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1. 发明申请

US20110201007A1 DIAGNOSTIC TEST FOR STREPTOCOCCUS EQUI 审中-公开
标题翻译： STREPTOCOCCUS EQUI的诊断测试
公开(公告)号：US20110201007A1
公开(公告)日：2011-08-18
申请号：US13125539
申请日：2009-10-21
申请人： Andrew Stephen Waller , Carl Robinson , Zoe Heather
发明人： Andrew Stephen Waller , Carl Robinson , Zoe Heather
IPC分类号： C12Q1/68 , C07H21/00 , C07H21/04
CPC分类号： C12Q1/689
摘要： The invention relates generally to methods and materials concerning diseases caused by Streptococcus equi, and in particular relating to the detection of this pathogen by assessing the presence or absence of the S. equi eqbE gene sequence.
摘要翻译：本发明一般涉及关于由马链球菌引起的疾病的方法和材料，特别涉及通过评估S. equi eqbE基因序列的存在或不存在来检测该病原体。

2. 发明申请

US20100297184A1 Vaccines 有权
标题翻译：疫苗
公开(公告)号：US20100297184A1
公开(公告)日：2010-11-25
申请号：US12864034
申请日：2009-01-20
申请人： Andrew Stephen Waller , Carl Robinson , Zoe Heather
发明人： Andrew Stephen Waller , Carl Robinson , Zoe Heather
IPC分类号： A61K39/09 , C12N1/21 , C12N15/00 , A61P37/04 , A61P31/04
CPC分类号： A61K39/09 , A61K2039/521 , A61K2039/552
摘要： The invention provides Streptococcus vaccine strains (e.g. S. equi which is causative of ‘strangles’) comprising the following modifications in their genomes: (i) attenuation of one or more essential biosynthetic genes, (ii) attenuation of one or more genes which encode a haemolytic toxin, or protein involved in the production thereof, plus preferably any one, two, or most preferably three of the following modifications: (iii) attenuation of one or more genes which encode a protein responsible for immune evasion (iv) modification of one or more genes such as to permit serological discrimination of the vaccine strain based on analysis of a protein encoded by said genes, and (v) attenuation of one or more genes which encode an enzyme responsible for recombination repair of the genome. The invention provides inter alia live attenuated vaccine strains which generate an immune response to multiple protective epitopes presented in a context resembling the live pathogen.
摘要翻译：本发明提供了链球菌疫苗菌株（例如，引起“扼杀”的马氏足疟原虫），其包含其基因组中的以下修饰：（i）减少一种或多种必需生物合成基因，（ii）减少一个或多个编码的基因溶血素毒素或参与其生产的蛋白质，优选任何一种，两种，或最优选三种以下修饰：（iii）减少编码负责免疫逃避的蛋白质的一种或多种基因（iv）基于对由所述基因编码的蛋白质的分析来允许对疫苗株进行血清学鉴定的一个或多个基因，以及（v）减少编码负责基因组重组修复的酶的一个或多个基因。本发明特别提供减毒疫苗菌株，其产生对类似于活病原体的上下文中呈现的多种保护性表位的免疫应答。

3. 发明授权

US08187610B2 Streptococcus equi strain 有权
标题翻译：马链球菌菌株
公开(公告)号：US08187610B2
公开(公告)日：2012-05-29
申请号：US12864034
申请日：2009-01-20
申请人： Andrew Stephen Waller , Carl Robinson , Zoe Heather
发明人： Andrew Stephen Waller , Carl Robinson , Zoe Heather
IPC分类号： A61K39/09 , C12N1/21 , C12N15/00 , A61P37/04 , A61P31/04
CPC分类号： A61K39/09 , A61K2039/521 , A61K2039/552
摘要： The invention provides Streptococcus vaccine strains (e.g. S. equi which is causative of ‘strangles’) comprising the following modifications in their genomes: (i) attenuation of one or more essential biosynthetic genes, (ii) attenuation of one or more genes which encode a haemolytic toxin, or protein involved in the production thereof, plus preferably any one, two, or most preferably three of the following modifications: (iii) attenuation of one or more genes which encode a protein responsible for immune evasion (iv) modification of one or more genes such as to permit serological discrimination of the vaccine strain based on analysis of a protein encoded by said genes, and (v) attenuation of one or more genes which encode an enzyme responsible for recombination repair of the genome. The invention provides inter alia live attenuated vaccine strains which generate an immune response to multiple protective epitopes presented in a context resembling the live pathogen.
摘要翻译：本发明提供了链球菌疫苗菌株（例如，引起“扼杀”的马氏足疟原虫），其包含其基因组中的以下修饰：（i）减少一种或多种必需生物合成基因，（ii）减少一个或多个编码的基因溶血素毒素或参与其生产的蛋白质，优选任何一种，两种，或最优选三种以下修饰：（iii）减少编码负责免疫逃避的蛋白质的一种或多种基因（iv）基于对由所述基因编码的蛋白质的分析来允许对疫苗株进行血清学鉴定的一个或多个基因，以及（v）减少编码负责基因组重组修复的酶的一个或多个基因。本发明特别提供减毒疫苗菌株，其产生对类似于活病原体的上下文中呈现的多种保护性表位的免疫应答。

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