47/023 , B29C47/027 , A61M2025/0062 , A61M25/001 , A61M25/0053 , B29C47/0026 , B29K2105/101 , B29L2023/18 , B29L2024/003 , B29L2031/7542 , Y10T156/1023 , Y10T156/1057 , Y10T156/1064
摘要： A method of manufacturing, extruding, milling and welding a high torque, thin monolithic walled guiding catheter having resilient reinforcement material (8, 23, 29, 70, 73) integrally spiralled or braided into monolithic walls (21) of flexible material. A solid lubricant, also referred to as dry lubricant, comprised of either special fluorine containing materials or polymeric organic silicon compounds is embedded into interior and exterior wall surfaces of the catheters. Smooth interior walls (11) are channeled (10) to decrease friction resistance, to trap resistance particles and to dissipate friction heat in the high ratio of surface area to cross-sectional area of small catheters. Number of spirals or braids of reinforcement strands per unit of length, number of layers of strands of the catheters, catheter diameter and progressiveness thereof are designedly different for separate portions of particular catheters. Catheter tips (6) arc machinable immediately adjacent to select density of strands of reinforcement material. Perfusion ports are machinable where desired. Directional bends (7) are positional selectively at distal ends (5) of the catheters (1).
摘要翻译：一种制造，挤压，铣削和焊接具有弹性增强材料（8,23,29,70,73）的高扭矩，薄整体壁导向导管的方法，其一体地螺旋化或编织成柔性材料的整体壁（21）。由特殊含氟材料或聚合有机硅化合物组成的固体润滑剂也称为干性润滑剂，被嵌入导管的内壁和外壁表面。平滑的内壁（11）被引导（10）以降低摩擦阻力，捕获电阻颗粒并以高比例的表面积与小导管的横截面面积消散摩擦热。每单位长度的增强线的螺旋或编织物的数量，导管的股数，导管直径和进行性的数量对于特定导管的分开的部分设计上是不同的。导管尖端（6）可立即切割加工，以选择强化材料股线的密度。灌注口可根据需要加工。定向弯头（7）在导管（1）的远端（5）处有选择性地位置。

5. 发明授权

US5334169A Reinforced catheter with thin monolithic walls 失效
标题翻译：加强导管与薄的整体墙
公开(公告)号：US5334169A
公开(公告)日：1994-08-02
申请号：US881422
申请日：1992-05-11
申请人： Joe E. Brown , Matt D. Pursley
发明人： Joe E. Brown , Matt D. Pursley
IPC分类号： A61M25/00 , A61M25/01 , B29C47/02
CPC分类号： A61M25/0012 , A61M25/0023 , A61M25/005 , B29C47/0016 , B29C47/0023 , B29C47/003 , B29C47/0033 , B29C47/023 , B29C47/027 , A61M2025/0062 , A61M25/001 , A61M25/0053 , B29C47/0026 , B29K2105/101 , B29L2023/18 , B29L2024/003 , B29L2031/7542 , Y10T156/1023 , Y10T156/1057 , Y10T156/1064
摘要： A high torque, thin walled guiding catheter has resilient reinforcement material (8, 23, 29, 70, 73) integrally spiraled or braided into monolithic walls (21) of flexible material. A solid lubricant, also referred to as dry lubricant, comprised of either special fluorine containing materials or polymeric organic silicon compounds is embedded into interior and exterior wall surfaces of the catheters. Smooth interior walls (11) are channeled (10) to decrease friction resistance, to trap resistance particles and to dissipate friction heat in the high ratio of surface area to cross-sectional area of small catheters. Number of spirals or braids of reinforcement strands per unit of length, number of layers of strands of the catheters, catheter diameter and progressiveness thereof are designedly different for separate portions of particular catheters. Catheter tips (6) are weldable immediately adjacent to select density of strands of reinforcement material. Perfusion ports are weldable where desired. Directional bends (7) are positional selectively at distal ends (5) of the catheters (1). Methods for manufacture and modification with co-extrusion, miniature milling and welding while maintaining structural integrity with monolithic wall structure are described.
摘要翻译：高扭矩薄壁引导导管具有一体地螺旋化或编织成柔性材料的整体壁（21）的弹性增强材料（8,23,29,70,73）。由特殊含氟材料或聚合有机硅化合物组成的固体润滑剂也称为干性润滑剂，被嵌入导管的内壁和外壁表面。平滑的内壁（11）被引导（10）以降低摩擦阻力，捕获电阻颗粒并且以高比例的表面积与小导管的横截面面积消散摩擦热。每单位长度的增强线的螺旋或编织物的数量，导管的股数，导管直径和进行性的数量对于特定导管的分开的部分设计上是不同的。导管尖端（6）可直接焊接，以选择密度增强材料的股线。灌注口可以焊接在需要的地方。定向弯头（7）在导管（1）的远端（5）处有选择性地位置。描述了通过共挤出，微型铣削和焊接进行制造和改进的方法，同时保持具有整体壁结构的结构完整性。

6. 发明授权

US08784439B1 Percutaneous medical procedures and devices for closing vessels using mechanical closures 失效
标题翻译：经皮医疗程序和关闭使用机械闭合的血管的装置
公开(公告)号：US08784439B1
公开(公告)日：2014-07-22
申请号：US13413156
申请日：2012-03-06
申请人： Stephen V. Ward , Kenneth Salce , Matt D. Pursley , Joe E. Brown
发明人： Stephen V. Ward , Kenneth Salce , Matt D. Pursley , Joe E. Brown
IPC分类号： A61B17/12 , A61B17/064 , A61B17/06 , A61B17/00 , A61B17/03
CPC分类号： A61B17/12172 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0487 , A61B17/06066 , A61B17/06109 , A61B17/0644 , A61B17/068 , A61B17/12013 , A61B17/12031 , A61B17/12036 , A61B17/12109 , A61B17/12131 , A61B2017/00526 , A61B2017/00778 , A61B2017/00867 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0437 , A61B2017/0445 , A61B2017/0448 , A61B2017/0464 , A61B2017/0472 , A61B2017/06052 , A61B2017/0608 , A61B2017/06095 , A61B2017/061 , A61B2017/0641 , A61B2017/0645 , A61B2017/0649 , A61B2017/12054
摘要： Percutaneous medical procedures are provided, which use endovascular instruments to install mechanical closures for closing vessels, such as veins. The mechanical closures can be one or more sutures that are anchored to the vessel walls and then cinched to closed the vessel. The mechanical closures can also be resilient clips or stents that are expanded within the vessel to pierce the vessel walls, and are then contracted to pull the vessel closed. Various techniques for installing the mechanical closures are also described.
摘要翻译：提供经皮医学程序，其使用血管内仪器来安装用于封闭血管（如静脉）的机械闭合件。机械闭合件可以是一个或多个缝合线，其被锚定到血管壁上，然后固定以封闭血管。机械闭合件也可以是在容器内膨胀以刺穿血管壁的弹性夹子或支架，然后收缩以使容器闭合。还描述了用于安装机械闭合件的各种技术。

7. 发明申请

US20120232541A1 Multiple Sclerosis Therapeutic Methods Using Therapeutic Ablation Devices and Systems 有权
标题翻译：使用治疗消融装置和系统的多发性硬化治疗方法
公开(公告)号：US20120232541A1
公开(公告)日：2012-09-13
申请号：US13340553
申请日：2011-12-29
申请人： Joe E. Brown , Marja Pauliina Margolis , Mary L. Gaddis
发明人： Joe E. Brown , Marja Pauliina Margolis , Mary L. Gaddis
IPC分类号： A61B18/22 , A61B18/02 , A61B18/18 , A61B18/20
CPC分类号： A61B8/12 , A61B5/0066 , A61B5/02007 , A61B6/507 , A61B8/06 , A61B8/0891 , A61B8/463 , A61B8/488 , A61B8/5223 , A61B8/5246 , A61B17/12136 , A61B17/320725 , A61B18/1492 , A61B18/245 , A61B2018/00577 , A61B2018/0212 , A61B2090/3735 , A61B2090/3784 , A61M25/104 , A61M2025/105 , A61M2025/1052
摘要： Methods and devices are disclosed that, in various embodiments and permutations and combinations of inventions, diagnose and treat Pulmonary Embolism or associated symptoms. In one series of embodiments, the invention consists of methods and devices for identifying patients whose Pulmonary Embolism or associated symptoms are caused or exacerbated, at least in part, by blockages of one or more of the patient's internal pulmonary veins. In some instances, stenoses or other flow limiting structures or lesions in the patient's affected veins are identified. Further, in some instances the nature of such lesions and whether there is a significant disruption of blood pressure, or both, is ascertained. In some embodiments, methods and devices for applying one or more therapies to the blockages in the patient's pulmonary veins are provided.
摘要翻译：公开了在各种实施方案和发明的组合，诊断和治疗肺栓塞或相关症状中的方法和装置。在一系列实施方案中，本发明包括用于鉴定患者的肺栓塞或相关症状至少部分地通过阻塞一个或多个患者的内部肺静脉而引起或加剧的方法和装置。在某些情况下，确定患者受影响的静脉中的狭窄或其他限流结构或病变。此外，在某些情况下，确定了这种损伤的性质以及是否存在血压的显着破坏或两者。在一些实施例中，提供了用于将一种或多种疗法应用于患者肺静脉中的阻塞物的方法和装置。

8. 发明申请

US20120226109A1 Pulmonary Embolism Diagnostic Methods and Associated Devices and Systems 审中-公开
标题翻译：肺栓塞诊断方法及相关设备及系统
公开(公告)号：US20120226109A1
公开(公告)日：2012-09-06
申请号：US13339963
申请日：2011-12-29
申请人： Joe E. Brown , Marja Pauliina Margolis , Mary L. Gaddis
发明人： Joe E. Brown , Marja Pauliina Margolis , Mary L. Gaddis
IPC分类号： A61B5/02 , A61B8/14 , A61B8/06 , A61B5/021 , A61B5/0275
CPC分类号： A61B8/12 , A61B5/0066 , A61B5/02007 , A61B6/507 , A61B8/06 , A61B8/0891 , A61B8/463 , A61B8/488 , A61B8/5223 , A61B8/5246 , A61B17/12136 , A61B17/320725 , A61B18/1492 , A61B18/245 , A61B2018/00577 , A61B2018/0212 , A61B2090/3735 , A61B2090/3784 , A61M25/104 , A61M2025/105 , A61M2025/1052
摘要： Methods and devices are disclosed that, in various embodiments and permutations and combinations of inventions, diagnose and treat Pulmonary Embolism or associated symptoms. In one series of embodiments, the invention consists of methods and devices for identifying patients whose Pulmonary Embolism or associated symptoms are caused or exacerbated, at least in part, by blockages of one or more of the patient's internal pulmonary veins. In some instances, stenoses or other flow limiting structures or lesions in the patient's affected veins are identified. Further, in some instances the nature of such lesions and whether there is a significant disruption of blood pressure, or both, is ascertained. In some embodiments, methods and devices for applying one or more therapies to the blockages in the patient's pulmonary veins are provided.
摘要翻译：公开了在各种实施方案和发明的组合，诊断和治疗肺栓塞或相关症状中的方法和装置。在一系列实施方案中，本发明包括用于鉴定患者的肺栓塞或相关症状至少部分地通过阻塞一个或多个患者的内部肺静脉而引起或加剧的方法和装置。在某些情况下，确定患者受影响的静脉中的狭窄或其他限流结构或病变。此外，在某些情况下，确定了这种损伤的性质以及是否存在血压的显着破坏或两者。在一些实施例中，提供了用于将一种或多种疗法应用于患者肺静脉中的阻塞物的方法和装置。

9. 发明申请

US20120220867A1 Pulmonary Embolism Therapeutic Methods Using Therapeutic Cutting Devices and Systems 审中-公开
标题翻译：使用治疗切割装置和系统的肺栓塞治疗方法
公开(公告)号：US20120220867A1
公开(公告)日：2012-08-30
申请号：US13340545
申请日：2011-12-29
申请人： Joe E. Brown , Marja Pauliina Margolis , Mary L. Gaddis
发明人： Joe E. Brown , Marja Pauliina Margolis , Mary L. Gaddis
IPC分类号： A61B6/00 , A61B8/12
CPC分类号： A61B8/12 , A61B5/0066 , A61B5/02007 , A61B6/507 , A61B8/06 , A61B8/0891 , A61B8/463 , A61B8/488 , A61B8/5223 , A61B8/5246 , A61B17/12136 , A61B17/320725 , A61B18/1492 , A61B18/245 , A61B2018/00577 , A61B2018/0212 , A61B2090/3735 , A61B2090/3784 , A61M25/104 , A61M2025/105 , A61M2025/1052
摘要： Methods and devices are disclosed that, in various embodiments and permutations and combinations of inventions, diagnose and treat Pulmonary Embolism or associated symptoms. In one series of embodiments, the invention consists of methods and devices for identifying patients whose Pulmonary Embolism or associated symptoms are caused or exacerbated, at least in part, by blockages of one or more of the patient's internal pulmonary veins. In some instances, stenoses or other flow limiting structures or lesions in the patient's affected veins are identified. Further, in some instances the nature of such lesions and whether there is a significant disruption of blood pressure, or both, is ascertained. In some embodiments, methods and devices for applying one or more therapies to the blockages in the patient's pulmonary veins are provided.
摘要翻译：公开了在各种实施方案和发明的组合，诊断和治疗肺栓塞或相关症状中的方法和装置。在一系列实施方案中，本发明包括用于鉴定患者的肺栓塞或相关症状至少部分地通过阻塞一个或多个患者的内部肺静脉而引起或加剧的方法和装置。在某些情况下，确定患者受影响的静脉中的狭窄或其他限流结构或病变。此外，在某些情况下，确定了这种损伤的性质以及是否存在血压的显着破坏或两者。在一些实施例中，提供了用于将一种或多种疗法应用于患者肺静脉中的阻塞物的方法和装置。

10. 发明申请

US20120330334A1 Therapeutic Cutting Devices, Systems, and Methods for Multiple Sclerosis, Deep Vein Thrombosis, and Pulmonary Embolism 审中-公开
标题翻译：多发性硬化症，深静脉血栓形成和肺栓塞的治疗切割装置，系统和方法
公开(公告)号：US20120330334A1
公开(公告)日：2012-12-27
申请号：US13340496
申请日：2011-12-29
申请人： Joe E. Brown , Marja Pauliina Margolis , Mary L. Gaddis
发明人： Joe E. Brown , Marja Pauliina Margolis , Mary L. Gaddis
IPC分类号： A61B17/22
CPC分类号： A61B8/12 , A61B5/0066 , A61B5/02007 , A61B6/507 , A61B8/06 , A61B8/0891 , A61B8/463 , A61B8/488 , A61B8/5223 , A61B8/5246 , A61B17/12136 , A61B17/320725 , A61B18/1492 , A61B18/245 , A61B2018/00577 , A61B2018/0212 , A61B2090/3735 , A61B2090/3784 , A61M25/104 , A61M2025/105 , A61M2025/1052
摘要： Methods and devices are disclosed that, in various embodiments and permutations and combinations of inventions, diagnose and treat Multiple Sclerosis, Deep Vein Thrombosis, and/or Pulmonary Embolism or symptoms associated with these maladies. In one series of embodiments, the invention consists of methods and devices for identifying patients whose Multiple Sclerosis, Deep Vein Thrombosis, and/or Pulmonary Embolism or associated symptoms are caused or exacerbated, at least in part, by blockages of one or more of the patient's veins. In some instances, stenoses or other flow limiting structures or lesions in the patient's affected veins are identified. Further, in some instances the nature of such lesions and whether there is a significant disruption of blood pressure, or both, is ascertained. In some embodiments, methods and devices for applying one or more therapies to the blockages in the patient's veins are provided.
摘要翻译：公开了在各种实施方案和发明的组合，诊断和治疗多发性硬化，深静脉血栓形成和/或肺栓塞或与这些疾病相关的症状的方法和装置。在一系列实施方案中，本发明包括用于鉴定多发性硬化症，深静脉血栓形成和/或肺栓塞或相关症状至少部分地由一种或多种病人的静脉在某些情况下，确定患者受影响的静脉中的狭窄或其他限流结构或病变。此外，在某些情况下，确定了这种损伤的性质以及是否存在血压的显着破坏或两者。在一些实施例中，提供了用于将一种或多种疗法应用于患者静脉中的阻塞物的方法和装置。

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