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1. 发明授权

US08808681B2 Crosslinked, degradable polymers and uses thereof 有权
标题翻译：交联的可降解聚合物及其用途
公开(公告)号：US08808681B2
公开(公告)日：2014-08-19
申请号：US11758078
申请日：2007-06-05
申请人： Daniel Griffith Anderson , Jason Alan Burdick , Robert S. Langer
发明人： Daniel Griffith Anderson , Jason Alan Burdick , Robert S. Langer
IPC分类号： A61K47/32 , A61K35/00 , C08F2/48 , C08G73/00 , C08F299/04 , C08F290/06 , C08F283/00 , C08G73/02 , C08F299/02 , C08L79/02 , C08G63/685
CPC分类号： C08L79/02 , C08F283/00 , C08F290/06 , C08F290/061 , C08F290/065 , C08F299/024 , C08F299/0485 , C08G63/6858 , C08G73/02
摘要： Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture for cross-linking is heated or exposed to light depending on the initiator used. The resulting materials due to the hydrolysable ester bond in the polymer backbone are biodegradable under physiological conditions. These cross-linked materials are particular useful as drug delivery vehicles, tissue engineering scaffolds, and in fabricating microdevices. The materials may also be used as plastics, coating, adhesives, inks, etc. The cross-linked materials prepared exhibit a wide range of degradation times, mass loss profiles, and mechanical properties. Therefore, the properties of the material may be tuned for the desired use. The high-throughput approach to preparing a library of cross-linked poly(beta-amino esters) allows for the rapid screening and design of degradable polymers for a variety of applications.
摘要翻译：丙烯酸酯封端的聚（β-氨基酯）被交联以形成用于医疗和非医学领域的材料。将聚合起始材料与自由基引发剂，热引发剂或光引发剂组合，并且根据所使用的引发剂将用于交联的混合物加热或暴露于光。由于聚合物骨架中的可水解的酯键导致的所得材料在生理条件下是可生物降解的。这些交联材料特别用作药物递送载体，组织工程支架和制造微型装置。这些材料也可以用作塑料，涂料，粘合剂，油墨等。制备的交联材料表现出广泛的降解时间，质量损失曲线和机械性能。因此，可以调整材料的性质以达到期望的用途。制备交联聚（β-氨基酯）文库的高通量方法允许快速筛选和设计可降解聚合物用于各种应用。

2. 发明申请

US20080145338A1 CROSSLINKED, DEGRADABLE POLYMERS AND USES THEREOF 有权
标题翻译：交联，可降解的聚合物及其用途
公开(公告)号：US20080145338A1
公开(公告)日：2008-06-19
申请号：US11758078
申请日：2007-06-05
申请人： Daniel Griffith Anderson , Jason Alan Burdick , Robert S. Langer
发明人： Daniel Griffith Anderson , Jason Alan Burdick , Robert S. Langer
IPC分类号： A61K47/32 , C08G73/00 , C08F2/48 , A61K35/00
CPC分类号： C08L79/02 , C08F283/00 , C08F290/06 , C08F290/061 , C08F290/065 , C08F299/024 , C08F299/0485 , C08G63/6858 , C08G73/02
摘要： Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture for cross-linking is heated or exposed to light depending on the initiator used. The resulting materials due to the hydrolysable ester bond in the polymer backbone are biodegradable under physiological conditions. These cross-linked materials are particular useful as drug delivery vehicles, tissue engineering scaffolds, and in fabricating microdevices. The materials may also be used as plastics, coating, adhesives, inks, etc. The cross-linked materials prepared exhibit a wide range of degradation times, mass loss profiles, and mechanical properties. Therefore, the properties of the material may be tuned for the desired use. The high-throughput approach to preparing a library of cross-linked poly(beta-amino esters) allows for the rapid screening and design of degradable polymers for a variety of applications.
摘要翻译：丙烯酸酯封端的聚（β-氨基酯）被交联以形成用于医疗和非医学领域的材料。将聚合起始材料与自由基引发剂，热引发剂或光引发剂组合，并且根据所使用的引发剂将用于交联的混合物加热或暴露于光。由于聚合物骨架中的可水解的酯键导致的所得材料在生理条件下是可生物降解的。这些交联材料特别用作药物递送载体，组织工程支架和制造微型装置。这些材料也可以用作塑料，涂料，粘合剂，油墨等。制备的交联材料表现出广泛的降解时间，质量损失曲线和机械性能。因此，可以调整材料的性质以达到期望的用途。制备交联聚（β-氨基酯）文库的高通量方法允许快速筛选和设计可降解聚合物用于各种应用。

3. 发明申请

US20130302401A1 POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF 有权
标题翻译：聚（氨基 - 氨基醇），其制备及其用途
公开(公告)号：US20130302401A1
公开(公告)日：2013-11-14
申请号：US13819280
申请日：2011-08-26
申请人： Minglin Ma , Wendy F. Liu , Robert S. Langer , Daniel Griffith Anderson
发明人： Minglin Ma , Wendy F. Liu , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： C08G73/02 , C09D179/02
CPC分类号： C08G73/0206 , A61K9/1273 , A61K31/7088 , A61K47/34 , A61K47/59 , A61L31/10 , C08G59/22 , C08G59/306 , C08G59/50 , C08G73/02 , C09D5/1637 , C09D179/02 , Y10T428/31725
摘要： A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.
摘要翻译：使用组合聚合制备了一类新的聚（β-氨基醇）（PBAAs）。本发明的PBAAs可用于生物技术和生物医学应用中，作为涂层（例如用于医疗装置或植入物的膜或多层膜的涂层），添加剂，材料，赋形剂，非生物污垢剂，微图案化剂和细胞包封剂。当用作表面涂层时，这些PBAAs根据其化学结构在体外和体内引起不同程度的炎症。这类材料的大化学多样性使我们能够鉴定体外抑制巨噬细胞活化的聚合物涂层。此外，在皮下植入羧化聚苯乙烯微粒之后，这些涂层减少了炎性细胞的募集，并减少了纤维化。这些聚合物可用于形成用于细胞包封的聚电解质复合物胶囊。本发明还可以具有许多其他生物学应用，例如抗微生物涂层，DNA或siRNA递送以及干细胞组织工程。

4. 发明申请

US20110293703A1 AMINOALCOHOL LIPIDOIDS AND USES THEREOF 有权
标题翻译：氨基酚脂质体及其用途
公开(公告)号：US20110293703A1
公开(公告)日：2011-12-01
申请号：US13128020
申请日：2009-11-06
申请人： Kerry Peter Mahon , Kevin Thomas Love , Christopher G. Levins , Kathryn Ann Whitehead , Robert S. Langer , Daniel Griffith Anderson
发明人： Kerry Peter Mahon , Kevin Thomas Love , Christopher G. Levins , Kathryn Ann Whitehead , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： A61K9/127 , C07C217/42 , C07C215/18 , C07H21/00 , A61K47/18 , A61K38/02 , A61K31/7088 , A61K31/7105 , C07D295/13 , C07C215/42
CPC分类号： C07D295/13 , A61K9/107 , A61K9/1271 , A61K9/5123 , A61K31/7088 , A61K38/02 , A61K47/16 , A61K47/54 , A61K47/545 , A61K48/0025 , B01J2531/0252 , B01J2531/845 , C07C215/14 , C07C217/08 , C12N15/111 , C12N15/1137 , C12N15/88 , C12N2310/14 , C12N2310/3515 , C12N2320/32
摘要： Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
摘要翻译：氨基醇类固醇通过使胺与环氧化物封端的化合物反应来制备。还提供了从市售的原料制备氨基醇类固醇的方法。氨基醇类固醇可以由外消旋或立体化学纯环氧化物制备。氨基醇类固醇或其盐形式优选是可生物降解的和生物相容的并且可以用于各种药物递送系统中。鉴于这些氨基醇类脂质化合物的氨基部分，它们特别适用于递送多核苷酸。已经制备了含有本发明的类脂和多核苷酸的复合物，胶束，脂质体或颗粒。本发明的类脂质也可用于制备用于药物递送的微粒。考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。

5. 发明申请

US20110077216A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF ATHEROSCLEROSIS AND OTHER RELATED DISEASES 审中-公开
标题翻译：用于治疗甲状腺功能亢进症和其他相关疾病的组合物和方法
公开(公告)号：US20110077216A1
公开(公告)日：2011-03-31
申请号：US12895278
申请日：2010-09-30
申请人： Christian Kastrup , Daniel Griffith Anderson , Robert S. Langer , Haeshin Lee , Matthias Nahrendorf , Ralph Weissleder , Jose Luiz Figueiredo
发明人： Christian Kastrup , Daniel Griffith Anderson , Robert S. Langer , Haeshin Lee , Matthias Nahrendorf , Ralph Weissleder , Jose Luiz Figueiredo
IPC分类号： A61K31/728 , A61P9/10 , C08B37/04 , A61K31/734 , C07C237/20 , A61K31/165
CPC分类号： A61K47/6903 , A61K47/60 , A61K47/61
摘要： The present invention provides compositions and methods for the treatment of atherosclerosis and other related diseases. In some embodiments, a method comprises providing a composition and forming a coating of the composition on at least a portion of the interior and/or exterior surface of a tissue lumen or other body surface. The composition may remain associated with the tissue lumen or other body surface even in the presence of a strong flow of a fluid (e.g., blood flow in a blood vessel). The composition may associate with the tissue lumen via a plurality of covalent bonds. In some cases, the compositions may comprise at least one additive, for example, a therapeutically active agent or an imaging agent.
摘要翻译：本发明提供了治疗动脉粥样硬化和其它相关疾病的组合物和方法。在一些实施方案中，方法包括提供组合物并在组织内腔或其他身体表面的内部和/或外表面的至少一部分上形成组合物的涂层。即使在存在强流动的流体（例如血管中的血液流动）的情况下，组合物也可能与组织腔或其他身体表面相关联。组合物可以经由多个共价键与组织内腔结合。在一些情况下，组合物可以包含至少一种添加剂，例如治疗活性剂或成像剂。

6. 发明授权

US09193827B2 Poly(beta-amino alcohols), their preparation, and uses thereof 有权
标题翻译：聚（β-氨基醇），它们的制备及其用途
公开(公告)号：US09193827B2
公开(公告)日：2015-11-24
申请号：US13819280
申请日：2011-08-26
申请人： Minglin Ma , Wendy F. Liu , Robert S. Langer , Daniel Griffith Anderson
发明人： Minglin Ma , Wendy F. Liu , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： C08G73/02 , A61L31/10 , C09D5/16 , C08G59/22 , C08G59/30 , C08G59/50 , C09D179/02
CPC分类号： C08G73/0206 , A61K9/1273 , A61K31/7088 , A61K47/34 , A61K47/59 , A61L31/10 , C08G59/22 , C08G59/306 , C08G59/50 , C08G73/02 , C09D5/1637 , C09D179/02 , Y10T428/31725
摘要： A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.
摘要翻译：使用组合聚合制备了一类新的聚（β-氨基醇）（PBAAs）。本发明的PBAAs可用于生物技术和生物医学应用中，作为涂层（例如用于医疗装置或植入物的膜或多层膜的涂层），添加剂，材料，赋形剂，非生物污垢剂，微图案化剂和细胞包封剂。当用作表面涂层时，这些PBAAs根据其化学结构在体外和体内引起不同程度的炎症。这类材料的大化学多样性使我们能够鉴定体外抑制巨噬细胞活化的聚合物涂层。此外，在皮下植入羧化聚苯乙烯微粒之后，这些涂层减少了炎性细胞的募集，并减少了纤维化。这些聚合物可用于形成用于细胞包封的聚电解质复合物胶囊。本发明还可以具有许多其他生物学应用，例如抗微生物涂层，DNA或siRNA递送以及干细胞组织工程。

7. 发明授权

US08562966B2 End-modified poly(beta-amino esters) and uses thereof 有权
标题翻译：末端改性的聚（β-氨基酯）及其用途
公开(公告)号：US08562966B2
公开(公告)日：2013-10-22
申请号：US13312224
申请日：2011-12-06
申请人： Gregory T. Zugates , Andreas Zumbuehl , Robert S. Langer , Daniel Griffith Anderson
发明人： Gregory T. Zugates , Andreas Zumbuehl , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： A61K31/765 , A61K9/14 , A61K38/00 , A61K48/00 , A61K47/00 , C08G63/91
CPC分类号： C12N15/87 , A61K9/5138 , A61K47/34 , C08G63/6856 , C08G73/02 , C08L79/02
摘要： Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.
摘要翻译：聚（β-氨基酯）被末端修饰以形成用于医疗和非医学领域的材料。使胺封端的聚（β-氨基酯）与亲电子试剂或丙烯酸酯封端的聚（β-氨基酯）与亲核试剂反应。本发明的末端改性聚合物可用于已经发现聚合物有用的任何领域，包括药物递送领域。末端修饰的聚合物特别可用于递送核酸如DNA或RNA。本发明还提供包含本发明的端基改性聚合物，制备本发明聚合物的方法和使用本发明聚合物的方法的组合物。

8. 发明申请

US20120149630A1 END-MODIFIED POLY(BETA-AMINO ESTERS) AND USES THEREOF 有权
标题翻译：末端改性多糖（BETA-AMINO ESTERS）及其用途
公开(公告)号：US20120149630A1
公开(公告)日：2012-06-14
申请号：US13312224
申请日：2011-12-06
申请人： Gregory T. Zugates , Andreas Zumbuehl , Robert S. Langer , Daniel Griffith Anderson
发明人： Gregory T. Zugates , Andreas Zumbuehl , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： A61K38/02 , A61K31/7088 , C08G63/91 , A61K47/34 , B82Y5/00
CPC分类号： C12N15/87 , A61K9/5138 , A61K47/34 , C08G63/6856 , C08G73/02 , C08L79/02
摘要： Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.
摘要翻译：聚（β-氨基酯）被末端修饰以形成用于医疗和非医学领域的材料。使胺封端的聚（β-氨基酯）与亲电子试剂或丙烯酸酯封端的聚（β-氨基酯）与亲核试剂反应。本发明的末端改性聚合物可用于已经发现聚合物有用的任何领域，包括药物递送领域。末端修饰的聚合物特别可用于递送核酸如DNA或RNA。本发明还提供包含本发明的端基改性聚合物，制备本发明聚合物的方法和使用本发明聚合物的方法的组合物。

9. 发明申请

US20120009222A1 MODULATION OF THE IMMUNE RESPONSE 审中-公开
标题翻译：调节免疫应答
公开(公告)号：US20120009222A1
公开(公告)日：2012-01-12
申请号：US13126260
申请日：2009-10-27
申请人： David-Huy Nhu Nguyen , Daniel Griffith Anderson , Robert S. Langer , Kerry Peter Mahon
发明人： David-Huy Nhu Nguyen , Daniel Griffith Anderson , Robert S. Langer , Kerry Peter Mahon
IPC分类号： A61K31/7088 , A61P37/02 , B82Y5/00
CPC分类号： A61K39/39 , A61K31/132 , A61K47/6911 , A61K47/6921 , A61K2039/55561 , A61K2039/55572 , C12N2760/16011
摘要： The present invention provides lipidoids that can be used to modulate the immune response in a subject. Lipidoids are prepared by the conjugate addition of an amine to an acrylate to acrylamide. The lipidoids form complexes or particles with an immunostimulatory polynucleotide, which are then administerd to a subject. Such compositions have been found to stimulate the production of cytokines and increase both humoral and cell-mediate immune response. The invention also provides pharmaceuti-cal compositions thereof and methods for using the same.
摘要翻译：本发明提供可用于调节受试者的免疫应答的类脂质。通过将丙烯酸丁酯偶联加成丙烯酰胺制备脂质体。脂类与免疫刺激多核苷酸形成复合物或颗粒，然后将其施用于受试者。已经发现这些组合物刺激细胞因子的产生并增加体液和细胞中介免疫应答。本发明还提供其药物组合物及其使用方法。

10. 发明申请

US20110280912A1 DEGRADABLE POLYMER NANOSTRUCTURE MATERIALS 审中-公开
标题翻译：可降解聚合物纳米结构材料
公开(公告)号：US20110280912A1
公开(公告)日：2011-11-17
申请号：US12969558
申请日：2010-12-15
申请人： Robert S. Langer , Ana Jaklenec , Daniel Alan Heller , Daniel Griffith Anderson , Michael S. Strano
发明人： Robert S. Langer , Ana Jaklenec , Daniel Alan Heller , Daniel Griffith Anderson , Michael S. Strano
IPC分类号： A61K9/00 , C08L47/00 , A61K35/12 , C08L67/02 , C08L67/00 , B82Y5/00
CPC分类号： C08J5/005 , B82Y30/00 , C08J2379/00
摘要： This invention relates generally to composites comprising a plurality of nanostructures, and methods of making the same. In some embodiments, the composites further comprise a polymer. In some embodiments, the composites may have desirable properties such as, for example, biodegradability, biocompatibility, and/or high tensile strength. In one embodiment, the plurality of nanostructures comprises carbon nanotubes, and the polymer comprises a poly(beta-amino ester). Various methods are provided for preparing the composites. For example, the polymer and the plurality of nanostructures may, in some embodiments, be combined in a layer-by-layer process to form the composite. High throughput methods for preparing composites having different compositions also are provided for screening composites for desirable properties.
摘要翻译：本发明一般涉及包含多个纳米结构的复合材料及其制备方法。在一些实施方案中，复合材料还包含聚合物。在一些实施方案中，复合材料可具有期望的性质，例如生物降解性，生物相容性和/或高拉伸强度。在一个实施方案中，多个纳米结构包含碳纳米管，并且聚合物包含聚（β-氨基酯）。提供了各种制备复合材料的方法。例如，在一些实施方案中，聚合物和多个纳米结构可以以逐层方法组合以形成复合材料。还提供了用于制备具有不同组成的复合材料的高通量方法用于筛选复合材料以获得所需性能。

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