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1. 发明申请

US20130011342A1 SURFACTANT-FREE, WATER-FREE FORMABLE COMPOSITION AND BREAKABLE FOAMS AND THEIR USES 审中-公开
标题翻译：无表面活性剂，无水无机组合物和破碎物质及其用途
公开(公告)号：US20130011342A1
公开(公告)日：2013-01-10
申请号：US13499709
申请日：2010-10-01
申请人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan , Nukzi Papiashvile
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan , Nukzi Papiashvile
IPC分类号： A61K47/44 , A61K31/593 , A61K31/167 , A61K31/65 , A61K31/58 , A61K47/46 , A61K9/12 , A61P17/00 , A61P17/10 , A61P37/08 , A61P17/14 , A61P31/04 , A61P35/00 , A61P17/02 , A61P25/00 , A61P29/00 , A61P31/10 , A61P17/04 , A61P17/06 , A61P17/08 , A61K31/327
CPC分类号： A61K47/44 , A61K8/31 , A61K8/342 , A61K8/361 , A61K9/0014 , A61K9/0048 , A61K9/12 , A61K9/122 , A61K9/124 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K2800/31 , A61K2800/33 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： A substantially surface active agent-free and foam adjuvant-free composition which includes a hydrophobic solvent, a wax and a propellant. A substantially surface active agent-free and foam adjuvant-free composition, further comprising, a tetracycline antibiotic, or one or More other active agents. A method of treatment, using a substantially surface active agent-free and substantially foam adjuvant-free composition.
摘要翻译：一种基本上无表面活性剂和无泡沫助剂的组合物，其包括疏水性溶剂，蜡和推进剂。一种基本上无表面活性剂和无泡沫助剂的组合物，还包含四环素抗生素或一种或多种其它活性剂。一种治疗方法，使用基本上无表面活性剂的和基本上不含泡沫的佐剂的组合物。

2. 发明申请

US20110281827A1 COMPOSITIONS, GELS AND FOAMS WITH RHEOLOGY MODULATORS AND USES THEREOF 有权
标题翻译：组成，凝胶和流变学调节剂及其用途
公开(公告)号：US20110281827A1
公开(公告)日：2011-11-17
申请号：US13100724
申请日：2011-05-04
申请人： Dov TAMARKIN , Elana GAZAL , Yohan HAZOT , David SCHUZ , Irakliy PAPIASHVILI
发明人： Dov TAMARKIN , Elana GAZAL , Yohan HAZOT , David SCHUZ , Irakliy PAPIASHVILI
IPC分类号： A61K31/65 , A61K31/575 , A61P17/10 , A61K31/58 , A61P31/04 , A61P29/00 , A61K31/60 , A61K31/327
CPC分类号： A61K47/44 , A61K8/31 , A61K8/342 , A61K8/361 , A61K9/0014 , A61K9/0048 , A61K9/12 , A61K9/122 , A61K9/124 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K2800/31 , A61K2800/33 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.
摘要翻译：本公开一般涉及用于化妆品或药物应用的组合物。组合物包括载体和流变学调节剂。

3. 发明授权

US09167813B2 Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses 有权
标题翻译：非表面活性剂水醇发泡组合物，易碎泡沫及其用途
公开(公告)号：US09167813B2
公开(公告)日：2015-10-27
申请号：US13359709
申请日：2012-01-27
申请人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
发明人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
IPC分类号： A61K9/12 , A61P17/00 , A01N25/16 , A61K9/00
CPC分类号： A61K31/7056 , A01N25/16 , A61K9/0014 , A61K9/122 , A61K31/196 , A61K31/327 , A61K31/573 , A61K31/58 , A61K47/10 , A61K47/38
摘要： A substantially surface active agent-free foamable composition which includes short-chain alcohol, water, polymer, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free foamable composition which includes, water, polymer, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent-free foamable compositions.
摘要翻译：一种基本上无表面活性剂的可发泡组合物，其包括短链醇，水，聚合物，脂肪醇或脂肪酸，或脂肪醇和脂肪酸与推进剂的组合。一种基本上无表面活性剂的可发泡组合物，其包括水，聚合物，脂肪醇或脂肪酸和推进剂。一种使用基本上无表面活性剂的可发泡组合物的处理方法。

4. 发明授权

US08617100B2 Device for delivery of a foamable composition 有权
标题翻译：用于递送可发泡组合物的装置
公开(公告)号：US08617100B2
公开(公告)日：2013-12-31
申请号：US12204771
申请日：2008-09-04
申请人： Meir Eini , David Schuz , Helen Shifrin , Yohan Hazot , Dov Tamarkin
发明人： Meir Eini , David Schuz , Helen Shifrin , Yohan Hazot , Dov Tamarkin
IPC分类号： A61M1/06 , A61M31/00
CPC分类号： A61M31/00
摘要： A device for delivery of a foamable composition to a body cavity includes a pressurized composition reservoir; a hollow body having a longitudinally extending wall and having at least one aperture provided through a wall of said body, the proximal end in fluid communication with the reservoir for receiving a foamable composition from said composition reservoir; and an actuator operatively connected to the composition reservoir for effecting release of a foamable composition from said composition reservoir into a body cavity through said hollow body; wherein said body has a length less than about 125 mm and internal diameter in the range of about 1.5 mm to about 3.5 mm, wherein said length and internal diameter are selected to provide a delivery of at least about 70% of the foamable composition during operation. The foam delivery device can have multiple apertures.
摘要翻译：用于将可发泡组合物递送到体腔的装置包括加压组合物储存器; 具有纵向延伸的壁并具有通过所述主体的壁设置的至少一个孔的空心体，所述近端与所述储存器流体连通以从所述组合物储存器接收可发泡组合物; 以及致动器，其可操作地连接到所述组合物储存器，用于通过所述中空体从所述组合物储存器中释放可发泡组合物到体腔中; 其中所述主体具有小于约125mm的长度，并且内径在约1.5mm至约3.5mm的范围内，其中所述长度和内径被选择为在操作期间提供至少约70％的可发泡组合物的输送。泡沫输送装置可以具有多个孔。

5. 发明申请

US20120213710A1 Non Surface Active Agent Non Polymeric Agent Hydro-Alcoholic Foamable Compositions, Breakable Foams and Their Uses 有权
标题翻译：非表面活性剂非聚合物水可发泡组合物，可破坏泡沫及其用途
公开(公告)号：US20120213710A1
公开(公告)日：2012-08-23
申请号：US13359787
申请日：2012-01-27
申请人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
发明人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
IPC分类号： A61K9/12 , A61P17/00
CPC分类号： A61K9/122 , A61K8/046 , A61K8/34 , A61K8/342 , A61K9/12 , A61K31/573 , A61K47/10 , A61K47/12 , A61K47/44 , A61Q19/00
摘要： A substantially surface active agent-free and substantially polymeric agent-free foamable composition which includes short-chain alcohol, water, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free and substantially polymeric agent-free foamable composition which includes water, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent-free and substantially polymeric agent-free foamable composition.
摘要翻译：一种基本上无表面活性剂和基本上无聚合物的可发泡组合物，其包括短链醇，水，脂肪醇或脂肪酸，或脂肪醇和脂肪酸与推进剂的组合。一种基本上无表面活性剂和基本上无聚合物的可发泡组合物，其包括水，脂肪醇或脂肪酸和推进剂。一种使用基本上无表面活性剂和基本上不含聚合物的可发泡组合物进行处理的方法。

6. 发明授权

US08871184B2 Topical tetracycline compositions 有权
标题翻译：局部四环素组合物
公开(公告)号：US08871184B2
公开(公告)日：2014-10-28
申请号：US13499475
申请日：2010-10-01
申请人： Dov Tamarkin , Elana Gazal , Yohan Hazot , David Schuz , Rita Keynan , Nukri Papiashvili
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K8/18 , A61K35/50 , A61K31/65 , C07C50/36 , C07C237/26 , A61K31/4164 , A61K47/10 , A61K8/34 , A61K31/593 , A61K31/57 , A61K9/00 , A61K8/36 , A61K31/573 , A61K9/12 , A61K47/12
CPC分类号： A61K47/44 , A61K8/31 , A61K8/342 , A61K8/361 , A61K9/0014 , A61K9/0048 , A61K9/12 , A61K9/122 , A61K9/124 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K2800/31 , A61K2800/33 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents; and the amount of viscosity modifying agents can optionally be reduced by at least an amount by weight that would have increased the viscosity of the carrier without the tetracycline antibiotic by at least 30%; wherein the tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down; wherein when packaged in an aerosol container to which is added a liquefied or compressed gas propellant the composition affords upon release from the container a breakable foam of at least good quality that breaks easily upon application of shear force.
摘要翻译：一种局部治疗疏水性可破坏组合物包括载体，其包含（a）约60％至约99％重量的至少一种疏水性油; （b）至少一种选自脂肪醇，脂肪酸和蜡的粘度调节剂; 和（c）四环素抗生素，其特征在于至少部分四环素抗生素悬浮于组合物中; 组合物的粘度比没有四环素抗生素的载体的粘度高至少约30％; 并且高于没有粘度改性剂的疏水性油和四环素类抗生素的粘度; 并且粘度调节剂的量可以任选地减少至少一种使四环素类抗生素的载体的粘度增加至少30％的重量; 其中四环素在组合物中化学稳定至少六个月; 其中大于约90％的四环素未分解; 其中当包装在添加了液化或压缩气体推进剂的气溶胶容器中时，组合物在从容器释放至少良好质量的可施加剪切力的容易破裂的泡沫时提供。

7. 发明申请

US20120087872A1 Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof 审中-公开
标题翻译：可泡沫车辆和包含非质子极性溶剂的药物组合物及其用途
公开(公告)号：US20120087872A1
公开(公告)日：2012-04-12
申请号：US13263201
申请日：2010-04-28
申请人： Dov Tamarkin , David Schuz , Tal Berman , Yohan Hazot
发明人： Dov Tamarkin , David Schuz , Tal Berman , Yohan Hazot
IPC分类号： A61K9/12 , A61P17/00 , A61P29/00
CPC分类号： A61K9/122 , A61K8/046 , A61K8/46 , A61K9/0014 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/38 , A61K2800/31 , A61Q19/00
摘要： The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.
摘要翻译：本发明教导了包含非质子极性溶剂的可发泡药物和化妆品组合物; 泡沫组合物及其用途。

8. 发明申请

US20090068118A1 DEVICE FOR DELIVERY OF A FOAMABLE COMPOSITION 有权
标题翻译：用于输送可发泡组合物的装置
公开(公告)号：US20090068118A1
公开(公告)日：2009-03-12
申请号：US12204771
申请日：2008-09-04
申请人： Meir EINI , David SCHUZ , Helen SHIFRIN , Yohan HAZOT , Dov TAMARKIN
发明人： Meir EINI , David SCHUZ , Helen SHIFRIN , Yohan HAZOT , Dov TAMARKIN
IPC分类号： A61K9/12 , A61M31/00
CPC分类号： A61M31/00
摘要： A device for delivery of a foamable composition to a body cavity includes a pressurized composition reservoir; a hollow body having a longitudinally extending wall and having at least one aperture provided through a wall of said body, the proximal end in fluid communication with the reservoir for receiving a foamable composition from said composition reservoir; and an actuator operatively connected to the composition reservoir for effecting release of a foamable composition from said composition reservoir into a body cavity through said hollow body; wherein said body has a length less than about 125 mm and internal diameter in the range of about 1.5 mm to about 3.5 mm, wherein said length and internal diameter are selected to provide a delivery of at least about 70% of the foamable composition during operation. The foam delivery device can have multiple apertures.
摘要翻译：用于将可发泡组合物递送到体腔的装置包括加压组合物储存器; 具有纵向延伸的壁并具有通过所述主体的壁设置的至少一个孔的空心体，所述近端与所述储存器流体连通以从所述组合物储存器接收可发泡组合物; 以及致动器，其可操作地连接到所述组合物储存器，用于通过所述中空体从所述组合物储存器中释放可发泡组合物到体腔中; 其中所述主体具有小于约125mm的长度，并且内径在约1.5mm至约3.5mm的范围内，其中所述长度和内径被选择为在操作期间提供至少约70％的可发泡组合物的输送。泡沫输送装置可以具有多个孔。

9. 发明授权

US10029013B2 Surfactant-free, water-free formable composition and breakable foams and their uses 有权
公开(公告)号：US10029013B2
公开(公告)日：2018-07-24
申请号：US13499709
申请日：2010-10-01
申请人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K47/44 , A61K31/593 , A61K31/167 , A61K31/65 , A61K31/58 , A61K47/46 , A61K9/12 , A61P17/00 , A61P17/10 , A61P37/08 , A61P17/14 , A61P31/04 , A61P35/00 , A61P17/02 , A61P25/00 , A61P29/00 , A61P31/10 , A61P17/04 , A61P17/06 , A61P17/08 , A61K31/327 , A61K47/06 , A61K9/00 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K8/34 , A61K8/36 , A61K47/10 , A61K47/12 , A61K31/137 , A61K31/192 , A61K45/06 , A61K47/02 , A61K47/24 , A61K8/31 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： A substantially surface active agent-free and foam adjuvant-free composition which includes a hydrophobic solvent, a wax and a propellant. A substantially surface active agent-free and foam adjuvant-free composition, further comprising, a tetracycline antibiotic, or one or More other active agents. A method of treatment, using a substantially surface active agent-free and substantially foam adjuvant-free composition.

10. 发明授权

US09072667B2 Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses 有权
标题翻译：非表面活性剂非聚合剂水醇发泡组合物，易碎泡沫及其用途
公开(公告)号：US09072667B2
公开(公告)日：2015-07-07
申请号：US13359787
申请日：2012-01-27
申请人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
发明人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
IPC分类号： A01N25/02 , A61K8/04 , A61K8/34 , A61K31/573 , A61K47/10 , A61Q19/00 , A61K9/12 , A61K47/12
CPC分类号： A61K9/122 , A61K8/046 , A61K8/34 , A61K8/342 , A61K9/12 , A61K31/573 , A61K47/10 , A61K47/12 , A61K47/44 , A61Q19/00
摘要： A substantially surface active agent-free and substantially polymeric agent-free foamable composition which includes short-chain alcohol, water, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free and substantially polymeric agent-free foamable composition which includes water, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent-free and substantially polymeric agent-free foamable composition.
摘要翻译：一种基本上无表面活性剂和基本上无聚合物的可发泡组合物，其包括短链醇，水，脂肪醇或脂肪酸，或脂肪醇和脂肪酸与推进剂的组合。一种基本上无表面活性剂和基本上无聚合物的可发泡组合物，其包括水，脂肪醇或脂肪酸和推进剂。一种使用基本上无表面活性剂和基本上不含聚合物的可发泡组合物进行处理的方法。

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