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1. 发明授权

US08398656B2 Clip applier and methods of use 有权
标题翻译：夹子施放器和使用方法
公开(公告)号：US08398656B2
公开(公告)日：2013-03-19
申请号：US13039087
申请日：2011-03-02
申请人： Thomas J. Palermo , William M. Belef , Michael T. Carley , Richard S. Ginn , Anthony J. Pantages , Ronald J. Jabba , Brian A. Ellingwood , Laveille Kao Voss , Kelly J. McCrystle , T. Daniel Gross , Arkady Kokish
发明人： Thomas J. Palermo , William M. Belef , Michael T. Carley , Richard S. Ginn , Anthony J. Pantages , Ronald J. Jabba , Brian A. Ellingwood , Laveille Kao Voss , Kelly J. McCrystle , T. Daniel Gross , Arkady Kokish
IPC分类号： A61B17/08 , A61B17/10
CPC分类号： A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/10 , A61B17/1227 , A61B2017/0003 , A61B2017/00106 , A61B2017/00349 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/0649 , A61B2017/12018 , A61B2090/065
摘要： An apparatus for delivering a closure element can include a splittable carrier tube and a splitter to split the tube. The carrier tube can have an outer surface retaining a closure element in a tubular configuration and can be split into radially-expandable flaps. A closure element can have a shape-memory body having a relaxed configuration with a planar-annular body defining a lumen with tines directed inwardly from the body. The clip can be held in a retaining configuration having a substantially asymmetrically-elongated tubular shape with a trapezoidal longitudinal cross-sectional profile and a proximal end having the tines being longitudinally directed with a first tine being more distally oriented compared to a substantially opposite second tine being more proximal, and retracting to a deploying configuration having a tubular shape with a rectangular longitudinal cross-sectional profile with the first tine being even with the second tine when being delivered.
摘要翻译：用于传送闭合元件的装置可以包括可拆卸的载体管和用于分裂管的分离器。载体管可以具有将封闭元件保持为管状构造的外表面，并且可以被分割成径向可膨胀的瓣。封闭元件可以具有形状记忆体，该形状记忆体具有松弛构型，其中平面环形主体限定具有从身体向内指向的尖齿的内腔。夹具可以保持在具有梯形纵截面轮廓的基本上不对称的细长管状形状的保持构造中，并且具有尖端的尖端与第一齿纵向对准，该第一齿与基本上相对的第二齿相比更向远侧取向更靠近并且缩回到具有矩形纵向截面轮廓的管状形状的展开构造，其中第一齿在被递送时与第二齿均匀。

2. 发明申请

US20110230897A1 CLIP APPLIER AND METHODS OF USE 有权
标题翻译：夹具应用和使用方法
公开(公告)号：US20110230897A1
公开(公告)日：2011-09-22
申请号：US13039087
申请日：2011-03-02
申请人： Thomas J. Palermo , William M. Belef , Michael T. Carley , Richard S. Ginn , Anthony J. Pantages , Ronald J. Jabba , Brian A. Ellingwood , Laveille Kao Voss , Kelly J. McCrystle , T. Daniel Gross , Arkady Kokish
发明人： Thomas J. Palermo , William M. Belef , Michael T. Carley , Richard S. Ginn , Anthony J. Pantages , Ronald J. Jabba , Brian A. Ellingwood , Laveille Kao Voss , Kelly J. McCrystle , T. Daniel Gross , Arkady Kokish
IPC分类号： A61B17/10
CPC分类号： A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/10 , A61B17/1227 , A61B2017/0003 , A61B2017/00106 , A61B2017/00349 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/0649 , A61B2017/12018 , A61B2090/065
摘要： An apparatus for delivering a closure element can include a splittable carrier tube and a splitter to split the tube. The carrier tube can have an outer surface retaining a closure element in a tubular configuration and can be split into radially-expandable flaps. A closure element can have a shape-memory body having a relaxed configuration with a planar-annular body defining a lumen with tines directed inwardly from the body. The clip can be held in a retaining configuration having a substantially asymmetrically-elongated tubular shape with a trapezoidal longitudinal cross-sectional profile and a proximal end having the tines being longitudinally directed with a first tine being more distally oriented compared to a substantially opposite second tine being more proximal, and retracting to a deploying configuration having a tubular shape with a rectangular longitudinal cross-sectional profile with the first tine being even with the second tine when being delivered.
摘要翻译：用于传送闭合元件的装置可以包括可拆卸的载体管和用于分裂管的分离器。载体管可以具有将封闭元件保持为管状构造的外表面，并且可以被分割成径向可膨胀的瓣。封闭元件可以具有形状记忆体，该形状记忆体具有松弛构型，其中平面环形主体限定具有从身体向内指向的尖齿的内腔。夹具可以保持在具有梯形纵截面轮廓的基本上不对称的细长管状形状的保持构造中，并且具有尖端的尖端与第一齿纵向对准，该第一齿与基本上相对的第二齿相比更向远侧取向更靠近并且缩回到具有矩形纵向截面轮廓的管状形状的展开构造，其中第一齿在被递送时与第二齿均匀。

3. 发明授权

US07905900B2 Clip applier and methods of use 有权
标题翻译：夹子施放器和使用方法
公开(公告)号：US07905900B2
公开(公告)日：2011-03-15
申请号：US10356214
申请日：2003-01-30
申请人： Thomas J. Palermo , William M. Belef , Michael T. Carley , Richard S. Ginn , Ronald J. Jabba , Anthony J. Pantages , Francisco Javier Sagastegui
发明人： Thomas J. Palermo , William M. Belef , Michael T. Carley , Richard S. Ginn , Ronald J. Jabba , Anthony J. Pantages , Francisco Javier Sagastegui
IPC分类号： A61B17/08
CPC分类号： A61B17/064 , A61B17/0057 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/1227 , A61B17/1285 , A61B2017/00637 , A61B2017/00672
摘要： An apparatus for delivering a closure element into an opening formed in a blood vessel or other body lumen and methods for manufacturing and using same. The apparatus is configured to retain the closure element such that the closure element is disposed substantially within the apparatus. The apparatus also can engage, and position the closure element substantially adjacent to, the blood vessel wall adjacent to the opening. During deployment of the closure element, the apparatus expands the closure element beyond a natural cross-section of the closure element such that the closure element, when deployed, is configured to engage a significant amount of the blood vessel wall and/or tissue. Engaging the blood vessel wall and/or tissue, the closure element is further configured to return to the natural cross-section, thereby drawing the engaged blood vessel wall and/or tissue substantially closed and/or sealed, such that hemostasis within the opening is enhanced.
摘要翻译：一种用于将闭合元件输送到形成在血管或其他体腔中的开口中的装置及其制造和使用方法。该装置构造成保持封闭元件，使得封闭元件基本上设置在该装置内。该装置还可以将封闭件基本上邻近开口附近的血管壁接合并定位。在封闭元件的展开过程中，该装置将闭合元件膨胀超过封闭元件的自然横截面，使得封闭元件在展开时构造成与大量的血管壁和/或组织接合。接合血管壁和/或组织，闭合元件进一步构造成返回到自然横截面，从而将所接合的血管壁和/或组织基本上闭合和/或密封，使得开口内止血增强。

4. 发明授权

US07695487B2 Balloon dissection apparatus 有权
标题翻译：气球解剖仪
公开(公告)号：US07695487B2
公开(公告)日：2010-04-13
申请号：US10422874
申请日：2003-04-24
申请人： Kenneth A. Peartree , Thomas J. Palermo , Shigeru Tanaka , Ferolyn T. Powell
发明人： Kenneth A. Peartree , Thomas J. Palermo , Shigeru Tanaka , Ferolyn T. Powell
IPC分类号： A61B17/00
CPC分类号： A61B17/00234 , A61B17/02 , A61B2017/00557 , A61B2017/320044 , A61B2017/320048 , A61B2017/3419 , A61B2017/3486 , A61F2/0063 , A61F2002/0072
摘要： Apparatus for creating an anatomic space in tissue in a body including an introducer device having a tubular member with a bore extending therethrough. A tunneling shaft assembly is slidably mounted in the bore of the introducer device. The tunneling shaft assembly includes a tunneling shaft having proximal and distal extremities. A blunt tip is secured to the distal extremity of the tunneling shaft. A balloon assembly is provided. The balloon assembly is removably secured to the tunneling shaft. The balloon assembly includes a deflated collapsed balloon. A sheath encloses the balloon and is carried by the tunneling shaft. The sheath has a weakened region extending longitudinally thereof permitting the sheath to be removed to release the balloon.
摘要翻译：用于在身体中的组织中产生解剖空间的装置，包括具有带有延伸穿过其中的孔的管状构件的导引器装置。隧道轴组件可滑动地安装在导引器装置的孔中。隧道轴组件包括具有近端和远端的隧道轴。钝头固定到隧道轴的远端。提供气球组件。气囊组件可移除地固定到隧道轴。气囊组件包括放气的折叠气球。护套围绕气球并由隧道轴承载。护套具有沿其纵向延伸的弱化区域，允许护套被移除以释放气囊。

5. 再颁专利

USRE37117E1 Detachable embolic coil assembly using interlocking clasps and method of use 失效
标题翻译：可拆卸栓塞线圈组件采用互锁扣和使用方法
公开(公告)号：USRE37117E1
公开(公告)日：2001-03-27
申请号：US08888495
申请日：1997-07-07
申请人： Thomas J. Palermo
发明人： Thomas J. Palermo
IPC分类号： A61B1700
CPC分类号： A61F2/01 , A61B17/12022 , A61B17/12145 , A61B2017/1205 , A61F2002/011 , A61F2002/016 , A61F2230/0091 , A61M25/0905
摘要： This invention is a surgical instrument and specifically is a device for delivering an embolic coil to a selected site within the vasculature of a human body via use of a catheter. In particular, the device uses embolic coils having interlocking clasps on the coils which are secured to each other by a control wire within the catheter. Retraction of the control wire into the catheter body uncouples the distal coil.
摘要翻译：本发明是一种手术器械，具体地说是一种用于通过使用导管将栓塞线圈输送到人体脉管系统内的选定部位的装置。特别地，该装置使用在线圈上具有互锁扣环的栓塞线圈，其通过导管内的控制线彼此固定。将控制线缩回到导管体中使远端线圈脱开。

6. 发明授权

US5925059A Detachable embolic coil assembly 失效
标题翻译：可拆卸栓塞线圈组件
公开(公告)号：US5925059A
公开(公告)日：1999-07-20
申请号：US361330
申请日：1994-12-21
申请人： Thomas J. Palermo , Son Gia
发明人： Thomas J. Palermo , Son Gia
IPC分类号： A61B17/12 , A61F2/01 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12145 , A61F2/01 , A61M25/0905 , A61B2017/1205 , A61B90/39 , A61F2002/011 , A61F2002/016 , A61F2230/0091
摘要： This invention is a surgical instrument and specifically is a device for delivering embolic coils to a selected site within the vasculature of a human body via use of a catheter. The invention further includes the coils. In particular, the device uses embolic coils having interlocking ends, e.g., clasps or hooks, on the ends of the coils. The coils may further be secured to each other by a control wire within the catheter. Retraction of the optional control wire into the catheter body uncouples the distal coil.
摘要翻译：本发明是一种手术器械，特别是用于通过使用导管将栓塞线圈递送到人体脉管系统内的选定部位的装置。本发明还包括线圈。特别地，该装置在线圈的端部使用具有互锁端的栓塞线圈，例如钩扣或钩。线圈可以进一步通过导管内的控制线彼此固定。将可选择的控制线缩回到导管体中使远端线圈脱开。

7. 发明授权

US5772609A Guidewire with variable flexibility due to polymeric coatings 失效
标题翻译：导丝由于聚合物涂层而具有可变的柔性
公开(公告)号：US5772609A
公开(公告)日：1998-06-30
申请号：US672637
申请日：1996-06-28
申请人： Kim Nguyen , Chi J. Chung , Thomas J. Palermo
发明人： Kim Nguyen , Chi J. Chung , Thomas J. Palermo
IPC分类号： A61M25/00 , A61B5/00
CPC分类号： A61M25/09 , A61M2025/0046 , A61M2025/09091 , A61M2025/09133 , A61M2025/09175
摘要： This invention is a guidewire for guiding a catheter and is used for accessing a targeted site within a lumen system in a body. The guidewire or guidewire section has a wire core, a distal tip region, a polymeric tie layer, and a lubricious coating. The tie layer is preferably constructed to provide for sections of varying flexibility along the length of the guidewire. Variations of the tie layer provide for axially spaced sections of varying flexibility, radially layers of varying flexibility of both. In a special variation, the tie layer is constructed with at least one section providing increased stiffness distally.
摘要翻译：本发明是用于引导导管的导丝，并且用于进入体内管腔系统内的目标部位。导线或导丝部分具有线芯，远端尖端区域，聚合物连接层和光滑涂层。连接层优选构造成沿着导丝的长度提供具有不同柔性的部分。连接层的变化提供了具有不同柔性的轴向间隔的部分，两者具有不同柔性的径向层。在一个特殊的变化中，连接层被构造成具有至少一个向远端提供增加的刚度的部分。

8. 发明授权

US5131407A Guidewire with tracking member and catheter exchange system 失效
标题翻译：导丝跟踪构件和导管交换系统
公开(公告)号：US5131407A
公开(公告)日：1992-07-21
申请号：US700104
申请日：1991-05-08
申请人： Thomas A. Ischinger , Thomas J. Palermo
发明人： Thomas A. Ischinger , Thomas J. Palermo
IPC分类号： A61M25/00
CPC分类号： A61M25/09041 , A61M2025/09083
摘要： A guidewire and method of using same for tracking an indwelling device such as a catheter previously positioned within a body lumen. The guidewire includes an elongate flexible body shaft having proximal and distal ends, and a tracking member disposed at the region of the distal end. The tracking member defines an opening passable over the shaft of the indwelling device. During use, the tracking member is slid along the indwelling device toward its distal end to enable the guidewire to track the path of the indwelling device. The indwelling device then may be withdrawn from the patient's body lumen and an over-the-wire catheter may be threaded onto and advanced along the guidewire into the patient's body lumen. The tracking member is retractable within and removable from the guidewire. The invention is useful particularly in catheterization procedures where it is desired to exchange an over-the-wire catheter for a catheter having a fixed or integral guidewire.
摘要翻译：引导线及其使用方法，用于跟踪预先位于体腔内的导管等留置装置。导线包括具有近端和远端的细长柔性主体轴和设置在远端区域的跟踪构件。跟踪构件限定可在该居留装置的轴上通过的开口。在使用期间，跟踪构件沿着留置装置向其远端滑动，以使引导线能够跟踪留置装置的路径。然后，留置装置可以从患者的体腔抽出，并且线上导管可以沿导丝螺纹穿过并进入患者体腔内。跟踪构件可伸缩并且可从导丝移除。本发明特别适用于需要在具有固定或整体导丝的导管上更换线上导管的导管术过程。

9. 发明授权

US08172869B2 Balloon dissection apparatus 有权
标题翻译：气球解剖仪
公开(公告)号：US08172869B2
公开(公告)日：2012-05-08
申请号：US12758340
申请日：2010-04-12
申请人： Kenneth A Peartree , Thomas J Palermo , Shigeru Tanaka , Ferolyn T Powell
发明人： Kenneth A Peartree , Thomas J Palermo , Shigeru Tanaka , Ferolyn T Powell
IPC分类号： A61B17/00
CPC分类号： A61B17/00234 , A61B17/02 , A61B2017/00557 , A61B2017/320044 , A61B2017/320048 , A61B2017/3419 , A61B2017/3486 , A61F2/0063 , A61F2002/0072
摘要： Apparatus for creating an anatomic space in tissue in a body including an introducer device having a tubular member with a bore extending therethrough. A tunneling shaft assembly is slidably mounted in the bore of the introducer device. The tunneling shaft assembly includes a tunneling shaft having proximal and distal extremities. A blunt tip is secured to the distal extremity of the tunneling shaft. A balloon assembly is provided. The balloon assembly is removably secured to the tunneling shaft. The balloon assembly includes a deflated collapsed balloon. A sheath encloses the balloon and is carried by the tunneling shaft. The sheath has a weakened region extending longitudinally thereof permitting the sheath to be removed to release the balloon.
摘要翻译：用于在身体中的组织中产生解剖空间的装置，包括具有带有延伸穿过其中的孔的管状构件的导引器装置。隧道轴组件可滑动地安装在导引器装置的孔中。隧道轴组件包括具有近端和远端的隧道轴。钝头固定到隧道轴的远端。提供气球组件。气囊组件可移除地固定到隧道轴。气囊组件包括放气的折叠气球。护套围绕气球并由隧道轴承载。护套具有沿其纵向延伸的弱化区域，允许护套被移除以释放气囊。

10. 发明授权

US08083768B2 Vascular plug having composite construction 有权
标题翻译：具有复合结构的血管塞
公开(公告)号：US08083768B2
公开(公告)日：2011-12-27
申请号：US11038995
申请日：2005-01-19
申请人： Richard S. Ginn , Thomas J Palermo , Phil Olsen , Tellis Hartridge , Adam Shively
发明人： Richard S. Ginn , Thomas J Palermo , Phil Olsen , Tellis Hartridge , Adam Shively
IPC分类号： A61B17/04 , A61F13/00
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12109 , A61B17/12159 , A61B17/12163 , A61B17/12172 , A61B17/1219 , A61B2017/00004 , A61B2017/00654 , A61B2017/00778 , A61B2017/00898
摘要： This invention relates to apparatus and methods for use in sealing a vascular puncture site, particularly sites of punctures that are the result of catheterization or other interventional procedures. In several of the preferred embodiments, the sealing device includes a sealing member and a tether. The sealing member generally performs the function of occupying a space in an incision, puncture, or other wound and sealing the space in the incision, puncture, or wound that it occupies, to prevent further blood flow. The tether is typically attached in some manner to the sealing member, and provides the user with the ability to withdraw the sealing member if necessary. In a particularly preferred form, the sealing device further includes a restraining member associated with the sealing member. The restraining member provides the ability to more securely restrain the sealing member to prevent it from migrating from the deployment location within a tissue tract. The restraining member may also provide an additional capability of manipulating the sealing member after deployment.
摘要翻译：本发明涉及用于密封血管穿刺部位的装置和方法，特别是作为导管插入术或其他介入手术的结果的穿刺部位。在几个优选实施例中，密封装置包括密封构件和系绳。密封构件通常执行占据切口，穿刺或其他伤口中的空间并密封其占据的切口，穿刺或伤口中的空间的功能，以防止进一步的血液流动。系绳通常以某种方式附接到密封构件上，并且如果需要，使用者能够抽出密封构件。在特别优选的形式中，密封装置还包括与密封构件相关联的限制构件。限制构件提供了更可靠地限制密封构件以防止其从组织道内的展开位置迁移的能力。限制构件还可以在部署之后提供操纵密封构件的附加能力。

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