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1. 发明申请

US20200093820A1 ABUSE-DETERRENT PHARMACEUTICAL COMPOSITIONS OF OPIOIDS AND OTHER DRUGS 审中-公开
公开(公告)号：US20200093820A1
公开(公告)日：2020-03-26
申请号：US16697938
申请日：2019-11-27
申请人： Collegium Pharmaceutical, Inc.
发明人： Roman V. RARIY , Alison B. FLEMING , Jane HIRSH , Alexander M. KLIBANOV
IPC分类号： A61K31/485 , A61K9/00 , A61K31/135 , A61K31/4458 , A61K9/50
摘要： An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opioids. In a preferred embodiment, a drug is modified to increase its lipophilicity. In some embodiments the modified drug is homogeneously dispersed within spherical microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and/or organic solvent insoluble. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is passes through the GI tract.

2. 发明申请

US20160074326A1 ABUSE-DETERRENT PHARMACEUTICAL COMPOSITIONS OF OPIOIDS AND OTHER DRUGS 有权
公开(公告)号：US20160074326A1
公开(公告)日：2016-03-17
申请号：US14946275
申请日：2015-11-19
申请人： COLLEGIUM PHARMACEUTICAL, INC.
发明人： Roman V. RARIY , Alison B. FLEMING , Jane HIRSH , Alexander M. KLIBANOV
IPC分类号： A61K9/16 , A61K31/485
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/145 , A61K9/148 , A61K9/1617 , A61K9/1664 , A61K9/2013 , A61K9/4808 , A61K9/4858 , A61K9/5015 , A61K9/5042 , A61K31/13 , A61K31/20 , A61K45/06 , A61K47/12 , A61K2300/00
摘要： An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opioids. In a preferred embodiment, a drug is modified to increase its lipophilicity. In some embodiments the modified drug is homogeneously dispersed within spherical microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and/or organic solvent insoluble. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is passes through the GI tract.

3. 发明公开

US20240122920A1 PROCESS OF MAKING STABLE ABUSE-DETERRENT ORAL FORMULATIONS 审中-公开
公开(公告)号：US20240122920A1
公开(公告)日：2024-04-18
申请号：US18394475
申请日：2023-12-22
申请人： Collegium Pharmaceutical, Inc.
发明人： Said SAIM , Alison B. FLEMING , Ravi K. VARANASI
IPC分类号： A61K31/485 , A61K9/16 , A61K9/48 , A61K47/12 , A61K47/26 , A61K47/44
CPC分类号： A61K31/485 , A61K9/1617 , A61K9/1694 , A61K9/4808 , A61K9/4833 , A61K9/4858 , A61K9/4875 , A61K47/12 , A61K47/26 , A61K47/44
摘要： The present disclosure relates to cured pharmaceutical compositions designed to reduce the potential for improper administration of drugs that are subject to abuse, the process of curing such composition in order to improve the dissolution stability, method of using the same for treatment of pain.

4. 发明申请

US20200345723A1 ABUSE-DETERRENT PHARMACEUTICAL COMPOSITIONS OF OPIOIDS AND OTHER DRUGS 审中-公开
公开(公告)号：US20200345723A1
公开(公告)日：2020-11-05
申请号：US16932647
申请日：2020-07-17
申请人： Collegium Pharmaceutical, Inc.
发明人： Roman V. RARIY , Alison B. FLEMING , Jane HIRSH , Alexander M. KLIBANOV
IPC分类号： A61K31/485 , A61K9/00 , A61K9/50 , A61K31/135 , A61K31/4458 , G06Q20/20 , G06Q20/32
摘要： An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opioids. In a preferred embodiment, a drug is modified to increase its lipophilicity. In some embodiments the modified drug is homogeneously dispersed within spherical microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and/or organic solvent insoluble. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is passes through the GI tract.

5. 发明申请

US20140105987A1 ABUSE-DETERRENT PHARMACEUTICAL COMPOSITIONS OF OPIOIDS AND OTHER DRUGS 有权
标题翻译：阿片类药物和其他药物的滥用药物组合物
公开(公告)号：US20140105987A1
公开(公告)日：2014-04-17
申请号：US14054513
申请日：2013-10-15
申请人： COLLEGIUM PHARMACEUTICAL, INC.
发明人： Roman V. RARIY , Alison B. FLEMING , Jane HIRSH , Alexander M. KLIBANOV
IPC分类号： A61K47/46 , A61K31/485 , A61K45/06 , A61K47/12
CPC分类号： A61K47/46 , A61K9/1617 , A61K9/5026 , A61K31/485 , A61K45/06 , A61K47/12
摘要： An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opioids. In a preferred embodiment, a drug is modified to increase its lipophilicity. In some embodiments the modified drug is homogeneously dispersed within spherical microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and/or organic solvent insoluble. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is passes through the GI tract.
摘要翻译：已经开发了一种滥用威慑药物组合物，以减少药物不当管理的可能性，特别是阿片样物质等药物。在优选的实施方案中，修饰药物以增加其亲油性。在一些实施方案中，改性药物均匀地分散在由缓慢溶解或不溶于水的材料组成的球形微粒内。在一些实施方案中，含有微粒或药物颗粒的药物涂覆有一个或多个涂层，其中至少一种涂层是不溶于水的和/或有机溶剂不溶的。即使制剂的物理完整性受到损害（例如通过用刀片切碎或破碎）并且将所得材料置于水中，嗅到或吞咽，滥用威慑组合物也会延缓释放药物。然而，当按照指导给药时，当组合物通过胃肠道时，药物从组合物缓慢释放。

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