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1. 发明授权

US07955806B2 Detection of a therapeutic antibody in an experimental animal 有权
标题翻译：实验动物中治疗性抗体的检测
公开(公告)号：US07955806B2
公开(公告)日：2011-06-07
申请号：US11792910
申请日：2005-12-22
申请人： Helmut Lenz , Kay-Gunnar Stubenrauch
发明人： Helmut Lenz , Kay-Gunnar Stubenrauch
IPC分类号： G01N33/53 , G01N33/564
CPC分类号： G01N33/6854 , C07K16/4283
摘要： The present invention relates to the field of therapeutic antibodies. It especially relates to the study of therapeutic antibodies in an experimental animal. The present invention discloses a method of detecting a therapeutic antibody in a sample obtained from an experimental animal comprising the steps of a) providing the sample to be analyzed, b) incubating said sample with an antibody binding to a therapeutic antibody and not binding to the immunoglobulin of said experimental animal, c) optionally incubating said sample with a reagent appropriate for the selective detection of total, active or antigen-bound therapeutic antibody, and d) correlating the complex formed in (b) or (c) to the concentration of said therapeutic antibody. A monoclonal antibody directed to a certain epitope that is present on all classes of human immunoglobulin of class G, but not on the immunoglobulin of any experimental animal except on the IgG of chimpanzees was used (MAB-M-R10Z8E9).
摘要翻译：本发明涉及治疗性抗体领域。它特别涉及实验动物中治疗性抗体的研究。本发明公开了一种检测从实验动物获得的样品中的治疗性抗体的方法，包括以下步骤：a）提供待分析的样品，b）将所述样品与结合治疗性抗体的抗体孵育，所述实验动物的免疫球蛋白，c）任选地使用适于选择性检测总体，活性或抗原结合的治疗性抗体的试剂培养所述样品，以及d）使（b）或（c）中形成的复合物与所述治疗性抗体。（MAB-M-R10Z8E9）使用针对存在于G类人免疫球蛋白的所有类别但不在任何实验动物的免疫球蛋白上的特定表位的单克隆抗体，除了黑猩猩的IgG。

2. 发明申请

US20080102474A1 Detection of a Therapeutic Antibody in an Experimental Animal 有权
标题翻译：实验动物中治疗性抗体的检测
公开(公告)号：US20080102474A1
公开(公告)日：2008-05-01
申请号：US11792910
申请日：2005-12-22
申请人： Helmut Lenz , Kay-Gunnar Stubenrauch
发明人： Helmut Lenz , Kay-Gunnar Stubenrauch
IPC分类号： G01N33/53
CPC分类号： G01N33/6854 , C07K16/4283
摘要： The present invention relates to the field of therapeutic antibodies. It especially relates to the study of therapeutic antibodies in an experimental animal. The present invention discloses a method of detecting a therapeutic antibody in a sample obtained from an experimental animal comprising the steps of a) providing the sample to be analyzed, b) incubating said sample with an antibody binding to a therapeutic antibody and not binding to the immunoglobulin of said experimental animal, c) optionally incubating said sample with a reagent appropriate for the selective detection of total, active or antigen-bound therapeutic antibody, and d) correlating the complex formed in (b) or (c) to the concentration of said therapeutic antibody. A monoclonal antibody directed to a certain epitope that is present on all classes of human immunoglobulin of class G, but not on the immunoglobulin of any experimental animal except on the IgG of chimpanzees was used (MAB-M-R10Z8E9).
摘要翻译：本发明涉及治疗性抗体领域。它特别涉及实验动物中治疗性抗体的研究。本发明公开了一种检测从实验动物获得的样品中的治疗性抗体的方法，包括以下步骤：a）提供待分析的样品，b）将所述样品与结合治疗性抗体的抗体孵育，所述实验动物的免疫球蛋白，c）任选地使用适于选择性检测总体，活性或抗原结合的治疗性抗体的试剂培养所述样品，以及d）使（b）或（c）中形成的复合物与所述治疗性抗体。（MAB-M-R10Z8E9）使用针对存在于G类人免疫球蛋白的所有类别但不在任何实验动物的免疫球蛋白上的特定表位的单克隆抗体，除了黑猩猩的IgG。

3. 发明授权

US08809005B2 Conjugate and its use as a standard in an immunoassay 有权
标题翻译：共轭及其在免疫测定中作为标准使用
公开(公告)号：US08809005B2
公开(公告)日：2014-08-19
申请号：US11941116
申请日：2007-11-16
申请人： Kay-Gunnar Stubenrauch , Rudolf Vogel , Uwe Wessels
发明人： Kay-Gunnar Stubenrauch , Rudolf Vogel , Uwe Wessels
IPC分类号： C07K16/42 , G01N33/543 , G01N33/553 , G01N33/563 , G01N33/68 , C07K16/46 , C12P21/08 , G01N21/59
CPC分类号： C07K16/4283 , C07K16/4208 , C07K16/4258 , C07K16/4291 , C07K16/461 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/54 , C07K2319/30 , G01N33/531 , G01N33/543 , G01N33/553 , G01N33/6857 , G01N33/686 , G01N2021/5903 , G01N2333/435 , G01N2800/24 , G01N2800/52
摘要： A composition comprising a conjugate of an anti-idiotype antibody specifically binding to a CDR region of a parent antibody and method of using polyclonal human serum immunoglobulin of class E, G, M, or A, and the use of said composition as a standard in an immunoassay is presented.
摘要翻译：一种组合物，其包含与亲本抗体的CDR区特异性结合的抗独特型抗体的缀合物和使用E，G，M或A类的多克隆人血清免疫球蛋白的方法，以及所述组合物作为标准的用途提供免疫测定。

4. 发明授权

US08614297B2 Anti-idiotype antibody against an antibody against the amyloid β peptide 有权
标题翻译：针对淀粉样β肽的抗体的抗独特型抗体
公开(公告)号：US08614297B2
公开(公告)日：2013-12-24
申请号：US12637833
申请日：2009-12-15
申请人： Ulrich Essig , Wolfgang Hoesel , Kay-Gunnar Stubenrauch , Rudolf Vogel
发明人： Ulrich Essig , Wolfgang Hoesel , Kay-Gunnar Stubenrauch , Rudolf Vogel
IPC分类号： C07K16/42 , C12P21/08 , C12N5/20
CPC分类号： G01N33/686 , C07K16/4241 , C07K2317/56 , C07K2317/565 , G01N2333/4709 , G01N2469/20
摘要： The present invention is directed to an anti-idiotype antibody binding to the complementary determining region of an antibody against the amyloid β peptide. In one embodiment said antibody binds to the same epitope or an overlapping epitope as the antibody obtainable from the cell line DSM ACC2939. Also reported is an immunoassay for the determination of an antibody against the amyloid β peptide and for determination of an anti-idiotype antibody binding to an antibody against the amyloid β peptide.
摘要翻译：本发明涉及与抗Aβ淀粉样蛋白抗体的互补决定区结合的抗独特型抗体。在一个实施方案中，所述抗体结合与从细胞系DSM ACC2939获得的抗体相同的表位或重叠表位。还报道了用于测定针对淀粉样蛋白β肽的抗体的免疫测定和用于测定与针对淀粉状蛋白β肽的抗体结合的抗独特型抗体。

5. 发明申请

US20120208216A1 NON-CROSS-REACTIVE ANTI IGG ANTIBODIES 有权
标题翻译：非交叉反应性抗IGG抗体
公开(公告)号：US20120208216A1
公开(公告)日：2012-08-16
申请号：US13502687
申请日：2010-10-18
申请人： Ulrich Essig , Stefan Klostermann , Frank Kowalewsky , Kay-Gunnar Stubenrauch , Rudolf Vogel , Uwe Wessels
发明人： Ulrich Essig , Stefan Klostermann , Frank Kowalewsky , Kay-Gunnar Stubenrauch , Rudolf Vogel , Uwe Wessels
IPC分类号： G01N33/53 , C12N5/071 , G01N33/82 , C07K16/18
CPC分类号： C07K16/4283 , G01N33/6854
摘要： Herein are reported the cell lines DSM ACC3006, DSM ACC3007, and DSM ACC3008, as well as the antibodies obtained from the cell lines and the use of an antibody obtained from the cell lines in an immunoassay. Also are reported antibodies binding to human or chimpanzee IgG and not binding to canine and marmoset IgG and antibodies specifically binding to an IgG1 that comprises a kappa light chain constant domain.
摘要翻译：本文报道了细胞系DSM ACC3006，DSM ACC3007和DSM ACC3008，以及从细胞系获得的抗体以及在免疫测定中从细胞系获得的抗体的用途。还报告了与人或黑猩猩IgG结合的抗体，并且不结合犬和m猴IgG以及特异性结合包含κ轻链恒定结构域的IgG1的抗体。

6. 发明授权

US07563441B2 Anti-P-selectin antibodies 有权
标题翻译：抗P-选择素抗体
公开(公告)号：US07563441B2
公开(公告)日：2009-07-21
申请号：US11102403
申请日：2005-04-08
申请人： Yvo Graus , Jacques Himber , Miranda Jansen-Molenaar , Dorothee Kling , Erhard Kopetzki , Paul Parren , Frank Rebers , Beat Steiner , Anne Stern , Pamela Strein , Kay-Gunnar Stubenrauch , Jan van de Winkel , Martine van Vugt
发明人： Yvo Graus , Jacques Himber , Miranda Jansen-Molenaar , Dorothee Kling , Erhard Kopetzki , Paul Parren , Frank Rebers , Beat Steiner , Anne Stern , Pamela Strein , Kay-Gunnar Stubenrauch , Jan van de Winkel , Martine van Vugt
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2854 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要： This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from critical limb ischemia or peripheral arterial occlusive disease (CLI/PAOD).
摘要翻译：本发明涉及抗P-选择素抗体，特别涉及含有源自人源的Fc部分并且不结合补体因子C1q的抗P-选择素抗体及其变体。这些抗体具有新的和本发明的性质，为患有严重肢体缺血或外周动脉闭塞性疾病（CLI / PAOD）的患者带来益处。

7. 发明申请

US20130323762A1 ANTI-IDIOTYPE ANTIBODY AGAINST AN ANTIBODY AGAINST THE AMYLOID BETA PEPTIDE 有权
标题翻译：抗抗原抗体对抗AMYLOID BETA肽的抗体
公开(公告)号：US20130323762A1
公开(公告)日：2013-12-05
申请号：US13960893
申请日：2013-08-07
申请人： Ulrich Essig , Wolfgang Hoesel , Kay-Gunnar Stubenrauch , Rudolf Vogel
发明人： Ulrich Essig , Wolfgang Hoesel , Kay-Gunnar Stubenrauch , Rudolf Vogel
IPC分类号： G01N33/68
CPC分类号： G01N33/686 , C07K16/4241 , C07K2317/56 , C07K2317/565 , G01N2333/4709 , G01N2469/20
摘要： The present invention is directed to an anti-idiotype antibody binding to the complementary determining region of an antibody against the amyloid β peptide. In one embodiment said antibody binds to the same epitope or an overlapping epitope as the antibody obtainable from the cell line DSM ACC2939. Also reported is an immunoassay for the determination of an antibody against the amyloid β peptide and for determination of an anti-idiotype antibody binding to an antibody against the amyloid β peptide.
摘要翻译：本发明涉及与抗Aβ淀粉样蛋白抗体的互补决定区结合的抗独特型抗体。在一个实施方案中，所述抗体结合与从细胞系DSM ACC2939获得的抗体相同的表位或重叠表位。还报道了用于测定针对淀粉样蛋白β肽的抗体的免疫测定和用于测定与针对淀粉状蛋白β肽的抗体结合的抗独特型抗体。

8. 再颁专利

USRE43568E1 Anti-P-selectin antibodies 有权
标题翻译：抗P-选择素抗体
公开(公告)号：USRE43568E1
公开(公告)日：2012-08-07
申请号：US13187586
申请日：2011-07-21
申请人： Yvo Graus , Jacques Himber , Miranda Jansen-Molenaar , Dorothee Kling , Erhard Kopetzki , Paul Parren , Frank Rebers , Beat Steiner , Anne Stern , Pamela Strein , Kay-Gunnar Stubenrauch , Jan Van de Winkel , Martine Van Vugt
发明人： Yvo Graus , Jacques Himber , Miranda Jansen-Molenaar , Dorothee Kling , Erhard Kopetzki , Paul Parren , Frank Rebers , Beat Steiner , Anne Stern , Pamela Strein , Kay-Gunnar Stubenrauch , Jan Van de Winkel , Martine Van Vugt
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2854 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要： This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from critical limb ischemia or peripheral arterial occlusive disease (CLI/PAOD).
摘要翻译：本发明涉及抗P-选择素抗体，特别涉及含有源自人源的Fc部分并且不结合补体因子C1q的抗P-选择素抗体及其变体。这些抗体具有新的和本发明的性质，为患有严重肢体缺血或外周动脉闭塞性疾病（CLI / PAOD）的患者带来益处。

9. 发明申请

US20110236388A1 BISPECIFIC, BIVALENT ANTI-VEGF/ANTI-ANG-2 ANTIBODIES 有权
标题翻译： BISPECIFIC，BIVALENT ANTI-VEGF / ANTI-ANG-2 ANTIBODIES
公开(公告)号：US20110236388A1
公开(公告)日：2011-09-29
申请号：US13071127
申请日：2011-03-24
申请人： Monika Baehner , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Kay-Gunnar Stubenrauch , Markus Thomas
发明人： Monika Baehner , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Kay-Gunnar Stubenrauch , Markus Thomas
IPC分类号： A61K39/395 , C07K16/22 , C07H21/00 , A61P9/00 , A61P35/00 , C12N15/63 , C12P21/02 , C12N5/10 , C12N1/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/3015 , C07K16/3046 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/56 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to bispecific, bivalent antibodies against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及针对人血管内皮生长因子（VEGF / VEGF-A）和针对人血管生成素-2（ANG-2）的双特异性二价抗体，其生产方法，含有所述抗体的药物组合物及其用途。

10. 发明申请

US20100304400A1 DISTINGUISHING ASSAY 有权
标题翻译：鉴别测定
公开(公告)号：US20100304400A1
公开(公告)日：2010-12-02
申请号：US12745565
申请日：2008-12-12
申请人： Kay-Gunnar Stubenrauch , Markus Zadak
发明人： Kay-Gunnar Stubenrauch , Markus Zadak
IPC分类号： G01N33/53
CPC分类号： G01N33/94 , G01N33/6854
摘要： The current invention comprises a method for determining of an antibody against a drug antibody in a sample using an immunoassay comprising a capture drug antibody and a tracer drug antibody, wherein the method comprises providing i) a capture drug antibody, which is the drug antibody conjugated to a solid phase, ii) a tracer drug antibody, which is the drug antibody conjugated to a detectable label, contacting the capture drug antibody separately with i) the sample, ii) the sample, to which the drug antibody in monomeric form has been added, iii) the sample, to which the drug antibody in oligomeric form has been added, and determining an antibody against the drug antibody in the sample by a positive immunoassay in i) and a negative immunoassay in ii) and iii).
摘要翻译：本发明包括使用包含捕获药物抗体和示踪药物抗体的免疫测定来测定样品中抗体的抗体的方法，其中所述方法包括提供i）捕获药物抗体，其为药物抗体缀合的 ii）示踪剂药物抗体，其是与可检测标记缀合的药物抗体，其将捕获药物抗体与i）样品分开接触，ii）样品，单体形式的药物抗体已经 iii）已经加入寡聚形式的药物抗体的样品，并且通过i）中的阳性免疫测定和ii）和iii）中的阴性免疫测定法确定样品中抗体的抗体。

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