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1. 发明授权

US5866140A Type I surface antigen associated with staphylococcus epidermidis 失效
公开(公告)号：US5866140A
公开(公告)日：1999-02-02
申请号：US361821
申请日：1994-12-22
申请人： Ali Ibrahim Fattom , Walter W. Karakawa, deceased , D. Craig Wright
发明人： Ali Ibrahim Fattom , Walter W. Karakawa, deceased , D. Craig Wright
IPC分类号： A61K39/395 , A61K39/00 , A61K39/002 , A61K39/085 , A61K39/09 , A61P31/04 , A61P37/04 , C07K14/195 , C07K14/41 , C07K14/705 , C07K16/00 , C07K16/12 , C12P19/04 , C12Q1/14 , G01N33/569 , A61K39/02 , A61K45/00
CPC分类号： A61K39/085 , C07K16/1271 , C12P19/04 , A61K39/00
摘要： A process is disclosed for culturing clinical Staphylococcus epidermidis cells that reproducibly enables identification of a limited number of predominant serotypes. Two predominant serotypes common to most clinical cases of S. epidermidis have been identified and are denoted Type I and Type II. A particular polysaccharide surface antigen is associated with each of the Type I and Type II serotypes. The surface antigens can be used to provide active and passive immunization against S. epidermidis infection and to produce a hyperimmune immunoglobulin or antibodies for treatment of S. epidermidis infection.

2. 发明授权

US5961975A Type I surface antigen associated with staphylococcus epidermidis 失效
标题翻译：与表皮葡萄球菌相关的I型表面抗原
公开(公告)号：US5961975A
公开(公告)日：1999-10-05
申请号：US472211
申请日：1995-06-07
申请人： Ali Ibrahim Fattom , Walter W. Karakawa , D. Craig Wright
发明人： Ali Ibrahim Fattom , Walter W. Karakawa , D. Craig Wright
IPC分类号： A61K39/395 , A61K39/00 , A61K39/002 , A61K39/085 , A61K39/09 , A61P31/04 , A61P37/04 , C07K14/195 , C07K14/41 , C07K14/705 , C07K16/00 , C07K16/12 , C12P19/04 , C12Q1/14 , G01N33/569 , A61K39/40
CPC分类号： A61K39/085 , C07K16/1271 , C12P19/04 , A61K39/00
摘要： A process is disclosed for culturing clinical Staphylococcus epidermidis cells that reproducibly enables identification of a limited number of predominant serotypes. Two predominant serotypes common to most clinical cases of S. epidermidis have been identified and are denoted Type I and Type II. A particular polysaccharide surface antigen is associated with each of the Type I and Type II serotypes. The surface antigens can be used to provide active and passive immunization against S. epidermidis infection and to produce a hyperimmune immunoglobulin or antibodies for treatment of S. epidermidis infection.
摘要翻译：公开了用于培养临床表皮葡萄球菌细胞的方法，其可再现地使得能够鉴定有限数量的主要血清型。已经鉴定了大多数表皮葡萄球菌临床病例常见的两种主要血清型，并且表示为I型和II型。特定的多糖表面抗原与I型和II型血清型各自相关。表面抗原可用于提供针对表皮葡萄球菌感染的主动和被动免疫，并产生用于治疗表皮葡萄球菌感染的超免疫免疫球蛋白或抗体。

3. 发明授权

US06387373B1 Vaccines containing paucilsmellar lipid vesicles as immunological adjuvants 失效
标题翻译：含有微囊脂质囊泡作为免疫佐剂的疫苗
公开(公告)号：US06387373B1
公开(公告)日：2002-05-14
申请号：US08840034
申请日：1997-04-24
申请人： D. Craig Wright , Donald F. H. Wallach
发明人： D. Craig Wright , Donald F. H. Wallach
IPC分类号： A61K3900
CPC分类号： A61K39/39 , A61K9/1272 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/543 , A61K2039/55555 , C12N2760/16134 , C12N2760/16234
摘要： The present invention features an adjuvanted vaccine, and methods for preparing an adjuvanted vaccine, preferably for immunizing against influenza, where the adjuvant is a lipid vesicle, and preferably is a nonphospholipid, paucilamellar lipid vesicle. The antigen may be encapsulated in the central cavity of the adjuvant, or mixed in solution with the adjuvant. Moreover, the adjuvant may carry a secondary adjuvant to further improve the immune response.
摘要翻译：本发明的特征在于佐剂疫苗，以及用于制备佐剂化疫苗的方法，优选用于免疫流感，其中佐剂是脂质囊泡，并且优选是非磷脂，薄膜脂质囊泡。抗原可以封装在佐剂的中心腔中，或者与佐剂在溶液中混合。此外，佐剂可以携带辅助佐剂以进一步改善免疫应答。

4. 发明授权

US5549901A Antimicrobial oil-in-water emulsions 失效
标题翻译：抗菌油包水乳剂
公开(公告)号：US5549901A
公开(公告)日：1996-08-27
申请号：US322827
申请日：1994-10-13
申请人： D. Craig Wright
发明人： D. Craig Wright
IPC分类号： A61K9/127 , A61K31/14 , A61K31/23 , A61K45/06 , A61K7/40
CPC分类号： A61K9/1272 , A61K31/14 , A61K31/23 , A61K45/06
摘要： An antimicrobial lipid-containing oil-in-water emulsion comprising an agent selected from the group consisting of glycerol monooleate, glycerol trioleate, glycerol monolaurate, and glycerol dilaurate as the primary lipid and a cationic halogen-containing compound having a C.sub.12 -C.sub.16 chain as a positive charge producing agent is disclosed. The antimicrobial emulsion can be used in the form of a pharmaceutical preparation to inhibit the growth of a wide variety of infectious pathogens.
摘要翻译：一种含抗菌脂质的水包油乳液，其包含选自甘油单油酸酯，甘油三油酸酯，甘油单月桂酸酯和甘油二月桂酸酯作为主要脂质的试剂和具有C12-C16链的阳离子含卤素化合物公开了一种正电荷产生剂。抗微生物乳剂可以以药物制剂的形式使用，以抑制多种感染性病原体的生长。

5. 发明授权

US4824666A Method of large scale growth of toxoplasmic microorganisms 失效
标题翻译：大量生长弓形虫微生物的方法
公开(公告)号：US4824666A
公开(公告)日：1989-04-25
申请号：US120041
申请日：1987-11-13
申请人： D. Craig Wright
发明人： D. Craig Wright
IPC分类号： A61K39/002 , C12N1/10 , G01N33/569 , G01N33/54
CPC分类号： A61K39/002 , C12N1/10 , G01N33/56905
摘要： A method of producing large scale growth of parasites of the genus Toxoplasma is disclosed which comprises inoculating the microorganisms into a non-adherent human cell line, such as a monocytoid lymphoma cell line, and maintaining the cell line in tissue culture media capable of supporting the growth of the microorgranism while the cell line is being maintained. This large scale production allows for the development of vaccines for Toxoplasma microorganisms which previously have been hard to grow in the numbers needed to readily prepare vaccines, and allows for more rapid antibody detection procedures with regard to these microorganisms. There are also disclosed methods for preparing such vaccines, and methods for carrying out antibody detection assays.
摘要翻译：公开了一种产生弓形虫属寄生虫大规模生长的方法，其包括将微生物接种到非贴壁人细胞系如单核细胞淋巴瘤细胞系中，并将细胞系保持在能够支持在保持细胞系的同时微生物的生长。这种大规模生产允许开发以前难以在容易制备疫苗所需的数量生长的弓形虫微生物的疫苗，并且允许针对这些微生物的更快速的抗体检测程序。还公开了制备这种疫苗的方法和用于进行抗体检测测定的方法。

6. 发明授权

US6034073A Solvent detergent emulsions having antiviral activity 失效
标题翻译：具有抗病毒活性的溶剂洗涤剂乳液
公开(公告)号：US6034073A
公开(公告)日：2000-03-07
申请号：US593651
申请日：1996-01-29
申请人： D. Craig Wright
发明人： D. Craig Wright
IPC分类号： A61K9/107 , A01N25/04 , A01N57/12 , A61K31/66 , A61K47/44 , A61L2/00 , G11B20/10 , A01N57/26 , A01N43/08 , A01N43/16
CPC分类号： G11B20/10009 , A01N25/04 , A01N57/12 , A61L2/0088
摘要： Methods and pharmaceutical compositions for inactivating an envelope virus using an oil-in-water emulsion including an oil, a surfactant, and an organic phosphate-based solvent are disclosed. These methods can be used to inactivate a wide variety of envelope viruses, such as HIV.
摘要翻译：公开了使用包含油，表面活性剂和有机磷酸酯基溶剂的水包油乳液灭活包膜病毒的方法和药物组合物。这些方法可用于灭活多种包膜病毒，如HIV。

7. 发明授权

US6015832A Methods of inactivating bacteria including bacterial spores 失效
标题翻译：使细菌灭活的方法包括细菌孢子
公开(公告)号：US6015832A
公开(公告)日：2000-01-18
申请号：US2228
申请日：1997-12-31
申请人： James R. Baker, Jr. , D. Craig Wright , Michael M. Hayes , Tarek Hamouda , Joan Brisker
发明人： James R. Baker, Jr. , D. Craig Wright , Michael M. Hayes , Tarek Hamouda , Joan Brisker
IPC分类号： A01N25/04 , A01N25/30 , A01N59/12 , A61K9/107 , A61K31/075 , A61K31/10 , A61K31/185 , A61K31/198 , A61K31/22 , A61K31/23 , A61K31/341 , A61K47/06 , A61K47/44 , A61P31/04 , A61K31/225
CPC分类号： A61K31/661 , A01N25/04 , A01N59/12 , A61K31/075 , A61K31/10 , A61K31/185 , A61K31/198 , A61K31/341 , A61K9/107 , Y10S514/938 , Y10S514/939 , Y10S514/943
摘要： Methods for inactivating bacteria including bacterial spores using an oil-in-water emulsion are provided. The oil-in-water emulsion comprises an oil, a surfactant and an organic phosphate-based solvent. These methods can be used to inactivate a wide variety of bacteria such as Bacillus.
摘要翻译：提供了使用水包油乳液灭活细菌（包括细菌孢子）的方法。水包油乳液包含油，表面活性剂和有机磷酸盐基溶剂。这些方法可用于灭活多种细菌如芽孢杆菌。

8. 发明授权

US5626844A Monoclonal antibody against ricin A chain 失效
标题翻译：针对蓖麻毒素A链的单克隆抗体
公开(公告)号：US5626844A
公开(公告)日：1997-05-06
申请号：US363204
申请日：1994-12-27
申请人： Paul V. Lemley , D. Craig Wright
发明人： Paul V. Lemley , D. Craig Wright
IPC分类号： A61K38/00 , C07K16/16 , A61K39/395 , A61M5/20
CPC分类号： C07K16/16 , A61K38/00
摘要： Monoclonal antibodies against the A chain of ricin have been found to be ective in protecting mammals from morbidity arising from exposure to ricin toxin. The neutralizing action of the antibodies does not appear to be mediated by complement or by immunoprecipitation. The antibodies of the invention are characterized as of isotype IgG1 having the binding characteristics which include: a) binding specifically to the neutralizing epitope of the ricin A chain and b) providing in vitro protection of at least 95% of EL-4 cells from 100 .eta.g/mL ricin challenge when said antibody is present in the tissue culture at a level of at least 1000 .eta.g/mL.
摘要翻译：已经发现针对A蓖麻毒素链的单克隆抗体在保护哺乳动物免受暴露于蓖麻毒素的发病率方面是有效的。抗体的中和作用似乎不被补体或免疫沉淀介导。本发明的抗体的特征在于具有结合特征的同种型IgG1，其包括：a）特异性结合蓖麻毒素A链的中和表位，和b）提供体外保护至少95％的EL-4细胞从100 当所述抗体以至少1000等于/ mL的水平存在于组织培养物中时，其质量/ mL蓖麻毒蛋白攻击。

9. 发明授权

US5618840A Antibacterial oil-in-water emulsions 失效
标题翻译：抗菌水包油乳剂
公开(公告)号：US5618840A
公开(公告)日：1997-04-08
申请号：US443937
申请日：1995-05-18
申请人： D. Craig Wright
发明人： D. Craig Wright
IPC分类号： A61K9/107 , A01N25/04 , A01N33/12 , A61K9/127 , A61K31/14 , A61K31/23 , A61K31/231 , A61K31/57 , A61K31/575 , A61K45/06 , A61K47/44 , A61P17/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61K7/40
CPC分类号： A61K45/06 , A61K31/14 , A61K31/23 , A61K31/231 , A61K9/1272 , Y10S514/943
摘要： An antibacterial oil-in-water emulsion for inhibiting the growth of Helicobacter pylori is disclosed. The oil-in-water emulsion of the invention comprises droplets of an oily discontinuous phase dispersed in a continuous phase. The oily discontinuous phase contains an oil carrier and a glycerol ester selected from the group consisting of glycerol monooleate and glycerol monostearate. The emulsion can be positively charged, negatively charged or chargeless. In one embodiment, the emulsion is positively charged and further comprises a cationic halogen-containing compound having a C.sub.12 -C.sub.16 chain as a positive charge producing agent. In another embodiment, the emulsion is negatively charged and further comprises an negative charge producing agent having a C.sub.12 -C.sub.22 chain. The disclosed emulsions can be administered to individuals, for example, orally, to treat or prevent Helicobacter pylori infections.
摘要翻译：公开了一种用于抑制幽门螺杆菌生长的抗菌水包油乳剂。本发明的水包油乳液包含分散在连续相中的油性不连续相的液滴。油相不连续相含有选自甘油单油酸酯和甘油单硬脂酸酯的油载体和甘油酯。乳液可以带正电，带负电荷或无电荷。在一个实施方案中，乳液是带正电荷的，并且还包含具有C12-C16链作为正电荷产生剂的阳离子含卤素化合物。在另一个实施方案中，乳液是带负电荷的，并且还包含具有C12-C22链的负电荷产生剂。所公开的乳剂可以例如口服给予个体，以治疗或预防幽门螺杆菌感染。

10. 发明授权

US5730989A Oral vaccine against gram negative bacterial infection 失效
标题翻译：针对革兰氏阴性细菌感染的口服疫苗
公开(公告)号：US5730989A
公开(公告)日：1998-03-24
申请号：US482552
申请日：1995-06-07
申请人： D. Craig Wright
发明人： D. Craig Wright
IPC分类号： A61K9/00 , A61K9/127 , A61K39/02 , A61K39/39 , A61K39/08 , A61K39/112
CPC分类号： A61K39/0275 , A61K39/0258 , A61K39/0266 , A61K39/39 , A61K9/1272 , A61K2039/521 , A61K2039/55555
摘要： The present invention concerns an oral preparation useful as an immunizing agent or vaccine against gram negative bacterial infection. This oral preparation can also be used as a treatment for those infected with gam negative bacteria. The preparations can be used against any gram negative bacterial infection, including Escherichia coli, Shigella flexneri 2a, and Salmonella enteriditis.
摘要翻译：本发明涉及可用作抗革兰氏阴性细菌感染的免疫剂或疫苗的口服制剂。这种口服制剂也可以用作感染gam阴性细菌的人的治疗。制剂可用于抗革兰氏阴性细菌感染，包括大肠杆菌，志贺氏菌志贺氏菌2a和沙门氏菌肠炎。

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