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1. 发明申请

US20140221908A1 SURFACTANT PORTED DEVICE FOR TREATMENT OF BLEPHARITIS AND APPLICATIONS OF SAME 审中-公开
标题翻译：用于治疗芽孢杆菌的表面活性剂和其应用的应用
公开(公告)号：US20140221908A1
公开(公告)日：2014-08-07
申请号：US14129755
申请日：2012-07-02
申请人： Jeffrey Sonsino , John P. Wikswo , David Schaffer , Kevin Seale , Phillip C. Samson , Ronald S. Reiserer
发明人： Jeffrey Sonsino , John P. Wikswo , David Schaffer , Kevin Seale , Phillip C. Samson , Ronald S. Reiserer
IPC分类号： A61F9/007
CPC分类号： A61F9/00772 , A61B17/3203 , A61B2017/320012 , A61H23/02 , A61H23/04 , A61H35/02 , A61H2033/068 , A61H2201/0153 , A61H2201/105 , A61M1/0058 , A61M1/0084 , A61M3/0283
摘要： Certain aspects of the present disclosure are directed to a system for treating a gland of a patient. The system includes a handheld device including a probe, a tip of the probe being formed with a suction opening and a delivery opening; a backend apparatus including a fluid reservoir configured to contain a fluid, an agent reservoir configured to contain agent particles, and a suction force generator; a delivery channel in fluid communication with the delivery opening and the fluid reservoir and the agent reservoir, the delivery channel allowing a mixture of the fluid and the agent particles to travel through the delivery channel and exit at the delivery opening; and a suction channel in fluid communication with the suction opening and the suction force generator, the suction channel allowing a suction force being generated at the suction opening by the suction force generator.
摘要翻译：本公开的某些方面涉及用于治疗患者的腺体的系统。该系统包括手持式装置，其包括探针，探针的尖端形成有吸入口和输送口; 一种后端装置，包括：构造成容纳流体的流体储存器，构造成容纳试剂颗粒的试剂储存器和吸力产生器; 与所述输送开口和所述流体储存器和所述药剂储存器流体连通的输送通道，所述输送通道允许所述流体和所述药剂颗粒的混合物穿过所述输送通道并在所述输送口处离开; 以及与吸入口和吸力发生器流体连通的吸入通道，吸引通道允许通过吸力产生器在吸入口处产生吸力。

2. 发明申请

US20120015428A1 METERING ROTARY NANOPUMP, METHOD OF FABRICATING SAME, AND APPLICATIONS OF SAME 审中-公开
标题翻译：测量旋转NANOPUMP，其制备方法及其应用
公开(公告)号：US20120015428A1
公开(公告)日：2012-01-19
申请号：US13183287
申请日：2011-07-14
申请人： Kevin T. Seale , John P. Wikswo , David Schaffer , Ronald S. Reiserer , Scott Darby
发明人： Kevin T. Seale , John P. Wikswo , David Schaffer , Ronald S. Reiserer , Scott Darby
IPC分类号： C12M1/00 , B29C65/14 , F04D3/02
CPC分类号： F04B19/006 , B01L3/502707 , B01L3/50273 , B01L2300/0816 , B01L2400/0481 , B29C35/0894 , B29C65/14 , B29C66/028 , B29C66/53461 , B29C2035/0827 , B29L2031/756
摘要： In one aspect of the present invention, a pump includes a cam having a cam shaft, wherein the cam shaft has an axis, an exterior surface and M fins spaced-apart formed on the exterior surface along the axis; and at least one fluidic flow channel having an inlet and an outlet, disposed on a substrate, wherein the at least one fluidic flow channel helically surrounds the cam shaft such that when the cam shaft driven by the cam rotates, the M fins of the cam shaft compresses the at least one fluidic flow channels to produce a wave of compression that actuates a peristaltic flow of fluid therein so as to direct a desired amount of the fluid toward one of the inlet and the outlet.
摘要翻译：在本发明的一个方面，一种泵包括具有凸轮轴的凸轮，其中所述凸轮轴具有沿所述轴线形成在所述外表面上的轴线，外表面和间隔开的M个翅片; 以及设置在基板上的至少一个具有入口和出口的流体流动通道，其中所述至少一个流体流动通道螺旋地包围所述凸轮轴，使得当由凸轮驱动的凸轮轴旋转时，凸轮的M个翅片轴压缩至少一个流体流动通道以产生压缩波，其致动其中的蠕动流体流，以将期望量的流体引向入口和出口中的一个。

3. 发明申请

US20060026642A1 Method and apparatus for predicting a number of individuals interested in an item based on recommendations of such item 审中-公开
标题翻译：根据该项目的建议预测对项目感兴趣的个人数量的方法和装置
公开(公告)号：US20060026642A1
公开(公告)日：2006-02-02
申请号：US10538210
申请日：2003-12-10
申请人： David Schaffer , Yasser Alsafadi , Amr Yassin
发明人： David Schaffer , Yasser Alsafadi , Amr Yassin
IPC分类号： H04N7/025 , H04N7/10 , H04N5/445 , G06F13/00
CPC分类号： G06Q30/02 , H04H60/33 , H04H60/61 , H04N5/44543 , H04N7/17318 , H04N21/252 , H04N21/2547 , H04N21/4532 , H04N21/482 , H04N21/6582 , H04N21/812
摘要： A method (800) and apparatus (100) are disclosed for predicting a level of interest in an item, such as the size of an audience for a television program, based on the selection history (120) of multiple users and the extent to which the item is recommended (220) to the multiple users. The size of an audience for a given program can be predicted based on, for example, the percentage of users to which the given program is “highly recommended.” A method (900) for calibrating the accuracy of the predictions using measurement data indicating the actual size of the audience is also disclosed. A comparison of the predicted and actual audiences allows a correction factor to be generated to improve subsequent predictions.
摘要翻译：公开了一种方法（800）和装置（100），用于基于多个用户的选择历史（120）来预测项目中的兴趣水平，例如电视节目的观众的大小，以及多少用户的选择历史该项目被推荐（220）给多个用户。可以基于例如“强烈推荐”给定程序的用户的百分比来预测给定节目的观众的大小。还公开了一种使用指示观众的实际大小的测量数据来校准预测精度的方法（900）。预测和实际受众的比较允许生成修正因子以改进后续预测。

4. 发明申请

US20070197900A1 Magnetic flow cytometer with SQUID microscopy 审中-公开
标题翻译：具有SQUID显微镜的磁流式细胞仪
公开(公告)号：US20070197900A1
公开(公告)日：2007-08-23
申请号：US11604018
申请日：2006-11-22
申请人： Franz Baudenbacher , Luis Fong , Eduardo Lima , David Schaffer , John Wikswo
发明人： Franz Baudenbacher , Luis Fong , Eduardo Lima , David Schaffer , John Wikswo
IPC分类号： A61B5/05
CPC分类号： G01R33/0354 , G01N33/54333
摘要： A flow cytometer. In one embodiment, the flow cytometer has a microfluidic structure defining a channel with a periodically modulated path for transporting a stream of fluid with magnetic particles along the modulated path, and a superconducting quantum interference device (SQUID) sensor positioned over the microfluidic structure to define a detecting zone in the microfluidic structure for detecting magnetic signatures of a magnetic particle passing along the periodically modulated path through the detecting zone, where in use the stream of fluid with magnetic particles is regulated such that each magnetic particle passes singly along the periodically modulated path through the detecting zone.
摘要翻译：流式细胞仪在一个实施方案中，流式细胞计数器具有限定具有周期性调制路径的通道的微流体结构，用于沿着调制路径输送具有磁性颗粒的流体流，以及定位在微流体结构上方的超导量子干涉装置（SQUID）微流体结构中的检测区域，用于检测通过检测区域沿着周期性调制路径的磁性粒子的磁特征，其中在使用中调节具有磁性颗粒的流体流，使得每个磁性颗粒沿着周期性调制路径单独通过通过检测区。

5. 发明申请

US20090316982A1 TRANSFORMING MEASUREMENT DATA FOR CLASSIFICATION LEARNING 审中-公开
公开(公告)号：US20090316982A1
公开(公告)日：2009-12-24
申请号：US11914978
申请日：2006-05-14
申请人： David Schaffer
发明人： David Schaffer
IPC分类号： G06K9/62
CPC分类号： G06N3/0481
摘要： A system (600), apparatus (500), and method is provided for a combined transformation of measurement data so that the transformed data are suitable for input by pattern classification learning methods. Sensitivity of transformed data is reduced in the unreliable region while it is largely unchanged or enhanced everywhere else. A Gaussian transform is combined with a sigmoid function, using a combined transform module (502) in the apparatus (500) and system (600) to achieve the sensitivity reduction. A user can direct the processing via a user control subsystem (604) of the system (600) and by providing user analysis input (508) input to the apparatus (500).

6. 发明申请

US20090208096A1 TRANSFORMING MEASUREMENT DATA FOR CLASSIFICATION LEARNING 审中-公开
标题翻译：改变用于分类学习的测量数据
公开(公告)号：US20090208096A1
公开(公告)日：2009-08-20
申请号：US12299828
申请日：2007-04-10
申请人： David Schaffer
发明人： David Schaffer
IPC分类号： G06K9/62
CPC分类号： G06N3/0481
摘要： A system (600), apparatus (500), and method is provided for a combined transformation of measurement data so that the transformed data are suitable for input by pattern classification learning methods. Sensitivity of transformed data is reduced in the unreliable region while it is largely unchanged or enhanced everywhere else. A Gaussian transform is combined with a sigmoid function, using a combined transform module (502) in the apparatus (500) and system (600) to achieve the sensitivity reduction. A user can direct the processing via a user control subsystem (604) of the system (600) and by providing user analysis input (508) input to the apparatus (500).
摘要翻译：提供了一种用于组合变换测量数据的系统（600），装置（500）和方法，使得经变换的数据适合于通过模式分类学习方法的输入。转化数据的敏感度在不可靠区域减少，而其他地方大部分不变或增强。高斯变换与S形函数组合，使用装置（500）和系统（600）中的组合变换模块（502）来实现灵敏度降低。用户可以经由系统（600）的用户控制子系统（604）指导处理，并且通过向设备（500）提供输入的用户分析输入（508）。

7. 发明申请

US20070026518A1 Controlling stem cell destiny with tunable matrices 审中-公开
标题翻译：用可调矩阵控制干细胞命运
公开(公告)号：US20070026518A1
公开(公告)日：2007-02-01
申请号：US11394042
申请日：2006-03-29
申请人： Kevin Healy , Beth Irwin , Jacob Pollock , David Schaffer , Krishanu Saha , Ying Li , Samuel Wall
发明人： Kevin Healy , Beth Irwin , Jacob Pollock , David Schaffer , Krishanu Saha , Ying Li , Samuel Wall
IPC分类号： C12N5/08 , C12N5/00 , C12N5/02 , C08G63/91
CPC分类号： C12N5/0068 , C08J3/246 , C12N2533/30 , C12N2533/50 , C12N2533/80 , C12N2539/10
摘要： The present invention provides a class of interpenetrating polymeric networks (IPNs) and semi-interpenetrating polymeric networks (sIPNs) which include a covalently grafted growth factor or differentiation factor for a stem cell.
摘要翻译：本发明提供了一类互穿聚合物网络（IPN）和半互穿聚合物网络（sIPN），其包括用于干细胞的共价移植的生长因子或分化因子。

8. 发明申请

US20050053922A1 Mutant adeno-associated virus virions and methods of use thereof 有权
标题翻译：突变型腺相关病毒颗粒及其使用方法
公开(公告)号：US20050053922A1
公开(公告)日：2005-03-10
申请号：US10880297
申请日：2004-06-28
申请人： David Schaffer , Brian Kaspar , Narendra Maheshri
发明人： David Schaffer , Brian Kaspar , Narendra Maheshri
IPC分类号： C07H21/04 , C07K1/00 , C07K14/015 , C12N20060101 , C12N7/00 , C12N7/01 , C12N7/02 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , C12N15/864 , C12Q1/68 , C12Q1/70
CPC分类号： C07K14/005 , C12N15/86 , C12N2750/14122 , C12N2750/14143
摘要： The present invention provides mutant adeno-associated virus (AAV) that exhibit altered capsid properties, e.g., reduced binding to neutralizing antibodies in serum and/or altered heparin binding and/or altered infectivity of particular cell types. The present invention further provides libraries of mutant AAV comprising one or more mutations in a capsid gene. The present invention further provides methods of generating the mutant AAV and mutant AAV libraries, and compositions comprising the mutant AAV. The present invention further provides recombinant AAV (rAAV) virions that comprise a mutant capsid protein. The present invention further provides nucleic acids comprising nucleotide sequences that encode mutant capsid proteins, and host cells comprising the nucleic acids. The present invention further provides methods of delivering a gene product to an individual, the methods generally involving administering an effective amount of a subject rAAV virion to an individual in need thereof.
摘要翻译：本发明提供突变型腺相关病毒（AAV），其显示改变的衣壳性质，例如减少与血清中的中和抗体的结合和/或肝素结合的变化和/或特定细胞类型的改变的感染性。本发明还提供了在衣壳基因中包含一个或多个突变的突变AAV的文库。本发明还提供了产生突变AAV和突变AAV文库的方法，以及包含突变体AAV的组合物。本发明还提供了包含突变型衣壳蛋白的重组AAV（rAAV）病毒粒子。本发明还提供了包含编码突变衣壳蛋白的核苷酸序列的核酸和包含核酸的宿主细胞。本发明进一步提供将基因产物递送给个体的方法，所述方法通常涉及向有需要的个体施用有效量的受试者rAAV病毒粒子。

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