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1. 发明申请

US20170067900A1 PREDICTING CANCER PROGRESSION 审中-公开
标题翻译：预测癌症进展
公开(公告)号：US20170067900A1
公开(公告)日：2017-03-09
申请号：US15357762
申请日：2016-11-21
申请人： AROCELL AB
发明人： Sven SKOG , Staffan ERIKSSON , Bernard TRIBUKAIT , Qimin HE
IPC分类号： G01N33/574
CPC分类号： G01N33/57488 , G01N2333/91215 , G01N2800/54
摘要： Method of determining a likelihood of cancer relapse in a subject who has completed cancer tumor surgery, radiotherapy treatment and/or chemotherapy treatment comprises contacting an antibody that binds specifically to a serum form of thymidine kinase 1 (STK1) protein with a blood serum sample one to six months after completing the surgery and/or treatment, and before any cancer relapse has been detected; determining an amount of antibody binding to STK1 protein in the sample; correlating the amount of antibody binding to STK1 protein to a concentration of STK1 protein in the sample; and based on the concentration of STK1 protein in the sample, generating decision support information representative of a likelihood of cancer relapse in the subject one to ten years after completion of the surgery and/or treatment, the decision support information comprising a likelihood value defining one of a high or low likelihood of cancer relapse.
摘要翻译：确定完成癌肿瘤手术，放射治疗和/或化学疗法治疗的受试者中癌症复发的可能性的方法包括将与血清形式的胸苷激酶1（STK1）蛋白特异性结合的抗体与血清样品一在完成手术和/或治疗后6个月，并且在检测到任何癌症复发之前; 测定样品中与STK1蛋白结合的抗体量; 将抗体与STK1蛋白的结合量与样品中STK1蛋白的浓度相关联; 并且基于样品中STK1蛋白的浓度，产生代表手术和/或治疗完成后1至10年在受试者中癌症复发的可能性的决策支持信息，所述决策支持信息包括定义一个的似然值癌症复发的可能性很高或很低。

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