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1. 发明授权

US06183658B2 Process for preparing agglomerate-free nanoscalar iron oxide particles with a hydrolysis resistant coating 有权
标题翻译：用耐水解涂层制备无团聚的纳米级氧化铁颗粒的方法
公开(公告)号：US06183658B2
公开(公告)日：2001-02-06
申请号：US09171065
申请日：1998-10-09
申请人： Christoph Lesniak , Thomas Schiestel , Rüdiger Nass , Helmut Schmidt
发明人： Christoph Lesniak , Thomas Schiestel , Rüdiger Nass , Helmut Schmidt
IPC分类号： C09D1700
CPC分类号： B82Y30/00 , C01G49/02 , C01P2004/64 , C01P2006/80 , C01P2006/90 , C09C1/24 , C09C3/006 , C09C3/045 , C09C3/12 , Y10T428/2995
摘要： A process for preparing an agglomerate-free suspension of nanosize iron-containing oxide particles coated in a stable manner comprises preparing an aqueous suspension of nanosize iron-containing oxide particles which are partially or completely in the form of agglomerates; adding a trialkoxysilane and a water-miscible polar organic solvent which has a boiling point at least 10° C. higher than the boiling point of water; treating the resulting suspension with ultrasound until at least 70% of the particles present are in the range of ±20% of the average particle diameter; removing the water by distillation under the action of ultrasound; and separating the non-disintegrated agglomerates.
摘要翻译：制备以稳定方式包被的纳米尺寸含铁氧化物颗粒的无附聚物悬浮液的方法包括制备部分或全部为附聚物形式的纳米级含铁氧化物颗粒的水性悬浮液; 加入沸点比水的沸点高至少10℃的三烷氧基硅烷和水混溶性极性有机溶剂; 用超声波处理所得到的悬浮液，直到存在的颗粒的至少70％在平均粒径的±20％的范围内; 在超声波作用下通过蒸馏除去水分; 并分离未崩解的附聚物。

2. 发明授权

US06979466B2 Nanoscale particles having an iron oxide-containing core enveloped by at least two shells 失效
标题翻译：具有包含至少两个壳的含氧化铁芯的纳米级颗粒
公开(公告)号：US06979466B2
公开(公告)日：2005-12-27
申请号：US10391356
申请日：2003-03-17
申请人： Christoph Lesniak , Thomas Schiestel , Helmut Schmidt , Andreas Jordan
发明人： Christoph Lesniak , Thomas Schiestel , Helmut Schmidt , Andreas Jordan
IPC分类号： A61K9/16 , A61K41/00 , A61P35/00 , A61K9/51
CPC分类号： A61K41/0052
摘要： The invention relates to nanoscale particles suited especially for use in tumor therapy by hyperthermia. Said particles comprise a (preferably superparamagnetic) iron oxide-containing core and at least two shells surrounding said core. The (innermost) shell adjoining the core is an envelope which comprises groups capable of forming cationic groups and is broken down by human or animal tissue at such a slow rate as to allow for association of the core surrounded by said envelope with the surface of cells and/or for absorption of said core into the inside of cells. The outer shell(s) consist(s) of species having neutral and/or anionic groups which allow the nanoscale particles to appear to the outside as having a neutral or negative charge and which are broken down by human or animal tissue more rapidly than the innermost shell—and in so doing uncover the shells underneath—but still sufficiently slowly so as to ensure that the nanoscale particles are adequately distributed in a tissue infiltrated with same particles in a particular point.
摘要翻译：本发明涉及特别适用于通过高热治疗肿瘤治疗的纳米级颗粒。所述颗粒包含（优选超顺磁性）含氧化铁的芯和围绕所述芯的至少两个壳。与核心相邻的（最内侧）壳是包含能够形成阳离子基团并且以如此慢的速率被人或动物组织分解以允许由所述包膜包围的核与细胞表面缔合的基团和/或用于将所述核吸收到细胞内部。外壳由具有中性和/或阴离子基团的物质组成，其允许纳米级颗粒以外面的形式出现在外部，具有中性或负电荷，并且比人或动物组织更快地分解最内层的壳体，并且在其中露出壳下面，但是仍然足够缓慢，以便确保纳米级颗粒在特定的点上适当地分布在渗透有相同颗粒的组织中。

3. 发明授权

US06541039B1 Nanoscale particles having an iron oxide-containing core enveloped by at least two shells 有权
标题翻译：具有包含至少两个壳的含氧化铁芯的纳米级颗粒
公开(公告)号：US06541039B1
公开(公告)日：2003-04-01
申请号：US09446438
申请日：1999-12-20
申请人： Christoph Lesniak , Thomas Schiestel , Helmut Schmidt , Andreas Jordan
发明人： Christoph Lesniak , Thomas Schiestel , Helmut Schmidt , Andreas Jordan
IPC分类号： A61K3326
CPC分类号： A61K41/0052
摘要： The invention relates to nanoscale particles suited especially for use in tumor therapy by hyperthermia. Said particles comprise a (preferably superparamagnetic) iron oxide-containing core and at least two shells surrounding said core. The (innermost) shell adjoining the core is an envelope which comprises groups capable of forming cationic groups and is broken down by human or animal tissue at such a slow rate as to allow for association of the core surrounded by said envelope with the surface of cells and/or for absorption of said core into the inside of cells. The outer shell(s) consist(s) of species having neutral and/or anionic groups which allow the nanoscale particles to appear to the outside as having a neutral or negative charge and which are broken down by human or animal tissue more rapidly than the innermost shell—and in so doing uncover the shells underneath—but still sufficiently slowly so as to ensure that the nanoscale particles are adequately distributed in a tissue infiltrated with same particles in a particular point.
摘要翻译：本发明涉及特别适用于通过高热治疗肿瘤治疗的纳米级颗粒。所述颗粒包含（优选超顺磁性）含氧化铁的芯和围绕所述芯的至少两个壳。与核心相邻的（最内侧）壳是包含能够形成阳离子基团并且以如此慢的速率被人或动物组织分解以允许由所述包膜包围的核与细胞表面缔合的基团和/或用于将所述核吸收到细胞内部。外壳由具有中性和/或阴离子基团的物质组成，其允许纳米级颗粒以外面的形式出现在外部，具有中性或负电荷，并且比人或动物组织更快地分解最内层的壳体，并且在其中露出壳下面，但是仍然足够缓慢，以便确保纳米级颗粒在特定的点上适当地分布在渗透有相同颗粒的组织中。

4. 发明授权

US06576182B1 Process for producing shrinkage-matched ceramic composites 失效
标题翻译：生产收缩匹配陶瓷复合材料的方法
公开(公告)号：US06576182B1
公开(公告)日：2003-06-10
申请号：US08930241
申请日：1997-09-30
申请人： Alberto Ravagni , Rüdiger Nass , Helmut Schmidt , Bernhard Walter
发明人： Alberto Ravagni , Rüdiger Nass , Helmut Schmidt , Bernhard Walter
IPC分类号： B32B1800
CPC分类号： B32B18/00 , C04B35/117 , C04B35/488 , C04B35/63416 , C04B35/63488 , C04B2235/656 , C04B2235/6567 , C04B2237/34 , C04B2237/341 , C04B2237/343 , C04B2237/346 , C04B2237/348 , C04B2237/36 , C04B2237/365 , C04B2237/62 , C04B2237/704 , Y10S264/48
摘要： A process for producing a composite, containing at least one shrinkage-matched ceramic layer, wherein a starting material for the ceramic layer(s) has shrinkage behavior on sintering which is matched to remaining layer(s), and which is selected such that the ceramic-forming constituent of the same contains at least one ceramic powder of a specific size, and which process entails joining the layers of the composite by sintering.
摘要翻译：一种复合材料的制造方法，其含有至少一个收缩匹配陶瓷层，其中，所述陶瓷层的原料具有与剩余层相匹配的烧结时的收缩特性，其陶瓷形成成分含有至少一种特定尺寸的陶瓷粉末，该方法需要通过烧结将复合材料层接合。

5. 发明授权

US06187256B1 Method of producing a conductive silicon carbide-based sintered compact 失效
标题翻译：制造导电碳化硅类烧结体的方法
公开(公告)号：US06187256B1
公开(公告)日：2001-02-13
申请号：US09051375
申请日：1998-04-08
申请人： Mesut Aslan , Rüdiger Nass , Helmut Schmidt
发明人： Mesut Aslan , Rüdiger Nass , Helmut Schmidt
IPC分类号： C04B35565
CPC分类号： H05B3/148 , C04B35/565 , F01N3/022 , F01N2330/14
摘要： A process is described for producing a conductive sintered body based on silicon carbide, in which a) silicon carbide particles, optionally pretreated with a surface modifier, are dispersed in an aqueous and/or organic medium and positive or negative surface charges are generated on the silicon carbide particles by adjustment of the pH of the dispersion obtained; b) carbon black and boron carbide are mixed in as sintering aids, where at least the carbon black particles have a surface charge opposite to the surface charge of the silicon carbide particles and the boron carbide can also be added, completely or in part, at a later point in time (stage c′)); c) the slip thus obtained is shaped directly to form a green body or c′) a sinterable powder is isolated from the slip obtained and is shaped to form a green body, where the above boron carbide can also be added to this sinterable powder; and d) the green body obtained is subjected to pressureless sintering to form a sintered body in essentially three successive steps, namely (i) preheating to 1200-1900° C. in a nitrogen containing atmosphere (ii), sintering at 1900-2200° C. in a noble gas atmospher and (iii) post-heating at 2150-1850° C. and subsequent cooling to ambient temperature in an atomosphere containing nitrogen and/or carbon monoxide.
摘要翻译：描述了一种用于制造基于碳化硅的导电烧结体的方法，其中a）任选地用表面改性剂预处理的碳化硅颗粒分散在水性和/或有机介质中，并且在硅上产生正或负表面电荷碳化物颗粒通过调节获得的分散体的pH调节; b）炭黑和碳化硼作为烧结助剂混合，其中至少炭黑颗粒具有与碳化硅颗粒和硼的表面电荷相反的表面电荷也可以在稍后的时间点（阶段c'）完全或部分地添加碳化物; c）由此获得的滑移物直接成形以形成生坯体，或者从可获得的滑动体中分离出可烧结粉末并且成形为形成生坯体，其中也可以将上述碳化硼添加到该可烧结粉末中; 和）将所得生坯进行无压烧结，以基本上三个连续的步骤形成烧结体，即（i）在含氮气氛（ii）中预热至1200-1900℃，在1900-2200℃烧结在惰性气体气氛中和（iii）在2150-1850℃下进行后加热，随后在含有氮和/或一氧化碳的大气中冷却至环境温度。

6. 发明授权

US06255477B1 Particles having a magnetic core and outer glass layer for separating biological material 失效
标题翻译：具有用于分离生物材料的磁芯和外部玻璃层的颗粒
公开(公告)号：US06255477B1
公开(公告)日：2001-07-03
申请号：US08952969
申请日：1998-03-11
申请人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
发明人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
IPC分类号： C12N1500
CPC分类号： C03C3/111 , B03C1/01 , B82Y25/00 , C03C3/078 , C03C3/083 , C03C3/085 , C03C3/087 , C03C3/089 , C03C3/091 , C03C3/102 , C03C3/105 , C03C3/108 , C07H21/00 , C12N15/1013 , C12Q1/6804 , C12Q1/6806 , C12Q1/6834 , H01F1/0063 , H01F1/112 , H01F1/36 , Y10S428/90 , Y10S435/814 , Y10T428/2996
摘要： Magnetic glass particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing the particles is by forming a mixture of magnetic cores with a sol formed from an alcohol and a metal alkoxide, spray-drying the mixture to coat the cores with a layer of gelled sol, and heating the coated cores to obtain the magnetic glass particles. Preferably, the particles have an average particle size of less than 100 &mgr;m and any pores of the glass surface have a diameter of less than 10 nm. The magnetic core may be a composite material containing a mica core and magnetite particles immobilized on the mica core, and the glass layer may contain boron oxide. Magnetic core materials include magnetite (Fe3O4) and Fe2O3. In using the magnetic glass particles to separate a biological material, the particles are contacted with a fluid containing the biological material such that the biological material binds to the glass surface, and the bound biological material is separated from the fluid such as by using a magnetic field. Before applying a magnetic field, the magnetic particles may sediment when contacted with the biological material.
摘要翻译：制备磁性玻璃颗粒，其包含涂覆有具有基本无孔玻璃表面的玻璃层的磁芯。颗粒用于分离生物材料如核酸。制备颗粒的优选方法是通过用由醇和金属醇盐形成的溶胶形成磁芯的混合物，喷雾干燥混合物以用一层凝胶溶胶涂覆芯，并加热涂覆的芯以获得磁性玻璃颗粒。优选地，颗粒的平均粒度小于100μm，并且玻璃表面的任何孔具有小于10nm的直径。磁芯可以是包含固定在云母芯上的云母芯和磁铁矿颗粒的复合材料，并且玻璃层可以含有氧化硼。磁芯材料包括磁铁矿（Fe3O4）和Fe2O3。在使用磁性玻璃颗粒分离生物材料时，颗粒与包含生物材料的流体接触，使得生物材料结合到玻璃表面，并且结合的生物材料与流体分离，例如通过使用磁性领域。在施加磁场之前，当与生物材料接触时，磁性颗粒可能沉淀。

7. 发明授权

US5837025A Method of producing fine-particle multicomponent glass powders for use as a glass flow for producing layers and decorations on glass, glass ceramic or ceramic 失效
标题翻译：制造微粒多组分玻璃粉末的方法，用于玻璃流动，用于生产玻璃，玻璃陶瓷或陶瓷上的层和装饰
公开(公告)号：US5837025A
公开(公告)日：1998-11-17
申请号：US660178
申请日：1996-06-03
申请人： Petra Auchter-Krummel , Waldemar Weinberg , Christoph Lesniak , Rudiger Nass , Helmut Schmidt , Nanning Arfsten
发明人： Petra Auchter-Krummel , Waldemar Weinberg , Christoph Lesniak , Rudiger Nass , Helmut Schmidt , Nanning Arfsten
IPC分类号： B01F17/42 , C03B8/00 , C03B8/02 , C03C12/00 , C09D1/00 , C03B9/00 , C03B19/00 , C03B23/00 , C03B37/00
CPC分类号： C03C12/00 , C09D1/00 , Y10S65/901
摘要： The invention is directed to a method for producing low sintering fine-particle multicomponent glass powder having a particle size of the primary particle in the nanometer range. The method utilizes microemulsion techniques with subsequent separation of the particles out of the emulsion and calcination for utilization as glass flow having a sintering temperature
摘要翻译：本发明涉及一种具有纳米范围内的一次粒子的粒径的低烧结微粒多组分玻璃粉末的制造方法。该方法利用微乳液技术，随后将颗粒从乳液中分离出来，并且煅烧以用作烧结温度<900℃的玻璃流或玻璃流，用于产生薄的透明层或用于在玻璃上产生颜色装饰，玻璃陶瓷或陶瓷基材，在玻璃流中加入着色颜料。用于生产纳米尺寸玻璃粉末颗粒的微乳液由乳液中10至15重量％组分的非离子型亲油性乳化剂，50至70重量％的油相和含有玻璃前体盐含量高达31.3重量％，盐含量高达45重量％。

8. 发明申请

US20120022246A1 Magnetic Pigment 审中-公开
标题翻译：磁性颜料
公开(公告)号：US20120022246A1
公开(公告)日：2012-01-26
申请号：US13269195
申请日：2011-10-07
申请人： Jorg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
发明人： Jorg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
IPC分类号： C07H21/04
CPC分类号： C23C30/00 , C12Q1/6806 , Y10S428/90 , Y10S435/814 , Y10T428/12042 , Y10T428/2996 , C12Q2563/149 , C12Q2563/143
摘要： Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.
摘要翻译：具有基本上无孔隙或具有小于10nm直径的孔的外部玻璃表面的磁性颗粒以及具有玻璃表面的铁磁颗粒优选用于从样品中分离生物材料。它们提供快速可靠的净化。

9. 发明授权

US06870047B2 Magnetic pigment 失效
标题翻译：磁性颜料
公开(公告)号：US06870047B2
公开(公告)日：2005-03-22
申请号：US09756743
申请日：2001-01-10
申请人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
发明人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
IPC分类号： G01N33/552 , B01J20/28 , B03C20060101 , B03C1/01 , C07H20060101 , C07H1/08 , C07H21/00 , C12N20060101 , C12N15/09 , C12N15/10 , C12N15/11 , C12Q20060101 , C12Q1/68 , G01N33/553 , H01F1/00 , H01F1/11 , H01F1/36 , C12N15/00 , C12N13/00 , C12P19/34
CPC分类号： C03C3/111 , B03C1/01 , B82Y25/00 , C03C3/078 , C03C3/083 , C03C3/085 , C03C3/087 , C03C3/089 , C03C3/091 , C03C3/102 , C03C3/105 , C03C3/108 , C07H21/00 , C12N15/1013 , C12Q1/6804 , C12Q1/6806 , C12Q1/6834 , H01F1/0063 , H01F1/112 , H01F1/36 , Y10S428/90 , Y10S435/814 , Y10T428/2996
摘要： Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free class surface or having pores with a diameter offices than 10 nm. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing the particles is by forming a mixture of magnetic cores with a sol formed from an alcohol and a metal alkoxide, spray-drying the mixture to coat the cores with a layer of gelled sol, and heating the coated cores to obtain the magnetic glass particles. Preferably, the particles have an average particle size of less than 100 μm. The magnetic core may be a composite material containing a mica core and magnetite particles immobilized on the mica core, and the glass layer may contain boron oxide. Magnetic core materials include magnetite (Fe3O4) and Fe2O3.
摘要翻译：制备磁性颗粒，其包含涂覆有具有基本上无孔的等级表面或具有直径为10nm以上的孔的玻璃层的磁芯。颗粒用于分离生物材料如核酸。制备颗粒的优选方法是通过用由醇和金属醇盐形成的溶胶形成磁芯的混合物，喷雾干燥混合物以用一层凝胶溶胶涂覆芯，并加热涂覆的芯以获得磁性玻璃颗粒。优选地，颗粒的平均粒度小于100μm。磁芯可以是包含固定在云母芯上的云母芯和磁铁矿颗粒的复合材料，并且玻璃层可以含有氧化硼。磁芯材料包括磁铁矿（Fe3O4）和Fe2O3。

10. 发明申请

US20110117561A1 Magnetic Pigment 审中-公开
标题翻译：磁性颜料
公开(公告)号：US20110117561A1
公开(公告)日：2011-05-19
申请号：US12957157
申请日：2010-11-30
申请人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
发明人： Jörg Kleiber , Thomas Walter , Herbert Harttig , Christoph Lesniak , Martin Mennig , Michael Riedling , Helmut Schmidt
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C23C30/00 , C12Q1/6806 , Y10S428/90 , Y10S435/814 , Y10T428/12042 , Y10T428/2996 , C12Q2563/149 , C12Q2563/143
摘要： Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.
摘要翻译：具有基本上无孔隙或具有小于10nm直径的孔的外部玻璃表面的磁性颗粒以及具有玻璃表面的铁磁颗粒优选用于从样品中分离生物材料。它们提供快速可靠的净化。

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