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1. 发明授权

US4711953A Process for obtaining an alpha-lactalbumin enriched product from whey and uses thereof 失效
标题翻译：从乳清获得富含α-乳白蛋白的产品及其用途的方法
公开(公告)号：US4711953A
公开(公告)日：1987-12-08
申请号：US883019
申请日：1986-07-09
申请人： Loic Roger , Jean-Louis Maubois , Gerard Brule , Michel Piot
发明人： Loic Roger , Jean-Louis Maubois , Gerard Brule , Michel Piot
IPC分类号： A23L33/20 , A23C9/142 , A23J1/20 , A61K35/20 , A61K38/00 , C07K14/435 , C07K14/76 , C07K3/26
CPC分类号： A23J1/205 , A23C9/1425 , A23V2002/00 , Y10S530/832 , Y10S530/833
摘要： A process of obtaining an .alpha.-lactalbumin enriched product from whey of various origins is disclosed. A first ultrafiltration is carried out on unpasteurized raw whey with membranes having cut-off greater that 5,000 (e.g. 50,000) at a pH between 6:3 and 7 (e.g. 6.6) and a temperature between 30.degree. and 60.degree. C. thereby retaining whey proteins. The ultrafiltrate then undergoes a second ultrafiltration with a membrane capable of retaining .alpha.-lactalbumin (cut-off about 1,200 and 2,000) which is preferably diafiltration. Depending on whether starting whey is acid whey or sweet whey the resulting product may contain practically no CMP or some (e.g. 25%). The resulting product is useful as a mother's milk substitute, pharmaceutical, intensive care or therapeutic food, or tryptophan enriched nutrient.
摘要翻译：公开了从各种来源的乳清获得富含α-乳白蛋白的产品的方法。在未消毒的原始乳清上进行第一次超滤，其中在6：3和7（例如6.6）之间的pH和30至60℃的温度下，截留值大于5,000（例如50,000）的膜进行第一次超滤，从而保留乳清蛋白质。然后，超滤液经过第二次超滤，其中膜能够保留α-乳白蛋白（截留值约1,200和2,000），优选为渗滤。取决于起始乳清是酸乳清还是甜乳清，所得产物实际上不含有CMP或一些（例如25％）。所得产品可用作母乳替代品，药物，重症监护或治疗食品或富含色氨酸的营养物质。

2. 发明授权

US4485040A Process for obtaining an .alpha.-lactalbumin enriched product from whey, and uses thereof 失效
标题翻译：从乳清获得富含α-乳白蛋白的产品的方法及其用途
公开(公告)号：US4485040A
公开(公告)日：1984-11-27
申请号：US338136
申请日：1982-01-08
申请人： Loic Roger , Jean-Louis Maubois , Gerard Brule , Michel Piot
发明人： Loic Roger , Jean-Louis Maubois , Gerard Brule , Michel Piot
IPC分类号： A23L33/20 , A23C9/142 , A23J1/20 , A61K35/20 , A61K38/00 , C07K14/435 , C07K14/76 , C07G7/00
CPC分类号： A23J1/205 , A23C9/1425 , A23V2002/00 , Y10S530/832 , Y10S530/833
摘要： A process of obtaining a .alpha.-lactalbumin enriched product from whey of various origins is disclosed. A first ultrafiltration is carried out on unpasteurized raw whey with membranes having cut-off greater than 5,000 (e.g. 50,000) at a pH between 6.3 and 7 (e.g. 6.6) and a temperature between 30.degree. and 60.degree. C. thereby retaining whey proteins. The ultrafiltrate then undergoes a second ultrafiltration with a membrane capable of retaining .alpha.-lactalbumin (cut-off about 1,200 and 2,000) which is preferably diafiltration. Depending on whether starting whey is acid whey or sweet whey the resulting product may contain practically no CMP or some (e.g. 25%). The resulting product is useful as a mother's milk substitute, pharmaceutical, intensive care or therapeutic food, or tryptophan enriched nutrient.
摘要翻译：公开了从各种来源的乳清中获得富含α-乳白蛋白的产品的方法。在pH7.3〜7（例如6.6），温度在30〜60℃之间，在具有截留值大于5,000（例如50,000）的膜的未经高温灭菌的生乳清上进行第一次超滤，从而保留乳清蛋白。然后，超滤液经过第二次超滤，其中膜能够保留α-乳白蛋白（截留值约1,200和2,000），优选为渗滤。取决于起始乳清是酸乳清还是甜乳清，所得产物实际上不含有CMP或一些（例如25％）。所得产品可用作母乳替代品，药物，重症监护或治疗食品或富含色氨酸的营养物质。

3. 发明授权

US4427658A Total enzymatic hydrolysate from whey proteins and process of obtaining the same 失效
标题翻译：来自乳清蛋白的总酶水解物和获得相同的过程
公开(公告)号：US4427658A
公开(公告)日：1984-01-24
申请号：US329000
申请日：1981-12-09
申请人： Jean-Louis Maubois , Loic Roger , Gerard Brule , Michel Piot
发明人： Jean-Louis Maubois , Loic Roger , Gerard Brule , Michel Piot
IPC分类号： A23J3/00 , A23J3/08 , A23J3/34 , A23L1/305 , A61K38/00 , A61P3/00 , C07K14/00 , C07K14/435 , C12P21/00 , C12P21/06 , A61K37/00 , A23C21/00 , A61K31/195
CPC分类号： A23J3/343 , A23J3/08
摘要： A total enzymatic hydrolysate from whey proteins is disclosed comprising peptidic hydrolysate with substantially no residual proteins, at least 50% of the peptides containing 2 to 5 amino acids. 70 to 90% of the nitrogen present as peptides has a number of amino acids less than 10. A process for obtaining the total enyzmatic hydrolysate is disclosed comprising hydrolysis of whey proteins with proteolytic enzyme (e.g. pancreatin), which is continued until there is no precipitable nitrogen with 12% trichloroacetic acid. Enzymatic hydrolysis may be carried out continuously. The total enzymatic hydrolysate has uses as food supplement, diet food or intensive care food, and in therapeutic nutrition.
摘要翻译：公开了一种来自乳清蛋白质的总酶水解物，其包含基本上没有残留蛋白质的肽水解产物，至少50％的含有2-5个氨基酸的肽。公开了作为肽存在的氮的70至90％具有小于10的氨基酸数。公开了获得全部乙酸水解产物的方法，其包括用蛋白水解酶（例如胰酶）水解乳清蛋白，其持续直至不存在可沉淀氮气与12％三氯乙酸。酶水解可以连续进行。酶的总酶水解产物可用作食品添加剂，饮食食品或重症监护食品以及治疗营养。

4. 发明授权

US5219735A Non-phosphorylated peptides from casein-based material 失效
标题翻译：来自CASEIN的材料的非磷酸化肽
公开(公告)号：US5219735A
公开(公告)日：1993-06-15
申请号：US599102
申请日：1990-10-17
申请人： Gerard Brule , Loic Roger , Jacques Fauquant , Michel Piot
发明人： Gerard Brule , Loic Roger , Jacques Fauquant , Michel Piot
IPC分类号： A23C9/142 , A23J3/34 , A23J7/00 , A61K38/01
CPC分类号： A61K38/01 , A23C9/1422 , A23J3/344 , A23J7/00
摘要： Nonphosphorylated peptides and phosphopeptides useful as alimentary products or medicaments are produced by proteolytic enzyme hydrolysis of a casein-based material. Membrane ultrafiltration is used to separate phosphopeptides which are retained by the membrane in a retentate from the nonphosphorylated peptides which pass through the membrane in an ultrafiltrate. The phosphopeptides in the retentate are disaggregated and are subjected to further membrane ultrafiltration where the phosphopeptides pass through the membrane and are separated from the enzyme. The phosphopeptides form salts, which have dietetic uses, with macroelements such as calcium and/or magnesium and/or oligoelements such as iron and zinc.
摘要翻译：用作消化产物或药物的非磷酸化肽和磷酸肽通过酪蛋白基材料的蛋白水解酶水解产生。膜超滤用于将由膜中保留的磷酸肽分离在非磷酸化肽中的渗余物中，所述非磷酸化肽以超滤液通过膜。分泌滞留物中的磷酸肽被分解，并进行进一步的膜超滤，其中磷酸肽通过膜并与酶分离。磷酸肽形成具有饮食用途的盐，其具有诸如钙和/或镁和/或稀土元素如铁和锌的大量元素。

5. 发明授权

US4980450A Phosphopeptides from casein-based raw material 失效
标题翻译：来自酪蛋白的原料的磷酸肽
公开(公告)号：US4980450A
公开(公告)日：1990-12-25
申请号：US734750
申请日：1985-05-15
申请人： Gerard Brule , Loic Roger , Jacques Fauquant , Michel Piot
发明人： Gerard Brule , Loic Roger , Jacques Fauquant , Michel Piot
IPC分类号： A23J3/00 , A23C9/142 , A23J3/10 , A23J3/34 , A23J7/00 , A23L1/305 , A61K38/00 , A61K38/01 , A61K38/17 , A61P3/00 , A61P3/14 , C07K1/00 , C07K2/00 , C07K14/435 , C12P21/06
CPC分类号： A23J3/344 , A23C9/1422 , A23J7/00 , A61K38/018 , Y10S530/832
摘要： The method consists in subjecting the raw material (milk or retentate) to enzymatic hydrolysis by means of at least one proteolytic enzyme able to reproduce the proteic digestion occuring in vivo in the human body; recovering the thus obtained hydrolyzate; subjecting the latter to at least one ultrafiltration step on membranes able to retaining the phosphopeptides while letting the peptides pass therethrough, the ultrafiltrate thus containing the non phosphorylated peptides; recovering the ultrafiltration retentate; disaggregating the phosphopeptides in the retentate; and subjecting the latter to at least one further ultrafiltration step on membranes which do not retain the phosphopeptides, these being thus separated from the enzyme and available to be recovered as product. The resulting products are useful as dietetic aliments, therapeutic nutriments or medicaments.

6. 发明授权

US5334408A Nutrient composition containing non-phosphorylated peptides from casin-based material 失效
标题翻译：含有酪蛋白基材料的非磷酸化肽的营养成分
公开(公告)号：US5334408A
公开(公告)日：1994-08-02
申请号：US888370
申请日：1992-05-26
申请人： Gerard Brule , Loic Roger , Jacques Fauquant , Michel Piot
发明人： Gerard Brule , Loic Roger , Jacques Fauquant , Michel Piot
IPC分类号： A23J3/34 , A23J3/00 , A61K37/18 , C07K1/00 , C12P21/06
CPC分类号： A23J3/344 , A23J3/34
摘要： Non-phosphorylated peptides and phosphopeptides useful as alimentary products or medicaments are produced. A hydrolyzate containing non-phosphorylated peptides and phosphopeptides is prepared by proteolytic enzyme hydrolysis of a casein-based material. The hydrolyzate is subjected to ultrafiltration with a membrane which allows peptides to pass through to produce a permeate containing the non-phosphorylated peptides and phosphopeptides. A bivalent cation-containing salt capable of aggregating the phosphopeptides is added to the permeate to produce a mixture containing phosphopeptide aggregates and non-phosphorylated peptides. The mixture is subjected to ultrafiltration with a membrane that retains the phosphopeptide aggregates and separates them from the non-phosphorylated peptides. The non-phosphorylated peptides have nutritive value and can be used to form compositions for providing nutrition. The phosphopeptides form salts, which have dietetic uses, with macroelements such as calcium and/or magnesium and/or oligoelements such as iron and zinc.
摘要翻译：产生用作消化产物或药物的非磷酸化肽和磷酸肽。通过酪蛋白基材料的蛋白水解酶水解制备含有非磷酸化肽和磷酸肽的水解产物。将水解产物用膜进行超滤，该膜允许肽通过以产生含有非磷酸化肽和磷酸肽的渗透物。将能聚集磷酸肽的含二价阳离子的盐加入到渗透物中以产生含有磷酸肽聚集体和非磷酸化肽的混合物。将混合物用保留磷酸肽聚集体的膜进行超滤，并将其与非磷酸化肽分离。非磷酸化肽具有营养价值，可用于形成用于提供营养的组合物。磷酸肽形成具有饮食用途的盐，其具有诸如钙和/或镁和/或稀土元素如铁和锌的大量元素。

7. 发明授权

US5216123A Non-phosphorylated peptides from casein-based material 失效
标题翻译：来自CASEIN的材料的非磷酸化肽
公开(公告)号：US5216123A
公开(公告)日：1993-06-01
申请号：US648129
申请日：1991-01-30
申请人： Gerard Brule , Loic Roger , Jacques Fauquant , Michel Piot
发明人： Gerard Brule , Loic Roger , Jacques Fauquant , Michel Piot
IPC分类号： A23J3/34 , A61K37/02 , A23J1/20 , A61K37/16 , C07K15/24
CPC分类号： A23J3/34 , A23J3/344
摘要： Non-phosphorylated peptides and phosphopeptides useful as alimentary products or medicaments are produced. A hydrolyzate containing non-phosphorylated peptides and phosphopeptides is prepared by proteolytic enzyme hydrolysis of a casein-based material. The hydrolyzate is subjected to ultrafiltration with a membrane which allows peptides to pass through to produce a permeate containing the non-phosphorylated peptides and phosphopeptides. A bivalent cation-containing salt capable of aggregating the phosphopeptides is added to the permeate to produce a mixture containing phosphopeptide aggregates and non-phosphorylated peptides. The mixture is subjected to ultrafiltration with a membrane that retains the phosphopeptide aggregates and separates them from the non-phosphorylated peptides. The phosphopeptides form salts, which have dietetic uses, with macroelements such as calcium and/or magnesium and/or oligoelements such as iron and zinc.
摘要翻译：产生用作消化产物或药物的非磷酸化肽和磷酸肽。通过酪蛋白基材料的蛋白水解酶水解制备含有非磷酸化肽和磷酸肽的水解产物。将水解产物用膜进行超滤，该膜允许肽通过以产生含有非磷酸化肽和磷酸肽的渗透物。将能够聚集磷酸肽的含二价阳离子的盐加入到渗透物中以产生含有磷酸肽聚集体和非磷酸化肽的混合物。将混合物用保留磷酸肽聚集体的膜进行超滤，并将其与非磷酸化肽分离。磷酸肽形成具有饮食用途的盐，其具有诸如钙和/或镁和/或稀土元素如铁和锌的大量元素。

8. 发明授权

US5028589A Casein phosphopeptide salts 失效
标题翻译：酪蛋白磷酸肽盐
公开(公告)号：US5028589A
公开(公告)日：1991-07-02
申请号：US342701
申请日：1989-04-26
申请人： Gerard Brule , Loic Roger , Jacques Fauquant , Michel Piot
发明人： Gerard Brule , Loic Roger , Jacques Fauquant , Michel Piot
IPC分类号： A23J3/00 , A23J3/10 , A23J3/34 , A23L1/305 , A61K38/00 , A61K38/01 , A61K38/17 , C07K1/14 , C12P21/06
CPC分类号： A61K38/018 , A23J3/34 , A23J3/344 , A23L33/19
摘要： Casein phosphopeptide salts of calcium, magnesium or both are produced having less than 4% by weight of aromatic amino acids, greater than 8% and less than 20% by weight serine, less than 3% free amino acid content and a ratio of total calcium, magnesium and phosphorus to total nitrogen greater than 0.2. The phosphopeptides are produced by subjecting a casein material to proteolytic enzyme hydrolysis ultrafiltering the resulting hydrolyzate to produce a permeate containing phosphopeptides, adding a bivalent cation salt to the peptides to form phosphopeptide aggregates and separating by ultrafiltration the phosphopeptide aggregates from non phosphorylated peptides. The phosphopeptides obtained are useful as aliments for dietetic or therapeutic nutrition and as medicines.

9. 发明授权

US4495176A Phosphopeptides from casein-based material 失效
标题翻译：来自酪蛋白的材料的磷酸肽
公开(公告)号：US4495176A
公开(公告)日：1985-01-22
申请号：US388931
申请日：1982-06-16
申请人： Gerard Brule , Loic Roger , Jacques Fauquant , Michel Piot
发明人： Gerard Brule , Loic Roger , Jacques Fauquant , Michel Piot
IPC分类号： A23J3/00 , A23J3/10 , A23J3/34 , A23L1/305 , A61K38/00 , A61K38/01 , A61K38/17 , C07K1/14 , C12P21/06 , A61K33/42 , A61K33/24 , C07G7/00
CPC分类号： A61K38/018 , A23J3/34 , A23J3/344 , A23L33/19
摘要： Phosphopeptides useful as alimentary products or as medicaments are obtained by a method of subjecting phosphocaseinates of monovalent cations or paracasein derived therefrom to enzymatic hydrolysis with at least one proteolytic enzyme that simulates proteic digestion in vivo in the human body, ultrafiltering the resultant hydrolysate with a membrane that retains the enzyme to obtain a permeate containing phosphopeptides and non-phosphorylated peptides, adding to the permeate a bivalent cation salt to form aggregates of the phosphopeptides, subjecting the resultant solution to ultrafiltration with a membrane that retains the phosphopeptide aggregates, and recovering the retained phosphopeptides. The phosphopeptides form salts, which have dietetic uses, with macroelements such as calcium and/or magnesium and/or oligoelements such as iron and zinc.
摘要翻译：可用作消化产物或作为药物的磷酸肽通过使一价阳离子的磷酸酯化物或其衍生的副干酪糖酶的方法通过使用至少一种在体内模拟蛋白酶消化的蛋白水解酶进行酶水解的方法获得，用膜过滤所得的水解产物其保留酶以获得含有磷酸肽和非磷酸化肽的渗透物，向渗透物中加入二价阳离子盐以形成磷酸肽的聚集体，将所得溶液用保留磷酸肽聚集体的膜进行超滤，并回收保留的磷酸肽。磷酸肽形成具有饮食用途的盐，其具有诸如钙和/或镁和/或稀土元素如铁和锌的大量元素。

10. 发明授权

US4358465A Phosphopeptides from casein-based material 失效
标题翻译：来自酪蛋白的材料的磷酸肽
公开(公告)号：US4358465A
公开(公告)日：1982-11-09
申请号：US229062
申请日：1981-01-28
申请人： Gerard Brule , Loic Roger , Jacques Fauquant , Michel Piot
发明人： Gerard Brule , Loic Roger , Jacques Fauquant , Michel Piot
IPC分类号： A23J3/00 , A23J3/10 , A23J3/34 , A23L1/305 , A61K38/00 , A61K38/01 , A61K38/17 , C07K1/14 , C12P21/06 , A23C23/00 , C07G7/00
CPC分类号： A61K38/018 , A23J3/34 , A23J3/344 , A23L33/19
摘要： Phosphopeptides useful as alimentary products or as medicaments are obtained by a method of subjecting phosphocaseinates of monovalent cations or paracasein derived therefrom to enzymatic hydrolysis with at least one proteolytic enzyme that simulates proteic digestion in vivo in the human body, ultrafiltering the resultant hydrolysate with a membrane that retains the enzyme to obtain a permeate containing phosphopeptides and non-phosphorylated peptides, adding to the permeate a bivalent cation salt to form aggregates of the phosphopeptides, subjecting the resultant solution to ultrafiltration with a membrane that retains the phosphopeiptide aggregates, and recovering the retained phosphopeptides. The phosphopeptides form salts, which have dietetic uses, with macroelements such as calcium and/or magnesium and/or oligoelements such as iron and zinc.
摘要翻译：可用作消化产物或作为药物的磷酸肽通过使一价阳离子的磷酸酯化物或其衍生的副干酪糖酶的方法通过使用至少一种在体内模拟蛋白酶消化的蛋白水解酶进行酶水解的方法获得，用膜过滤所得的水解产物其保留酶以获得含有磷酸肽和非磷酸化肽的渗透物，向渗透物中加入二价阳离子盐以形成磷酸肽的聚集体，使所得溶液用保留磷酸三聚体聚集体的膜进行超滤，并回收保留的磷酸肽。磷酸肽形成具有饮食用途的盐，其具有诸如钙和/或镁和/或稀土元素如铁和锌的大量元素。

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