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1. 发明授权

US06254784B1 Optical interface detection system for centrifugal blood processing 失效
标题翻译：用于离心血液处理的光学界面检测系统
公开(公告)号：US06254784B1
公开(公告)日：2001-07-03
申请号：US08961340
申请日：1997-10-30
申请人： Abinash Nayak , Clint D. Luckinbill , John T. Foley , Minh D. Tran , James R. Bradley , Timothy J. Patno
发明人： Abinash Nayak , Clint D. Luckinbill , John T. Foley , Minh D. Tran , James R. Bradley , Timothy J. Patno
IPC分类号： B01D1712
CPC分类号： B01D17/0217 , B04B2013/006 , G01N15/042 , G01N15/05 , G01N2015/045
摘要： A centrifuge for continuously separating the various constituents of blood or other biological fluids includes a rotating bowl having high-G and low-G walls. An inwardly directed ramped surface on the high-G wall interacts with an interface region between the separated fluid constituents to provide an optically detectable indication of the position of the interface between the high-G and low-G walls. An optical sensor sensing each passage of the ramped surface past a point develops a changing signal indicative of the interface position. Signal processing circuitry responsive to the signal measures such signal parameters as peak amplitude, signal area and signal shape. By so monitoring these signal parameters, a better indication of actual interface position between the high-G and low-G walls can be obtained. This, in turn, results in better control over centrifuge operation and improved separation of the desired fluid components.
摘要翻译：用于连续分离血液或其他生物流体的各种成分的离心机包括具有高G和低G壁的旋转碗。高G壁上的向内倾斜的表面与分离的流体组分之间的界面区域相互作用，以提供高G和低G壁之间界面的位置的可光学检测的指示。感测倾斜表面的每个通过点的光学传感器产生指示接口位置的变化信号。响应于信号的信号处理电路测量诸如峰值幅度，信号面积和信号形状的信号参数。通过监测这些信号参数，可以获得高G和低G壁之间的实际界面位置的更好的指示。这反过来导致更好地控制离心机操作和改进所需流体组分的分离。

2. 外观设计

USD389916S Blood processing device 失效
公开(公告)号：USD389916S
公开(公告)日：1998-01-27
申请号：US49263
申请日：1996-01-22
申请人： Paul M. DiPerna , Michael J. Scola , Russell W. Wade , Richard L. West , Timothy J. Patno , William H. Cork , Leif Huff
设计人： Paul M. DiPerna , Michael J. Scola , Russell W. Wade , Richard L. West , Timothy J. Patno , William H. Cork , Leif Huff

3. 发明授权

US5989177A Umbilicus gimbal with bearing retainer 失效
标题翻译： Umbilicus万向节带轴承座
公开(公告)号：US5989177A
公开(公告)日：1999-11-23
申请号：US835928
申请日：1997-04-11
申请人： Richard L. West , Timothy J. Patno
发明人： Richard L. West , Timothy J. Patno
IPC分类号： A61M1/02 , B04B1/04 , B04B5/04 , B04B7/00 , B04B9/00 , F16C1/26 , F16D3/00
CPC分类号： B04B5/0442 , B04B2005/045 , B04B2005/0492
摘要： A blood processing centrifuge includes a disposable fluid processing assembly having a fluid processing chamber. Fluid is communicated to and from the fluid processing chamber through a flexible umbilicus. The fluid processing chamber spins while the centrifuge pulls the umbilicus around an axis of centrifugation. The centrifuge engages the umbilicus through a thrust bearing received in a gimbal assembly carried on a rotating wing plate. The gimbal assembly allows the umbilicus to pivot relative to the wing plate under the forces developed during centrifugation. The gimbal assembly includes a bearing retainer adapted to securely retain umbilicus thrust bearings of differing sizes a gimbal that loosely but securely retains the bearing retainer. Clearance between the gimbal and the bearing retainer enable the bearing retainer to accommodate thrust bearings of differing sizes without causing gimbal binding. The ability to accommodate umbilicus thrust bearing of differing sizes enables the thrust bearings to be manufactured to looser tolerances, thereby improving manufacturing ease and economy.
摘要翻译：血液处理离心机包括具有流体处理室的一次性流体处理组件。流体通过柔性脐管与流体处理室连通。流体处理室旋转，同时离心机绕着离心轴拉脐。离心机通过承载在旋转翼板上的万向节组件中的止推轴承接合脐带。万向节组件允许脐带在离心过程中产生的力下相对翼板枢转。万向节组件包括轴承保持器，其适于牢固地保持具有不同尺寸的脐轴推力轴承，万向节松动地但可靠地保持轴承保持器。万向节和轴承保持架之间的间隙使得轴承保持架能够适应不同尺寸的推力轴承，而不会造成万向接头。容纳不同尺寸的脐带推力轴承的能力使推力轴承的制造更宽松，从而提高了制造的便利性和经济性。

4. 外观设计

USD367534S Blood processing machine 失效
公开(公告)号：USD367534S
公开(公告)日：1996-02-27
申请号：US25482
申请日：1994-07-01
申请人： Paul M. DiPerna , Michael J. Scola , Russell W. Wade , Richard L. West , Timothy J. Patno , William H. Cork
设计人： Paul M. DiPerna , Michael J. Scola , Russell W. Wade , Richard L. West , Timothy J. Patno , William H. Cork

5. 发明申请

US20100168639A1 System and Method For Controlling Patient Fluid Balance And/Or Flow Rate For A Therapeutic Plasma Exchange Procedure 有权
标题翻译：用于控制治疗性血浆交换程序的患者液体平衡和/或流速的系统和方法
公开(公告)号：US20100168639A1
公开(公告)日：2010-07-01
申请号：US12394340
申请日：2009-02-27
申请人： Robert Cantu , Timothy J. Patno , Timothy A. Johnson , David L. Bonnett , Russell D. Stinaff , Carole Lynn Stinaff
发明人： Robert Cantu , Timothy J. Patno , Timothy A. Johnson , David L. Bonnett , Russell D. Stinaff , Carole Lynn Stinaff
IPC分类号： A61M1/14
CPC分类号： A61M1/342 , A61M1/3441 , A61M1/3451 , A61M1/3672 , A61M1/3693 , A61M1/3696
摘要： Systems and methods for controlling fluid flow during a fluid exchange procedure. In one aspect, a system is provided for controlling a net fluid volume difference of a patient during and/or after a fluid exchange procedure. The system comprises a first flow path for flowing at least a first fluid from the patient and a second flow path for flowing at least a second fluid to the patient. First and second reservoirs are respectively associated with the first and second flow paths. A controller is associated with the first and second flow paths for controlling first and second flow rates and operable to determine an actual flow rate for each first and second fluid and to change a first or second flow rate in response to a difference between at least one of such flow rates and its respective actual flow rate.
摘要翻译：在流体交换过程中控制流体流动的系统和方法。在一个方面，提供一种用于控制患者在流体交换过程中和/或之后的净流体体积差异的系统。该系统包括用于使来自患者的至少第一流体流动的第一流动路径和用于使至少第二流体流动至患者的第二流路。第一和第二储存器分别与第一和第二流动路径相关联。控制器与第一和第二流动路径相关联，用于控制第一和第二流量并且可操作以确定每个第一和第二流体的实际流速，并响应于至少一个流体的差异来改变第一或第二流量的这种流量及其各自的实际流量。

6. 发明授权

US5445506A Self loading peristaltic pump tube cassette 失效
标题翻译：自载蠕动泵管盒
公开(公告)号：US5445506A
公开(公告)日：1995-08-29
申请号：US172130
申请日：1993-12-22
申请人： Richard L. Afflerbaugh , Richard L. West , Timothy J. Patno , Arthur S. Chapman
发明人： Richard L. Afflerbaugh , Richard L. West , Timothy J. Patno , Arthur S. Chapman
IPC分类号： A61M1/02 , A61M1/10 , A61M1/36 , F04B43/12 , F04B43/08
CPC分类号： F04B43/1253 , A61M1/3693 , A61M2205/12
摘要： A self-loading peristaltic pumping apparatus includes a pump race for receiving a tubing loop, a pump rotor carrying a roller, and a drive mechanism for rotating the rotor within the pump race. The apparatus also includes a roller locating mechanism that moves the pump roller between a retracted position, free of contact with the received tubing loop, and an extended position, at least partially within the pump race for operative contact with the received tubing loop. The apparatus includes at least one tubing guide element carried by the rotor. The guide element extends from the rotor at least partially into the pump race. The guide element serves during rotation of the rotor with the roller in its retracted position, for contacting the received tubing loop to orient the tubing loop within the pump race.
摘要翻译：自加载蠕动泵送装置包括用于接收管道回路的泵座，承载辊的泵转子和用于在泵座内旋转转子的驱动机构。该设备还包括一个滚子定位机构，该滚轮定位机构使泵滚轮在与接收的管道回路无接触的缩回位置和延伸位置之间移动，该延伸位置至少部分地在泵座内用于与接收的管道回路有效接触。该装置包括由转子承载的至少一个导管元件。引导元件至少部分地从转子延伸到泵座中。引导元件在转子旋转期间用于辊子处于缩回位置，用于使接收的管道回路定位在泵座内的管道回路。

7. 发明授权

US08545426B2 System and method for controlling patient fluid balance and/or flow rate for a therapeutic plasma exchange procedure 有权
标题翻译：用于控制治疗性血浆置换程序的患者液体平衡和/或流速的系统和方法
公开(公告)号：US08545426B2
公开(公告)日：2013-10-01
申请号：US12394340
申请日：2009-02-27
申请人： Robert J. Cantu , Timothy J. Patno , Timothy A. Johnson , David L. Bonnett , Carole Lynn Stinaff
发明人： Robert J. Cantu , Timothy J. Patno , Timothy A. Johnson , David L. Bonnett , Russell D. Stinaff
IPC分类号： A61M1/14
CPC分类号： A61M1/342 , A61M1/3441 , A61M1/3451 , A61M1/3672 , A61M1/3693 , A61M1/3696
摘要： Systems and methods for controlling fluid flow during a fluid exchange procedure. In one aspect, a system is provided for controlling a net fluid volume difference of a patient during and/or after a fluid exchange procedure. The system comprises a first flow path for flowing at least a first fluid from the patient and a second flow path for flowing at least a second fluid to the patient. First and second reservoirs are respectively associated with the first and second flow paths. A controller is associated with the first and second flow paths for controlling first and second flow rates and operable to determine an actual flow rate for each first and second fluid and to change a first or second flow rate in response to a difference between at least one of such flow rates and its respective actual flow rate.
摘要翻译：在流体交换过程中控制流体流动的系统和方法。在一个方面，提供一种用于控制患者在流体交换过程中和/或之后的净流体体积差异的系统。该系统包括用于使来自患者的至少第一流体流动的第一流动路径和用于使至少第二流体流动至患者的第二流路。第一和第二储存器分别与第一和第二流动路径相关联。控制器与第一和第二流动路径相关联，用于控制第一和第二流量并且可操作以确定每个第一和第二流体的实际流速，并响应于至少一个流体的差异来改变第一或第二流量的这种流量及其各自的实际流量。

8. 发明授权

US5868696A Peristaltic pump tube holder with pump tube shield and cover 失效
标题翻译：蠕动泵管支架，带泵管屏蔽和盖
公开(公告)号：US5868696A
公开(公告)日：1999-02-09
申请号：US848020
申请日：1997-04-28
申请人： Richard C. Giesler , Myra P. Miles , Susan L. Lovelace , Timothy J. Patno , Richard L. West
发明人： Richard C. Giesler , Myra P. Miles , Susan L. Lovelace , Timothy J. Patno , Richard L. West
IPC分类号： A61M1/02 , A61M1/10 , A61M1/36 , F02B75/02 , F04B43/12 , A61M37/00
CPC分类号： F04B43/1253 , A61M1/3693 , A61M2205/12 , F02B2075/025
摘要： A peristaltic pump tube holder includes a body that supports a flexible tubing loop in an erect, outwardly bowed position extending from the body for engagement with a peristaltic pump rotor. The holder also includes a receptacle carrying the body. The receptacle includes a wall forming a chamber that covers the flexible tubing loop and at least partially shields it from contact. The chamber further serves, during engagement between the tubing loop and a peristaltic pump rotor, as a cover for the peristaltic pump rotor.
摘要翻译：蠕动泵管保持器包括主体，该主体支撑柔性管路环，该柔性管路环从主体延伸的直立的向外弯曲位置，用于与蠕动泵转子接合。保持器还包括承载身体的容器。该容器包括一个壁，该壁形成一个覆盖柔性管道环并且至少部分地将其遮蔽的接触的室。在管道回路和蠕动泵转子之间的接合期间，腔室还用作蠕动泵转子的盖子。

9. 发明授权

US5746708A Peristaltic pump tube holder with pump tube shield and cover 失效
公开(公告)号：US5746708A
公开(公告)日：1998-05-05
申请号：US172135
申请日：1993-12-22
申请人： Richard C. Giesler , Myra P. Miles , Susan L. Lovelace , Timothy J. Patno , Richard L. West
发明人： Richard C. Giesler , Myra P. Miles , Susan L. Lovelace , Timothy J. Patno , Richard L. West
IPC分类号： A61M1/02 , A61M1/10 , A61M1/36 , F02B75/02 , F04B43/12 , A61M37/00
CPC分类号： F04B43/1253 , A61M1/3693 , A61M2205/12 , F02B2075/025
摘要： A peristaltic pump tube holder includes a body that supports a flexible tubing loop in an erect, outwardly bowed position extending from the body for engagement with a peristaltic pump rotor. The holder also includes a receptacle carrying the body. The receptacle includes a wall forming a chamber that covers the flexible tubing loop and at least partially shields it from contact. The chamber further serves, during engagement between the tubing loop and a peristaltic pump rotor, as a cover for the peristaltic pump rotor.

10. 发明授权

US5538405A Peristaltic pulse pumping systems and methods 失效
标题翻译：蠕动脉冲泵送系统及方法
公开(公告)号：US5538405A
公开(公告)日：1996-07-23
申请号：US269933
申请日：1994-07-01
申请人： Timothy J. Patno , Richard I. Brown , William H. Cork
发明人： Timothy J. Patno , Richard I. Brown , William H. Cork
IPC分类号： A61M1/10 , A61M1/36 , F04B43/00 , F04B43/12 , F04B43/08
CPC分类号： F04B43/0081 , A61M1/3693 , A61M1/3696 , F04B43/1253 , A61M2205/12 , F04B2203/0209
摘要： A peristaltic pumping apparatus and associated method to control power to the pump rotor to establish, during a preestablished first time period, a selected first angular velocity and sequentially establishing during a preestablished second time period immediately following the first time period a second angular velocity different than the first angular velocity. In this fashion, the apparatus and method achieve flow rates well below the minimum continuous flow rate of the rotor.
摘要翻译：一种蠕动泵送装置和相关联的方法，用于控制泵转子的功率，以在预先建立的第一时间段期间建立所选择的第一角速度并且在紧接着第一时间段之后的预先建立的第二时间段内顺序地建立不同于第一时间段的第二角速度第一个角速度。以这种方式，该装置和方法实现远低于转子的最小连续流速的流速。

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