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1. 发明申请

US20100028259A1 USE OF ORGANIC CATION TRANSPORTERS FOR CANCER DIAGNOSIS AND THERAPY 审中-公开
标题翻译：有机摄影机使用癌症诊断和治疗方法
公开(公告)号：US20100028259A1
公开(公告)日：2010-02-04
申请号：US12296887
申请日：2007-04-18
申请人： Kathleen M. Giacomini , Joe W. Gray , Anna Lapuk , Shuzhong Zhang
发明人： Kathleen M. Giacomini , Joe W. Gray , Anna Lapuk , Shuzhong Zhang
IPC分类号： A61K49/00 , C12Q1/68 , G01N33/53 , A61B5/05
CPC分类号： G01N33/57484 , G01N33/57407 , G01N33/57492 , G01N2800/52
摘要： The present invention provides, for the first time, the finding that organic cation transporters (OCTs) are major determinants of the anticancer activity of platinum-based drugs such as oxaliplatin, and therefore have clinical significance for selecting oxaliplatin as the preferred therapy for a cancer that expresses one or more OCTs, such as colorectal cancer or liver cancer. In addition, the OCT genotype can also be used to predict oxaliplatin response or to select therapy. The present invention also provides methods of treating or inhibiting cancers that expresses one or more OCTs by administering a therapeutically effective amount of a platinum-based drug such as an oxaliplatin analog having an organic non-leaving group with an increased size. The present invention further provides methods of sensitizing a therapy resistant cancer to a platinum-based drug such as oxaliplatin by administering a therapeutically effective amount of a nucleic acid encoding an OCT. Compositions, kits, and integrated systems for carrying out the diagnostic, prognostic, and therapeutic methods of the present invention are also provided.
摘要翻译：本发明首次提出有机阳离子转运蛋白（OCTs）是奥沙利铂等铂类药物的抗癌活性的主要决定因素，因此具有选择奥沙利铂作为癌症优选疗法的临床意义其表达一个或多个OCT，例如结肠直肠癌或肝癌。此外，OCT基因型也可用于预测奥沙利铂反应或选择治疗。本发明还提供了通过施用治疗有效量的具有增加大小的具有有机非离去基团的奥沙利铂类似物的铂基药物来治疗或抑制表达一种或多种OCT的癌症的方法。本发明进一步提供了通过施用治疗有效量的编码OCT的核酸来使耐药性癌症对铂类药物如奥沙利铂敏感的方法。还提供了用于实施本发明的诊断，预后和治疗方法的组合物，试剂盒和综合系统。

2. 发明授权

US07384882B2 Process for regenerating titanium-containing catalysts 有权
标题翻译：再生含钛催化剂的方法
公开(公告)号：US07384882B2
公开(公告)日：2008-06-10
申请号：US10448372
申请日：2003-05-30
申请人： Bin Sun , Wei Wu , Enquan Wang , Yongxiang Li , Shuzhong Zhang , Lingmin Hu
发明人： Bin Sun , Wei Wu , Enquan Wang , Yongxiang Li , Shuzhong Zhang , Lingmin Hu
IPC分类号： B01J20/34
CPC分类号： B01J38/60 , B01J21/20 , B01J29/89 , B01J29/90 , Y10S502/514
摘要： The present invention discloses a process for regenerating titanium-containing catalysts, characterized in that a deactivated catalyst is treated in an acidic solution having a pH value of ≦3, and then dried and calcined. The process is simple in procedure and can make the catalytic activity, selectivity and stability of the regenerated catalyst be recovered to the level of its fresh catalyst.
摘要翻译：本发明公开了一种再生含钛催化剂的方法，其特征在于，在pH值<= 3的酸性溶液中处理失活的催化剂，然后干燥和煅烧。该方法操作简单，可使再生催化剂的催化活性，选择性和稳定性达到新鲜催化剂的水平。

3. 发明申请

US20050215810A1 Process for ammoximation of carbonyl compounds 有权
标题翻译：羰基化合物氨肟化方法
公开(公告)号：US20050215810A1
公开(公告)日：2005-09-29
申请号：US10448282
申请日：2003-05-30
申请人： Wei Wu , Bin Sun , Yongxiang Li , Shibiao Cheng , Enquan Wang , Shuzhong Zhang
发明人： Wei Wu , Bin Sun , Yongxiang Li , Shibiao Cheng , Enquan Wang , Shuzhong Zhang
IPC分类号： C07C249/08 , C07B61/00 , C07C249/04 , C07C251/34 , C07C251/38 , C07C251/42 , C07C251/44 , C07C251/48 , C07C253/22
CPC分类号： C07C251/48 , C07C249/04 , C07C251/38 , C07C251/42 , C07C2601/08 , C07C2601/14
摘要： The present invention discloses a process for the ammoximation of carbonyl compounds, wherein a reaction in a liquid reaction system comprising a carbonyl compound, ammonia and hydrogen peroxide is carried out in the presence of a sillicon-containing catalyst, characterized in that a liquid silicon-containing assistant is added to the reaction system so that the silicon concentration in the system reaches a range of between 0.1 and 10000 ppm. In the process according to the present invention, the deactivation of catalyst due to dissolution of silicon in the catalyst can be reduced, thus lifetime of the catalyst extended and the stable operation time elongated.
摘要翻译：本发明公开了一种羰基化合物的肟化方法，其中在含有硅基催化剂的催化剂存在下进行包含羰基化合物，氨和过氧化氢的液体反应体系中的反应，其特征在于，加入到反应体系中，使得体系中的硅浓度达到0.1〜10000ppm的范围。在根据本发明的方法中，可以减少由于硅在催化剂中的溶解导致的催化剂的失活，从而延长催化剂的寿命并延长稳定的操作时间。

4. 发明授权

US07408080B2 Process for ammoximation of carbonyl compounds 有权
标题翻译：羰基化合物氨肟化方法
公开(公告)号：US07408080B2
公开(公告)日：2008-08-05
申请号：US10448282
申请日：2003-05-30
申请人： Wei Wu , Bin Sun , Yongxiang Li , Shibiao Cheng , Enquan Wang , Shuzhong Zhang
发明人： Wei Wu , Bin Sun , Yongxiang Li , Shibiao Cheng , Enquan Wang , Shuzhong Zhang
IPC分类号： C07C249/04
CPC分类号： C07C251/48 , C07C249/04 , C07C251/38 , C07C251/42 , C07C2601/08 , C07C2601/14
摘要： The present invention discloses a process for the ammoximation of carbonyl compounds, wherein a reaction in a liquid reaction system comprising a carbonyl compound, ammonia and hydrogen peroxide is carried out in the presence of a sillicon-containing catalyst, characterized in that a liquid silicon-containing assistant is added to the reaction system so that the silicon concentration in the system reaches a range of between 0.1 and 10000 ppm. In the process according to the present invention, the deactivation of catalyst due to dissolution of silicon in the catalyst can be reduced, thus lifetime of the catalyst extended and the stable operation time elongated.
摘要翻译：本发明公开了一种羰基化合物的肟化方法，其中在含有硅基催化剂的催化剂存在下进行包含羰基化合物，氨和过氧化氢的液体反应体系中的反应，其特征在于，加入到反应体系中，使得体系中的硅浓度达到0.1〜10000ppm的范围。在根据本发明的方法中，可以减少由于硅在催化剂中的溶解导致的催化剂的失活，从而延长催化剂的寿命并延长稳定的操作时间。

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