专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090318521A1 Synthesis of 4-Bromomethyl-2'-Formylbiphenyl and 4-Bromomethyl-2'-Hydroxymethylbiphenyl and Its Use in Preparation of Giotensin II Antagonists 失效
标题翻译： 4-溴甲基-2'-甲酰基联苯和4-溴甲基-2'-羟甲基联苯的合成及其在制备高血压素II拮抗剂中的应用
公开(公告)号：US20090318521A1
公开(公告)日：2009-12-24
申请号：US11887637
申请日：2006-03-30
申请人： Anton Copar , Ljubomic Antoncic , Matej Antoncic
发明人： Anton Copar , Ljubomic Antoncic , Matej Antoncic
IPC分类号： A61K31/4184 , C07C33/46 , C07C22/04 , C07D403/04
CPC分类号： C07D235/02 , C07C33/46 , C07C45/44 , C07C47/55 , C07D403/04 , C07D417/08 , C07C47/546
摘要： 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl are useful starting material for the preparation various angiotenzin II antagonists, which are prepared from 4-bromomethyl-2′-cyanobiphenyl or 4′-bromomethylbiphenylcarboxyilic derivatives using selected hydride reagent.
摘要翻译： 4-溴甲基-2'-甲酰基联苯和4-溴甲基-2'-羟甲基联苯是用于制备各种血管紧张素II拮抗剂的起始原料，其由4-溴甲基-2'-氰基联苯或4'-溴甲基联苯羧基衍生物制备，使用所选择的氢化物试剂。

2. 发明授权

US07968727B2 Synthesis of 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl and its use in preparation of angiotensin II antagonists 失效
标题翻译： 4-溴甲基-2'-甲酰基联苯和4-溴甲基-2'-羟甲基联苯的合成及其在制备血管紧张素II拮抗剂中的应用
公开(公告)号：US07968727B2
公开(公告)日：2011-06-28
申请号：US11887637
申请日：2006-03-30
申请人： Anton Copar , Ljubomir Antoncic , Matej Antoncic
发明人： Anton Copar , Ljubomir Antoncic , Matej Antoncic
IPC分类号： C07D235/06 , C07C255/03 , C07C47/54 , C07C33/24
CPC分类号： C07D235/02 , C07C33/46 , C07C45/44 , C07C47/55 , C07D403/04 , C07D417/08 , C07C47/546
摘要： 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl are useful starting material for the preparation various angiotenzin II antagonists, which are prepared from 4-bromomethyl-2′-cyanobiphenyl or 4′-bromomethylbiphenylcarboxyilic derivatives using selected hydride reagent.
摘要翻译： 4-溴甲基-2'-甲酰基联苯和4-溴甲基-2'-羟甲基联苯是用于制备各种血管紧张素II拮抗剂的起始原料，其由4-溴甲基-2'-氰基联苯或4'-溴甲基联苯羧基衍生物制备，使用所选择的氢化物试剂。

3. 发明授权

US08697741B2 Process for the preparation of amorphous calcium salt of atorvastatin 失效
标题翻译：阿托伐他汀无定形钙盐的制备方法
公开(公告)号：US08697741B2
公开(公告)日：2014-04-15
申请号：US12397981
申请日：2009-03-04
申请人： Ljubomir Antoncic , Gorazd Sorsak , Anton Copar
发明人： Ljubomir Antoncic , Gorazd Sorsak , Anton Copar
IPC分类号： C07D207/34 , A61K31/40
CPC分类号： C07D207/34
摘要： A process for the preparation of amorphous atorvastatin calcium. The process includes providing a reaction mixture having a pH between 6.5 and 8.0 containing a sodium salt of atorvastatin and tetrahydrofuran. A non-cyclic chlorinated organic solvent selected from the group consisting of dichloromethane, trichloroethane, tetrachloroethane and chloroform or addition of cyclic hydrocarbon solvent selected from the group consisting of cyclohexane, cyclopentane and methyl cyclohexane is added to provide a mixture of organic solvents. An equivalent or an excess quantity of a source of calcium ions selected from the group consisting of calcium acetate and calcium chloride is added. Amorphous atorvastatin calcium is isolated from an organic phase comprising the mixture of organic solvents.
摘要翻译：一种制备无定形阿托伐他汀钙的方法。该方法包括提供pH为6.5至8.0的含有阿托伐他汀和四氢呋喃的钠盐的反应混合物。加入选自二氯甲烷，三氯乙烷，四氯乙烷和氯仿的非环状氯化有机溶剂或加入选自环己烷，环戊烷和甲基环己烷的环状烃溶剂以提供有机溶剂的混合物。加入等量或过量的钙离子源，其选自乙酸钙和氯化钙。从包含有机溶剂的混合物的有机相中分离无定形阿托伐他汀钙。

4. 发明授权

US07553856B2 Crystalline form of omeprazole 有权
标题翻译：奥美拉唑的结晶形式
公开(公告)号：US07553856B2
公开(公告)日：2009-06-30
申请号：US11248461
申请日：2005-10-12
申请人： Natasa H Milac , Anton Copar , Barbara Podobnik , Andreja C Belcic , Alenka Kosak , Brina Ornik , Uros Urleb
发明人： Natasa H Milac , Anton Copar , Barbara Podobnik , Andreja C Belcic , Alenka Kosak , Brina Ornik , Uros Urleb
IPC分类号： A61K31/4439
CPC分类号： C07D401/12
摘要： A novel crystalline form of the substrate known under the chemical name 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfiny]-1H-benzimidazole, and having the generic name omeprazole, hereinafter referred to as omeprozole form C, is disclosed. Further, a process for the preparation of omeprazole form C, a pharmaceutical formulation containing omeprazole form C in admixture with pharmaceutically acceptable excipients and the use of omeprazole form C for treatment of gastrointestinal disorders are disclosed.
摘要翻译：以化学名称为5-甲氧基-2 - [[（4-甲氧基-3,5-二甲基-2-吡啶基）甲基]亚磺酰基] -1H-苯并咪唑的新颖的底物结晶形式，具有通用名奥美拉唑，以下称为奥美曲唑C型。此外，公开了制备奥美拉唑C型的方法，一种含有与药学上可接受的赋形剂混合的奥美拉唑C形式的药物制剂以及奥美拉唑C型用于治疗胃肠道疾病的用途。

5. 发明申请

US20090012140A1 Preparation of Telmisartan Salts with Improved Solubility 审中-公开
标题翻译：改善溶解度的替米沙坦盐的制备
公开(公告)号：US20090012140A1
公开(公告)日：2009-01-08
申请号：US11718838
申请日：2005-11-09
申请人： Ljubomir Antoncic , Anton Copar
发明人： Ljubomir Antoncic , Anton Copar
IPC分类号： A61K31/4184 , C07D403/04 , A61P9/12
CPC分类号： C07D235/20
摘要： New alkali and earth-alkali salts of telmisartan in amorphous form and a new crystalline sodium salt of telmisartan have been prepared by preparing a solution despite low solubility of telmisartan and rapidly vacuum evaporating to dryness.
摘要翻译：通过制备溶液，尽管替米沙坦的溶解度低，并且迅速真空蒸发至干，已经制备了无定形形式的替米沙坦替代米沙坦的新碱和碱 - 碱盐和替米沙坦的新结晶钠盐。

6. 发明授权

US5389654A 3-ethyl 5-methyl(.+-.)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-d ihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate 失效
标题翻译：（+/-）2- [2-（N-三苯甲基氨基）乙氧基甲基] -4-（2-氯苯基）-1,4-二氢-6-甲基-6-甲基-3,5- 吡啶二羧酸酯
公开(公告)号：US5389654A
公开(公告)日：1995-02-14
申请号：US149735
申请日：1993-11-10
申请人： Borut Furlan , Anton Copar , Alenka Jeriha
发明人： Borut Furlan , Anton Copar , Alenka Jeriha
IPC分类号： C07D211/90 , A61K31/455 , C07D211/86
CPC分类号： C07D211/90
摘要： There is disclosed a process for the preparation of 3-ethyl 5-methyl (.+-.) 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridine-dicarboxylate monobenzenesulphonate (amlodipine benzenesulphonate) of formula ##STR1## wherein 3-ethyl 5-methyl (.+-.) 2-[2-(N-tritylamino)-ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate is reacted with benzenesulphonic acid in a methanolic or an aqueous methanolic medium at a temperature from 20.degree. C. to the reflux temperature and the title compound is isolated and purified.Amlodipine benzene sulphonate is a valuable anti-ischaemic and anti-hypertensive agent.
摘要翻译：公开了制备3-乙基5-甲基（+/-）2 - [（2-氨基乙氧基）甲基] -4-（2-氯苯基）-1,4-二氢-6-甲基-3 ，其中3-乙基5-甲基（+/-）2- [2-（N-三苯甲基氨基） - 乙氧基甲基] -4-（2-氯苯基） - 苯并噻唑-5-磺酸盐（氨氯地平苯磺酸盐） 1,4-二氢-6-甲基-3,5-吡啶二羧酸酯与苯磺酸在甲醇或甲醇水溶液中在20℃至回流温度下反应，分离纯化标题化合物。氨氯地平苯磺酸盐是有价值的抗缺血和抗高血压药物。

7. 发明申请

US20090182030A1 PROCESS FOR THE PREPARATION OF AMORPHOUS CALCIUM SALT OF ATORVASTATIN 失效
标题翻译：制备ATORVASTATIN的无定形钙盐的方法
公开(公告)号：US20090182030A1
公开(公告)日：2009-07-16
申请号：US12397981
申请日：2009-03-04
申请人： Ljubomir Antoncic , Gorazd Sorsak , Anton Copar
发明人： Ljubomir Antoncic , Gorazd Sorsak , Anton Copar
IPC分类号： A61K31/40 , C07D207/34
CPC分类号： C07D207/34
摘要： A process for the preparation of amorphous atorvastatin calcium. The process includes providing a reaction mixture having a pH between 6.5 and 8.0 containing a sodium salt of atorvastatin and tetrahydrofuran. A non-cyclic chlorinated organic solvent selected from the group consisting of dichloromethane, trichloroethane, tetrachloroethane and chloroform or addition of cyclic hydrocarbon solvent selected from the group consisting of cyclohexane, cyclopentane and methyl cyclohexane is added to provide a mixture of organic solvents. An equivalent or an excess quantity of a source of calcium ions selected from the group consisting of calcium acetate and calcium chloride is added. Amorphous atorvastatin calcium is isolated from an organic phase comprising the mixture of organic solvents.
摘要翻译：一种制备无定形阿托伐他汀钙的方法。该方法包括提供pH为6.5至8.0的含有阿托伐他汀和四氢呋喃的钠盐的反应混合物。加入选自二氯甲烷，三氯乙烷，四氯乙烷和氯仿的非环状氯化有机溶剂或加入选自环己烷，环戊烷和甲基环己烷的环状烃溶剂以提供有机溶剂的混合物。加入等量或过量的钙离子源，其选自乙酸钙和氯化钙。从包含有机溶剂的混合物的有机相中分离无定形阿托伐他汀钙。

8. 发明申请

US20080033207A1 Preparation of R-5- (2-(2-Ethoxyphenoxyetylamino) -2-Methoxybenzen-Sulphonamide Hydrochloride of High Chemical 审中-公开
标题翻译：高效化学制备R-5-（2-（2-乙氧基苯氧乙酰基氨基）-2-甲氧基苯磺酰胺盐酸盐
公开(公告)号：US20080033207A1
公开(公告)日：2008-02-07
申请号：US10584651
申请日：2004-12-27
申请人： Borut Furlan , Anton Copar
发明人： Borut Furlan , Anton Copar
IPC分类号： C07C311/16 , C07C303/40 , C07C303/44
CPC分类号： C07C311/37 , C07C303/40 , C07C303/44
摘要： In the present invention, the process for the preparation of tamsulosin hydrochloride and subsequent purification with thermal crystallisation to provide essentially pure tamsulosin hydrochloride is disclosed.
摘要翻译：在本发明中，公开了制备盐酸坦洛新并随后用热结晶纯化以提供基本上纯的坦索罗辛盐酸盐的方法。

9. 发明授权

US5438145A Process for the preparation of amlodipine benzenesulphonate 失效
标题翻译：制备苯磺酸氨氯地平的方法
公开(公告)号：US5438145A
公开(公告)日：1995-08-01
申请号：US295023
申请日：1994-08-25
申请人： Borut Furlan , Anton Copar , Alenka Jeriha
发明人： Borut Furlan , Anton Copar , Alenka Jeriha
IPC分类号： C07D211/90 , C07D211/86
CPC分类号： C07D211/90
摘要： There is disclosed a process for the preparation of 3-ethyl 5-methyl (.+-.) 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridine-dicarboxylate monobenzenesulphonate (amlodipine benzenesulphonate) of formula ##STR1## wherein 3-ethyl 5-methyl (.+-.) 2-[2-(N-tritylamino)-ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinecarboxylate is reacted with benzenesulphonic acid in a methanolic or an aqueous methanolic medium at a temperature from 20.degree. C. to the reflux temperature and the title compound is isolated and purified.Amlodipine benzene sulphonate is a valuable anti-ischaemic and anti-hypertensive agent.
摘要翻译：公开了制备3-乙基5-甲基（+/-）2 - [（2-氨基乙氧基）甲基] -4-（2-氯苯基）-1,4-二氢-6-甲基-3 ，其中3-乙基5-甲基（+/-）2- [2-（N-三苯甲基氨基） - 乙氧基甲基] -4-（2-氯苯基） - 苯并噻唑-5-磺酸盐（氨氯地平苯磺酸盐） 1,4-二氢-6-甲基-3,5-吡啶羧酸甲酯与苯磺酸在甲醇或甲醇水溶液中在20℃至回流温度下反应，分离纯化标题化合物。氨氯地平苯磺酸盐是有价值的抗缺血和抗高血压药物。

10. 发明授权

US09512097B2 Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives 有权
标题翻译： 3-芳酰基-5-氨基苯并呋喃衍生物的制备方法
公开(公告)号：US09512097B2
公开(公告)日：2016-12-06
申请号：US13884179
申请日：2011-11-11
申请人： Frank Richter , Erwin Schreiner , Samo Pirc , Anton Copar
发明人： Frank Richter , Erwin Schreiner , Samo Pirc , Anton Copar
IPC分类号： C07D307/00 , C07D307/81 , C07D307/82 , C07D307/84 , A61K31/343
CPC分类号： C07D307/81 , A61K31/343 , C07D307/82 , C07D307/84
摘要： The present invention relates to a process for the preparation of 3-aroyl-5-aminobenzofuran derivatives useful as antiarrhythmic drugs which avoids the use of nitro intermediates.
摘要翻译：本发明涉及一种制备可用作抗心律失常药物的3-芳酰基-5-氨基苯并呋喃衍生物的方法，其避免使用硝基中间体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式