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1. 发明授权

US5666954A Therapeutic endo-rectal probe, and apparatus constituting an application thereof for destroying cancer tissue, in particular of the prostate, and preferably in combination with an imaging endo-cavitary-probe 失效
标题翻译：治疗性内直肠探针和构成其用于破坏癌组织，特别是前列腺的应用的装置，优选与成像内腔探针
公开(公告)号：US5666954A
公开(公告)日：1997-09-16
申请号：US486738
申请日：1995-06-07
申请人： Jean-Yves Chapelon , Dominique Cathignol , Albert Gelet , Emmanuel Blanc
发明人： Jean-Yves Chapelon , Dominique Cathignol , Albert Gelet , Emmanuel Blanc
IPC分类号： A61B18/00 , A61B1/00 , A61B8/12 , A61B17/00 , A61B17/22 , A61B17/225 , A61F7/00 , A61N7/02 , B06B1/06
CPC分类号： A61B17/22004 , A61B17/22012 , A61B17/2202 , A61N7/02 , A61N7/022 , B06B1/06 , A61B2017/00274 , A61B2017/22021 , A61B2017/22025 , A61B2017/22028 , A61B2018/00547
摘要： A therapeutic endo-rectal probe comprises at least a piezoelectric transducer element mounted in a support member itself connected to a rigid guide means enabling endo-rectal insertion of said probe, the outside shape of said support member preferably being that of a disk having an outline that is for the most part substantially circular or substantially elliptical, thereby facilitating endo-rectal insertion.
摘要翻译：治疗性内直肠探针至少包括安装在支撑构件中的压电换能器元件，该支撑构件本身连接到能够直接插入所述探针的刚性引导装置，所述支撑构件的外部形状优选为具有轮廓的盘这大部分是大致圆形或基本上椭圆形的，从而便于内直肠插入。

2. 发明授权

US5316000A Use of at least one composite piezoelectric transducer in the manufacture of an ultrasonic therapy apparatus for applying therapy, in a body zone, in particular to concretions, to tissue, or to bones, of a living being and method of ultrasonic therapy 失效
标题翻译：使用至少一个复合压电换能器来制造超声波治疗装置，用于在身体区域，特别是用于生物体的结构，组织或骨骼的治疗，以及超声治疗方法
公开(公告)号：US5316000A
公开(公告)日：1994-05-31
申请号：US823306
申请日：1992-01-21
申请人： Jean-Yves Chapelon , Dominique Cathignol , Emmanuel Blanc
发明人： Jean-Yves Chapelon , Dominique Cathignol , Emmanuel Blanc
IPC分类号： A61B18/00 , A61B1/00 , A61B8/12 , A61B17/00 , A61B17/22 , A61B17/225 , A61F7/00 , A61N7/02 , B06B1/06 , A61B8/00
CPC分类号： A61B17/22004 , A61B17/22012 , A61B17/2202 , A61N7/02 , A61N7/022 , B06B1/06 , A61B2017/00274 , A61B2017/22021 , A61B2017/22025 , A61B2017/22028 , A61B2018/00547
摘要： The invention relates to a composite piezoelectric transducer for making an acoustic or an ultrasonic therapeutic apparatus. The transducer may be a single large-size transducer or it may be a multi-transducer device and it advantageously emits ultrasonic waves that are focused on a focal point.
摘要翻译：本发明涉及一种用于制造声学或超声治疗仪的复合压电换能器。换能器可以是单个大尺寸换能器，或者它可以是多换能器装置，并且其有利地发射聚焦在焦点上的超声波。

3. 发明授权

US5601526A Ultrasound therapy apparatus delivering ultrasound waves having thermal and cavitation effects 失效
标题翻译：提供具有热和空穴作用的超声波的超声治疗仪
公开(公告)号：US5601526A
公开(公告)日：1997-02-11
申请号：US244953
申请日：1994-11-29
申请人： Jean-Yves Chapelon , Dominique Cathignol , Albert Gelet , Emmanuel Blanc
发明人： Jean-Yves Chapelon , Dominique Cathignol , Albert Gelet , Emmanuel Blanc
IPC分类号： A61F7/00 , A61B17/22 , A61N7/02 , A61N7/00
CPC分类号： A61N7/02 , A61B2017/22008 , A61B2017/22009 , A61F2007/0086
摘要： A method and apparatus for performing therapy using ultrasound. The apparatus uses a treatment device having at least one piezoelectric transducer element to supply ultrasonic waves focussed onto a focal point or region that determines the tissue zone submitted to therapy. The treatment device, which is controlled by a control device, supplies two types of ultrasonic waves, the first one being thermal waves that produce a predominantly thermal effect on the tissue being treated and the second one being cavitation waves that produce a predominantly cavitation effect on the tissue to be treated.
摘要翻译： PCT No.PCT / FR92 / 01210 Sec。 371日期：1994年11月29日 102（e）1994年11月29日PCT PCT 1992年12月21日PCT公布。出版物WO93 / 日期1993年7月8日使用超声波进行治疗的方法和装置。该装置使用具有至少一个压电换能器元件的治疗装置，以提供聚焦到焦点或区域上的超声波，该焦点或区域决定了进行治疗的组织区域。由控制装置控制的治疗装置提供两种类型的超声波，第一种是在所治疗的组织上产生主要热效应的热波，第二种是产生主要为空穴作用的空化波待处理的组织。

4. 发明授权

US5738635A Adjustable focusing therapeutic apparatus with no secondary focusing 失效
标题翻译：无二次聚焦的可调聚焦治疗仪
公开(公告)号：US5738635A
公开(公告)日：1998-04-14
申请号：US629922
申请日：1996-04-10
申请人： Jean-Yves Chapelon , Dominique Cathignol , Emmanuel Blanc
发明人： Jean-Yves Chapelon , Dominique Cathignol , Emmanuel Blanc
IPC分类号： A61B17/225 , A61F7/00 , A61N7/02 , G10K11/34 , A61B17/22
CPC分类号： A61F7/00 , A61N7/02 , G10K11/346
摘要： The invention relates to the use of Dirac-type autocorrelation function signals for powering multielements ultrasonic transducers used in therapeutic application in order to minimize or eliminate secondary focusing. The Dirac-type autocorrelation function signals may be generated by a pseudo random binary code.
摘要翻译：本发明涉及使用Dirac型自相关函数信号来为治疗应用中使用的多元素超声换能器供电，以便最小化或消除二次聚焦。 Dirac型自相关函数信号可以由伪随机二进制码产生。

5. 发明授权

US09737324B2 Therapeutic probe for treating tissue using focused intersecting ultrasonic waves 有权
公开(公告)号：US09737324B2
公开(公告)日：2017-08-22
申请号：US14007333
申请日：2012-03-15
申请人： David Melodelima , Jeremy Vincenot , Emmanuel Blanc , Jean-Yves Chapelon
发明人： David Melodelima , Jeremy Vincenot , Emmanuel Blanc , Jean-Yves Chapelon
IPC分类号： A61B17/32 , A61N7/02 , A61N7/00 , A61B90/00
CPC分类号： A61B17/320068 , A61B2090/378 , A61N7/02 , A61N2007/0065 , A61N2007/0078 , A61N2007/027
摘要： A therapeutic probe having a transducer for focusing the ultrasonic waves into a first focal area, the emission surface of which has, within a profile plane, two concave curve segments which have a finite length and which are symmetrical relative to a plane of symmetry, or to an axis of symmetry. Within the profile plane, both concave curve segments extend along arcs of first and second non-coincident circles that intersect each other, and each curve segment has an acoustic axis intersecting the axis of symmetry, or the plane of symmetry, between the first focal area and the emission surface, the acoustic axes being spaced apart from each other such that the beams from the emission surface intersect each other so as to create a second focal area located in and situated between the first focal area and the emission surface.

6. 发明授权

US5720287A Therapy and imaging probe and therapeutic treatment apparatus utilizing it 失效
标题翻译：治疗和成像探针和治疗仪器利用它
公开(公告)号：US5720287A
公开(公告)日：1998-02-24
申请号：US659581
申请日：1996-06-06
申请人： Jean-Yves Chapelon , Emmanuel Blanc , Francois Lacoste
发明人： Jean-Yves Chapelon , Emmanuel Blanc , Francois Lacoste
IPC分类号： A61B1/00 , A61B8/12 , A61B17/00 , A61B18/00 , A61N7/02 , G10K11/35
CPC分类号： A61B8/4461 , A61B18/00 , A61B8/12 , A61B8/4209 , A61B8/445 , A61N7/022 , G10K11/35 , G10K11/355 , A61B2017/00106
摘要： The therapy and imaging probe of the invention comprises a probe body (20') of an elongate shape defining a general axis (X--X), one imaging transducer (40') for transmitting imaging waves, and one therapy transducer (30') for transmitting therapy waves. The imaging transducer is mounted on first support means providing translational movement of the imaging transducer within the probe, parallel to the general axis (X--X) of the probe, between a withdrawn position and an extended position. The therapy transducer is mounted on second support means providing rotation of the therapy transducer within the probe, about an axis of rotation (X1--X1) parallel to the general axis (X--X) of the probe but offset with respect to the imaging transducer, to allow rotation of the therapy transducer between a withdrawn position and a treatment position. In the withdrawn or non-active position of the therapy transducer, the imaging transducer may be brought by translational movement to its extended position to occupy the place occupied by the therapy transducer in its treatment position. Thus, the imaging transducer may form an image of a region for treatment by the therapy transducer. In the treatment position of the therapy transducer, the imaging transducer is at its withdrawn position. The therapy transducer, during the transmission of therapy waves, directly transmits the therapy waves in a direction substantially identical to the direction in which the imaging transducer transmits the imaging waves when imaging waves are being transmitted.
摘要翻译：本发明的治疗和成像探针包括限定总轴线（XX）的细长形状的探针体（20'），用于传输成像波的一个成像传感器（40'）和用于传输成像波的一个治疗传感器（30'）治疗波。成像传感器安装在第一支撑装置上，其提供平行于探针的总轴（X-X）的探针内的成像传感器在撤回位置和延伸位置之间的平移运动。所述治疗传感器安装在第二支撑装置上，所述第二支撑装置提供所述探针内的所述治疗换能器的旋转，所述第二支撑装置绕所述探针的平行于所述探针的所述总轴线（XX）的旋转轴线（X1-X1）相对于所述成像换能器偏移，允许治疗换能器在撤回位置和治疗位置之间旋转。在治疗换能器的撤回或非活动位置，成像换能器可以通过平移运动而被带到其延伸位置，以占据治疗换能器处于其治疗位置所占据的位置。因此，成像换能器可以形成用于由治疗换能器进行治疗的区域的图像。在治疗传感器的治疗位置，成像换能器处于其撤回位置。治疗传感器在治疗波的传送期间，在成像波被传送时，以与成像传感器发射成像波的方向基本相同的方向直接传递治疗波。

7. 再颁专利

USRE38030E1 Use of a-mode echography for monitoring the position of a patient during ultrasound therapy 有权
标题翻译：在超声治疗期间使用a-mode echography来监测患者的位置
公开(公告)号：USRE38030E1
公开(公告)日：2003-03-11
申请号：US09512190
申请日：2000-02-22
申请人： Jean-Yves Chapelon , Emmanuel Blanc
发明人： Jean-Yves Chapelon , Emmanuel Blanc
IPC分类号： A61B800
CPC分类号： A61N7/022 , A61B8/12 , A61B8/4272 , A61B2017/00119 , A61B2017/00274 , A61B2018/00547 , A61B2090/3784
摘要： An A-mode ultrasound echography method is employed for monitoring the position of a patient during hyperthermia treatment. A therapy apparatus includes a therapy device having at least one ultrasound therapy transducer and at least one monitoring ultrasound transducer, where the ultrasound monitoring transducer is linked to an electronic circuit for processing A-mode signals and is part of an A-mode echography device. The therapy apparatus further includes a device for causing the ultrasound transducer operating in A-mode to transmit a brief signal and to receive the echo of the brief signal. A comparing device compares the echo received with a reference echo, and transmits the result of the comparison to a control device.
摘要翻译：采用A模式超声回波法，用于监测患者在高热治疗期间的位置。治疗装置包括具有至少一个超声治疗换能器和至少一个监测超声换能器的治疗装置，其中所述超声监测换能器连接到用于处理A模式信号的电子电路，并且是A模式回波成像装置的一部分。治疗装置还包括用于使超声换能器以A模式工作以传送简短信号并接收短信号的回波的装置。比较装置将收到的回波与参考回波进行比较，并将比较结果发送到控制装置。

8. 发明授权

US6071238A Therapy probe 失效
标题翻译：治疗探针
公开(公告)号：US6071238A
公开(公告)日：2000-06-06
申请号：US884336
申请日：1997-06-27
申请人： Jean-Yves Chapelon , Emmanuel Blanc , Fran.cedilla.ois Lacoste
发明人： Jean-Yves Chapelon , Emmanuel Blanc , Fran.cedilla.ois Lacoste
IPC分类号： A61B8/12 , A61B17/00 , A61B17/225 , A61B18/00 , A61B19/00 , A61F7/12 , A61N7/02 , A61B17/22
CPC分类号： A61B8/12 , A61B8/4461 , A61N7/02 , A61B18/00 , A61B2017/00274 , A61B2017/00694 , A61B2018/00547 , A61B2090/378 , A61F7/12
摘要： An ultrasound therapy probe is provided comprising a therapy transducer movably mounted on a probe body, an at least partially deformable flexible casing around the therapy transducer, and a guard ring limiting deformations of the flexible casing when the transducer moves with respect to the probe body. The therapy transducer can be moved between a therapy position and a retracted position, the guard ring constituting an end-of-travel stop against which the therapy transducer bears in a therapy position. This ensures that movements of the organ to be treated are kept to a minimum when the therapy transducer moves with respect to the probe body.
摘要翻译：提供了一种超声治疗探针，其包括可移动地安装在探针主体上的治疗传感器，围绕治疗换能器的至少部分可变形的柔性外壳，以及当换能器相对于探针主体移动时限制柔性外壳变形的保护环。治疗传感器可以在治疗位置和缩回位置之间移动，保护环构成治疗传感器在治疗位置所处的行程终点。这确保当治疗传感器相对于探针体移动时待处理器官的运动保持最小。

9. 发明授权

US09936969B2 Method and apparatus for generating focused ultrasonic waves with surface modulation 有权
公开(公告)号：US09936969B2
公开(公告)日：2018-04-10
申请号：US14007918
申请日：2012-03-15
申请人： Jeremy Vincenot , David Melodelima , Emmanuel Blanc , Jean-Yves Chapelon
发明人： Jeremy Vincenot , David Melodelima , Emmanuel Blanc , Jean-Yves Chapelon
IPC分类号： A61B17/32 , G10K11/32
CPC分类号： A61B17/320068 , G10K11/32
摘要： The invention relates to a method for generating ultrasonic waves focused on a focal zone (5) in order to carry out biological lesions, comprising the activation of a plurality of ultrasonic transducer elements (3).According to the invention: a target zone, in which homogenization of the supply of energy of the ultrasonic waves emitted by the ultrasonic transducer elements is desired, is chosen, the focusing effect and the acoustic attenuations of the ultrasonic waves on their path between the target zone and the ultrasonic transducer elements (3) are determined, the focusing effect and the acoustic attenuations of the ultrasonic waves are compensated, with ultrasonic transducer elements (3) at least some of which have non-identical emission surfaces such that in the target zone, the supply of energy of the ultrasonic waves emitted by the different ultrasonic transducer elements (3) is more or less identical.

10. 发明申请

US20140081300A1 THERAPEUTIC PROBE FOR TREATING TISSUE USING FOCUSED INTERSECTING ULTRASONIC WAVES 有权
标题翻译：使用聚焦的超声波进行治疗组织的治疗性探针
公开(公告)号：US20140081300A1
公开(公告)日：2014-03-20
申请号：US14007333
申请日：2012-03-15
申请人： David Melodelima , Jeremy Vincenot , Emmanuel Blanc , Jean-Yves Chapelon
发明人： David Melodelima , Jeremy Vincenot , Emmanuel Blanc , Jean-Yves Chapelon
IPC分类号： A61B17/32
CPC分类号： A61B17/320068 , A61B2090/378 , A61N7/02 , A61N2007/0065 , A61N2007/0078 , A61N2007/027
摘要： The invention relates to a therapeutic probe comprising a transducer (2) for focusing the ultrasonic waves into a first focal area (Z1), the emission surface (8) of which has, within a profile plane (Pp), two concave curve segments (s1) which have a finite length and which are symmetrical relative to a plane of symmetry (A1) or to an axis of symmetry (S).According to the invention: within the profile plane (Pp), both concave curve segments (s1) extend along arcs of first and second non-coincident circles that intersect each other. each curve segment (s1) has an acoustic axis (a) intersecting the axis of symmetry (S) or the plane of symmetry (A1) between the first focal area (Z1) and the emission surface (8), the acoustic axes (a) being spaced apart from each other such that the beams from the emission surface (8) intersect each other so as to create a second focal area (Z2) located in situated between the first focal area (Z1) and the emission surface (8).
摘要翻译：本发明涉及一种治疗探针，其包括用于将超声波聚焦到第一焦点区域（Z1）中的换能器（2），其发射表面（8）在轮廓平面（Pp）内具有两个凹曲线段 s1），其具有有限的长度并且相对于对称平面（A1）或对称轴线（S）对称。根据本发明：在轮廓平面（Pp）内，两个凹曲线段（s1）沿着彼此相交的第一和第二非重合圆弧线延伸。每个曲线段（s1）具有与第一焦点区域（Z1）和发射表面（8）之间的对称轴（S）或对称平面（A1）相交的声轴（a），声轴（a ）彼此间隔开，使得来自发射表面（8）的光束彼此相交，以便产生位于第一焦点区域（Z1）和发射表面（8）之间的第二焦点区域（Z2）。

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