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1. 发明授权

US10851119B2 Boron-containing diacylhydrazines 有权
公开(公告)号：US10851119B2
公开(公告)日：2020-12-01
申请号：US16580343
申请日：2019-09-24
申请人： Intrexon Corporation
发明人： Sheela K. Chellappan , Robert E. Hormann , Inna Shulman
IPC分类号： C07F5/02 , C07F5/04 , C07F7/08
摘要： The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

2. 发明授权

US10464951B2 Boron-containing diacylhydrazines 有权
公开(公告)号：US10464951B2
公开(公告)日：2019-11-05
申请号：US15354239
申请日：2016-11-17
申请人： Intrexon Corporation
发明人： Sheela K. Chellappan , Robert E. Hormann , Inna Shulman
IPC分类号： C07F5/02 , C07F5/04 , C07F7/08
摘要： The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

3. 发明授权

US09127024B2 Boron-containing diacylhydrazines 有权
标题翻译：含硼二酰肼
公开(公告)号：US09127024B2
公开(公告)日：2015-09-08
申请号：US14212526
申请日：2014-03-14
申请人： Intrexon Corporation
发明人： Sheela K. Chellappan , Robert E. Hormann , Inna Shulman
IPC分类号： C07F5/04 , C07F5/02
CPC分类号： C07F5/025 , C07F5/027 , C07F5/04 , C07F7/0803
摘要： The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.
摘要翻译：本公开提供了具有式I的含硼二酰基肼及其药学上可接受的盐和溶剂化物，其中R1，R2，R3，R4和R5如说明书所述定义。本公开还提供了含硼二酰肼的用途是基于蜕皮激素受体的诱导型基因表达系统。因此，本公开对于诸如基因治疗，疾病治疗，蛋白质和抗体的大规模生产，基于细胞的筛选测定，功能基因组学，蛋白质组学，代谢组学和调控转基因生物中的性状等应用是有用的，其中基因表达水平是理想的。

4. 发明申请

US20200157122A1 BORON-CONTAINING DIACYLHYDRAZINES 审中-公开
公开(公告)号：US20200157122A1
公开(公告)日：2020-05-21
申请号：US16580343
申请日：2019-09-24
申请人： Intrexon Corporation
发明人： Sheela K. Chellappan , Robert E. Hormann , Inna Shulman
IPC分类号： C07F5/02 , C07F5/04 , C07F7/08
摘要： The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

5. 发明授权

US10570158B2 Boron-containing diacylhydrazine compounds 有权
公开(公告)号：US10570158B2
公开(公告)日：2020-02-25
申请号：US15915415
申请日：2018-03-08
申请人： Intrexon Corporation
发明人： Ray A. James , Sheela K. Chellappan , Robert E. Hormann
IPC分类号： A61K31/69 , C07F5/02 , C07D263/06 , A01N37/28 , A01N55/08 , A61K45/06
摘要： The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

6. 发明申请

US20160083403A1 Boron-Containing Diacylhydrazine Compounds 有权
标题翻译：含硼的二酰基肼化合物
公开(公告)号：US20160083403A1
公开(公告)日：2016-03-24
申请号：US14855646
申请日：2015-09-16
申请人： Intrexon Corporation
发明人： Ray A. JAMES , Sheela K. Chellappan , Robert E. Hormann
IPC分类号： C07F5/02 , C07D263/06 , C07C243/38
CPC分类号： C07F5/025 , A01N37/28 , A01N55/08 , A61K31/69 , A61K45/06 , C07D263/06 , A61K2300/00
摘要： The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.
摘要翻译：本公开提供了具有式I的含硼二酰基肼及其药学上可接受的盐和溶剂合物，其中A，R4和R5如说明书所述定义。本公开还提供了含硼二酰肼的用途是基于蜕皮激素受体的诱导型基因表达系统。因此，本公开对于诸如基因治疗，疾病治疗，蛋白质和抗体的大规模生产，基于细胞的筛选测定，功能基因组学，蛋白质组学，代谢组学和调控转基因生物中的性状等应用是有用的，其中基因表达水平是理想的。

7. 发明申请

US20180201628A1 Boron-Containing Diacylhydrazine Compounds 审中-公开
公开(公告)号：US20180201628A1
公开(公告)日：2018-07-19
申请号：US15915415
申请日：2018-03-08
申请人： Intrexon Corporation
发明人： Ray A. James , Sheela K. Chellappan , Robert E. Hormann
IPC分类号： C07F5/02 , C07D263/06 , A01N37/28 , A01N55/08 , A61K31/69 , A61K45/06
摘要： The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

8. 发明授权

US09944659B2 Boron-containing diacylhydrazine compounds 有权
公开(公告)号：US09944659B2
公开(公告)日：2018-04-17
申请号：US14855646
申请日：2015-09-16
申请人： Intrexon Corporation
发明人： Ray A. James , Sheela K. Chellappan , Robert E. Hormann
IPC分类号： C07F5/02 , C07D263/06 , A01N37/28 , A01N55/08 , A61K31/69 , A61K45/06
CPC分类号： C07F5/025 , A01N37/28 , A01N55/08 , A61K31/69 , A61K45/06 , C07D263/06 , A61K2300/00
摘要： The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

9. 发明授权

US09512148B2 Boron-containing diacylhydrazines 有权
标题翻译：含硼二酰肼
公开(公告)号：US09512148B2
公开(公告)日：2016-12-06
申请号：US14805837
申请日：2015-07-22
申请人： Intrexon Corporation
发明人： Sheela K. Chellappan , Robert E. Hormann , Inna Shulman
IPC分类号： C07F5/04 , C07F5/02 , C07F7/08
CPC分类号： C07F5/025 , C07F5/027 , C07F5/04 , C07F7/0803
摘要： The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

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