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1. 发明申请

US20070255357A1 NASAL DECOLONIZATION OF MICROBES 审中-公开
标题翻译：微生物的NASAL分解
公开(公告)号：US20070255357A1
公开(公告)日：2007-11-01
申请号：US11741627
申请日：2007-04-27
申请人： Andreas Rose , Nicolas G. Loebel , Guenter Herr , Kyle Johnston , Cale Street , Roger Andersen
发明人： Andreas Rose , Nicolas G. Loebel , Guenter Herr , Kyle Johnston , Cale Street , Roger Andersen
IPC分类号： A61N5/06
CPC分类号： A61N5/0603 , A61B2018/2261 , A61N5/0601 , A61N5/062 , A61N5/0624 , A61N2005/0605 , A61N2005/0607 , A61N2005/0644 , A61N2005/0645 , A61N2005/0662
摘要： The present invention presents devices, kits, systems and methods that can be used for nasal decolonization of microbes and treatment of MRSA, E. coli, and E. fecalis. For example, it includes a method for nasal decolonization of microbes comprising: applying a photosensitizing composition comprising methylene blue to anterior nares; inserting at least a portion of a light delivery device into the nasal cavity; and applying light to the anterior nares at a wavelength ranges from about 650 nm to 680 nm; wherein the light is delivered by the light delivery device to the anterior nares; the light delivery device is in light communication with a light source via a waveguide; and over 90% of the microbes at the anterior nares is eliminated by the nasal decolonization.
摘要翻译：本发明提供了可用于微生物鼻非殖民化和MRSA，大肠杆菌和E.粪便的治疗的装置，试剂盒，系统和方法。例如，它包括一种用于微生物鼻腔非殖民化的方法，包括：将包含亚甲蓝的光敏组合物施用于前鼻孔; 将光输送装置的至少一部分插入鼻腔中; 并在约650nm至680nm的波长范围内向前鼻孔施加光; 其中所述光由所述光输送装置输送到所述前鼻孔; 光输送装置经由波导与光源光连通; 前鼻孔的超过90％的微生物被鼻非殖民化所消除。

2. 发明申请

US20080119914A1 TREATMENT FOR OTITIS EXTERNA 有权
标题翻译： OTITIS EXTERNA治疗
公开(公告)号：US20080119914A1
公开(公告)日：2008-05-22
申请号：US11741604
申请日：2007-04-27
申请人： Andreas Rose , Nicolas G. Loebel , Guenter Herr , Kyle Johnston , Cale Street , Roger Andersen
发明人： Andreas Rose , Nicolas G. Loebel , Guenter Herr , Kyle Johnston , Cale Street , Roger Andersen
IPC分类号： A61N5/06
CPC分类号： A61N5/0603 , A61B2018/2261 , A61N5/0601 , A61N5/062 , A61N5/0624 , A61N2005/0605 , A61N2005/0607 , A61N2005/0644 , A61N2005/0645 , A61N2005/0662
摘要： The present invention presents devices, kits, systems and methods that can be used to otitis externa. For example, a method of present invention includes applying a photosensitizing composition to treatment site within ear cavity where microbes causing otitis externa are located; inserting at least a portion of a light delivery device into the cavity; and applying light to the treatment site at a wavelength absorbed by the photosensitizing composition so as to inhibit or eliminate the microbes and/or to reduce inflammation at the treatment site but without causing physiological damage to host tissue within the ear cavity; wherein the light is delivered by the light delivery device to the treatment site and the light delivery device is in light communication with a light source via a waveguide.
摘要翻译：本发明提供了可用于外耳炎的装置，试剂盒，系统和方法。例如，本发明的方法包括将光敏组合物施用于引起耳外耳道微生物的耳腔内的治疗部位; 将光输送装置的至少一部分插入空腔中; 并以由光敏组合物吸收的波长对处理部位施加光，以抑制或消除微生物和/或减少治疗部位的炎症，但不会对耳腔内的宿主组织造成生理损伤; 其中所述光被所述光输送装置输送到所述处理部位，并且所述光输送装置经由波导与光源光连通。

3. 发明申请

US20070255356A1 PHOTODISINFECTION DELIVERY DEVICES AND METHODS 审中-公开
标题翻译：光电传输装置和方法
公开(公告)号：US20070255356A1
公开(公告)日：2007-11-01
申请号：US11741584
申请日：2007-04-27
申请人： Andreas Rose , Nicolas G. Loebel , Guenter Herr , Kyle Johnson , Cale Street , Roger Anderson
发明人： Andreas Rose , Nicolas G. Loebel , Guenter Herr , Kyle Johnson , Cale Street , Roger Anderson
IPC分类号： A61N5/06
CPC分类号： A61N5/0603 , A61B2018/2261 , A61N5/0601 , A61N5/062 , A61N5/0624 , A61N2005/0605 , A61N2005/0607 , A61N2005/0644 , A61N2005/0645 , A61N2005/0662
摘要： The present invention presents devices, kits, systems and methods that can be used to deliver and activate a photosensitizing composition in a cavity. For example, a device of the present invention includes a member having a base portion, an insert portion adapted for insertion into the cavity, and a pocket adapted for communication with a waveguide which is connected to a light source for delivering light to the device, wherein the pocket includes a light dispersing section that is adapted for light communication with distal end of the waveguide and desired illumination pattern for photodisinfection of the cavity is provided by at least one of the elements selected from the group consisting of: surface finish of the light dispersing section, geometry of the light dispersing section, surface finish of the member, geometry of the member, and a combination thereof. The present invention can be used for humans, other animals, and inanimate objects.
摘要翻译：本发明提供可用于在空腔中递送和激活光敏组合物的装置，试剂盒，系统和方法。例如，本发明的装置包括具有底座部分，适于插入空腔中的插入部分和适于与波导连通的口，该波导连接到用于将光传送到设备的光源，其中所述口袋包括适于与所述波导的远端进行光连通的光分散部分，并且由所述光源的表面光洁度中的至少一种元件提供用于对所述空腔进行光学感应的所需照明图案。分散部分，光分散部分的几何形状，部件的表面光洁度，部件的几何形状及其组合。本发明可用于人类，其他动物和无生命物体。

4. 发明授权

US07950396B2 Treatment for otitis externa 有权
标题翻译：外耳炎治疗
公开(公告)号：US07950396B2
公开(公告)日：2011-05-31
申请号：US11741604
申请日：2007-04-27
申请人： Andreas Rose , Nicholas G. Loebel , Cale Street , Roger Andersen
发明人： Andreas Rose , Nicholas G. Loebel , Cale Street , Roger Andersen
IPC分类号： A61B19/00
CPC分类号： A61N5/0603 , A61B2018/2261 , A61N5/0601 , A61N5/062 , A61N5/0624 , A61N2005/0605 , A61N2005/0607 , A61N2005/0644 , A61N2005/0645 , A61N2005/0662
摘要： The present invention presents devices, kits, systems and methods that can be used to otitis externa. For example, a method of present invention includes applying a photosensitizing composition to treatment site within ear cavity where microbes causing otitis externa are located; inserting at least a portion of a light delivery device into the cavity; and applying light to the treatment site at a wavelength absorbed by the photosensitizing composition so as to inhibit or eliminate the microbes and/or to reduce inflammation at the treatment site but without causing physiological damage to host tissue within the ear cavity; wherein the light is delivered by the light delivery device to the treatment site and the light delivery device is in light communication with a light source via a waveguide.
摘要翻译：本发明提供了可用于外耳炎的装置，试剂盒，系统和方法。例如，本发明的方法包括将光敏组合物施用于引起耳外耳道微生物的耳腔内的治疗部位; 将光输送装置的至少一部分插入空腔中; 以光吸收组合物吸收的波长向处理部位施加光，以抑制或消除微生物和/或减少治疗部位的炎症，但不会对耳腔内的宿主组织造成生理损伤; 其中所述光被所述光输送装置输送到所述处理部位，并且所述光输送装置经由波导与光源光连通。

5. 发明申请

US20080269845A1 WAVEGUIDE CONNECTION DEVICE 审中-公开
标题翻译：波形连接装置
公开(公告)号：US20080269845A1
公开(公告)日：2008-10-30
申请号：US11876376
申请日：2007-10-22
申请人： Andreas Rose , Kyle Johnston , Guenter Herr
发明人： Andreas Rose , Kyle Johnston , Guenter Herr
IPC分类号： A61N5/06 , G02B6/38
CPC分类号： A61N5/0624 , A61N5/0601 , A61N5/062 , G02B6/3806 , G02B6/3809 , G02B6/3825 , G02B6/3855 , G02B6/3858
摘要： A connector for interconnecting a waveguide with a light component (e.g., another waveguide) for allowing light communication therebetween. Assemblies for connecting a waveguide can be formed with the connector. In one embodiment, the connector is employed for connecting to a waveguide useful in performing medical applications such as provision of photodynamic therapy.
摘要翻译：用于将波导与光分量（例如，另一波导）互连的连接器，用于允许光之间的光通信。可以用连接器形成用于连接波导的组件。在一个实施例中，连接器用于连接到用于执行诸如提供光动力疗法的医学应用的波导管。

6. 发明授权

US07334947B2 Alignment system and method 失效
标题翻译：校准系统和方法
公开(公告)号：US07334947B2
公开(公告)日：2008-02-26
申请号：US11549702
申请日：2006-10-16
申请人： Andreas Rose , Guenter Herr , Kyle Johnston
发明人： Andreas Rose , Guenter Herr , Kyle Johnston
IPC分类号： G02B6/36
CPC分类号： G02B6/4292 , G02B6/4204 , G02B6/4234 , G02B6/4236
摘要： The present invention provides an alignment system comprising a base having a feature that accepts a first optical element, a first eccentric element having a through hole that accepts an eccentric assembly comprising a second eccentric element having a feature that accepts a second optical element and is attached to the second optical element via second attachment means, wherein the first eccentric element is engaged with the base via first attachment means and axial alignment between optical axis of the first optical element and optical axis of the second optical element is achieved by rotationally adjusting at least one of the eccentric elements relative to the base. The present invention also provides methods to make and use this alignment system.
摘要翻译：本发明提供了一种对准系统，其包括具有接受第一光学元件的特征的基座，具有通孔的第一偏心元件，该偏心元件接收偏心组件，该偏心组件包括具有接受第二光学元件的特征的第二偏心元件，通过第二附接装置到达第二光学元件，其中第一偏心元件通过第一附接装置与基座接合，并且通过至少旋转地调节第一光学元件的光轴和第二光学元件的光轴之间的轴向对准来实现相对于基地的偏心元素之一。本发明还提供了制造和使用该对准系统的方法。

7. 发明申请

US20070260231A1 Optical probe for delivery of light 审中-公开
标题翻译：用于发光的光学探头
公开(公告)号：US20070260231A1
公开(公告)日：2007-11-08
申请号：US11397768
申请日：2006-04-04
申请人： Andreas Rose , Guenter Herr , Joe Ridge , Kyle Johnston
发明人： Andreas Rose , Guenter Herr , Joe Ridge , Kyle Johnston
IPC分类号： A61B18/18
CPC分类号： A61B18/14 , A61B2018/2238 , A61B2018/2261 , A61N5/06 , A61N5/0601 , A61N5/0603 , A61N5/062 , A61N2005/0606 , A61N2005/0644 , A61N2005/066 , A61N2005/0661
摘要： The present invention discloses an optical probe employed for the delivery of light. More particularly, the present invention relates to an optical probe, a probe tip or combination thereof and its uses for delivery of light to upon surfaces of tissue and other portions of the human body or other organisms.
摘要翻译：本发明公开了一种用于发光的光探头。更具体地，本发明涉及光学探针，探针尖端或其组合，以及其用于将光传递到人体或其他生物体的组织和其它部分的表面上的用途。

8. 发明申请

US20070165985A1 ALIGNMENT SYSTEM AND METHOD 失效
标题翻译：对准系统和方法
公开(公告)号：US20070165985A1
公开(公告)日：2007-07-19
申请号：US11549702
申请日：2006-10-16
申请人： Andreas Rose , Guenter Herr , Kyle Johnston
发明人： Andreas Rose , Guenter Herr , Kyle Johnston
IPC分类号： G02B6/36
CPC分类号： G02B6/4292 , G02B6/4204 , G02B6/4234 , G02B6/4236
摘要： The present invention provides an alignment system comprising a base having a feature that accepts a first optical element, a first eccentric element having a through hole that accepts an eccentric assembly comprising a second eccentric element having a feature that accepts a second optical element and is attached to the second optical element via second attachment means, wherein the first eccentric element is engaged with the base via first attachment means and axial alignment between optical axis of the first optical element and optical axis of the second optical element is achieved by rotationally adjusting at least one of the eccentric elements relative to the base. The present invention also provides methods to make and use this alignment system.
摘要翻译：本发明提供了一种对准系统，其包括具有接受第一光学元件的特征的基座，具有通孔的第一偏心元件，该偏心元件接收偏心组件，该偏心组件包括具有接受第二光学元件的特征的第二偏心元件，通过第二附接装置到达第二光学元件，其中第一偏心元件通过第一附接装置与基座接合，并且通过至少旋转地调节第一光学元件的光轴和第二光学元件的光轴之间的轴向对准来实现相对于基地的偏心元素之一。本发明还提供了制造和使用该对准系统的方法。

9. 发明申请

US20080255549A1 PHOTODYNAMIC THERAPY DEVICE 审中-公开
标题翻译：光电疗法装置
公开(公告)号：US20080255549A1
公开(公告)日：2008-10-16
申请号：US11868677
申请日：2007-10-08
申请人： Andreas Rose , Guenter Herr , Kyle Johnston
发明人： Andreas Rose , Guenter Herr , Kyle Johnston
IPC分类号： A61B18/18
CPC分类号： A61C17/20 , A61C19/004 , A61C19/06 , A61N5/0601 , A61N5/062 , A61N2005/0606
摘要： The invention described herein is an apparatus for performing photodynamic therapy comprising: a waveguide, a light source in communication with one end of the waveguide, a photodynamic tip in communication with another end of the waveguide wherein the photodynamic tip is designed to be securely but removably attached to a scaling tip of a scaler and the apparatus delivers light in a desired illumination pattern and in at least one predetermined wavelength to activate a photosensitizing composition for the killing of microbes. The invention also includes a method for using the apparatus in conjunction with a scaler to perform sonophotodynamic therapy and a method for making the apparatus.
摘要翻译：本文描述的本发明是一种用于执行光动力学治疗的装置，包括：波导，与波导的一端连通的光源，与波导的另一端连通的光动力尖端，其中光动力尖端被设计成可靠地但可拆卸的附着到定标器的缩放尖端，并且该设备以期望的照明图案和至少一个预定波长递送光，以激活用于杀死微生物的光敏组合物。本发明还包括一种使用该设备结合定标器执行超声光动力学治疗的方法和一种制造该装置的方法。

10. 发明申请

US20070027443A1 HAND PIECE FOR THE DELIVERY OF LIGHT AND SYSTEM EMPLOYING THE HAND PIECE 审中-公开
标题翻译：用于交付轻型手柄和使用手柄的系统
公开(公告)号：US20070027443A1
公开(公告)日：2007-02-01
申请号：US11425548
申请日：2006-06-21
申请人： Andreas Rose , Guenter Herr , Nicolas Loebel
发明人： Andreas Rose , Guenter Herr , Nicolas Loebel
IPC分类号： A61B18/18 , A61C1/00 , A61C3/00
CPC分类号： A61B18/22 , A61B5/0088 , A61B2018/225 , A61B2090/0813 , A61B2090/306 , A61C1/088 , A61C19/004 , A61F9/008 , A61F9/00802 , A61N5/0601 , A61N5/0603 , A61N5/062 , A61N2005/0606 , A61N2005/0644 , G02B6/381
摘要： The invention described here is an improved hand piece for the delivery of light and a system employing the hand piece. The hand piece typically includes a body and an optical element such as an optical fiber coextensive with the body. The system can include a remote light source and an optical element (e.g., a source optical fiber) for providing light to the hand piece.
摘要翻译：这里描述的发明是用于传送光的改进的手部件和使用手持件的系统。手持件通常包括主体和诸如与身体共同延伸的光纤的光学元件。该系统可以包括远程光源和用于向手持件提供光的光学元件（例如，源光纤）。

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