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1. 发明授权

US5942430A Esterases 失效
标题翻译：酯酶
公开(公告)号：US5942430A
公开(公告)日：1999-08-24
申请号：US602359
申请日：1996-02-16
申请人： Dan E. Robertson , Dennis Murphy , John Reid , Anthony M. Maffia , Steven Link , Ronald V. Swanson , Patrick V. Warren , Anna Kosmotka
发明人： Dan E. Robertson , Dennis Murphy , John Reid , Anthony M. Maffia , Steven Link , Ronald V. Swanson , Patrick V. Warren , Anna Kosmotka
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N9/18 , C12N15/55 , C12P13/02 , C12P13/04
CPC分类号： C12N9/16 , C12N9/18 , C12P13/04
摘要： Esterase enzymes derived from various Staphylothermus, Pyrodictium, Archaeoglobus, Aquifex, M11TL, Thermococcus, Teredinibacter and Sulfolobus organisms are disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the pharmaceutical, agricultural and other industries.
摘要翻译：公开了衍生自各种葡萄球菌，火炬蒿，古细血管，Aquifex，M11TL，Thermococcus，Teredinibacter和Sulfolobus生物体的酯酶。酶由天然或重组宿主细胞产生，可用于制药，农业和其他工业。

2. 发明授权

US07288400B2 Nucleic acids encoding esterases and methods of making and using them 有权
标题翻译：编码酯酶的核酸及其制备和使用方法
公开(公告)号：US07288400B2
公开(公告)日：2007-10-30
申请号：US09903410
申请日：2001-07-10
申请人： Dan E. Robertson , Dennis Murphy , John Reid , Anthony M. Maffia , Steven Link , Ronald V. Swanson , Patrick V. Warren , Anna Kosmotka , Jay M. Short , Eric J. Mathur
发明人： Dan E. Robertson , Dennis Murphy , John Reid , Anthony M. Maffia , Steven Link , Ronald V. Swanson , Patrick V. Warren , Anna Kosmotka , Jay M. Short , Eric J. Mathur
IPC分类号： C12N15/55 , C12N9/15
CPC分类号： C12N9/18 , A01K2217/05 , A61K38/00 , C12N9/16 , C12P13/04
摘要： The invention relates to esterases and to polynucleotides encoding the esterases. In addition methods of designing new esterase method of use thereof are also provided. The esterases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及酯酶和编码酯酶的多核苷酸。此外，还提供了设计新的酯酶方法的方法。酯酶在增加的pH和温度下具有增加的活性和稳定性。

3. 发明授权

US06987016B2 α-galactosidases and methods for making and using them 失效
标题翻译： α-半乳糖苷酶及其制备和使用的方法
公开(公告)号：US06987016B2
公开(公告)日：2006-01-17
申请号：US09886400
申请日：2001-06-20
申请人： Dennis Murphy , John Reid , Dan E. Robertson
发明人： Dennis Murphy , John Reid , Dan E. Robertson
IPC分类号： C12N9/40 , C12Q1/34 , C12P21/06 , C07K17/00 , C07H21/04
CPC分类号： C12N9/2465
摘要： The invention relates to α-galactosidase and to polynucleotides encoding the α-galactosidase. In addition methods of designing new α-galactosidases and method of use thereof are also provided. The α-galactosidases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及α-半乳糖苷酶和编码α-半乳糖苷酶的多核苷酸。另外还提供了设计新的α-半乳糖苷酶的方法及其使用方法。在增加的pH和温度下，α-半乳糖苷酶具有增加的活性和稳定性。

4. 发明授权

US06949369B2 α-galactosidases and methods for making and using them 失效
标题翻译： α-半乳糖苷酶及其制备和使用的方法
公开(公告)号：US06949369B2
公开(公告)日：2005-09-27
申请号：US10114083
申请日：2002-04-01
申请人： Dennis Murphy , John Reid , Dan E. Robertson
发明人： Dennis Murphy , John Reid , Dan E. Robertson
IPC分类号： C12N9/40 , C12Q1/34 , C07H21/04 , C07K17/00 , C12P21/06
CPC分类号： C12N9/2465
摘要： The invention relates to α-galactosidase and to polynucleotides encoding the α-galactosidase. In addition methods of designing new α-galactosidases and method of use thereof are also provided. The α-galactosidases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及α-半乳糖苷酶和编码α-半乳糖苷酶的多核苷酸。另外还提供了设计新的α-半乳糖苷酶的方法及其使用方法。在增加的pH和温度下，α-半乳糖苷酶具有增加的活性和稳定性。

5. 发明授权

US5877001A Amidase 失效
标题翻译：酰胺酶
公开(公告)号：US5877001A
公开(公告)日：1999-03-02
申请号：US664646
申请日：1996-06-17
申请人： Dennis Murphy , John Reid , Dan Robertson
发明人： Dennis Murphy , John Reid , Dan Robertson
IPC分类号： C12N15/09 , C07H21/02 , C07H21/04 , C07K16/40 , C12N1/20 , C12N1/21 , C12N9/48 , C12N9/78 , C12N9/80 , C12N15/00 , C12P21/06 , C12P21/08 , C12Q1/34 , C12R1/01 , C12R1/19
CPC分类号： C12P21/06 , C12N9/80
摘要： A purified thermostable enzyme is derived from the archael bacterium Thermococcus GU5L5. The enzyme has a molecular weight of about 68.5 kilodaltons and has cellulase activity. The enzyme can be produced from native or recombinant host cells and can be used for the removal of arginine, phenylalanine, or methionine amino acids from the N-terminal end of peptides in peptide or peptidomimetic synthesis. The enzyme is selective for the L, or `natural` enantiomer of the amino acid derivatives and is therefore useful for the production of optically active compounds. These reactions can be performed in the presence of the chemically more reactive ester functionality, a step which is very difficult to achieve with nonenzymatic methods.
摘要翻译：纯化的热稳定性酶来源于弓形虫Thermococcus GU5L5。该酶的分子量约为68.5千道尔顿，具有纤维素酶活性。该酶可以由天然的或重组的宿主细胞产生，并且可用于从肽或肽模拟合成中的肽的N-末端去除精氨酸，苯丙氨酸或甲硫氨酸氨基酸。该酶对氨基酸衍生物的L或“天然”对映异构体是选择性的，因此可用于制备光学活性化合物。这些反应可以在化学上更具反应性的酯官能团的存在下进行，这是非常难以用非酶法实现的步骤。

6. 发明授权

US06465204B1 Amidase 有权
公开(公告)号：US06465204B1
公开(公告)日：2002-10-15
申请号：US09609570
申请日：2000-06-30
申请人： Dennis Murphy , John Reid , Dan Robertson
发明人： Dennis Murphy , John Reid , Dan Robertson
IPC分类号： C12Q134
CPC分类号： C12P21/06 , C12N9/80
摘要： A purified thermostable enzyme is derived from the archael bacterium Thermococcus GU5L5. The enzyme has a molecular weight of about 68.5 kilodaltons and has cellulase activity. The enzyme can be produced from native or recombinant host cells and can be used for the removal of arginine, phenylalanine, or methionine amino acids from the N-terminal end of peptides in peptide or peptidomimetic synthesis. The enzyme is selective for the L, or ‘natural’ enantiomer of the amino acid derivatives and is therefore useful for the production of optically active compounds. These reactions can be performed in the presence of the chemically more reactive ester functionally, a step which is very difficult to achieve with nonenzymatic methods.

7. 发明授权

US6136583A AMIDASE 失效
公开(公告)号：US6136583A
公开(公告)日：2000-10-24
申请号：US951088
申请日：1997-10-15
申请人： Dennis Murphy , John Reid , Dan Robertson
发明人： Dennis Murphy , John Reid , Dan Robertson
IPC分类号： C12N15/09 , C07H21/02 , C07H21/04 , C07K16/40 , C12N1/20 , C12N1/21 , C12N9/48 , C12N9/78 , C12N9/80 , C12N15/00 , C12P21/06 , C12P21/08 , C12Q1/34 , C12R1/01 , C12R1/19
CPC分类号： C12P21/06 , C12N9/80
摘要： A purified thermostable enzyme is derived from the archael bacterium Thermococcus GU5L5. The enzyme has a molecular weight of about 68.5 kilodaltons and has cellulase activity. The enzyme can be produced from native or recombinant host cells and can be used for the removal of arginine, phenylalanine, or methionine amino acids from the N-terminal end of peptides in peptide or peptidomimetic synthesis. The enzyme is selective for the L, or `natural` enantiomer of the amino acid derivatives and is therefore useful for the production of optically active compounds. These reactions can be performed in the presence of the chemically more reactive ester functionality, a step which is very difficult to achieve with nonenzymatic methods.
摘要翻译：纯化的热稳定性酶来源于弓形虫Thermococcus GU5L5。该酶的分子量约为68.5千道尔顿，具有纤维素酶活性。该酶可以由天然的或重组的宿主细胞产生，并且可用于从肽或肽模拟合成中的肽的N-末端去除精氨酸，苯丙氨酸或甲硫氨酸氨基酸。该酶对氨基酸衍生物的L或“天然”对映异构体是选择性的，因此可用于制备光学活性化合物。这些反应可以在化学上更具反应性的酯官能团的存在下进行，这是非常难以用非酶法实现的步骤。

8. 发明授权

US06987009B1 αgalactosidases and methods of using them 失效
标题翻译：吗啡糖苷酶和使用它们的方法
公开(公告)号：US06987009B1
公开(公告)日：2006-01-17
申请号：US09619032
申请日：2000-07-19
申请人： Dennis Murphy , John Reid
发明人： Dennis Murphy , John Reid
IPC分类号： C12N9/40 , C12Q1/34 , C12P19/12 , C12P19/02 , C07K1/00
CPC分类号： C12N9/2465
摘要： A thermostable alpha-glycosidase derived from various Thermococcus, alcaliphilus AEDII12RA is disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the food processing industry.
摘要翻译：公开了衍生自各种Thermococcus，alcaliphilus AEDII12RA的热稳定性α-糖苷酶。酶由天然或重组宿主细胞产生，可用于食品加工业。

9. 发明授权

US06525190B1 Amidase 失效
标题翻译：酰胺酶
公开(公告)号：US06525190B1
公开(公告)日：2003-02-25
申请号：US09693554
申请日：2000-10-20
申请人： Dennis Murphy , John Reid , Dan Robertson
发明人： Dennis Murphy , John Reid , Dan Robertson
IPC分类号： C07H2104
CPC分类号： C12P21/06 , C12N9/80
摘要： A purified thermostable enzyme is derived from the archael bacterium Thermococcus GU5L5. The enzyme has a molecular weight of about 68.5 kilodaltons and has cellulase activity. The enzyme can be produced from native or recombinant host cells and can be used for the removal of arginine, phenylalanine, or methionine amino acids from the N-terminal end of peptides in peptide or peptidomimetic synthesis. The enzyme is selective for the L, or ‘natural’ enantiomer of the amino acid derivatives and is therefore useful for the production of optically active compounds. These reactions can be performed in the presence of the chemically more reactive ester functionality, a step which is very difficult to achieve with nonenzymatic methods.
摘要翻译：纯化的热稳定性酶来源于弓形虫Thermococcus GU5L5。该酶的分子量约为68.5千道尔顿，具有纤维素酶活性。该酶可以由天然的或重组的宿主细胞产生，并且可用于从肽或肽模拟合成中的肽的N-末端去除精氨酸，苯丙氨酸或甲硫氨酸氨基酸。该酶对于氨基酸衍生物的L或“天然”对映异构体是选择性的，因此可用于制备光学活性化合物。这些反应可以在化学上更具反应性的酯官能团的存在下进行，用非酶法很难实现。

10. 发明授权

US06429004B1 Amidase 失效
公开(公告)号：US06429004B1
公开(公告)日：2002-08-06
申请号：US09609566
申请日：2000-06-30
申请人： Dennis Murphy , John Reid , Dan Robertson
发明人： Dennis Murphy , John Reid , Dan Robertson
IPC分类号： C12N120
CPC分类号： C12P21/06 , C12N9/80
摘要： A purified thermostable enzyme is derived from the archael bacterium Thermococcus GU5L5. The enzyme has a molecular weight of about 68.5 kilodaltons and has cellulase activity. The enzyme can be produced from native or recombinant host cells and can be used for the removal of arginine, phenylalanine, or methionine amino acids from the N-terminal end of peptides in peptide or peptidomimetic synthesis. The enzyme is selective for the L, or ‘natural’ enantiomer of the amino acid derivatives and is therefore useful for the production of optically active compounds. These reactions can be performed in the presence of the chemically more reactive ester functionally, a step which is very difficult to achieve with nonenzymatic methods.

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