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1. 发明申请

US20100199750A1 Microfludic Analysis System and Method 审中-公开
标题翻译：微流体分析系统与方法
公开(公告)号：US20100199750A1
公开(公告)日：2010-08-12
申请号：US12367407
申请日：2009-02-06
申请人： Don W. Arnold , Nicole E. Hebert , Patrick Leung , David W. Wyrick , Phillip H. Paul
发明人： Don W. Arnold , Nicole E. Hebert , Patrick Leung , David W. Wyrick , Phillip H. Paul
IPC分类号： G01N30/02 , G01N27/26
CPC分类号： B01L3/502715 , B01L2200/027 , B01L2200/10 , B01L2200/141 , B01L2300/021 , B01L2300/18
摘要： A microfluidic processing system having a manifold with at least one inlet; at least one outlet; and a plurality of microfluidic chip holders. A fluidic jumper is coupled to one of the chip holders and at least two fluidic elements are coupled to at least one of the chip holders. The fluidic jumper controls the fluidic path through the system.
摘要翻译：一种具有至少一个入口的歧管的微流体处理系统; 至少一个出口; 和多个微流体芯片保持器。流体跳线耦合到芯片保持器中的一个，并且至少两个流体元件耦合到至少一个芯片保持器。流体跳线控制通过系统的流体路径。

2. 发明申请

US20080182136A1 Microscale Electrochemical Cell And Methods Incorporating The Cell 审中-公开
标题翻译：微电极电化学电池和结合细胞的方法
公开(公告)号：US20080182136A1
公开(公告)日：2008-07-31
申请号：US11627877
申请日：2007-01-26
申请人： Don W. Arnold , Guifeng Jiang , Nicole E. Hebert
发明人： Don W. Arnold , Guifeng Jiang , Nicole E. Hebert
IPC分类号： H01M14/00 , G01N27/26
CPC分类号： G01N27/403 , G01N21/66 , G01N21/76 , G01N30/7233 , G01N30/74
摘要： An electrochemical cell for processing a sample fluid, has a body with a flow path, the flow path having an inlet and an outlet; a reference electrode in fluid communication with the flow path; a counter electrode in fluid communication with the flow path; a porous working electrode in fluid communication with the flow path, the working electrode having a working electrode material; an electrical connection for the working electrode in electrical contact with the working electrode; and a working electrode section in the flow path. The working electrode is positioned inside the working electrode section. The working electrode section has a volume of from about 1 pL to about 1 μL.
摘要翻译：用于处理样品流体的电化学电池具有带流路的主体，所述流路具有入口和出口; 与流路连通的基准电极; 与流路流体连通的对电极; 与所述流路流体连通的多孔工作电极，所述工作电极具有工作电极材料; 用于与工作电极电接触的工作电极的电连接; 和流路中的工作电极部。工作电极位于工作电极部分内。工作电极部分具有约1pL至约1μL的体积。

3. 发明授权

US08685218B2 Precision flow control system 有权
标题翻译：精密流量控制系统
公开(公告)号：US08685218B2
公开(公告)日：2014-04-01
申请号：US13046496
申请日：2011-03-11
申请人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
发明人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
IPC分类号： G05B24/04
CPC分类号： G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要： A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.
摘要翻译：精密流量控制器能够提供小于100微升/分钟的流量，并以规定的方式改变流速，既可预测又可再现，其中流量的精度和精度小于流量的5％。多个可变压力流体通过单个出口泵送流体。流量计测量流量，并且控制器将流量与所需流量进行比较，并且如果需要，调整多个可变压力流体供应，使得可变压力流体以期望的流速供应泵流体。可变压力流体供应可以气动驱动。

4. 发明授权

US06572749B1 Electrokinetic high pressure hydraulic system 有权
标题翻译：电动高压液压系统
公开(公告)号：US06572749B1
公开(公告)日：2003-06-03
申请号：US09912154
申请日：2001-07-23
申请人： Phillip H. Paul , David J. Rakestraw , Don W. Arnold , Kenneth R. Hencken , Joseph S. Schoeniger , David W. Neyer
发明人： Phillip H. Paul , David J. Rakestraw , Don W. Arnold , Kenneth R. Hencken , Joseph S. Schoeniger , David W. Neyer
IPC分类号： B05B500
CPC分类号： G01N30/32 , F04B19/006 , G01N2030/285 , G01N2030/326
摘要： An electrokinetic high pressure hydraulic pump for manipulating fluids in capillary-based system. The pump uses electro-osmotic flow to provide a high pressure hydraulic system, having no moving mechanical parts, for pumping and/or compressing fluids, for providing valve means and means for opening and closing valves, for controlling fluid flow rate, and manipulating fluid flow generally and in capillary-based systems (microsystems), in particular. The compact nature of the inventive high pressure hydraulic pump provides the ability to construct a micro-scale or capillary-based HPLC system that fulfills the desire for small sample quantity, low solvent consumption, improved efficiency, the ability to run samples in parallel, and field portability. Control of pressure and solvent flow rate is achieved by controlling the voltage applied to an electrokinetic pump.
摘要翻译：一种电动高压液压泵，用于在毛细管系统中操纵流体。泵使用电渗流提供高压液压系统，没有移动的机械部件，用于泵送和/或压缩流体，用于提供阀装置和用于打开和关闭阀门的装置，用于控制流体流速和操纵流体特别是在毛细管系统（微系统）中流动。本发明的高压液压泵的紧凑特性提供构建基于微量或基于毛细管的HPLC系统的能力，其满足对小样品量，低溶剂消耗，提高的效率，并行运行样品的能力的需求，以及现场可携带性。通过控制施加到电动泵的电压来实现压力和溶剂流速的控制。

5. 发明授权

US06460420B1 Flowmeter for pressure-driven chromatography systems 有权
标题翻译：用于压力驱动色谱系统的流量计
公开(公告)号：US06460420B1
公开(公告)日：2002-10-08
申请号：US09548474
申请日：2000-04-13
申请人： Phillip H. Paul , Don W. Arnold
发明人： Phillip H. Paul , Don W. Arnold
IPC分类号： G01F137
CPC分类号： G01N30/36 , B01D15/14 , B01D15/163 , G01F1/36 , G01N2030/324
摘要： A flowmeter for accurately measuring the flowrate of fluids in high pressure chromatography systems. The flowmeter is a porous bed of a material, the porous bed having a porosity in the range of about 0.1 to 0.6 and a pore size in the range of about 50 nm to 1 &mgr;m, disposed between a high pressure pumping means and a chromatography column. The flowmeter is provided with pressure measuring means at both the inlet and outlet of the porous bed for measuring the pressure drop through the porous bed. This flowmeter system provides not only the ability to measure accurately flowrates in the range of &mgr;L/min to nL/min but also to provide a signal that can be used for a servo loop or feedback control system for high pressure pumping systems.
摘要翻译：一种用于精确测量高压色谱系统中流体流量的流量计。流量计是材料的多孔床，多孔床的孔隙率在约0.1至0.6范围内，孔径在约50nm至1μm的范围内，设置在高压泵送装置和色谱柱之间。流量计在多孔床的入口和出口处设有压力测量装置，用于测量通过多孔床的压降。该流量计系统不仅提供了在muL / min至nL / min的范围内精确测量流量的能力，而且提供了可用于高压泵送系统的伺服回路或反馈控制系统的信号。

6. 发明授权

US07927477B2 Precision flow control system 有权
标题翻译：精密流量控制系统
公开(公告)号：US07927477B2
公开(公告)日：2011-04-19
申请号：US12334375
申请日：2008-12-12
申请人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
发明人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
IPC分类号： G05B24/04
CPC分类号： G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要： A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.
摘要翻译：精密流量控制器能够提供小于100微升/分钟的流量，并以规定的方式改变流速，既可预测又可再现，其中流量的精度和精度小于流量的5％。多个可变压力流体通过单个出口泵送流体。流量计测量流量，并且控制器将流量与所需流量进行比较，并且如果需要，调整多个可变压力流体供应，使得可变压力流体以期望的流速供应泵流体。可变压力流体供应可以气动驱动。

7. 发明授权

US07559356B2 Electrokinetic pump driven heat transfer system 有权
标题翻译：电动泵驱动传热系统
公开(公告)号：US07559356B2
公开(公告)日：2009-07-14
申请号：US10827799
申请日：2004-04-19
申请人： Phillip H. Paul , Deon S. Anex , Don W. Arnold
发明人： Phillip H. Paul , Deon S. Anex , Don W. Arnold
IPC分类号： F28D15/00
CPC分类号： G06F1/20 , C02F1/02 , C02F2001/46128 , F04B19/006 , F28D15/00 , F28D15/0266 , F28F2250/08 , G06F2200/201
摘要： A heat transfer system comprising a primary heat exchanger for receiving heat from a heat source; a secondary heat exchanger for exhausting heat to a heat sink; a conduit connecting the primary heat exchanger and the secondary heat exchanger; and an electrokinetic pump for pumping a heat exchange fluid between the primary heat exchanger and the secondary heat exchanger through the conduit.
摘要翻译：一种传热系统，包括用于从热源接收热量的主热交换器; 用于将热量排放到散热器的二次热交换器; 连接主热交换器和二次热交换器的导管; 以及用于在主热交换器和次级热交换器之间通过导管泵送热交换流体的电动泵。

8. 发明申请

US20090090174A1 Precision Flow Control System 有权
标题翻译：精密流量控制系统
公开(公告)号：US20090090174A1
公开(公告)日：2009-04-09
申请号：US12334375
申请日：2008-12-12
申请人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
发明人： Phillip H. Paul , Jason E. Rehm , Don W. Arnold
IPC分类号： G01N30/32 , B01D35/14 , G05D7/06
CPC分类号： G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要： A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.
摘要翻译：精密流量控制器能够提供小于100微升/分钟的流量，并以规定的方式改变流速，既可预测又可再现，其中流量的精度和精度小于流量的5％。多个可变压力流体通过单个出口泵送流体。流量计测量流量，并且控制器将流量与所需流量进行比较，并且如果需要，调整多个可变压力流体供应，使得可变压力流体以期望的流速供应泵流体。可变压力流体供应可以气动驱动。

9. 发明授权

US06287440B1 Method for eliminating gas blocking in electrokinetic pumping systems 有权
标题翻译：在动力泵送系统中消除气体阻塞的方法
公开(公告)号：US06287440B1
公开(公告)日：2001-09-11
申请号：US09336535
申请日：1999-06-18
申请人： Don W. Arnold , Phillip H. Paul , Joseph S. Schoeniger
发明人： Don W. Arnold , Phillip H. Paul , Joseph S. Schoeniger
IPC分类号： B01D5702
CPC分类号： F04B53/06 , F04B19/006
摘要： A method for eliminating gas bubble blockage of current flow during operation of an electrokinetic pump. By making use of the ability to modify the surface charge on the porous dielectric medium used in electrokinetic pumps, it becomes possible to place electrodes away from the pressurized region of the electrokinetic pump. While gas is still generated at the electrodes they are situated such that the generated gas can escape into a larger buffer reservoir and not into the high pressure region of the pump where the gas bubbles can interrupt current flow. Various combinations of porous dielectric materials and ionic conductors can be used to create pumps that have desirable electrical, material handling, and flow attributes.
摘要翻译：一种在电动泵运行过程中消除气流阻塞电流的方法。通过利用在电动泵中使用的多孔介电介质上的表面电荷的修饰能力，可以将电极放置在电动泵的加压区域之外。虽然在电极处仍然产生气体，但是它们被定位成使得所产生的气体可以逸出到更大的缓冲容器中，而不会进入泵的高压区域，在该高压区域中气泡可以中断电流。可以使用多孔介电材料和离子导体的各种组合来产生具有期望的电气，材料处理和流动属性的泵。

10. 发明授权

US06277257B1 Electrokinetic high pressure hydraulic system 有权
标题翻译：电动高压液压系统
公开(公告)号：US06277257B1
公开(公告)日：2001-08-21
申请号：US09271687
申请日：1999-03-18
申请人： Phillip H. Paul , David J. Rakestraw , Don W. Arnold , Kenneth R. Hencken , Joseph S. Schoeniger , David W. Neyer
发明人： Phillip H. Paul , David J. Rakestraw , Don W. Arnold , Kenneth R. Hencken , Joseph S. Schoeniger , David W. Neyer
IPC分类号： B01D6144
CPC分类号： G01N30/32 , F04B19/006 , G01N2030/285 , G01N2030/326
摘要： An electrokinetic high pressure hydraulic pump for manipulating fluids in capillary-based systems. The pump uses electro-osmotic flow to provide a high pressure hydraulic system, having no moving mechanical parts, for pumping and/or compressing fluids, for providing valve means and means for opening and closing valves, for controlling fluid flow rate, and manipulating fluid flow generally and in capillary-based systems (Microsystems), in particular. The compact nature of the inventive high pressure hydraulic pump provides the ability to construct a micro-scale or capillary-based HPLC system that fulfills the desire for small sample quantity, low solvent consumption, improved efficiency, the ability to run samples in parallel, and field portability. Control of pressure and solvent flow rate is achieved by controlling the voltage applied to an electrokinetic pump.
摘要翻译：一种电动高压液压泵，用于在毛细管系统中操纵流体。泵使用电渗流提供高压液压系统，没有移动的机械部件，用于泵送和/或压缩流体，用于提供阀装置和用于打开和关闭阀门的装置，用于控制流体流速和操纵流体特别是在毛细管系统（Microsystems）中通常流动。本发明的高压液压泵的紧凑特性提供构建基于微量或基于毛细管的HPLC系统的能力，其满足对小样品量，低溶剂消耗，提高的效率，并行运行样品的能力的需求，以及现场可携带性。通过控制施加到电动泵的电压来实现压力和溶剂流速的控制。

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