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1. 发明授权

US5068231A Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides 失效
标题翻译：用3-芳氧基和3-芳硫基氮杂环丁烷酰胺治疗肌肉紧张，肌肉痉挛和焦虑的方法
公开(公告)号：US5068231A
公开(公告)日：1991-11-26
申请号：US921521
申请日：1986-10-22
申请人： Chandler R. Taylor, Jr. , Albert D. Cale. Jr. , David N. Johnson , Harold F. Stauffer. Jr.
发明人： Chandler R. Taylor, Jr. , Albert D. Cale. Jr. , David N. Johnson , Harold F. Stauffer. Jr.
IPC分类号： A61K31/395 , A61K31/415 , A61K31/44 , A61K31/495 , C07D205/04 , C07D401/12 , C07D521/00
CPC分类号： C07D231/12 , A61K31/395 , A61K31/415 , A61K31/44 , A61K31/495 , C07D205/04 , C07D233/56 , C07D249/08 , C07D401/12
摘要： A method of treating animals to obtain muscle relaxation and/or to relieve anxiety is disclosed utilizing novel and known 3-aryloxy and 3-arylthioazetidinecarbonxamides having the formula: ##STR1## wherein Z is oxygen or sulfur; B is oxygen or sulfur; Ar is pyridyl or halo substituted pyridyl, phenyl or substituted phenyl; R.sup.1 and R.sup.2 are hydrogen, loweralkyl, aryl, allyl groups, propargyl, cycloalkyl, loweralkylcycloalkyl, cycloakylloweralkyl, arylloweralkyl and diloweralkylaminoalkyl, and R.sup.1 and R.sup.2 when taken together with the adjacent nitrogen atom may form a heterocyclic amine radical; R.sup.3 is hydrogen, loweralkyl, aryl or arylloweralkyl, and the geometrical isomers thereof and pharmaceutical salts thereof and hydrates thereof when they are possible.
摘要翻译：公开了一种用于治疗动物以获得肌肉松弛和/或减轻焦虑的方法，其利用新颖且已知的具有下式的其中Z为氧或硫的3-芳氧基和3-芳基硫代氮杂环丁烷酰胺。 B是氧或硫; Ar是吡啶基或卤素取代的吡啶基，苯基或取代的苯基; R1和R2是氢，低级烷基，芳基，烯丙基，炔丙基，环烷基，低级烷基环烷基，环亚烷基低级烷基，芳基低级烷基和二低级烷基氨基烷基，当与相邻的氮原子一起时，R 1和R 2可以形成杂环胺基; 当可能时，R3是氢，低级烷基，芳基或芳基低级烷基，及其几何异构体及其药用盐及其水合物。

2. 发明授权

US5151418A Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides 失效
标题翻译：用3-芳氧基和3-芳硫基氮杂环丁烷酰胺治疗肌肉紧张，肌肉痉挛和焦虑的方法
公开(公告)号：US5151418A
公开(公告)日：1992-09-29
申请号：US743486
申请日：1991-08-09
申请人： Chandler R. Taylor, Jr. , Albert D. Cale, Jr. , David N. Johnson , Harold F. Stauffer, Jr.
发明人： Chandler R. Taylor, Jr. , Albert D. Cale, Jr. , David N. Johnson , Harold F. Stauffer, Jr.
IPC分类号： A61K31/395 , A61K31/415 , A61K31/44 , A61K31/495 , C07D205/04 , C07D401/12 , C07D521/00
CPC分类号： C07D231/12 , A61K31/395 , A61K31/415 , A61K31/44 , A61K31/495 , C07D205/04 , C07D233/56 , C07D249/08 , C07D401/12
摘要： A method of treating animals to obtain muscle relaxation and/or to relieve anxiety is disclosed utilizing novel and known 3-aryloxy and 3-arylthioazetidinecarboxamides having the formula: ##STR1## wherein Z is oxygen or sulfur; B is oxygen or sulfur; Ar is pyridyl or halo substituted pyridyl, phenyl or substituted phenyl; R.sup.1 and R.sup.2 are hydrogen, loweralkyl, aryl, allyl groups, propargyl, cycloalkyl, loweralkylcycloalkyl, cycloalkylloweralkyl, arylloweralkyl and diloweralkylaminoalkyl, and R.sup.1 and R.sup.2 when taken together with the adjacent nitrogen atom may form a heterocyclic amine radical; R.sup.3 is hydrogen, loweralkyl, aryl or arylloweralkyl, and the geometrical isomers thereof and pharmaceutical salts thereof and hydrates thereof when they are possible.
摘要翻译：公开了一种用于治疗动物以获得肌肉松弛和/或缓解焦虑的方法，其利用新颖且已知的具有下列结构式的3-芳氧基和3-芳硫基氮杂环丁烷酰胺：其中Z是氧或硫; B是氧或硫; Ar是吡啶基或卤素取代的吡啶基，苯基或取代的苯基; R1和R2是氢，低级烷基，芳基，烯丙基，炔丙基，环烷基，低级烷基环烷基，环烷基低级烷基，芳基低级烷基和二低级烷基氨基烷基，当与相邻的氮原子一起时，R 1和R 2可以形成杂环胺基; 当可能时，R3是氢，低级烷基，芳基或芳基低级烷基，及其几何异构体及其药用盐及其水合物。

3. 发明授权

US08109183B2 Impact resistant tool bit and tool bit holder 有权
标题翻译：耐冲击刀头和刀柄
公开(公告)号：US08109183B2
公开(公告)日：2012-02-07
申请号：US12472623
申请日：2009-05-27
申请人： Aland Santamarina , Michael P. Peters , Abhijeet Joshi , David N. Johnson , Hans Peter Paulus , Matthias Mertmann , Francesco Butera , Luca Fumagalli
发明人： Aland Santamarina , Michael P. Peters , Abhijeet Joshi , David N. Johnson , Hans Peter Paulus , Matthias Mertmann , Francesco Butera , Luca Fumagalli
IPC分类号： B25B23/159
CPC分类号： B25B23/0035 , B25B15/001 , B25B15/002 , B25B23/1405 , Y10T279/3406 , Y10T279/3493 , Y10T408/957
摘要： An impact resistant tool or tool bit holder has an active end for driving a fastener and a shanking end for securing to a power tool. The active end includes a body with a bore to receive the shank and a pocket to receive a damping mechanism. The shank includes an end to engage the bore in the body, and a pocket to receive the damping mechanism. The shank is received in the bore in the body for limited rotation with respect to the body. A damping mechanism is positioned in the pockets to provide damping between the body and the shank during torque loading.
摘要翻译：耐冲击工具或工具钻头夹持器具有用于驱动紧固件的活动端和用于固定到电动工具的固定端。活动端包括具有用于接收柄的孔的主体和用于接收阻尼机构的口袋。柄部包括接合主体中的孔的端部和用于接收阻尼机构的口袋。柄部被容纳在身体的孔中，用于相对于身体的有限旋转。阻尼机构定位在凹穴中，以在扭矩加载期间在主体和柄之间提供阻尼。

4. 发明授权

US06993681B2 Remote administration in a distributed system 有权
公开(公告)号：US06993681B2
公开(公告)日：2006-01-31
申请号：US10122133
申请日：2002-04-15
申请人： Leon E. Haynes , David N. Johnson
发明人： Leon E. Haynes , David N. Johnson
IPC分类号： G06F11/00
CPC分类号： G06F11/0793 , G06F11/0715 , G06F11/076 , G06F11/324 , G06F11/3409 , G06F11/3495 , G06F2201/81 , G06F2201/86
摘要： A method and system for remote administration of clients performing critical processes are disclosed herein. A client management module is used to monitor a subset of processes performed by a client. When the client management module detects that a process of the subset has terminated or become inoperable, the client management module can restart the process, as well as notify a remote system manager. Additionally, the client management module is adapted to monitor the consumption of system resources by one or more processes. Using fuzzy logic to evaluate the system resource consumptions of one or more system resource types, the client management module can select an appropriate action response to improve the performance of the process and/or notify an administrator of a status of the process. The remote system manager is adapted to monitor a connection with the client. When a connection failure is detected, the system manager can diagnose a cause of the connection failure and take action accordingly, such as by resetting the client management module, resetting the client, or cycling power to the client using a power distribution unit. Additionally, the remote system manager provides various graphical user interfaces to a user or administrator to allow the administrator to assess the condition of the client and/or remotely control the operation of the one or more processes performed by the client.

5. 发明申请

US20090220183A1 Wheel bearing assembly 有权
标题翻译：车轮轴承总成
公开(公告)号：US20090220183A1
公开(公告)日：2009-09-03
申请号：US12291144
申请日：2008-11-06
申请人： Steven E. Meeker , David N. Johnson , Connie J. Buynacek , Martin P. Grover
发明人： Steven E. Meeker , David N. Johnson , Connie J. Buynacek , Martin P. Grover
IPC分类号： F16C13/00
CPC分类号： F16C19/505 , B60B27/0005 , B60B27/001 , B60B27/0084 , F16C19/184 , F16C19/186 , F16C19/386 , F16C19/52 , F16C19/522 , F16C33/583 , F16C33/586 , F16C39/02 , F16C2326/02
摘要： A bearing assembly having improved impact Brinell resistance is provided. Due to a controlled gap between a rotating component and a non-rotating component or a vehicle suspension structure, the non-rotating component or the vehicle suspension structure is permitted to share impact loads caused by a sufficient side impact to the rotating component, thus preventing excessive loads from being transmitted to rolling elements, and providing greater resistance against Brinell impact damage that would generate a noise and/or vibration condition in the bearing assembly. The width of the controlled gap and of the area of potential contact between the rotating component and the vehicle suspension structure or the non-rotating component are optimized to increase impact Brinell resistance while avoiding excessive contact between the rotating component and the non-rotating component or the vehicle suspension structure during extreme cornering maneuvers.
摘要翻译：提供了具有改善的耐冲击性的轴承组件。由于旋转部件和非旋转部件或车辆悬架结构之间的受控间隙，允许非旋转部件或车辆悬架结构共享由对旋转部件的足够的侧面冲击而引起的冲击载荷，从而防止过大的负载被传递到滚动元件，并且提供更大的抵抗布氏冲击损坏的阻力，这会在轴承组件中产生噪音和/或振动状况。优化了旋转部件与车辆悬架结构或非旋转部件之间的受控间隙和潜在接触面积的宽度以增加冲击布氏耐受性，同时避免旋转部件和非旋转部件之间的过度接触，或在极限转弯期间车辆悬架结构。

6. 发明申请

US20120301238A1 Chisels 有权
标题翻译：凿子
公开(公告)号：US20120301238A1
公开(公告)日：2012-11-29
申请号：US13425751
申请日：2012-03-21
申请人： Thomas J. Quinn , David N. Johnson , Florian Probst
发明人： Thomas J. Quinn , David N. Johnson , Florian Probst
IPC分类号： B25D17/02 , B28D1/26 , C21D8/00
CPC分类号： B25D17/02 , B23K31/025 , B23K37/00 , B25D2222/42 , B28D1/26 , C21D1/613 , C21D6/002 , C21D6/004 , C21D9/22 , C21D9/50 , C21D9/505 , C21D2211/002 , C21D2211/008 , C22C38/002 , C22C38/02 , C22C38/04 , C22C38/18 , C22C38/22 , C22C38/24 , C22C38/44 , E21C35/18 , Y10T408/89
摘要： A point chisel includes a substantially cylindrical shank and a working end region that tapers to a point. The working end region has at least three converging substantially planar surfaces, each with a protruding elongate rib extending along at least part of its length. Adjacent surfaces meet along at least part of their length at substantially straight edges between adjacent ribs. A flat chisel includes a substantially cylindrical shank and a working end region with a pair of converging substantially planar surfaces that include a plurality of protruding elongate ribs extending along at least part of its length. Each rib has, along the majority of its length, a substantially constant height above the surface from which it protrudes. Each chisel is made from steel, with the shank having a bainitic microstructure and the working end region having a martensitic microstructure.
摘要翻译：点凿包括基本上圆柱形的柄和逐渐变细的工作端区域。工作端区具有至少三个会聚的大致平坦的表面，每个表面具有沿其长度的至少一部分延伸的突出的细长肋。相邻的表面在相邻肋之间的基本上直的边缘处沿其长度的至少一部分相交。平的凿子包括基本上圆柱形的柄和具有一对会聚的基本平坦的表面的工作端区域，其包括沿其长度的至少一部分延伸的多个突出的细长肋。沿其大部分长度，每个肋条在其突出的表面上方具有基本恒定的高度。每个凿子由钢制成，柄部具有贝氏体组织，工作端部区域具有马氏体组织。

7. 发明申请

US20090311061A1 Impact Resistant Tool Bit and Tool Bit Holder 有权
标题翻译：耐冲击刀头和刀柄
公开(公告)号：US20090311061A1
公开(公告)日：2009-12-17
申请号：US12472623
申请日：2009-05-27
申请人： Aland Santamarina , Michael P. Peters , Abhijeet Joshi , David N. Johnson , Hans Peter Paulus , Matthias Mertmann , Francesco Butera , Luca Fumagalli
发明人： Aland Santamarina , Michael P. Peters , Abhijeet Joshi , David N. Johnson , Hans Peter Paulus , Matthias Mertmann , Francesco Butera , Luca Fumagalli
IPC分类号： B23B31/02 , B25B23/00
CPC分类号： B25B23/0035 , B25B15/001 , B25B15/002 , B25B23/1405 , Y10T279/3406 , Y10T279/3493 , Y10T408/957
摘要： An impact resistant tool or tool bit holder has an active end for driving a fastener and a shanking end for securing to a power tool. The active end includes a body with a bore to receive the shank and a pocket to receive a damping mechanism. The shank includes an end to engage the bore in the body, and a pocket to receive the damping mechanism. The shank is received in the bore in the body for limited rotation with respect to the body. A damping mechanism is positioned in the pockets to provide damping between the body and the shank during torque loading.
摘要翻译：耐冲击工具或工具钻头夹持器具有用于驱动紧固件的活动端和用于固定到电动工具的固定端。活动端包括具有用于接收柄的孔的主体和用于接收阻尼机构的口袋。柄部包括接合主体中的孔的端部和用于接收阻尼机构的口袋。柄部被容纳在身体的孔中，用于相对于身体的有限旋转。阻尼机构定位在凹穴中，以在扭矩加载期间在主体和柄之间提供阻尼。

8. 发明授权

US07504396B2 Substituted heterocyclic compounds and methods of use 失效
标题翻译：取代的杂环化合物及其使用方法
公开(公告)号：US07504396B2
公开(公告)日：2009-03-17
申请号：US10875896
申请日：2004-06-23
申请人： Joseph J. Nunes , Xiaotian Zhu , Patricia Amouzegh , Chiara Ghiron , David N. Johnson , Eoin Christopher Power
发明人： Joseph J. Nunes , Xiaotian Zhu , Patricia Amouzegh , Chiara Ghiron , David N. Johnson , Eoin Christopher Power
IPC分类号： C07D239/48 , C07D403/12 , A61K31/505
CPC分类号： C07D213/82 , C07D239/47 , C07D239/48
摘要： The present invention relates to pyrimidine or pyridine carboxamides or pharmaceutically-acceptable salts thereof. Also included is a method of treatment of inflammation, inhibition of T cell activation and proliferation, arthritis, rheumatoid arthritis, psoriatic arthritis, osteoarthritis, organ transplant, acute transplant or heterograft or homograft rejection, transplantation tolerance induction, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, including ulcerative colitis, Crohn's disease, lupus, contact hypersensitivity, delayed-type hypersensitivity, and gluten-sensitive enteropathy, type 1 diabetes, psoriasis, contact dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune polyglandular disease, autoimmune alopecia, pernicious anemia, vitiligo, autoimmune hypopituatarism, Guillain-Barre syndrome, glomerulonephritis, serum sickness, uticaria, allergic diseases, asthma, hayfever, allergic rhinitis, scleracielma, mycosis fungoides, dermatomyositis, alopecia areata, chronic actinic dermatitis, eczema, Behcet's disease, Pustulosis palmoplanteris, Pyoderma gangrenum, Sezary's syndrome, atopic dermatitis, systemic schlerosis, morphea, atopic dermatitis, colon carcinoma or thymoma in a mammal comprising administering a therapeutically-effective amount a compound as described above.
摘要翻译：本发明涉及嘧啶或吡啶甲酰胺或其药学上可接受的盐。还包括治疗炎症，抑制T细胞活化和增殖，关节炎，类风湿性关节炎，银屑病关节炎，骨关节炎，器官移植，急性移植或异种移植或同种移植物排斥，移植耐受性诱导，缺血或再灌注损伤，心肌梗死的方法，中风，多发性硬化，炎症性肠病，包括溃疡性结肠炎，克罗恩病，狼疮，接触性超敏反应，迟发型超敏反应和麸质敏感性肠病，1型糖尿病，牛皮癣，接触性皮炎，桥本氏甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进，艾迪生病，自身免疫性多腺病，自身免疫性脱发，恶性贫血，白癜风，自身免疫性低位症，吉兰巴利综合征，肾小球性肾炎，血清病，荨麻疹，过敏性疾病，哮喘，高粱，过敏性鼻炎，巩膜瘤，蕈样真菌病，皮肌炎，斑秃，慢性交感包括给予治疗有效量的如上所述的化合物，包括给予治疗有效量的上述化合物，其中，所述治疗有效量的治疗有效量的药物组合物包括给予治疗有效量的上述化合物。

9. 发明授权

US06979129B2 Self-lubricated connector 失效
标题翻译：自润滑连接器
公开(公告)号：US06979129B2
公开(公告)日：2005-12-27
申请号：US10664302
申请日：2003-09-16
申请人： Richard Farbaniec , Robert J. Taylor , Albert Lenac , David N. Johnson
发明人： Richard Farbaniec , Robert J. Taylor , Albert Lenac , David N. Johnson
IPC分类号： F16C13/00 , F16C33/20 , F16C33/04
CPC分类号： F16C13/006 , F16C33/201 , F16C33/206 , F16C33/208 , F16C2208/58 , F16C2220/04 , F16C2220/48 , Y10T403/25
摘要： A self-lubricating connector or roller is formed by molding a laminated bearing insert in-situ within a nylon support or member. The connector provides a one-piece, self-lubricating device to replace conventional multiple-piece bearing assemblies which typically include a nylon member having an integral metallic sleeve rotatably engaged with a conventional needle or journal bearing. An alternate embodiment of the present invention includes a connector fabricated by press-fitting the laminated bearing insert into a member fabricated from a metallic material. The connectors or rollers of the present invention have several advantages over the prior art, including improved concentricity between the load bearing layer and roller, closer tolerances and elimination of parts and assembly steps.
摘要翻译：通过在尼龙支撑件或构件内原位成型层叠的轴承插入件来形成自润滑连接器或辊。连接器提供一体式自润滑装置来代替传统的多件式轴承组件，其通常包括具有与常规针或轴颈轴承可旋转地接合的整体金属套筒的尼龙构件。本发明的替代实施例包括通过将层压的轴承插入件压入由金属材料制成的构件中而制造的连接器。本发明的连接器或滚子具有优于现有技术的几个优点，包括承载层和滚子之间的改进的同心度，较小的公差以及零件的消除和组装步骤。

10. 发明授权

US09085074B2 Chisels 有权
标题翻译：凿子
公开(公告)号：US09085074B2
公开(公告)日：2015-07-21
申请号：US13425751
申请日：2012-03-21
申请人： Thomas J. Quinn , David N. Johnson , Florian Probst
发明人： Thomas J. Quinn , David N. Johnson , Florian Probst
IPC分类号： B25D17/02 , E21C35/18 , C21D1/613 , C21D9/50 , C22C38/18 , B23K31/02 , B23K37/00 , B28D1/26 , C21D6/00 , C21D9/22 , C22C38/00 , C22C38/02 , C22C38/04 , C22C38/22 , C22C38/24 , C22C38/44
CPC分类号： B25D17/02 , B23K31/025 , B23K37/00 , B25D2222/42 , B28D1/26 , C21D1/613 , C21D6/002 , C21D6/004 , C21D9/22 , C21D9/50 , C21D9/505 , C21D2211/002 , C21D2211/008 , C22C38/002 , C22C38/02 , C22C38/04 , C22C38/18 , C22C38/22 , C22C38/24 , C22C38/44 , E21C35/18 , Y10T408/89
摘要： A point chisel includes a substantially cylindrical shank and a working end region that tapers to a point. The working end region has at least three converging substantially planar surfaces, each with a protruding elongate rib extending along at least part of its length. Adjacent surfaces meet along at least part of their length at substantially straight edges between adjacent ribs. A flat chisel includes a substantially cylindrical shank and a working end region with a pair of converging substantially planar surfaces that include a plurality of protruding elongate ribs extending along at least part of its length. Each rib has, along the majority of its length, a substantially constant height above the surface from which it protrudes. Each chisel is made from steel, with the shank having a bainitic microstructure and the working end region having a martensitic microstructure.
摘要翻译：点凿包括基本上圆柱形的柄和逐渐变细的工作端区域。工作端区具有至少三个会聚的大致平坦的表面，每个表面具有沿其长度的至少一部分延伸的突出的细长肋。相邻的表面在相邻肋之间的基本上直的边缘处沿其长度的至少一部分相交。平的凿子包括基本上圆柱形的柄和具有一对会聚的基本平坦的表面的工作端区域，其包括沿着其长度的至少一部分延伸的多个突出的细长肋。沿其大部分长度，每个肋条在其突出的表面上方具有基本恒定的高度。每个凿子由钢制成，柄部具有贝氏体组织，工作端部区域具有马氏体组织。

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