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1. 发明申请

US20110027325A1 ORALLY-ADMINISTERED AGENT 审中-公开
公开(公告)号：US20110027325A1
公开(公告)日：2011-02-03
申请号：US12934819
申请日：2009-03-09
申请人： Yusaku Sugiura , Akira Takahashi , Maki Hironaga , Akio Kabuto , Eiji Suzuki
发明人： Yusaku Sugiura , Akira Takahashi , Maki Hironaga , Akio Kabuto , Eiji Suzuki
IPC分类号： A61K9/00 , A61K31/426 , A61P1/04 , A61P25/20 , A61P9/04 , A61P9/06 , A61P9/12
CPC分类号： A61K9/7007 , A61K9/0053 , A61K9/2086 , A61K9/209 , A61K9/284 , A61K9/2853 , A61K9/2866 , A61K9/2886
摘要： An orally-administered agent according to the present invention comprises: a medicine-containing layer containing a medicine and having surfaces; collapse-controlling layers respectively provided on the surfaces of the medicine-containing layer; and gel-forming layers respectively provided on the collapse-controlling layers, wherein the gel-forming layers are swelled and gelatinized by absorbing water to form a gel. The collapse-controlling layers are constituted of a material containing a stomach-soluble material to be dissolved by being in contact with gastric juice. The orally-administered agent according to the present invention can be swallowed with ease and release the medicine in intended parts, in particular, the stomach of a living body.
摘要翻译：根据本发明的口服制剂包括：含有药物并具有表面的含药层; 分别设置在含药层的表面上的崩溃控制层; 以及分别设置在塌陷控制层上的凝胶形成层，其中凝胶形成层通过吸收水而膨胀并凝胶化以形成凝胶。崩解控制层由含有通过与胃液接触而溶解的胃溶性物质的材料构成。根据本发明的口服制剂可以容易地吞咽，并释放预期部位，特别是生物体的胃中的药物。

2. 发明申请

US20110182954A1 ORALLY-ADMINISTERED AGENT 审中-公开
公开(公告)号：US20110182954A1
公开(公告)日：2011-07-28
申请号：US13121378
申请日：2009-09-15
申请人： Akira Takahashi , Yusaku Sugiura , Maki Hironaga , Akio Kabuto , Eiji Suzuki
发明人： Akira Takahashi , Yusaku Sugiura , Maki Hironaga , Akio Kabuto , Eiji Suzuki
IPC分类号： A61K9/00
CPC分类号： A61K9/284 , A61K9/209 , A61K9/2886
摘要： An orally-administered agent is provided. The orally-administered agent comprises an intestinal medicine-containing layer containing a medicine to be released in intestines and having surfaces; intestinal collapse-controlling layers provided directly or through an arbitrary layer on the surfaces of the intestinal medicine-containing layer, respectively, at least a part of the intestinal collapse-controlling layers being collapsed in the intestines, and each of the intestinal collapse-controlling layers having a surface opposite to the intestinal medicine-containing layer; and gel-forming layers provided directly or through an arbitrary layer on the sides of the surfaces of the intestinal collapse-controlling layers, respectively, wherein the gel-forming layers are swelled and gelatinized by absorbing water to form a gel. The intestinal collapse-controlling layers are constituted of a material containing an enteric material to be dissolved by being in contact with a body fluid in the intestines. The orally-administered agent according to the present invention can be swallowed with ease and can release a medicine at intended parts of a living body (in particular, within intestines).
摘要翻译：提供口服制剂。口服制剂包含肠内药物含有层，其含有要在肠中释放并具有表面的药物; 肠内崩解控制层分别直接或通过肠道药物含有层的表面上的任意层设置，至少一部分肠内崩解控制层在肠中塌陷，并且每个肠塌陷控制具有与肠道药物含有层相反的表面的层; 以及凝胶形成层，其分别直接或通过肠崩解控制层的表面的任意层设置，其中凝胶形成层通过吸水而膨胀并凝胶化以形成凝胶。肠内崩解控制层由含肠内物质的材料构成，通过与肠液接触而溶解肠溶性物质。根据本发明的口服制剂可以容易地吞咽并且可以在生物体（特别是肠内）的目标部位释放药物。

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