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1. 发明申请

US20060140858A1 Drug pre-targeting by means of bi-specific antibodies and hapten constructs comprising a carrier peptide and the active agent(s) 审中-公开
标题翻译：通过双特异性抗体和包含载体肽和活性剂的半抗原构建体的药物预靶向，
公开(公告)号：US20060140858A1
公开(公告)日：2006-06-29
申请号：US10514632
申请日：2003-05-16
申请人： David Goldenberg , Hans Hansen , Shui-on Leung , William McBride , Zhengxing Gu
发明人： David Goldenberg , Hans Hansen , Shui-on Leung , William McBride , Zhengxing Gu
IPC分类号： A61K49/14 , A61K51/00 , C07K7/06
CPC分类号： A61K51/1048 , A61K47/665 , A61K47/6879 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/0215 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2319/00
摘要： The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds the targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the targetable constructs and bi-specific antibodies or antibody fragments, as well as methods for using them.
摘要翻译：本发明涉及可靶向的构建体，其可以由具有特异性结合靶组织的至少一个臂的双特异性抗体或抗体片段和至少一个特异性结合可靶向构建体的其它臂结合。可靶向构建体包含载体部分，其包含或携带至少一个可被所述双特异性抗体或抗体片段的至少一个臂识别的表位。可靶向构建物还包含一种或多种治疗剂或诊断剂或酶。本发明提供用于产生可靶向构建体和双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法。

2. 发明授权

US08187470B2 Enhancing sedimentation performance of clarifiers/thickeners 有权
标题翻译：提高澄清池/增稠剂的沉降性能
公开(公告)号：US08187470B2
公开(公告)日：2012-05-29
申请号：US12727326
申请日：2010-03-19
申请人： Guoxin Wang , Zhengxing Gu , Edward W. Gannon
发明人： Guoxin Wang , Zhengxing Gu , Edward W. Gannon
IPC分类号： C02F1/52 , B01D21/01
CPC分类号： C02F11/14 , C02F1/52
摘要： Some mineral processing plants encounter difficulties in dewatering pulps using clarifier/thickener (C/T) equipment due to a layer of fine particles, air bubbles and chemicals formed at the top of the liquid in the thickener. Such layers are very stable and form a cap on the C/T. The dewatering performance of the C/T then deteriorates under these conditions, and a high percentage of solids is contained in the thickener overflow. A process for removing water from rock slurry containing a wide range of particle sizes in mineral processing operations has been developed. The process includes: (a) classifying the feed slurry into two size fractions, namely a coarse fraction and a fine fraction, (b) treating the fine fraction (and the coarse fraction if required) with a selected flocculant, and (3) thickening the flocculated slurry in sedimentation equipment to separate liquid from solids.
摘要翻译：一些矿物加工厂由于在增稠器的液体顶部形成一层细小颗粒，气泡和化学物质，使用澄清器/增稠器（C / T）设备在脱浆纸浆中遇到困难。这些层是非常稳定的，并在C / T上形成一个盖子。在这些条件下，C / T的脱水性能变差，并且在增稠器溢流中含有高比例的固体。已经开发了一种在矿物加工操作中从含有大范围粒度的岩浆中去除水的方法。该方法包括：（a）将进料浆料分选成两个大小的馏分，即粗馏分和细馏分，（b）用选定的絮凝剂处理细馏分（和粗馏分），和（3）增稠沉淀设备中的絮凝浆液将液体与固体分离。

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