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1. 发明申请

US20030186406A1 Peptide capable of inducing immune response to human gastric cancer and agent for preventing or treating human gastric cancer, containing the peptide 审中-公开
公开(公告)号：US20030186406A1
公开(公告)日：2003-10-02
申请号：US10038899
申请日：2002-01-08
申请人： AJINOMOTO CO., INC.
发明人： Kokichi Kikuchi , Noriyuki Sato , Hiromitsu Sahara , Takahiro Yasojima , Yoshimasa Wada , Manabu Suzuki , Junji Hamuro
IPC分类号： A61K039/00 , C12N009/00
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , C07H21/04 , C07K14/4748 , C07K14/705
摘要： A peptide that induces CTL against human gastric cancer cells is provided. A peptide having a specific amino-acid sequence and induces cytotoxic T cells that targets gastric cancer cells may be used as an agent for preventing or treating gastric cancer.

2. 发明申请

US20030114490A1 New phenylalanine derivatives 失效
标题翻译：新型苯丙氨酸衍生物
公开(公告)号：US20030114490A1
公开(公告)日：2003-06-19
申请号：US10183729
申请日：2002-06-28
申请人： AJINOMOTO CO. INC
发明人： Yasuhiro Tanaka , Toshihiko Yoshimura , Chieko Ejima , Mitsuhiko Kojima , Eiji Nakanishi , Hiroyuki Izawa , Yuko Satake , Nobuyasu Suzuki , Manabu Suzuki , Masahiro Murata
IPC分类号： A61K031/445 , A61K031/198
CPC分类号： C07D295/185 , C07C233/63 , C07C243/36 , C07C311/21 , C07C311/46 , C07C323/40 , C07C2601/14 , C07D205/04 , C07D207/12 , C07D207/14 , C07D211/46 , C07D211/58 , C07D211/62 , C07D217/06 , C07D233/52 , C07D239/38 , C07D285/06 , C07D295/32
摘要： Phenylalanine derivatives of the following formula and analogues thereof have an antagonistic activity to null4null7 integrin and a selectivity toward null4null1 integrin. They are used as therapeutic agents for various diseases to which null4null7 integrin relates. 1
摘要翻译：下式的苯丙氨酸衍生物及其类似物对α4β7整联蛋白具有拮抗作用和对α4β1整联蛋白的选择性。它们被用作α4β7整联蛋白涉及的各种疾病的治疗剂。

3. 发明申请

US20020193434A1 Anti-tumor composition 审中-公开
标题翻译：抗肿瘤组成
公开(公告)号：US20020193434A1
公开(公告)日：2002-12-19
申请号：US10156105
申请日：2002-05-29
申请人： AJINOMOTO CO. INC
发明人： Yoshihiro Morinaga , Yukio Nihei , Yasuyo Suga , Manabu Suzuki , Kazuo Ohishi , Akira Okano
IPC分类号： A61K031/28 , A61K031/075
CPC分类号： A61K31/395 , A61K31/075 , A61K31/28 , A61K31/555 , A61K33/24 , A61K31/165 , A61K31/03 , A61K2300/00
摘要： The present invention provides composition having as active ingredients a stilbene derivative and a platinum coordination compound which is highly efficacious and highly safe for treating tumors, particularly for the treatment of solid or malignant tumors and thus methods of cancer and tumor treatment using the composition are also provided.
摘要翻译：本发明提供了作为活性成分的具有二苯乙烯衍生物和铂配位化合物的组合物，其对治疗肿瘤特别是用于治疗固体或恶性肿瘤是高度有效和高度安全的，因此使用该组合物的癌症和肿瘤治疗方法也是提供。

4. 发明申请

US20020173642A1 Human gastric cancer antigen gene and gastric cancer antigen protein 失效
标题翻译：人胃癌抗原基因和胃癌抗原蛋白
公开(公告)号：US20020173642A1
公开(公告)日：2002-11-21
申请号：US10191322
申请日：2002-07-10
申请人： AJINOMOTO CO. INC
发明人： Kokichi Kikuchi , Noriyuki Sato , Toshihiko Torigoe , Hiroeki Sahara , Manabu Suzuki , Junji Hamuro
IPC分类号： C12P021/02 , C12N005/06 , C07H021/04
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00
摘要： A tumor antigen gene is identified by screening a cDNA library derived from a gastric cancer cell line that can induce gastric cancer antigen specific cytotoxic T cell (CTL) by means of hybridization and PCR utilizing an amino acid sequence of peptide fragment of a known gastric cancer antigen protein, introducing a selected cDNA clone into a cell of gastric cancer cell line that cannot induce gastric cancer antigen specific CTL so that the clone should be expressed in the cell, and selecting a transgenic cell that has acquired the ability to induce CTL. According to the present invention, there are provided a protein capable of inducing immune response against human gastric cancer, DNA encoding the protein, as well as vaccine for treatment and prevention of human gastric cancer, and agent for treatment and prevention of human gastric cancer.
摘要翻译：通过筛选来自可以通过使用已知胃癌的肽片段的氨基酸序列的杂交和PCR来诱导胃癌抗原特异性细胞毒性T细胞（CTL）的胃癌细胞系的cDNA文库来鉴定肿瘤抗原基因将选择的cDNA克隆导入到不能诱导胃癌抗原特异性CTL的胃癌细胞系的细胞中，使得克隆应在细胞中表达，并选择已经获得诱导CTL的能力的转基因细胞。根据本发明，提供能够诱导针对人胃癌的免疫应答的蛋白质，编码该蛋白质的DNA，以及用于治疗和预防人胃癌的疫苗，以及用于治疗和预防人胃癌的药剂。

5. 发明申请

US20040192621A1 Anti-tumor agent 审中-公开
标题翻译：抗肿瘤剂
公开(公告)号：US20040192621A1
公开(公告)日：2004-09-30
申请号：US10743997
申请日：2003-12-24
申请人： AJINOMOTO CO., INC
发明人： Yukio Nihei , Yoshihiro Morinaga , Manabu Suzuki , Yasuyo Suga
IPC分类号： A61K031/7048 , A61K031/56 , A61K031/517 , A61K031/4745 , A61K031/427 , A61K031/075
CPC分类号： A61K31/05 , A61K31/167 , A61K31/573 , A61K45/06 , A61K2300/00
摘要： The present invention relates to an anti-tumor agent containing a tubulin polymerization-inhibitory active substance and an anti-inflammatory active substance. The present invention also relates to an anti-tumor pharmaceutical preparation containing one or more tubulin polymerization-inhibitory active substance and/or anti-inflammatory active substance, which can be individually combined with one or more additional tubulin polymerization-inhibitory active substance and/or anti-inflammatory active substance. The present invention also relates to methods and therapeutic regimens for administering the same to a subject in need thereof.
摘要翻译：本发明涉及含有微管蛋白聚合抑制活性物质和抗炎活性物质的抗肿瘤剂。本发明还涉及含有一种或多种微管蛋白聚合抑制活性物质和/或抗炎活性物质的抗肿瘤药物制剂，其可以单独与一种或多种另外的微管蛋白聚合抑制活性物质和/或抗炎活性物质。本发明还涉及将其给予有需要的受试者的方法和治疗方案。

6. 发明申请

US20030149083A1 Phenylalanine derivatives 失效
标题翻译：苯丙氨酸衍生物
公开(公告)号：US20030149083A1
公开(公告)日：2003-08-07
申请号：US10150067
申请日：2002-05-20
申请人： AJINOMOTO CO. INC
发明人： Yasuhiro Tanaka , Toshihiko Yoshimura , Hiroyuki Izawa , Chieko Ejima , Mitsuhiko Kojima , Yuko Satake , Eiji Nakanishi , Nobuyasu Suzuki , Shingo Makino , Manabu Suzuki , Masahiro Murata
IPC分类号： A61K031/44 , A61K031/40 , A61K031/255 , A61K031/198
CPC分类号： C07D239/42 , C07C235/74 , C07C275/42 , C07C311/08 , C07C311/10 , C07C311/13 , C07C311/16 , C07C311/21 , C07C311/29 , C07C311/44 , C07C317/44 , C07C323/25 , C07C323/60 , C07C323/62 , C07C335/22 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07C2602/42 , C07D207/12 , C07D207/14 , C07D207/16 , C07D239/38 , C07D295/185
摘要： Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to null 4 integrin. They are used as therapeutic agents for various diseases concerning null 4 integrin.
摘要翻译：指定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。它们被用作关于α4整联蛋白的各种疾病的治疗剂。

7. 发明申请

US20020193362A1 Anti-tumor composition 失效
公开(公告)号：US20020193362A1
公开(公告)日：2002-12-19
申请号：US10166763
申请日：2002-06-12
申请人： AJINOMOTO CO. INC
发明人： Yoshihiro Morinaga , Yukio Nihei , Yasuyo Suga , Manabu Suzuki , Kazuo Ohishi , Akira Okano
IPC分类号： A61K033/24 , A61K031/555 , A61K031/282 , A61K031/05
CPC分类号： A61K31/395 , A61K31/075 , A61K31/28 , A61K31/555 , A61K33/24 , A61K31/165 , A61K31/03 , A61K2300/00
摘要： The present invention provides composition having as active ingredients a stilbene derivative and a platinum coordination compound which is highly efficacious and highly safe for treating tumors, particularly for the treatment of solid or malignant tumors and thus methods of cancer and tumor treatment using the composition are also provided.

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