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1. 发明申请

US20090287172A1 ABSORBENT ARTICLE WITH LEAKAGE WARNING SYSTEMS AND METHOD OF USE THEREOF 审中-公开
标题翻译：具有泄漏警告系统的吸收性物品及其使用方法
公开(公告)号：US20090287172A1
公开(公告)日：2009-11-19
申请号：US12121980
申请日：2008-05-16
申请人： William Lowe
发明人： William Lowe
IPC分类号： A61F13/42
CPC分类号： A61F13/42
摘要： The present invention includes an absorbent article, more specifically, an absorbent article including a leakage warning system. The leakage warning system is located along the outer perimeter of the absorbent article. Fluids activate the leakage warning system. Thus, when fluids reach the outer perimeter of the absorbent article, the leakage warning system is activated. Once activated, the leakage warning system provides a warning signal that fluids have reached the edge of the absorbent article. In one embodiment, the leakage warning system is a liquid-activated band. Once activated, the band provides a temperature-change sensation to the user to signal that the fluids have reached the edge of the absorbent article and thus warns a user of possible leakage before it actually occurs.
摘要翻译：本发明包括吸收性物品，更具体地说，涉及包含泄漏警告系统的吸收性物品。泄漏警告系统位于吸收制品的外周边。液体激活泄漏警告系统。因此，当流体到达吸收制品的外周时，泄漏警告系统被激活。一旦被激活，泄漏警告系统提供流体已经到达吸收制品边缘的警告信号。在一个实施例中，泄漏警告系统是液体激活的带。一旦被激活，带对用户提供温度变化感觉，以表明流体已经到达吸收制品的边缘，因此在实际发生之前警告用户可能的泄漏。

2. 发明授权

US1789824A Telescopic tree pruner 失效
标题翻译：伸缩树修枝剪
公开(公告)号：US1789824A
公开(公告)日：1931-01-20
申请号：US35738729
申请日：1929-04-23
申请人： WILLIAM LOWE
发明人： WILLIAM LOWE
IPC分类号： A01G3/025
CPC分类号： A01G3/0255

3. 发明申请

US20100160882A1 HYGIENE APPARATUS, PERSONAL MONITORING SYSTEM, AND METHOD OF USE THEREOF 审中-公开
标题翻译：卫生设备，个人监控系统及其使用方法
公开(公告)号：US20100160882A1
公开(公告)日：2010-06-24
申请号：US12719806
申请日：2010-03-08
申请人： William Lowe
发明人： William Lowe
IPC分类号： A61F13/42 , A61F13/45
CPC分类号： A61F13/42 , A61F13/505 , A61F2013/15016
摘要： The present invention includes a hygiene apparatus, more specifically, the hygiene apparatus includes a housing and replaceable absorbent portion. The hygiene apparatus can include an electronic monitoring system and sensory feedback system. The absorbent portion and electronic monitoring system are retained within the housing. The electronic monitoring system includes an electronic portion which detects fluids and activates a sensory feedback signal to the user when fluids contact the system and can thereby warn the user before leakage of fluids beyond the article occurs. The user can remove and replace the absorbent cartridge accordingly. The electronic monitoring system can also include a biosensor to analyze the fluids discharged, process the analyzed information, and provide the physiological information regarding the fluids to the user. The electronic monitoring system can also transfer the information to a remote device so that the user can view the results of system's analysis.
摘要翻译：本发明包括卫生设备，更具体地说，卫生设备包括壳体和可更换的吸收部分。卫生设备可以包括电子监控系统和感觉反馈系统。吸收部分和电子监控系统保持在壳体内。电子监视系统包括电子部分，其检测流体并且当流体接触系统时向用户激活感觉反馈信号，并且因此可以在使物体泄漏超过物品之前发生警告。用户可以相应地拆卸和更换吸收剂盒。电子监控系统还可以包括用于分析排出的流体的生物传感器，处理所分析的信息，以及向用户提供关于流体的生理信息。电子监控系统还可以将信息传输到远程设备，以便用户可以查看系统分析的结果。

4. 发明授权

US06670139B1 Cell-free assay using oncogene-induced apoptosis to identify inhibitors of apoptosis in drug-resistant cells 失效
标题翻译：使用癌基因诱导的细胞凋亡来鉴定耐药细胞凋亡抑制剂的无细胞测定
公开(公告)号：US06670139B1
公开(公告)日：2003-12-30
申请号：US09235738
申请日：1999-01-22
申请人： Howard O. Fearnhead , Mila Elena McCurrach , Scott William Lowe , Yuri Lazebnik
发明人： Howard O. Fearnhead , Mila Elena McCurrach , Scott William Lowe , Yuri Lazebnik
IPC分类号： G01N33574
CPC分类号： G01N33/5011 , G01N33/5008 , G01N33/5017 , G01N2500/00 , G01N2510/00
摘要： The present invention relates to a method of identifying a compound (agent) which modulates apoptosis in transformed cells. In one embodiment, the invention is a method of identifying a compound which selectively activates apoptosis in transformed cells. In an alternative embodiment, the present invention can be used as a method of identifying a compound which inhibits apoptosis in cells. The invention also relates to a method of selectively killing transformed cells, wherein the transformed cell is contacted with a compound which selectively activates apoptosis in transformed cells, as described herein. The invention also relates to methods of treating diseases associated with defective apoptotic machinery (e.g., cancer, neurodegenerative disease). The methods of the present invention are useful for defining the biochemical mechanisms of apoptosis. In addition, the invention provides an assay to identify compounds which modulate (inhibit, activate) apoptosis, supplying new drugs which target defective apoptotic machinery associated with disease (e.g., cancer, neurodegenerative diseases such as Huntington's Disease and Alzheimers Disease).
摘要翻译：本发明涉及鉴定调节转化细胞凋亡的化合物（药剂）的方法。在一个实施方案中，本发明是鉴定选择性激活转化细胞中凋亡的化合物的方法。在替代实施方案中，本发明可用作鉴定抑制细胞凋亡的化合物的方法。本发明还涉及选择性杀死转化细胞的方法，其中转化的细胞与选择性地激活转化细胞中的细胞凋亡的化合物接触，如本文所述。本发明还涉及治疗与有缺陷的凋亡机制（例如癌症，神经变性疾病）相关的疾病的方法。本发明的方法可用于定义细胞凋亡的生物化学机制。此外，本发明提供了一种用于鉴定调节（抑制，激活）凋亡的化合物的测定，提供靶向与疾病相关的有缺陷的凋亡机制（例如，癌症，神经变性疾病如亨廷顿病和阿尔茨海默病）的新药物。

5. 发明授权

US5897992A Cell-free assay using oncogene-induced apoptosis in drug-resistant cells 失效
标题翻译：使用致癌基因诱导的耐药细胞凋亡的无细胞测定
公开(公告)号：US5897992A
公开(公告)日：1999-04-27
申请号：US720381
申请日：1996-09-27
申请人： Howard O. Fearnhead , Mila Elena McCurrach , Scott William Lowe , Yuri Lazebnik
发明人： Howard O. Fearnhead , Mila Elena McCurrach , Scott William Lowe , Yuri Lazebnik
IPC分类号： G01N33/50 , C12N15/85
CPC分类号： G01N33/5011 , G01N33/5008 , G01N33/5017 , G01N2500/00 , G01N2510/00
摘要： The present invention relates to a method of identifying a compound (agent) which modulates apoptosis in transformed cells. In one embodiment, the invention is a method of identifying a compound which selectively activates apoptosis in transformed cells. In an alternative embodiment, the present invention can be used as a method of identifying a compound which inhibits apoptosis in cells. The invention also relates to a method of selectively killing transformed cells, wherein the transformed cell is contacted with a compound which selectively activates apoptosis in transformed cells, as described herein. The invention also relates to methods of treating diseases associated with defective apoptotic machinery (e.g., cancer, neurodegenerative disease). The methods of the present invention are useful for defining the biochemical mechanisms of apoptosis. In addition, the invention provides an assay to identify compounds which modulate (inhibit, activate) apoptosis, supplying new drugs which target defective apoptotic machinery associated with disease (e.g., cancer, neurodegenerative diseases such as Huntington's Disease and Alzheimers Disease).
摘要翻译：本发明涉及鉴定调节转化细胞凋亡的化合物（药剂）的方法。在一个实施方案中，本发明是鉴定选择性激活转化细胞中凋亡的化合物的方法。在替代实施方案中，本发明可用作鉴定抑制细胞凋亡的化合物的方法。本发明还涉及选择性杀死转化细胞的方法，其中转化的细胞与选择性地激活转化细胞中的细胞凋亡的化合物接触，如本文所述。本发明还涉及治疗与有缺陷的凋亡机制（例如癌症，神经变性疾病）相关的疾病的方法。本发明的方法可用于定义细胞凋亡的生物化学机制。此外，本发明提供了一种用于鉴定调节（抑制，激活）凋亡的化合物的测定，提供靶向与疾病相关的有缺陷的凋亡机制（例如，癌症，神经变性疾病如亨廷顿病和阿尔茨海默病）的新药物。

6. 发明授权

US5723280A Photographic element comprising a red sensitive silver halide emulsion layer 失效
标题翻译：包含红色感光卤化银乳剂层的摄影元件
公开(公告)号：US5723280A
公开(公告)日：1998-03-03
申请号：US655109
申请日：1996-05-29
申请人： Steven George Link , James Kenneth Elwood , Frederick Charles Derks , Kenneth William Lowe
发明人： Steven George Link , James Kenneth Elwood , Frederick Charles Derks , Kenneth William Lowe
IPC分类号： G03C7/00 , G03C1/005 , G03C1/18 , G03C1/24
CPC分类号： G03C1/18 , G03C1/0053 , G03C1/24
摘要： A silver halide photographic element comprises a silver halide emulsion layer sensitized with a sensitizing dye of Formula I: ##STR1## wherein each of X.sub.1 and X.sub.2 is an oxygen atom, a sulfur atom, or a selenium atom, with the proviso that one of X.sub.1 and X.sub.2 is an oxygen atom and the other is a sulfur or selenium atom; V.sub.1 and V.sub.2 together or V.sub.2 and V.sub.3 together represent the atoms necessary to complete a fused benzene ring; each of V.sub.4 and V.sub.5 is independently a hydrogen or halogen atom, or an alkyl, alkoxy or aryl group; R.sub.1 is an acid substituted alkyl group; R.sub.2 is a 2-sulfoethyl group; and M is a counterion as necessary to balance the charge.
摘要翻译：卤化银照相元件包括用式I的敏化染料敏化的卤化银乳剂层：其中X1和X2各自为氧原子，硫原子或硒原子，条件是 X1和X2之一是氧原子，另一个是硫或硒原子; V1和V2一起或V2和V3一起表示完成稠合苯环所必需的原子; V4和V5各自独立地为氢或卤素原子，或烷基，烷氧基或芳基; R1是酸取代的烷基; R2是2-磺乙基; 并且M是平衡电荷所必需的抗衡离子。

7. 发明授权

US2679960A Fishing creel 失效
标题翻译：钓鱼架
公开(公告)号：US2679960A
公开(公告)日：1954-06-01
申请号：US19143050
申请日：1950-10-21
申请人： WILLIAM LOWE
发明人： WILLIAM LOWE
IPC分类号： A01K97/20
CPC分类号： A01K97/20 , Y10S224/92

8. 发明授权

US1701268A Tube and sheet connection 失效
标题翻译：管和片连接
公开(公告)号：US1701268A
公开(公告)日：1929-02-05
申请号：US51197421
申请日：1921-11-01
申请人： WILLIAM LOWE THOMAS
发明人： WILLIAM LOWE THOMAS
IPC分类号： F22B37/10
CPC分类号： F22B37/104 , Y10T29/49373 , Y10T403/46 , Y10T403/478

9. 发明授权

US5304275A Applying a reinforcement film to sheets 失效
标题翻译：在钢板上涂一层钢筋
公开(公告)号：US5304275A
公开(公告)日：1994-04-19
申请号：US25981
申请日：1993-03-03
申请人： William Lowe
发明人： William Lowe
IPC分类号： B31F5/08 , B65H37/04 , B26D5/00
CPC分类号： B31F5/085 , B65H37/04 , Y10T156/1011 , Y10T156/1085 , Y10T156/1343
摘要： A reinforcing strip is applied to sheets by longitudinally advancing a leading sheet while the strip is adhered to it along a travel path to a downstream stop station and thereby drawing the strip from a supply and extending it longitudinally through an upstream stop station while simultaneously adhering the strip to the full length of the leading sheet. Then the leading sheet is arrested in the downstream stop station while a trailing sheet upstream of the arrested leading sheet is advanced downstream until a leading edge of the trailing sheet engages an upstream stop in the upstream station immediately upstream of a trailing edge of the leading sheet. The trailing sheet is then arrested with its leading edge engaging the upstream stop which it pushes downstream against the upstream edge of the leading sheet. Generally simultaneously the strip is adhered upstream of the upstream stop to the trailing sheet and the strip is severed at the upstream stop between the leading and trailing sheets. The leading sheet is then advanced longitudinally away from the upstream stop and the upstream stop is moved out of the path to longitudinally advance the trailing sheet downstream while the strip is adhered to it to the downstream stop station while drawing the strip from the supply and extending the strip through the upstream stop station. The cycle is repeated with the trailing sheet taking the place of the leading sheet and with another sheet following the trailing sheet and taking its place.
摘要翻译：通过纵向推进前片而将钢筋沿着沿着行进路径粘附到下游停止站的方式将加强条施加到片材上，从而从供给部拉出条带并纵向延伸穿过上游停止站，同时将剥去前片的全长。然后，引导片在下游停止站停止，而在停止的前片的上游的拖尾片在下游前进，直到后片的前缘接合位于前片的后缘紧邻上游的上游站。然后，后片被阻止，其前缘接合上游止动件，其向下推动抵靠前片的上游边缘。通常同时将条带粘附在上游止挡件的上游到后片，并且在前片和后片之间的上游停止处切断带。然后，引导片纵向远离上游止动件，并且上游止动件移动出路径，以便在将带材从其供应部分拉出时将带粘附到下游停止站的同时向下延伸，穿过上游停站。重复循环，后续纸张取代前置纸张，另一张纸张跟随纸张并取代其位置。

10. 发明授权

US3473416A Epicyclic gearing 失效
公开(公告)号：US3473416A
公开(公告)日：1969-10-21
申请号：US3473416D
申请日：1966-04-20
申请人： JOSEPH A POPE , WILLIAM LOWE
发明人： POPE JOSEPH A , LOWE WILLIAM
IPC分类号： F16H1/46 , F16H1/48 , F16H1/32 , F16H1/34
CPC分类号： F16H1/48 , F16H1/46 , F16H2001/289 , Y10T74/19628

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