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1. 发明申请

US20110117190A1 Pharmaceutical Formulations 审中-公开
标题翻译：药物制剂
公开(公告)号：US20110117190A1
公开(公告)日：2011-05-19
申请号：US12741596
申请日：2008-11-07
申请人： Adrian Brown , Lee J. Gorringe , Stephen Mark McAllister , Wayne M. Matthews , Danielle Genevieve Rebecca Russell
发明人： Adrian Brown , Lee J. Gorringe , Stephen Mark McAllister , Wayne M. Matthews , Danielle Genevieve Rebecca Russell
IPC分类号： A61K9/48 , A61K9/00 , A61K47/38
CPC分类号： A61K9/4816
摘要： The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection moulding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.
摘要翻译：本发明涉及适于熔融挤出和注射成型单组分或多组分药物剂型的新型药学上可接受的聚合物组合物，其包含多个含药物物质的子单元，即胶囊隔室和/或固体亚单元，其包含含有药物的聚合物的固体基质，所述子单元在组装的剂型中连接在一起。

2. 发明申请

US20100074947A1 Pharmaceutical Formulations 审中-公开
标题翻译：药物制剂
公开(公告)号：US20100074947A1
公开(公告)日：2010-03-25
申请号：US12483477
申请日：2009-06-12
申请人： Adrian Brown , Wayne M. Matthews , Daniel N. Margetson , Stephen Mark McAllister , Danielle Genevieve Rebecca Russell
发明人： Adrian Brown , Wayne M. Matthews , Daniel N. Margetson , Stephen Mark McAllister , Danielle Genevieve Rebecca Russell
IPC分类号： A61K9/48
CPC分类号： A61K9/4816
摘要： The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection moulding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.
摘要翻译：本发明涉及适于熔融挤出和注射成型单组分或多组分药物剂型的新型药学上可接受的聚合物组合物，其包含多个含药物物质的子单元，即胶囊隔室和/或固体亚单元，其包含含有药物的聚合物的固体基质，所述子单元在组装的剂型中连接在一起。

3. 发明申请

US20090148518A1 Pharmaceutical Formulations 审中-公开
标题翻译：药物制剂
公开(公告)号：US20090148518A1
公开(公告)日：2009-06-11
申请号：US12266896
申请日：2008-11-07
申请人： Adrian Brown , Lee J. Gorringe , Stephen Mark McAllister , Wayne M. Matthews , Danielle G. R. Russell
发明人： Adrian Brown , Lee J. Gorringe , Stephen Mark McAllister , Wayne M. Matthews , Danielle G. R. Russell
IPC分类号： A61K9/52 , A61P43/00
CPC分类号： A61K9/4816
摘要： The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection moulding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.
摘要翻译：本发明涉及适于熔融挤出和注射成型单组分或多组分药物剂型的新型药学上可接受的聚合物组合物，其包含多个含药物物质的子单元，即胶囊隔室和/或固体亚单元，其包含含有药物的聚合物的固体基质，所述子单元在组装的剂型中连接在一起。

4. 发明申请

US20120196940A1 PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：药物制剂
公开(公告)号：US20120196940A1
公开(公告)日：2012-08-02
申请号：US13362429
申请日：2012-01-31
申请人： Adrian Brown , Wayne M. Matthews , Daniel M. Margetson , Stephen Mark McAllister , Ronald K. Raby
发明人： Adrian Brown , Wayne M. Matthews , Daniel M. Margetson , Stephen Mark McAllister , Ronald K. Raby
IPC分类号： A61K47/32
CPC分类号： A61K9/1617 , A61K9/1623 , A61K9/1647 , A61K9/1652 , A61K9/4816 , A61K9/5026 , A61K9/5047 , A61K47/32
摘要： The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.
摘要翻译：本发明涉及适于熔融挤出和注射成型单组分或多组分药物剂型的新型药学上可接受的聚合物组合物，其包含多个含药物物质的子单元，即胶囊隔室和/或固体亚单元，其包含含有药物的聚合物的固体基质，所述子单元在组装的剂型中连接在一起。

5. 发明授权

US08147871B2 Pharmaceutical formulations 失效
标题翻译：药物制剂
公开(公告)号：US08147871B2
公开(公告)日：2012-04-03
申请号：US11078077
申请日：2005-03-11
申请人： Adrian Brown , Wayne M. Matthews , Daniel M. Margetson , Stephen Mark McAllister , Ronald K. Raby
发明人： Adrian Brown , Wayne M. Matthews , Daniel M. Margetson , Stephen Mark McAllister , Ronald K. Raby
IPC分类号： A61K9/20 , A61K9/28 , A61K9/48 , A61K9/52 , A61K9/58 , A61K9/32
CPC分类号： A61K9/1617 , A61K9/1623 , A61K9/1647 , A61K9/1652 , A61K9/4816 , A61K9/5026 , A61K9/5047 , A61K47/32
摘要： The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.
摘要翻译：本发明涉及适于熔融挤出和注射成型单组分或多组分药物剂型的新型药学上可接受的聚合物组合物，其包含多个含药物物质的子单元，即胶囊隔室和/或固体亚单元，其包含含有药物的聚合物的固体基质，所述子单元在组装的剂型中连接在一起。

6. 发明申请

US20090148514A1 Multipart capsule for staged release of one or more pharmaceutical compositions 审中-公开
标题翻译：用于分离释放一种或多种药物组合物的多部分胶囊
公开(公告)号：US20090148514A1
公开(公告)日：2009-06-11
申请号：US12285854
申请日：2008-10-15
申请人： Wayne M. Matthews , Stephen Mark McAllister
发明人： Wayne M. Matthews , Stephen Mark McAllister
IPC分类号： A61K9/48
CPC分类号： A61K9/4808
摘要： A multipart capsule, e.g., a dosage form, is provided which includes a plurality of capsule portions, at least one of which contains a substance to be released into a gastro-intestinal environment and at least one link component interconnecting two adjacent capsule portions. At least one capsule portion is formed from a polymer that is a transitional polymer, for example, a polymer that changes shape, form, or structure within a gastro-intestinal environment, e.g., dispersible, dissolvable, disintegrable, fracturable, breachable, swellable, partially or completely soluble, or otherwise changeable when exposed to stomach pH and/or in intestine pH to thereby release the substance. The capsule portions are connected together in an assembled dosage form. The link component includes at least one aperture in flow communication with interiors of two adjacent capsule portions to control the release of the substance.
摘要翻译：提供了多部分胶囊，例如剂型，其包括多个胶囊部分，其中至少一个包含要释放到胃肠环境中的物质和至少一个连接两个相邻胶囊部分的连接部件。至少一个胶囊部分由聚合物形成，所述聚合物是过渡聚合物，例如在肠胃环境内改变形状，形式或结构的聚合物，例如可分散，可溶解，可崩解，可破碎，可破裂，可溶胀，部分或完全可溶，或当暴露于胃pH和/或肠内pH时可以变化，从而释放物质。胶囊部分以组合剂型连接在一起。连杆部件包括与两个相邻胶囊部分的内部流动连通的至少一个孔，以控制物质的释放。

7. 发明授权

US08361498B2 Pharmaceutical formulation 失效
公开(公告)号：US08361498B2
公开(公告)日：2013-01-29
申请号：US12952677
申请日：2010-11-23
申请人： Stephen Mark McAllister , Ronald K. Raby, Jr. , Adrian Brown , Allan J. Clarke
发明人： Stephen Mark McAllister , Ronald K. Raby, Jr. , Adrian Brown , Allan J. Clarke
IPC分类号： A61K9/48
CPC分类号： A61K9/4816 , A61K9/4808
摘要： The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.

8. 发明授权

US08673350B2 Pharmaceutical formulations 失效
标题翻译：药物制剂
公开(公告)号：US08673350B2
公开(公告)日：2014-03-18
申请号：US10565462
申请日：2004-07-21
申请人： Stephen Mark McAllister , Ronald K. Raby, Jr. , Adrian Brown
发明人： Stephen Mark McAllister , Ronald K. Raby, Jr. , Adrian Brown
IPC分类号： A61K9/48 , A61K9/52 , A61K9/62 , A61K9/66
CPC分类号： A61K9/4816 , A61K9/4808 , A61K9/4866
摘要： The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.
摘要翻译：本发明涉及适用于注射模塑单组分或多组分药物剂型的新型药学上可接受的聚合物组合物，其包含多个含药物物质的子单元，其为胶囊隔室和/或固体亚单位，其包含固体基质含有药物的聚合物，所述子单元通过组装的剂型的各部分之间的焊接在组装的剂型中连接在一起。

9. 发明授权

US07883721B2 Pharmaceutical formulation 有权
标题翻译：药物制剂
公开(公告)号：US07883721B2
公开(公告)日：2011-02-08
申请号：US10470438
申请日：2002-01-30
申请人： Stephen Mark McAllister , Ronald K. Raby, Jr. , Adrian Brown , Allan J. Clarke , Wayne Matthews , Daniel N. Margetson
发明人： Stephen Mark McAllister , Ronald K. Raby, Jr. , Adrian Brown , Allan J. Clarke , Wayne Matthews , Daniel N. Margetson
IPC分类号： A61K9/48
CPC分类号： A61K9/4808 , A61K9/4816
摘要： The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.
摘要翻译：本发明涉及适于注射模塑单组分或多组分药物剂型的药学上可接受的聚合物组合物，其包含多个含药物物质的子单元，包括胶囊隔室和/或包含固体基质的固体亚单元含有药物的聚合物，所述子单元通过组装的剂型的部分之间的焊接在组装的剂型中连接在一起。

10. 发明授权

US08367101B2 Pharmaceutical formulation 失效
公开(公告)号：US08367101B2
公开(公告)日：2013-02-05
申请号：US10060849
申请日：2002-01-30
申请人： Stephen Mark McAllister , Ronald K. Raby, Jr. , Adrian Brown , Allan J. Clarke , Daniel N. Margetson , Wayne Matthews
发明人： Stephen Mark McAllister , Ronald K. Raby, Jr. , Adrian Brown , Allan J. Clarke , Daniel N. Margetson , Wayne Matthews
IPC分类号： A61K9/48 , A61K9/52 , A61K9/58 , A61K9/62
CPC分类号： A61K9/4816 , A61K9/4808 , Y02A50/465
摘要： The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.

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