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1. 发明授权

US09239329B2 Method of measuring interaction between biomaterial and sugar chain, method of evaluating biomaterial in sugar chain selectivity, method of screening biomaterial, method of patterning biomaterials, and kits for performing these methods 有权
标题翻译：测量生物材料与糖链之间相互作用的方法，糖链选择性评估生物材料的方法，生物材料筛选方法，生物材料图案化方法以及执行这些方法的试剂盒
公开(公告)号：US09239329B2
公开(公告)日：2016-01-19
申请号：US11818695
申请日：2007-06-15
申请人： Yasuo Suda , Tomoaki Nishimura , Yuko Kishimoto , Sakiko Yamashita , Sachiko Tsuruta , Masahiro Wakao , Toshiomi Okuno
发明人： Yasuo Suda , Tomoaki Nishimura , Yuko Kishimoto , Sakiko Yamashita , Sachiko Tsuruta , Masahiro Wakao , Toshiomi Okuno
IPC分类号： G01N33/53 , G01N33/68 , G01N33/569 , G01N33/543 , G01N33/92
CPC分类号： G01N33/569 , G01N33/5308 , G01N33/5432 , G01N33/68 , G01N33/92 , G01N2400/00
摘要： This invention provides a method of screening or patterning a biomaterial in terms of their specificities to sugar chains by performing real-time and comprehensive measurement of an interaction between sugar chains and the biomaterial concurrently with a very small amount of the biomaterial without labeling. It is a method of measuring an interaction between a biomaterial and a sugar chain(s), the method including: bringing a solution containing the biomaterial in contact with a ligand carrier, the ligand carrier including a support whose surface includes a metal, and a ligand conjugate(s) immobilized independently on the surface, the ligand carrier carrying the ligand conjugate(s) in such a manner that 1 to 500 kinds of the ligand conjugate(s) is immobilized per cm2, and each ligand conjugate having a structure in which a sugar chain is bonded with a linker compound having a sulfur atom, and the biomaterial being at least one selected from the groups of proteins, viruses, cells, microorganisms, liposome, and micelles.
摘要翻译：本发明提供了一种通过与非标量的生物材料同时进行糖链与生物材料之间的相互作用的实时和全面测量来对其对糖链的特异性筛选或图案化生物材料的方法。它是测量生物材料和糖链之间的相互作用的方法，该方法包括：使含有生物材料的溶液与配体载体接触，所述配体载体包括其表面包括金属的载体，和配体缀合物独立地固定在表面上，配体载体携带配体缀合物，使得每cm 2固定1至500种配体缀合物，并且每个配体缀合物具有结构为其中糖链与具有硫原子的连接体化合物结合，所述生物材料是选自蛋白质，病毒，细胞，微生物，脂质体和胶束中的至少一种。

2. 发明授权

US08754976B2 Image-capturing apparatus including image sensor utilizing pairs of focus detection pixels 有权
标题翻译：包括使用焦点检测像素对的图像传感器的图像捕获装置
公开(公告)号：US08754976B2
公开(公告)日：2014-06-17
申请号：US12999735
申请日：2009-07-08
申请人： Makoto Oikawa , Akihiko Nagano , Yasuo Suda
发明人： Makoto Oikawa , Akihiko Nagano , Yasuo Suda
IPC分类号： H04N5/232
CPC分类号： G03B13/36 , G02B7/08 , H04N5/23212 , H04N5/3696 , H04N5/37457
摘要： In an image sensor having a plurality of pixels which photoelectrically convert a subject image, a plurality of pairs of focus detection pixels including first focus detection pixels (SHA) and second focus detection pixels (SHB) are arranged while being distributed. The layouts of the first focus detection pixel (SHA) and the second focus detection pixel (SHB) are switched in pairs of focus detection pixels adjacent in the focus detection direction. Focus detection is performed using image waveforms obtained from the first focus detection pixel (SHA) and the second focus detection pixel (SHB) whose layouts are switched. This reduces focus detection errors generated when the pixels included in the pairs of focus detection pixels receive light fluxes from different portions of the subject.
摘要翻译：在具有多个像素的图像传感器中，其对被摄体图像进行光电转换，包括第一焦点检测像素（SHA）和第二焦点检测像素（SHB）的多个焦点检测像素对被布置。第一焦点检测像素（SHA）和第二焦点检测像素（SHB）的布局以焦点检测方向相邻的成对的焦点检测像素切换。使用从布置被切换的第一焦点检测像素（SHA）和第二焦点检测像素（SHB）获得的图像波形执行焦点检测。这减少了包括在对焦点检测像素对中的像素从对象的不同部分接收光通量时产生的焦点检测误差。

3. 发明申请

US20140045169A1 GLYCAN IMMOBILIZED METAL NANOPARTICLES AND USE THEREOF FOR EARLY HIV-1 DETECTION 审中-公开
标题翻译： GLYCAN固定金属纳米颗粒及其早期HIV-1检测的应用
公开(公告)号：US20140045169A1
公开(公告)日：2014-02-13
申请号：US13584591
申请日：2012-08-13
申请人： Yasuo SUDA , Masanori BABA , Mika OKAMOTO
发明人： Yasuo SUDA , Masanori BABA , Mika OKAMOTO
IPC分类号： C12Q1/70 , C07H5/06 , G01N33/569 , C07H23/00 , B82Y15/00
CPC分类号： C12Q1/6806 , B82Y15/00 , C12Q1/703 , G01N33/531 , G01N33/553 , G01N33/56988 , G01N2400/00 , C12Q2523/308 , C12Q2563/131 , C12Q2563/155
摘要： Disclosed are glycan immobilized metal nanoparticles and a method used thereof for detecting HIV-1 in a saliva sample at early stages of viral infection. The method comprises the steps of: (A) providing glycan immobilized metal nanoparticles which can recognize HIV-1; (B) contacting the glycan immobilized metal nanoparticles with the saliva sample and a mixture is obtained; (C) concentrating the mixture; and (D) determining HIV-1 in the concentrated mixture by an appropriate detecting method.
摘要翻译：公开了聚糖固定的金属纳米颗粒及其用于在病毒感染早期阶段检测唾液样品中的HIV-1的方法。该方法包括以下步骤：（A）提供可识别HIV-1的聚糖固定金属纳米粒子; （B）使聚糖固定的金属纳米粒子与唾液样品接触并获得混合物; （C）浓缩混合物; 和（D）通过适当的检测方法测定浓缩混合物中的HIV-1。

4. 发明申请

US20110096211A1 IMAGE-CAPTURING APPARATUS 有权
标题翻译：图像捕获设备
公开(公告)号：US20110096211A1
公开(公告)日：2011-04-28
申请号：US12999735
申请日：2009-07-08
申请人： Makoto Oikawa , Akihiko Nagano , Yasuo Suda
发明人： Makoto Oikawa , Akihiko Nagano , Yasuo Suda
IPC分类号： H04N5/335
CPC分类号： G03B13/36 , G02B7/08 , H04N5/23212 , H04N5/3696 , H04N5/37457
摘要： In an image sensor having a plurality of pixels which photoelectrically convert a subject image, a plurality of pairs of focus detection pixels including first focus detection pixels (SHA) and second focus detection pixels (SHB) are arranged while being distributed. The layouts of the first focus detection pixel (SHA) and the second focus detection pixel (SHB) are switched in pairs of focus detection pixels adjacent in the focus detection direction. Focus detection is performed using image waveforms obtained from the first focus detection pixel (SHA) and the second focus detection pixel (SHB) whose layouts are switched. This reduces focus detection errors generated when the pixels included in the pairs of focus detection pixels receive light fluxes from different portions of the subject.
摘要翻译：在具有多个像素的图像传感器中，其对被摄体图像进行光电转换，包括第一焦点检测像素（SHA）和第二焦点检测像素（SHB）的多个焦点检测像素对被布置。第一焦点检测像素（SHA）和第二焦点检测像素（SHB）的布局以焦点检测方向相邻的成对的焦点检测像素切换。使用从布置被切换的第一焦点检测像素（SHA）和第二焦点检测像素（SHB）获得的图像波形执行焦点检测。这减少了包括在对焦点检测像素对中的像素从对象的不同部分接收光通量时产生的焦点检测误差。

5. 发明授权

US07465107B2 Photographing apparatus and control method therefor 失效
标题翻译：摄影装置及其控制方法
公开(公告)号：US07465107B2
公开(公告)日：2008-12-16
申请号：US11231525
申请日：2005-09-21
申请人： Koichi Washisu , Yasuo Suda , Takayuki Tsuboi
发明人： Koichi Washisu , Yasuo Suda , Takayuki Tsuboi
IPC分类号： G03B15/00 , G03B17/00
CPC分类号： G02B15/177 , G02B5/08 , G02B7/1805 , G02B7/1822 , G02B26/0816 , G02B27/646 , G03B17/17 , H04N5/2259 , H04N5/232
摘要： A photographing apparatus which realizes a taking lens barrel whose shape is not largely changed during panning or tilting shot, thereby being compact in size and easy to handle. In the photographing apparatus, an image pickup device (14i) outputs an electric signal from object light. A bending optical system (14) has a front lens (14f) and lens groups (14j, 14k, 14l, and 14m) and a mirror (14c) disposed between the front lens and the laminated lens 14j, to guide the object light to the image pickup device. A panning actuator (19) and a tilt actuator (15f) cause the mirror and the front lens or the lens groups to be pivotally moved in unison about respective different axes to thereby change a shooting direction.
摘要翻译：一种拍摄装置，其实现了在平移或倾斜拍摄期间形状没有大的变化的拍摄镜筒，从而尺寸紧凑并且易于处理。在拍摄装置中，摄像装置（14i）从物体光输出电信号。弯曲光学系统（14）具有前透镜（14f）和透镜组（14j，14k，14l和14m）和设置在前透镜和层叠透镜14j之间的反射镜（14c），以将物体光导向图像拾取装置。平移致动器（19）和倾斜致动器（15f）使得镜子和前透镜或透镜组能够围绕各个不同的轴线一致地枢轴运动，从而改变拍摄方向。

6. 发明授权

US07183067B2 Versatile linker compound, ligand, and producing method thereof 有权
标题翻译：多功能接头化合物，配体及其制备方法
公开(公告)号：US07183067B2
公开(公告)日：2007-02-27
申请号：US10526938
申请日：2003-08-06
申请人： Yasuo Suda , Akio Arano , Hideki Hayashi , Shoichi Kusumoto , Michael Sobel
发明人： Yasuo Suda , Akio Arano , Hideki Hayashi , Shoichi Kusumoto , Michael Sobel
IPC分类号： G01N33/53 , G01N33/532 , G01N33/547 , C12P7/58 , C07K1/13
CPC分类号： C07D495/04 , C07H15/203 , G01N33/531 , G01N33/54353 , Y10S435/961 , Y10S435/97 , Y10S530/813
摘要： A versatile linker compound has a structure represented by following general formula (1), wherein Y has a structure represented by O or NH, and X has a structure serving as a multi-branched moiety including four hydrocarbon derivative chains each of which has an aromatic amino group at an end thereof, and may or may not have a carbon-nitrogen bond in a backbone thereof. With the versatile linker compound, sugar molecules can be two-dimensionally arranged on a surface of a protein-analyzing supporter with high reproducibility. Also, a ligand includes the versatile linker compound and a sugar molecule introduced thereinto.
摘要翻译：通用的接头化合物具有由以下通式（1）表示的结构，其中Y具有由O或NH表示的结构，X具有用作多支链部分的结构，包括四个烃衍生物链，其各自具有芳族氨基，其末端可以具有或不具有碳 - 氮键。使用通用的接头化合物，糖分子可以二维排列在蛋白质分析支持物的表面上，具有高重现性。此外，配体包括通用连接体化合物和引入其中的糖分子。

7. 发明申请

US20060030699A1 Versatile linker compound and ligand, and method for preparation thereof 有权
标题翻译：通用接头化合物和配体，及其制备方法
公开(公告)号：US20060030699A1
公开(公告)日：2006-02-09
申请号：US10526775
申请日：2003-09-08
申请人： Yasuo Suda , Akio Arano , Shoichi Kusumoto , Michael Sobel
发明人： Yasuo Suda , Akio Arano , Shoichi Kusumoto , Michael Sobel
IPC分类号： C08B37/00
CPC分类号： C07H15/04 , A61K47/549 , C07D339/04 , C07D409/14 , Y10S435/961 , Y10S435/97
摘要： A linker compound has a structure represented by general formula (1) below, where n is an integer of 1 to 6, and X has a structure serving as a multi-branched structure moiety including three or four hydrocarbon derivative chains each having an aromatic amino group at an end and a carbon-nitrogen bond in a backbone. A ligand includes the linker compound and a sugar introduced into the linker compound.
摘要翻译：连接体化合物具有下述通式（1）表示的结构，其中n为1〜6的整数，X为具有多支链结构部分的结构，包括三个或四个具有芳香族氨基的烃衍生物链末端的基团和骨架中的碳 - 氮键。配体包括连接体化合物和引入接头化合物的糖。

8. 发明申请

US20060001765A1 Image sensing apparatus and its control method, control program, and storage medium 有权
公开(公告)号：US20060001765A1
公开(公告)日：2006-01-05
申请号：US11217467
申请日：2005-09-02
申请人： Yasuo Suda
发明人： Yasuo Suda
IPC分类号： H04N5/235
CPC分类号： H04N9/093 , H04N5/2254 , H04N5/3415
摘要： This invention has as its object to provide an image sensing apparatus which can satisfactorily correct misregistration among images, and can composite the images. To achieve this object, an image sensing apparatus includes: a plurality of apertures that receives external light from different positions; a plurality of image sensing units that outputs image signals obtained by independently receiving light that comes from an identical position of an object and is received via the plurality of apertures, and independently extracting predetermined color components for each received light; and a signal processing device that forms a signal that outputs an object image by mixing the image signals output from the plurality of image sensing units. When it is determined that a predetermined position deviation occurs between the image signals upon forming the signal that outputs the object image, the signal processing device corrects the predetermined position deviation by a signal process, and forms the signal that outputs the object image.

9. 发明授权

US06980248B1 Image pickup apparatus 有权
标题翻译：摄像设备
公开(公告)号：US06980248B1
公开(公告)日：2005-12-27
申请号：US09604744
申请日：2000-06-28
申请人： Yasuo Suda
发明人： Yasuo Suda
IPC分类号： H04N5/225 , H04N9/04
CPC分类号： H04N5/2254 , H04N9/045
摘要： An image pickup apparatus comprising first and second image pickup portions for receiving at least a first wavelength component of an object light and a second wavelength component of the object light different from the first wavelength component, respectively, a first optical system for projecting the object light onto the first image pickup portion, a second optical system for projecting the object light onto the first and second image pickup portions via an optical path different from that of the first optical system, and a guide path forming portion for forming a guide path for receiving the object light projected by the first optical system and guiding the received object light to the first image pickup portion, and for receiving the object light projected by the second optical system onto the first image pickup portion and not guiding the object light to the first image pickup portion.
摘要翻译：一种图像拾取装置，包括第一和第二图像拾取部分，用于分别接收与第一波长分量不同的物体光的物体光和第二波长分量的至少第一波长分量;第一光学系统，用于投射物体光在第一图像拾取部分上的第二光学系统，用于经由与第一光学系统不同的光路将物体光投射到第一和第二图像拾取部分上的第二光学系统，以及用于形成用于接收的引导路径的引导路径形成部分由第一光学系统投射的物体光并将接收的物体光引导到第一图像拾取部分，并且用于将由第二光学系统投影的物体光接收到第一图像拾取部分上，并且不将对象光引导到第一图像拾取部分。

10. 发明申请

US20050236553A1 Solid-state image sensing element and its design support method, and image sensing device 有权
公开(公告)号：US20050236553A1
公开(公告)日：2005-10-27
申请号：US11099447
申请日：2005-04-06
申请人： Goro Noto , Yasuo Suda , Akihiko Nagano
发明人： Goro Noto , Yasuo Suda , Akihiko Nagano
IPC分类号： G02B3/00 , G02B6/00 , H01L21/82 , H01L27/00 , H01L27/146 , H01L31/0216 , H01L31/0232
CPC分类号： H01L27/14629 , H01L27/14621 , H01L27/14625 , H01L27/14627 , H01L27/14685 , H01L31/02162 , H01L31/02327 , H04N2101/00
摘要： A solid-state image sensing element has a photoelectric conversion element which converts incoming light into an electrical signal in accordance with an amount of the light, a microlens which is arranged on an incident surface, a light guide which is arranged between the photoelectric conversion element and the microlens, and an insulating interlayer which is arranged around the light guide. The solid-state image sensing element located at a distance (H) satisfies: H · D L · P

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