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1. 发明授权

US09986942B2 Analyte sensor 有权
公开(公告)号：US09986942B2
公开(公告)日：2018-06-05
申请号：US11503367
申请日：2006-08-10
申请人： James H. Brauker , Robert Boock , Monica Rixman , Peter C. Simpson , Mark Brister , Mark Shults
发明人： James H. Brauker , Robert Boock , Monica Rixman , Peter C. Simpson , Mark Brister , Mark Shults
IPC分类号： A61B5/1486 , A61B5/1473 , G01N33/66 , A61B5/145 , A61B5/00 , C12Q1/00 , G01N33/543
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/411 , A61B5/418 , A61B5/6848 , A61B2562/08 , C12Q1/006 , G01N33/54366 , G01N33/66 , Y02A50/55 , Y02A50/58
摘要： Biointerface membranes are provided which can be utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device incorporating such membranes are provided.

2. 发明授权

US08792955B2 Transcutaneous analyte sensor 有权
公开(公告)号：US08792955B2
公开(公告)日：2014-07-29
申请号：US13157031
申请日：2011-06-09
申请人： Mark Brister , Paul V. Neale , Peter C. Simpson , James H. Brauker , James Patrick Thrower , Mark Shults , Rathburn K. Rhodes , Paul V. Goode, Jr. , Arnold L. Holmquist
发明人： Mark Brister , Paul V. Neale , Peter C. Simpson , James H. Brauker , James Patrick Thrower , Mark Shults , Rathburn K. Rhodes , Paul V. Goode, Jr. , Arnold L. Holmquist
IPC分类号： A61B5/1473 , A61B5/145
CPC分类号： A61B5/0015 , A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B2560/04 , A61B2560/0462 , A61B2562/247 , H04B1/03
摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

3. 发明申请

US20110290645A1 TRANSCUTANEOUS ANALYTE SENSOR 有权
公开(公告)号：US20110290645A1
公开(公告)日：2011-12-01
申请号：US13157031
申请日：2011-06-09
申请人： Mark Brister , Paul V. Neale , Peter C. Simpson , James H. Brauker , James Patrick Thrower , Mark Shults , Rathbun K. Rhodes , Paul V. Goode, JR. , Arnold L. Holmquist
发明人： Mark Brister , Paul V. Neale , Peter C. Simpson , James H. Brauker , James Patrick Thrower , Mark Shults , Rathbun K. Rhodes , Paul V. Goode, JR. , Arnold L. Holmquist
IPC分类号： G01N27/327
CPC分类号： A61B5/0015 , A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B2560/04 , A61B2560/0462 , A61B2562/247 , H04B1/03
摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

4. 发明申请

US20100041971A1 IMPLANTABLE ANALYTE SENSOR 审中-公开
标题翻译：可分析分析仪
公开(公告)号：US20100041971A1
公开(公告)日：2010-02-18
申请号：US12608872
申请日：2009-10-29
申请人： Paul V. Goode, JR. , Arnold L. Holmquist , Mark A. Tapsak , Mark Shults , Victoria Carr-Brendel , James H. Brauker , Paul V. Neale , Jason D. McClure , Mark Brister , Peter C. Simpson , Rathbun K. Rhodes
发明人： Paul V. Goode, JR. , Arnold L. Holmquist , Mark A. Tapsak , Mark Shults , Victoria Carr-Brendel , James H. Brauker , Paul V. Neale , Jason D. McClure , Mark Brister , Peter C. Simpson , Rathbun K. Rhodes
IPC分类号： A61B5/1468 , H01R43/00
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B2560/04 , A61B2560/0462 , H04B1/03 , Y10T29/49117
摘要： An implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.
摘要翻译：包括用于测量分析物的感测区域和用于将传感器主体固定在主机中的非感测区域的可植入分析物传感器。将传感器植入精确尺寸的袋中以在体内稳定分析物传感器，并且能够在形成传感器周围的异物胶囊之前和之后测量主体中分析物的浓度。传感器还提供用于通过传感器主体，电子电路和为在小型化传感器主体中长期使用而优化的电源的RF传输的发射器。

5. 发明申请

US20060258761A1 Silicone based membranes for use in implantable glucose sensors 审中-公开
公开(公告)号：US20060258761A1
公开(公告)日：2006-11-16
申请号：US11404418
申请日：2006-04-14
申请人： Robert Boock , Monica Rixman , Mark Tapsak , Mark Shults , Rathbun Rhodes
发明人： Robert Boock , Monica Rixman , Mark Tapsak , Mark Shults , Rathbun Rhodes
IPC分类号： C08J9/00
CPC分类号： C08L83/04 , A61B5/14532 , A61B5/14865 , A61B5/6848 , B01D69/141 , B01D71/54 , B01D71/80 , C08G77/12 , C08G77/20 , C08G77/46 , C12Q1/002 , C08L2666/14
摘要： Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.

6. 发明申请

US20090030294A1 IMPLANTABLE ANALYTE SENSOR 审中-公开
标题翻译：可分析分析仪
公开(公告)号：US20090030294A1
公开(公告)日：2009-01-29
申请号：US12247137
申请日：2008-10-07
申请人： James R. Petisce , Mark Brister , Mark Shults , James H. Brauker , Paul V. Neale
发明人： James R. Petisce , Mark Brister , Mark Shults , James H. Brauker , Paul V. Neale
IPC分类号： A61B5/07 , B28B11/04
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532
摘要： An implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.
摘要翻译：一种可植入分析物传感器，包括用于测量分析物的感测区域和用于将传感器主体固定在主机中的非感测区域。将传感器植入精确尺寸的袋中以在体内稳定分析物传感器，并且能够在形成传感器周围的异物胶囊之前和之后测量主体中分析物的浓度。传感器还提供用于通过传感器主体，电子电路和为在小型化传感器主体中长期使用而优化的电源的RF传输的发射器。

7. 发明授权

US08277713B2 Implantable analyte sensor 有权
标题翻译：植入式分析物传感器
公开(公告)号：US08277713B2
公开(公告)日：2012-10-02
申请号：US10838658
申请日：2004-05-03
申请人： James R. Petisce , Mark Brister , Mark Shults , James H. Brauker , Paul V. Neale
发明人： James R. Petisce , Mark Brister , Mark Shults , James H. Brauker , Paul V. Neale
IPC分类号： B29D7/00 , B28B7/22 , B28B1/00 , C12Q1/26 , A61B5/05 , H01H29/00
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532
摘要： An implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.
摘要翻译：包括用于测量分析物的感测区域和用于将传感器主体固定在主机中的非感测区域的可植入分析物传感器。将传感器植入精确尺寸的袋中以在体内稳定分析物传感器，并且能够在形成传感器周围的异物胶囊之前和之后测量主体中分析物的浓度。传感器还提供用于通过传感器主体，电子电路和为在小型化传感器主体中长期使用而优化的电源的RF传输的发射器。

8. 发明申请

US20100087724A1 MEMBRANE FOR USE WITH IMPLANTABLE DEVICES 有权
标题翻译：膜与可植入器件的使用
公开(公告)号：US20100087724A1
公开(公告)日：2010-04-08
申请号：US12633578
申请日：2009-12-08
申请人： James H. Brauker , Mark Shults , Mark A. Tapsak
发明人： James H. Brauker , Mark Shults , Mark A. Tapsak
IPC分类号： A61B5/1486 , A61B5/145
CPC分类号： A61B5/14735 , A61B5/076 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2562/02 , A61L31/10 , A61L31/14 , Y10T428/249921
摘要： The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.
摘要翻译：本发明提供了一种用于与可植入装置一起使用的生物界面膜，其干扰屏障细胞层的形成，包括：远离植入装置的第一区域，其中第一结构域支持组织附着并干扰阻挡细胞层形成，以及邻近可植入装置的第二结构域，其中第二结构域对细胞附着有抗性并且对细胞是不可渗透的。此外，本发明提供了包括生物界面膜，包括这些传感器或生物界面膜的可植入装置的传感器，以及利用本发明的分析物检测可植入装置监测宿主中的葡萄糖水平的方法。还提供了包括本发明的生物界面膜的其它可植入装置，例如用于细胞移植的装置，药物递送装置和电信号传送或测量装置。

9. 发明授权

US08840552B2 Membrane for use with implantable devices 有权
标题翻译：用于植入式装置的膜
公开(公告)号：US08840552B2
公开(公告)日：2014-09-23
申请号：US12633578
申请日：2009-12-08
申请人： James H. Brauker , Mark Shults , Mark A. Tapsak
发明人： James H. Brauker , Mark Shults , Mark A. Tapsak
IPC分类号： A61B5/00 , G01N27/40 , A61L31/14 , A61B5/07 , A61L31/10 , A61B5/1486
CPC分类号： A61B5/14735 , A61B5/076 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2562/02 , A61L31/10 , A61L31/14 , Y10T428/249921
摘要： The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.
摘要翻译：本发明提供了一种用于与可植入装置一起使用的生物界面膜，其干扰屏障细胞层的形成，包括：远离植入装置的第一区域，其中第一结构域支持组织附着并干扰阻挡细胞层形成，以及邻近可植入装置的第二结构域，其中第二结构域对细胞附着有抗性并且对细胞是不可渗透的。此外，本发明提供了包括生物界面膜，包括这些传感器或生物界面膜的可植入装置的传感器，以及利用本发明的分析物检测可植入装置监测宿主中的葡萄糖水平的方法。还提供了包括本发明的生物界面膜的其它可植入装置，例如用于细胞移植的装置，药物递送装置和电信号传递或测量装置。

10. 发明授权

US07875293B2 Biointerface membranes incorporating bioactive agents 有权
标题翻译：包含生物活性剂的生物界面膜
公开(公告)号：US07875293B2
公开(公告)日：2011-01-25
申请号：US10842716
申请日：2004-05-10
申请人： Mark Shults , James H. Brauker , Victoria Carr-Brendel , Mark Tapsak , Dubravka Markovic
发明人： Mark Shults , James H. Brauker , Victoria Carr-Brendel , Mark Tapsak , Dubravka Markovic
IPC分类号： A61K9/70 , A61F2/02 , C12Q1/54
CPC分类号： A61B5/14865 , A61B5/14532 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , G01N33/48707
摘要： A biointerface membrane for an implantable device including a nonresorbable solid portion with a plurality of interconnected cavities therein adapted to support tissue ingrowth in vivo, and a bioactive agent incorporated into the biointerface membrane and adapted to modify the tissue response is provided. The bioactive agents can be chosen to induce vascularization and/or prevent barrier cell layer formation in vivo, and are advantageous when used with implantable devices wherein solutes are transported across the device-tissue interface.
摘要翻译：一种用于可植入装置的生物界面膜，其包括不可再吸收的固体部分，其具有适于在体内支持组织向内生长的多个相互连接的空腔，以及并入生物界面膜中并适于修饰组织反应的生物活性剂。可以选择生物活性剂以诱导血管形成和/或预防体内阻隔细胞层形成，并且当与其中溶质被输送穿过装置 - 组织界面的可植入装置一起使用时是有利的。

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