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1. 发明授权

US06723710B2 Compositions for inhibiting arginase activity 有权
标题翻译：抑制精氨酸酶活性的组合物
公开(公告)号：US06723710B2
公开(公告)日：2004-04-20
申请号：US10053939
申请日：2002-01-23
申请人： David Christianson , Ricky Baggio , Daniel Elbaum
发明人： David Christianson , Ricky Baggio , Daniel Elbaum
IPC分类号： A61K3169
CPC分类号： A61K31/195 , A61K31/69 , C07F5/025
摘要： Compositions and methods for inhibiting arginase activity, including arginase activity in a mammal, are provided. Methods of making the compositions of the invention are also provided as are methods of using the compositions therapeutically. The compositions described herein are useful for alleviating or inhibiting a variety of arinase- and NO synthase-related disorders, including heart disease, gastrointestinal motility disorders, and penile erectile dysfunction in humans.
摘要翻译：提供了抑制精氨酸酶活性的组合物和方法，包括哺乳动物中的精氨酸酶活性。还提供了制备本发明组合物的方法，就是使用该组合物治疗的方法。本文描述的组合物可用于缓解或抑制人类中的多种arinase-和NO合酶相关病症，包括心脏病，胃肠蠕动障碍和阴茎勃起功能障碍。

2. 发明授权

US06387890B1 Compositions and methods for inhibiting arginase activity 有权
标题翻译：抑制精氨酸酶活性的组合物和方法
公开(公告)号：US06387890B1
公开(公告)日：2002-05-14
申请号：US09545737
申请日：2000-04-10
申请人： David Christianson , Ricky Baggio , Daniel Elbaum
发明人： David Christianson , Ricky Baggio , Daniel Elbaum
IPC分类号： A61K3169
CPC分类号： A61K31/195 , A61K31/69 , C07F5/025
摘要： Compositions and methods for inhibiting arginase activity, including arginase activity in a mammal, are provided. Methods of making the compositions of the invention are also provided as are methods of using the compositions therapeutically. The compositions described herein are useful for alleviating or inhibiting a variety of arinase- and NO synthase-related disorders, including heart diseae, gastrointestinal motility disorders, and penile erectile dysfunction in humans.
摘要翻译：提供了抑制精氨酸酶活性的组合物和方法，包括哺乳动物中的精氨酸酶活性。还提供了制备本发明组合物的方法，就是使用该组合物治疗的方法。本文所述的组合物可用于减轻或抑制人类中的多种arinase-和NO合酶相关病症，包括心脏病，胃肠蠕动障碍和阴茎勃起功能障碍。

3. 发明授权

US07842491B2 Determination of metal ions in solution by photoluminescence anisotropy 有权
标题翻译：通过光致发光各向异性测定溶液中的金属离子
公开(公告)号：US07842491B2
公开(公告)日：2010-11-30
申请号：US10982956
申请日：2004-11-08
申请人： Richard B. Thompson , Daniel Elbaum , Vincent L. Feliccia , David Christianson , Marcia W. Patchan , Zhengfang Ge , Badri P. Maliwal
发明人： Richard B. Thompson , Daniel Elbaum , Vincent L. Feliccia , David Christianson , Marcia W. Patchan , Zhengfang Ge , Badri P. Maliwal
IPC分类号： C12Q1/34 , C12Q1/00 , G01N21/00 , G01N33/20
CPC分类号： G01N33/542 , C12N9/88 , G01N21/6445 , Y10S435/975
摘要： The invention relates to compositions and kits for homogeneous fluorescence polarization (anisotropy) assays for detecting and quantifying metal ions in solution. Metal-dependent binding of a fluorescent ligand to an unlabeled macromolecule effects a measurable change in anisotropy as will the binding of metal ions to a fluorescent labeled macromolecule. Binding of the fluorescent ligand to the unlabeled macromolecule is metal dependent with the change in anisotropy being proportional to the concentration of bound metal ions. Conversely, if the fluorescent label is first conjugated to a macromolecule and the macromolecule is subsequently stripped of metal ion, it may then be used to signal binding of metal ions. The covalently bound fluorescent label exhibits changes in anisotropy proportional to the concentration of bound metal ions. Kits comprise a fluorescent molecule and a macromolecule.
摘要翻译：本发明涉及用于检测和定量溶液中的金属离子的均匀荧光偏振（各向异性）测定的组合物和试剂盒。荧光配体与未标记的大分子的金属依赖性结合影响各向异性的可测量的变化，以及金属离子与荧光标记的大分子的结合。荧光配体与未标记的大分子的结合是金属依赖性的，各向异性的变化与结合的金属离子的浓度成比例。相反，如果荧光标记首先与大分子缀合并且随后大分子被金属离子剥离，则可以用它来信号结合金属离子。共价结合的荧光标记表现出与结合金属离子浓度成比例的各向异性变化。试剂盒包含荧光分子和大分子。

4. 发明申请

US20050250170A1 Determination of metal ions in solution by photoluminescence anisotropy 有权
标题翻译：通过光致发光各向异性测定溶液中的金属离子
公开(公告)号：US20050250170A1
公开(公告)日：2005-11-10
申请号：US10982956
申请日：2004-11-08
申请人： Richard Thompson , Daniel Elbaum , Vincent Feliccia , David Christianson , Marcia Patchan , Zhengfang Ge , Badri Maliwal
发明人： Richard Thompson , Daniel Elbaum , Vincent Feliccia , David Christianson , Marcia Patchan , Zhengfang Ge , Badri Maliwal
IPC分类号： C12N9/16 , C12N9/88 , C12Q1/34 , G01N21/64 , G01N33/20 , G01N33/542
CPC分类号： G01N33/542 , C12N9/88 , G01N21/6445 , Y10S435/975
摘要： The invention relates to compositions and kits for homogeneous fluorescence polarization (anisotropy) assays for detecting and quantifying metal ions in solution. Metal-dependent binding of a fluorescent ligand to an unlabeled macromolecule effects a measurable change in anisotropy as will the binding of metal ions to a fluorescent labeled macromolecule. Binding of the fluorescent ligand to the unlabeled macromolecule is metal dependent with the change in anisotropy being proportional to the concentration of bound metal ions. Conversely, if the fluorescent label is first conjugated to a macromolecule and the macromolecule is subsequently stripped of metal ion, it may then be used to signal binding of metal ions. The covalently bound fluorescent label exhibits changes in anisotropy proportional to the concentration of bound metal ions. Kits comprise a fluorescent molecule and a macromolecule.
摘要翻译：本发明涉及用于检测和定量溶液中的金属离子的均匀荧光偏振（各向异性）测定的组合物和试剂盒。荧光配体与未标记的大分子的金属依赖性结合影响各向异性的可测量变化，以及金属离子与荧光标记的大分子的结合。荧光配体与未标记的大分子的结合是金属依赖性的，各向异性的变化与结合的金属离子的浓度成比例。相反，如果首先将荧光标记与大分子缀合并且随后剥离大分子金属离子，则可以用它来信号结合金属离子。共价结合的荧光标记表现出与结合金属离子浓度成比例的各向异性变化。试剂盒包含荧光分子和大分子。

5. 发明授权

US06284544B1 Determination of metal ions in solution by photoluminescence anisotropy 失效
标题翻译：通过光致发光各向异性测定溶液中的金属离子
公开(公告)号：US06284544B1
公开(公告)日：2001-09-04
申请号：US09071351
申请日：1998-04-30
申请人： Richard B. Thompson , Daniel Elbaum , Vincent L. Feliccia , David Christianson , Marcia W. Patchan , Zhengfang Ge , Badri P. Maliwal
发明人： Richard B. Thompson , Daniel Elbaum , Vincent L. Feliccia , David Christianson , Marcia W. Patchan , Zhengfang Ge , Badri P. Maliwal
IPC分类号： G01N3320
CPC分类号： G01N33/542 , G01N21/6445 , G01N33/20 , G01N33/582 , G01N2333/988
摘要： Homogeneous fluorescence polarization (anisotropy) assays for detecting and quantifying metal ions in solution, based the metal-dependent binding of a fluorescent ligand to an unlabeled macromolecule, or the binding of a metal ion to a fluorescent labeled macromolecule. The metal-dependent binding of a fluorescent ligand to an unlabeled macromolecule (metallo-macromolecule) effects a measurable change in anisotropy as will the binding of metal ions to a fluorescent labeled macromolecule. Binding of the fluorescent ligand to the unlabeled macromolecule is metal dependent with the change in anisotropy being proportional to the concentration of bound metal ions. No binding of the fluorescent ligand to the macromolecule occurs in the absence of metal ions. Conversely, if the fluorescent label is first conjugated to a metallo-macromolecule and the metallo-macromolecule is subsequently stripped of its metal ion, it may then be used to transduce the binding of metal ions. Transduction is provided wherein the covalently bound fluorescent label exhibits changes in anisotropy proportional to the concentration of bound metal ions. In all methods, the change in anisotropy may be simply related to the metal ion concentration of the test solution.
摘要翻译：基于荧光配体与未标记的大分子的金属依赖性结合，或金属离子与荧光标记的大分子的结合，用于检测和定量溶液中的金属离子的均匀荧光偏振（各向异性）测定。荧光配体与未标记的大分子（金属 - 大分子）的金属依赖性结合对金属离子与荧光标记的大分子的结合将产生各向异性的可测量的变化。荧光配体与未标记的大分子的结合是金属依赖性的，各向异性的变化与结合的金属离子的浓度成比例。在不存在金属离子的情况下，不发生荧光配体与大分子的结合。相反，如果荧光标记首先与金属 - 大分子缀合，并且金属 - 大分子随后被其金属离子剥离，则其可用于转导金属离子的结合。提供转导，其中共价结合的荧光标记表现出与结合的金属离子浓度成比例的各向异性变化。在各种方法中，各向异性的变化可能与测试溶液的金属离子浓度有关。

6. 发明申请

US20070042199A1 Anti-fouling materials containing cationic polysiloxanes 有权
标题翻译：含有阳离子聚硅氧烷的防污材料
公开(公告)号：US20070042199A1
公开(公告)日：2007-02-22
申请号：US11429923
申请日：2006-05-08
申请人： Bret Chisholm , Philip Boudjouk , Johnson Thomas , David Christianson , Shane Stafslien
发明人： Bret Chisholm , Philip Boudjouk , Johnson Thomas , David Christianson , Shane Stafslien
IPC分类号： B32B27/00 , C08G77/04 , C08L83/04
CPC分类号： B63B59/04 , C08G77/385 , C09D5/1675 , C09D179/02 , C09D183/04 , C09D183/10 , C09D183/14 , Y10T428/31663 , C08L2666/44
摘要： Polyamine cross-linked polysiloxanes, such as functionalized polysiloxane cross-linked with a polyalkylenepolyamine are described herein. The polyamine cross-linked polysiloxanes may be used in an antifouling composition to prevent biological fouling in marine environments.
摘要翻译：多胺交联聚硅氧烷，例如与聚亚烷基多胺交联的官能化聚硅氧烷。多胺交联聚硅氧烷可用于防污组合物中以防止海洋环境中的生物污染。

7. 发明申请

US20060265410A1 Method and apparatus for storing semi-structured data in a structured manner 有权
公开(公告)号：US20060265410A1
公开(公告)日：2006-11-23
申请号：US11493786
申请日：2006-07-25
申请人： David Christianson , Denise Draper , Konstantin Kommissarchik
发明人： David Christianson , Denise Draper , Konstantin Kommissarchik
IPC分类号： G06F7/00
CPC分类号： G06F17/30923 , Y10S707/99943
摘要： In response to the provision of a collection of semi-structured data (or its schema), a mapper generates a structured organization to store the collection of semi-structured data. The mapper further collaterally generates a description of how the semi-structured data are stored under the structured organization. In one embodiment, normalized relational tables are used for the structured organization. In alternate embodiments, non-normalized relational tables or other structured organization may also be used. The reverse, that is, the creation of a semistructured data organization for a collection of structured data may also be performed.

8. 发明申请

US20130002422A1 WIRELESS SHELF PUSHER ACTIVITY DETECTION SYSTEM AND ASSOCIATED METHODS 有权
标题翻译：无线手提式推动器活动检测系统及相关方法
公开(公告)号：US20130002422A1
公开(公告)日：2013-01-03
申请号：US13493627
申请日：2012-06-11
申请人： Brian Wiese , David Christianson , Mark Shafer
发明人： Brian Wiese , David Christianson , Mark Shafer
IPC分类号： G08B1/08
CPC分类号： G08B13/08 , G08B13/1654
摘要： According to some example embodiments, systems, apparatus, methods, computer readable media, and computer program products are provided for implementing a wireless shelf pusher activity detection system. One example apparatus is a monitoring device for monitoring theft or sales activity associated with a product pusher device. The monitoring device may include a sensor configured to detect movement of a pusher member of the product pusher device, a wireless communications interface, and a processor. The processor may be configured to receive at least one sensor signal from the sensor indicating movement of the pusher member, determine a product movement activity type based on characteristics of the at least one sensor signal, and generate, for transmission via the wireless communications interface, a pusher activity message indicating the product movement activity type.
摘要翻译：根据一些示例性实施例，提供了系统，装置，方法，计算机可读介质和计算机程序产品，用于实现无线货架推动器活动检测系统。一个示例性装置是用于监视与产品推送装置相关联的盗窃或销售活动的监视装置。监视装置可以包括被配置为检测产品推动装置的推动构件的移动的传感器，无线通信接口和处理器。处理器可以被配置为从传感器接收至少一个传感器信号，指示推动器构件的移动，基于至少一个传感器信号的特性来确定产品运动活动类型，并且为了经由无线通信接口进行传输，指示产品运动活动类型的推送器活动消息。

9. 发明授权

US06616502B1 Toys with sensors generally 失效
标题翻译：玩具与传感器一般
公开(公告)号：US06616502B1
公开(公告)日：2003-09-09
申请号：US10077666
申请日：2002-02-19
申请人： Elizabeth Pacza-Steim , David Christianson
发明人： Elizabeth Pacza-Steim , David Christianson
IPC分类号： A63H3300
CPC分类号： A63H3/00 , A63H2200/00
摘要： A toy with electronic sensing mechanism is disclosed. Specifically, the toy can detect the presence of an electrically conductive material and respond accordingly. Particularly disclosed is the use of modeling dough as the conductive material which allows a broad flexibility of play and response.
摘要翻译：公开了一种具有电子感应机构的玩具。具体地说，玩具可以检测导电材料的存在并作出相应的响应。特别公开的是使用模型面团作为导电材料，其允许播放和响应的广泛灵活性。

10. 发明授权

US6085186A Method and system using information written in a wrapper description language to execute query on a network 失效
标题翻译：方法和系统使用以包装器描述语言编写的信息，以在网络上执行查询
公开(公告)号：US6085186A
公开(公告)日：2000-07-04
申请号：US933782
申请日：1997-09-19
申请人： David Christianson , Robert B. Doorenbos , Oren Etzioni , Chung Kwok , Gregory Lauckhart , Erik Selberg , Daniel S. Weld
发明人： David Christianson , Robert B. Doorenbos , Oren Etzioni , Chung Kwok , Gregory Lauckhart , Erik Selberg , Daniel S. Weld
IPC分类号： G06F13/00 , G06F17/30 , H04L29/06 , H04L29/08
CPC分类号： G06F17/30864 , H04L29/06 , H04L67/02 , H04L67/2814 , H04L67/2819 , H04L67/2823 , H04L69/329 , H04L67/16 , Y10S707/99932 , Y10S707/99933 , Y10S707/99935 , Y10S707/99944
摘要： This invention provides assistance to a user in accessing network attached information sources. In one aspect, the invention is a method for intelligently routing a user query to information sources relevant to that query, extracting relevant data fields from received responses, and intelligently presenting the extracted data in order of estimated relevance. The system of this invention implements one or more steps of the method in a centralized or distributed manner on one or more network attached computers. Further, this invention provides a novel language and implementation that facilitates easily written and maintained descriptions of information source query and response formats.
摘要翻译：本发明提供对用户访问网络附加信息源的帮助。一方面，本发明是用于将用户查询智能地路由到与该查询相关的信息源的方法，从接收的响应中提取相关数据字段，并且以估计的相关性的顺序智能地呈现所提取的数据。本发明的系统在一个或多个网络连接的计算机上以集中或分布的方式实现该方法的一个或多个步骤。此外，本发明提供了一种新颖的语言和实现，其便于容易地编写和维护信息源查询和响应格式的描述。

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