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1. 发明授权

US06472869B1 Diode laser-pumped magnetometer 失效
标题翻译：二极管激光泵浦磁力仪
公开(公告)号：US06472869B1
公开(公告)日：2002-10-29
申请号：US09883166
申请日：2001-06-18
申请人： Bernard L. Upschulte , Steven J. Davis , Ludwig C. Balling , John J. Wright
发明人： Bernard L. Upschulte , Steven J. Davis , Ludwig C. Balling , John J. Wright
IPC分类号： G01V300
CPC分类号： G01R33/26
摘要： A diode laser-pumped magnetometer includes a diode laser that emits a polarized pumping laser beam with resonant optical radiation; and a K-cell through which a magnetic field is manifested from an independent source, the K-cell containing atoms with a dipole experiencing a torque due to the magnetic field. The atoms are excited by the resonant optical radiation of the pumping laser beam and periodically emitting a response radiation as they return to ground state such that the response radiation includes photons that indicate one unit of angular momentum indicative of the torque due to the magnetic field. Finally, a photodetector serves as a means for measuring the response radiation of the K-cell to indicate thereby a measure of the magnetic field in the K-cell from the independent magnetic source.
摘要翻译：二极管激光泵浦磁力计包括发射具有共振光辐射的偏振激光激光束的二极管激光器; 以及从独立的源表现出磁场的K电池，K电池含有具有由于磁场而产生转矩的偶极子的原子。原子被泵浦激光束的谐振光辐射激发，并且当它们返回到基态时周期性地发射响应辐射，使得响应辐射包括指示由于磁场引起的转矩的一个角度动量单位的光子。最后，光检测器用作测量K电池的响应辐射的装置，从而指示来自独立磁源的K电池中的磁场的测量。

2. 发明申请

US20110118248A1 Heteroaryl sulfonamides and CCR2/CCR9 有权
标题翻译：杂芳基磺酰胺和CCR2 / CCR9
公开(公告)号：US20110118248A1
公开(公告)日：2011-05-19
申请号：US12309314
申请日：2009-01-13
申请人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright , Antoni Krasinski , Qiang Wang
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright , Antoni Krasinski , Qiang Wang
IPC分类号： A61K31/538 , C07C311/29 , C07D213/76 , C07D401/12 , C07D401/06 , C07D413/06 , C07D405/04 , C07D471/04 , C07D417/12 , C07D498/04 , C07D401/04 , C07D413/10 , C07D401/10 , A61K31/18 , A61K31/44 , A61K31/444 , A61K31/443 , A61K31/5377 , A61K31/4375 , A61K31/4439 , A61K31/5383 , A61K31/517 , A61K31/437 , A61K31/502 , A61K31/519 , C12N5/071 , A61P9/10 , A61P9/00 , A61P25/28 , A61P29/00 , A61P3/04 , A61P3/10 , A61P13/12 , A61P1/00 , A61P11/00 , A61P37/06 , A61P35/00 , A61P25/04
CPC分类号： A61K31/5383 , A61K31/44 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4965 , A61K31/502 , A61K31/5377 , A61K31/538 , A61K45/06 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
摘要翻译：提供了作为CCR2受体的有效拮抗剂的化合物。动物实验表明，这些化合物可用于治疗炎症，CCR2的标志性疾病。化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病的方法，以及用于鉴定CCR2拮抗剂的测定中的对照。

3. 发明授权

US07741519B2 Bis-aryl sulfonamides 有权
标题翻译：双芳基磺酰胺
公开(公告)号：US07741519B2
公开(公告)日：2010-06-22
申请号：US12024860
申请日：2008-02-01
申请人： Solomon Ungashe , Zheng Wei , John J. Wright , Andrew Pennell , Brett Permack , Thomas Schall
发明人： Solomon Ungashe , Zheng Wei , John J. Wright , Andrew Pennell , Brett Permack , Thomas Schall
IPC分类号： C07C303/00 , A61K31/33 , A61K31/55 , A61K31/397
CPC分类号： C07D213/26 , A61K31/4245 , A61K31/433 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
摘要： Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
摘要翻译：提供了作为趋化因子受体的有效拮抗剂的化合物。化合物通常为芳基磺酰胺衍生物，可用于药物组合物，治疗趋化因子受体介导的疾病的方法，以及用于鉴定趋化因子拮抗剂的测定中的对照。

4. 发明申请

US20070066583A1 Monocyclic and bicyclic compounds and methods of use 有权
标题翻译：单环和双环化合物及其使用方法
公开(公告)号：US20070066583A1
公开(公告)日：2007-03-22
申请号：US11504215
申请日：2006-08-14
申请人： Penglie Zhang , Andrew Pennell , John J. Wright , Lianfa Li , Edward Sullivan , Wei Chen , Kevin Lloyd Greenman
发明人： Penglie Zhang , Andrew Pennell , John J. Wright , Lianfa Li , Edward Sullivan , Wei Chen , Kevin Lloyd Greenman
IPC分类号： A61K31/55 , A61K31/506 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D413/06 , C07D231/56 , C07D233/36 , C07D235/26 , C07D263/22 , C07D263/58 , C07D265/18 , C07D295/185 , C07D401/06 , C07D413/04 , C07D471/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally monocyclic and bicyclic compounds and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
摘要翻译：提供了作为CCR1受体的有效拮抗剂并具有体内抗炎活性的化合物。化合物通常是单环和双环化合物，并且可用于药物组合物，用于治疗CCR1介导的疾病的方法，以及用于鉴定竞争性CCR1拮抗剂的测定中的对照。

5. 发明申请

US20060074071A1 Substituted arylamides 有权
标题翻译：取代芳基酰胺
公开(公告)号：US20060074071A1
公开(公告)日：2006-04-06
申请号：US11202961
申请日：2005-08-11
申请人： Anita Melikian , John J. Wright
发明人： Anita Melikian , John J. Wright
IPC分类号： C07D417/02 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/428
CPC分类号： C07D401/12 , C07D207/09 , C07D277/28 , C07D295/13 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D451/02 , C07D471/04
摘要： Substituted benzamide compounds are provided along with methods for the use of those compounds for treating cancer.
摘要翻译：提供取代的苯甲酰胺化合物以及使用这些化合物治疗癌症的方法。

6. 发明授权

US5217992A Tocotrienols in the treatment of hypercholesterolemia, hyperlipidemia and thromboembolic disorders 失效
标题翻译：生育三烯酚治疗高胆固醇血症，高脂血症和血栓栓塞性疾病
公开(公告)号：US5217992A
公开(公告)日：1993-06-08
申请号：US583907
申请日：1990-09-17
申请人： John J. Wright , Bradley C. Pearce , Rex Parker , Asaf A. Qureshi
发明人： John J. Wright , Bradley C. Pearce , Rex Parker , Asaf A. Qureshi
IPC分类号： A61K31/352 , A61K31/355 , A61P3/06 , A61P7/02 , A61P43/00 , C07D311/72
CPC分类号： A61K31/355 , C07D311/72 , Y10S514/824
摘要： This invention relates to the use of tocotrienol, gamma-tocotrienol and delta-tocotrienol in reducing hypercholesterolemia, hyperlipidemia and thromboembolic disorders in mammals. [The isolation of these tocotrienols from natural sources and their chemical synthesis is disclosed.] The chemical synthesis of these tocotrienols is disclosed. The present invention also relates to prodrugs and pharmaceutical compositions of gamma-tocotrienol, delta-tocotrienol and tocotrienol and uses thereof.
摘要翻译：本发明涉及生育三烯酚，γ-生育三烯酚和δ-生育三烯酚在降低哺乳动物高胆固醇血症，高脂血症和血栓栓塞障碍中的应用。披露了这些生物三烯酚与天然来源的分离及其化学合成。]公开了这些生育三烯酚的化学合成。本发明还涉及γ-生育三烯酚，δ-生育三烯酚和生育三烯酚的前药和药物组合物及其用途。

7. 发明授权

US5070206A Tetrazol-1-yl containing intermediates 失效
标题翻译：含有中间体的四唑-1-基
公开(公告)号：US5070206A
公开(公告)日：1991-12-03
申请号：US654698
申请日：1991-02-13
申请人： Sing-Yuen Sit , John J. Wright
发明人： Sing-Yuen Sit , John J. Wright
IPC分类号： C07D257/04 , C07D405/06
CPC分类号： C07D257/04 , C07D405/06
摘要： Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each are independently hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or trifluoromethyl;R is hydrogen, C.sub.1-4 alkyl or phenyl;A is ##STR2## R.sup.5 is hydrogen, a hydrolyzable ester group or a cation to form a non-toxic pharmaceutically acceptable salt,are novel antihypercholesterolemic agents which inhibit cholesterol biosynthesis. Intermediates and processes for their preparation are disclosed.
摘要翻译：其中R 1，R 2，R 3和R 4各自独立地为氢，卤素，C 1-4烷基，C 1-4烷氧基或三氟甲基; R是氢，C 1-4烷基或苯基; A是R5，氢是可水解的酯基或形成无毒的药学上可接受的盐的阳离子，是抑制胆固醇生物合成的新型抗高胆固醇血症药。公开了中间体及其制备方法。

8. 发明授权

US4939265A Intermediates and process for the preparation of antihypercholesterolemic tetrazole compounds 失效
标题翻译：用于制备抗高胆固醇血症四唑化合物的中间体和方法
公开(公告)号：US4939265A
公开(公告)日：1990-07-03
申请号：US430029
申请日：1989-11-01
申请人： John J. Wright , Sing-Yuen Sit , Neelakantan Balasubramanian , Peter J. Brown
发明人： John J. Wright , Sing-Yuen Sit , Neelakantan Balasubramanian , Peter J. Brown
IPC分类号： C07D257/04 , C07D405/06 , C07F9/6524
CPC分类号： C07D257/04 , C07D405/06 , C07F9/6524
摘要： This invention provides novel tetrazole intermediates of the formula ##STR1## wherein R.sup.1 and R.sup.4 each are independently hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or trifluoromethyl;R.sup.2, R.sup.3, R.sup.5 and R.sup.6 each are independently hydrogen, halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy;B is hydrogen, C.sub.1-4 alkoxycarbonyl, CH.sub.2 Y or CH.sub.2 Z;Y is hydrogen, hydroxyl or X;Z is ##STR2## X is bromo, chloro or iodo; R.sup.10 is C.sub.1-4 alkyl; andR.sup.11 is phenyl which is unsubstituted or substituted by one or two C.sub.1-4 alkyl or chloro substituents.and processes thereof which are useful for the preparation of antihypercholesterolemic agents.
摘要翻译：本发明提供式IMA图的新型四唑中间体，其中R 1和R 4各自独立地为氢，卤素，C 1-4烷基，C 1-4烷氧基或三氟甲基; R 2，R 3，R 5和R 6各自独立地为氢，卤素，C 1-4烷基或C 1-4烷氧基; B是氢，C 1-4烷氧基羰基，CH 2 Y或CH 2 Z; Y是氢，羟基或X; Z是X，Y是溴，氯或碘; R 10是C 1-4烷基; 并且R 11是未被取代或被一个或两个C 1-4烷基或氯取代基取代的苯基。及其制备抗高胆固醇血症药物的方法。

9. 发明授权

US4757684A Fail-safe electric actuator 失效
标题翻译：故障安全电动执行器
公开(公告)号：US4757684A
公开(公告)日：1988-07-19
申请号：US252022
申请日：1981-04-08
申请人： John J. Wright
发明人： John J. Wright
IPC分类号： F16K31/04 , G05G15/00 , F15B15/12
CPC分类号： F16K31/047 , G05G15/00 , Y10S60/911
摘要： A fail-safe electric actuator, for use with a control mechanism such as a valve, is disclosed. The actuator device eliminates the possibility of the control mechanism being locked in operative position by the interruption of electric power, by automatically and mechanically returning the control mechanism to its inopertive position as soon as current is cut off. This is accomplished by the release of a torsion spring, wound previously by the rotation of a fluid-driven vaned torque actuator in turning both the control-mechanism and the electric fail-safe actuator into operative position.
摘要翻译：公开了一种用于诸如阀门的控制机构的故障安全电动致动器。致动器装置消除了通过电力中断将控制机构锁定在操作位置的可能性，一旦电流被切断，则通过自动和机械地将控制机构返回到其不起作用的位置。这是通过释放扭力弹簧来实现的，扭力弹簧先前通过流体驱动的无转矩扭矩致动器的旋转而被卷绕，从而将控制机构和电气故障安全致动器转动到操作位置。

10. 发明授权

US4668686A Imidazoquinoline antithrombrogenic cardiotonic agents 失效
标题翻译：咪唑喹啉抗血栓形成强心剂
公开(公告)号：US4668686A
公开(公告)日：1987-05-26
申请号：US832212
申请日：1986-02-26
申请人： Nicholas Meanwell , John J. Wright
发明人： Nicholas Meanwell , John J. Wright
IPC分类号： C07D487/04 , A61K31/4745 , A61P7/02 , A61P9/04 , C07D471/04 , A61K31/395
CPC分类号： C07D471/04
摘要： Novel series of 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones of the Formula ##STR1## wherein R.sub.1 is halogen, lower alkyl, lower alkoxy, trifluoromethyl; R.sub.2 is hydrogen, halogen, lower alkyl, lower alkoxy; R.sub.3 is hydrogen, halogen, lower alkyl, lower alkoxy; and R.sub.4 is hydrogen or lower alkyl. The compounds are therapeutically useful as inhibitors of blood platelet aggregation and/or as cardiotonic agents.
摘要翻译：新颖的式（XI）的1,3-二氢-2H-咪唑并[4,5-b]喹啉-2-酮系列其中R 1是卤素，低级烷基，低级烷氧基，三氟甲基; R2是氢，卤素，低级烷基，低级烷氧基; R3是氢，卤素，低级烷基，低级烷氧基; R4是氢或低级烷基。该化合物可用作血小板聚集抑制剂和/或作为强心剂。

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