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2. 发明授权

US6013855A Grafting of biocompatible hydrophilic polymers onto inorganic and metal surfaces 失效
标题翻译：将生物相容的亲水聚合物接枝到无机和金属表面上
公开(公告)号：US6013855A
公开(公告)日：2000-01-11
申请号：US774707
申请日：1996-12-26
申请人： Timothy McPherson , Kinam Park , Seongbong Jo
发明人： Timothy McPherson , Kinam Park , Seongbong Jo
IPC分类号： A61L27/34 , B05D7/16 , A61F2/02
CPC分类号： B05D7/16 , A61L27/34
摘要： Methods for grafting unmodified PEO or any other water-soluble polymers to the surfaces of metals and glasses to form biocompatible surfaces having low protein affinity is provided. One technique includes the steps of: (a) providing a support member having a plurality of hydroxyl or oxide groups attached to a surface of said support member; (b) exposing said surface to a silane coupling agent to cause the silane coupling agent to form a silane layer that is covalently bound to the surface wherein the silane layer comprises a plurality of vinyl groups; and (c) exposing the silane layer to a hydrophilic polymer and causing the silane layer to react with the hydrophilic polymer to covalently bond to the silane layer. Exposure of the silane layer to .gamma.-radiation to induce grafting with low radiation to induce grafting of the hydrophilic polymer to the silane layer. Another technique comprises grafting a silylated hydrophilic polymer or chain having a hydrophobic domain directly to the metal or inorganic surface.
摘要翻译：提供了将未改性的PEO或任何其它水溶性聚合物接枝到金属和玻璃的表面以形成具有低蛋白质亲和力的生物相容性表面的方法。一种技术包括以下步骤：（a）提供具有附着到所述支撑构件的表面上的多个羟基或氧化物基团的支撑构件; （b）将所述表面暴露于硅烷偶联剂以使硅烷偶联剂形成共价结合到表面的硅烷层，其中硅烷层包含多个乙烯基; 和（c）将硅烷层暴露于亲水性聚合物，并使硅烷层与亲水性聚合物反应以共价结合到硅烷层。将硅烷层暴露于γ-辐射以诱导低辐射接枝以诱导亲水性聚合物接枝到硅烷层。另一种技术包括将具有疏水性域的甲硅烷基化亲水性聚合物或链直接接枝到金属或无机表面。

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