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1. 发明申请

US20140355861A1 RETINAL ENCODER FOR MACHINE VISION 有权
标题翻译：用于机器视觉的视觉编码器
公开(公告)号：US20140355861A1
公开(公告)日：2014-12-04
申请号：US14239828
申请日：2012-08-24
申请人： Sheila Nirenberg , Illya Bomash
发明人： Sheila Nirenberg , Illya Bomash
IPC分类号： G06K9/46 , G06T7/00 , H04N19/85 , G06N3/04 , H04N19/60
CPC分类号： G06K9/4619 , G06K9/4628 , G06K2209/05 , G06N3/049 , G06T7/0012 , G06T9/00 , G06T9/002 , G06T9/007 , G06T2207/20024 , G06T2207/20048 , G06T2207/20084 , G06T2207/30041 , H04N19/60 , H04N19/62 , H04N19/85
摘要： A method is disclosed including: receiving raw image data corresponding to a series of raw images; processing the raw image data with an encoder to generate encoded data, where the encoder is characterized by an input/output transformation that substantially mimics the input/output transformation of one or more retinal cells of a vertebrate retina; and applying a first machine vision algorithm to data generated based at least in part on the encoded data.
摘要翻译：公开了一种方法，包括：接收与一系列原始图像相对应的原始图像数据; 用编码器处理原始图像数据以产生编码数据，其中编码器的特征在于基本上模拟脊椎动物视网膜的一个或多个视网膜细胞的输入/输出变换的输入/输出变换; 以及对至少部分地基于编码数据生成的数据应用第一机器视觉算法。

2. 发明申请

US20180104507A1 OPTOGENETIC THERAPEUTIC AND METHOD OF TREATING RETINAL DEGENERATIVE AND NEURODEGENERATIVE DISEASES 审中-公开
公开(公告)号：US20180104507A1
公开(公告)日：2018-04-19
申请号：US15786886
申请日：2017-10-18
申请人： Sheila Nirenberg
发明人： Sheila Nirenberg
IPC分类号： A61N5/06 , G01N33/50 , C07K14/47 , A61K41/00
CPC分类号： A61N5/062 , A61F9/00 , A61K41/0057 , A61K49/0045 , A61K49/0047 , A61K49/0056 , A61N5/0622 , A61N2005/0648 , C07K14/4702 , C07K14/705 , C07K2319/60 , G01N33/5058
摘要： A method of treating a subject afflicted with a retinal degenerative or neurodegenerative disease including administering an optogenetic therapeutic to the subject, where the optogenetic therapeutic includes an optogenetic protein fused or linked to a marker protein. An optogenetic therapeutic for use in treating a subject afflicted with a retinal degenerative or neurodegenerative disease, including an optogenetic protein fused or linked to a marker protein.

3. 发明授权

US09302103B1 Neurological prosthesis 有权
标题翻译：神经假体
公开(公告)号：US09302103B1
公开(公告)日：2016-04-05
申请号：US13230488
申请日：2011-09-12
申请人： Sheila Nirenberg
发明人： Sheila Nirenberg
IPC分类号： A61N1/36 , G06N3/04 , A61N5/06 , A61N1/05 , A61F9/08
CPC分类号： A61N1/36003 , A61F9/0079 , A61F2009/00863 , A61N1/0541 , A61N1/0543 , A61N1/36036 , A61N1/36046 , A61N1/3605 , A61N1/36067 , A61N1/36139 , A61N5/0622 , A61N2005/0605 , A61N2005/063 , A61N2005/0652
摘要： A method improving or restoring neural function in a mammalian subject in need thereof, the method including: using an input receiver to record an input signal generated by a first set of nerve cells; using an a encoder unit including a set of encoders to generate a set of coded outputs in response to the input signal; using the encoded outputs to drive an output generator; and using an output generator to activate a second set of nerve cells wherein the second set of nerve cells is separated from the first set of nerve cells by impaired set of signaling cells. In some embodiments, the second set of nerve cells produces a response that is substantially the same as the response in an unimpaired subject.
摘要翻译：一种在有需要的哺乳动物受试者中改善或恢复神经功能的方法，所述方法包括：使用输入接收器来记录由第一组神经细胞产生的输入信号; 使用包括一组编码器的编码器单元来响应于所述输入信号生成一组编码输出; 使用编码的输出来驱动输出发生器; 以及使用输出发生器来激活第二组神经细胞，其中所述第二组神经细胞通过受损的信号细胞组与所述第一组神经细胞分离。在一些实施例中，第二组神经细胞产生与未受损对象中的反应基本相同的应答。

4. 发明授权

US09220634B2 Retina prosthesis 有权
标题翻译：视网膜假体
公开(公告)号：US09220634B2
公开(公告)日：2015-12-29
申请号：US13595812
申请日：2012-08-27
申请人： Sheila Nirenberg
发明人： Sheila Nirenberg
IPC分类号： G06K9/00 , A61F9/08 , G06N3/04 , A61K35/30 , A61N1/05 , A61N1/36
CPC分类号： A61N1/36046 , A61F9/08 , A61N1/0543 , G06N3/049
摘要： The invention provides a retinal prosthetic method and device that mimics the responses of the retina to a broad range of stimuli, including natural stimuli. Ganglion cell firing patterns are generated in response to a stimulus using a set of encoders, interfaces, and transducers, where each transducer targets a single cell or a small number of cells. The conversion occurs on the same time scale as that carried out by the normal retina. In addition, aspects of the invention may be used with robotic or other mechanical devices, where processing of visual information is required. The encoders may be adjusted over time with aging or the progression of a disease.
摘要翻译：本发明提供了视网膜假体方法和装置，其模拟视网膜对广泛范围的刺激（包括天然刺激）的反应。响应于使用一组编码器，接口和换能器的刺激来产生神经节细胞发射模式，其中每个换能器靶向单个细胞或少量细胞。转换发生在与正常视网膜相同的时间尺度上。此外，本发明的方面可以与机器人或其他机械装置一起使用，其中需要视觉信息的处理。随着老化或疾病的进展，编码器可随时间而被调整。

5. 发明授权

US09180309B2 Retina prosthesis 有权
标题翻译：视网膜假体
公开(公告)号：US09180309B2
公开(公告)日：2015-11-10
申请号：US13821187
申请日：2011-08-25
申请人： Sheila Nirenberg , Chethan Pandarinath , Ifije Ohiorhenuan
发明人： Sheila Nirenberg , Chethan Pandarinath , Ifije Ohiorhenuan
IPC分类号： A61F2/16 , A61N5/06 , G06K9/60 , G06N3/04 , A61N1/36
CPC分类号： A61N5/0622 , A61N1/36046 , G06K9/605 , G06N3/049
摘要： This disclosure provides a retinal prosthetic method and device that mimics the responses of the retina to a broad range of stimuli, including natural stimuli. Ganglion cell firing patterns are generated in response to a stimulus using a set of encoders, interfaces, and transducers, where each transducer targets a single cell or a small number of cells. The conversion occurs on the same time scale as that carried out by the normal retina. In addition, aspects of the invention may be used with robotic or other mechanical devices, where processing of visual information is required. The encoders may be adjusted over time with aging or the progression of a disease.
摘要翻译：本公开提供了视网膜假体方法和装置，其模拟视网膜对广泛范围的刺激（包括天然刺激）的反应。响应于使用一组编码器，接口和换能器的刺激来产生神经节细胞发射模式，其中每个换能器靶向单个细胞或少量细胞。转换发生在与正常视网膜相同的时间尺度上。此外，本发明的方面可以与机器人或其他机械装置一起使用，其中需要视觉信息的处理。随着老化或疾病的进展，编码器可随时间而被调整。

6. 发明申请

US20200061387A1 OPTOGENETIC THERAPEUTIC AND METHOD OF TREATING RETINAL DEGENERATIVE AND NEURODEGENERATIVE DISEASES 审中-公开
公开(公告)号：US20200061387A1
公开(公告)日：2020-02-27
申请号：US16672899
申请日：2019-11-04
申请人： Sheila Nirenberg
发明人： Sheila Nirenberg
IPC分类号： A61N5/06 , G01N33/50 , A61K41/00 , C07K14/47 , A61K49/00 , C07K14/705
摘要： A method of treating a subject afflicted with a retinal degenerative or neurodegenerative disease including administering an optogenetic therapeutic to the subject, where the optogenetic therapeutic includes an optogenetic protein fused or linked to a marker protein. An optogenetic therapeutic for use in treating a subject afflicted with a retinal degenerative or neurodegenerative disease, including an optogenetic protein fused or linked to a marker protein.

7. 发明授权

US09547804B2 Retinal encoder for machine vision 有权
标题翻译：用于机器视觉的视网膜编码器
公开(公告)号：US09547804B2
公开(公告)日：2017-01-17
申请号：US14239828
申请日：2012-08-24
申请人： Sheila Nirenberg , Illya Bomash
发明人： Sheila Nirenberg , Illya Bomash
IPC分类号： G06T7/00 , G06K9/46 , G06T9/00 , G06N3/04 , H04N19/62 , H04N19/85 , H04N19/60
CPC分类号： G06K9/4619 , G06K9/4628 , G06K2209/05 , G06N3/049 , G06T7/0012 , G06T9/00 , G06T9/002 , G06T9/007 , G06T2207/20024 , G06T2207/20048 , G06T2207/20084 , G06T2207/30041 , H04N19/60 , H04N19/62 , H04N19/85
摘要： A method is disclosed including: receiving raw image data corresponding to a series of raw images; processing the raw image data with an encoder to generate encoded data, where the encoder is characterized by an input/output transformation that substantially mimics the input/output transformation of one or more retinal cells of a vertebrate retina; and applying a first machine vision algorithm to data generated based at least in part on the encoded data.
摘要翻译：公开了一种方法，包括：接收与一系列原始图像相对应的原始图像数据; 用编码器处理原始图像数据以产生编码数据，其中编码器的特征在于基本上模拟脊椎动物视网膜的一个或多个视网膜细胞的输入/输出变换的输入/输出变换; 以及对至少部分地基于编码数据生成的数据应用第一机器视觉算法。

8. 发明申请

US20130289668A1 RETINA PROSTHESIS 有权
公开(公告)号：US20130289668A1
公开(公告)日：2013-10-31
申请号：US13821187
申请日：2011-08-25
申请人： Sheila Nirenberg , Chethan Pandarinath , Ifije Ohiorhenuan
发明人： Sheila Nirenberg , Chethan Pandarinath , Ifije Ohiorhenuan
IPC分类号： A61N5/06
CPC分类号： A61N5/0622 , A61N1/36046 , G06K9/605 , G06N3/049
摘要： This disclosure provides a retinal prosthetic method and device that mimics the responses of the retina to a broad range of stimuli, including natural stimuli. Ganglion cell firing patterns are generated in response to a stimulus using a set of encoders, interfaces, and transducers, where each transducer targets a single cell or a small number of cells. The conversion occurs on the same time scale as that carried out by the normal retina. In addition, aspects of the invention may be used with robotic or other mechanical devices, where processing of visual information is required. The encoders may be adjusted over time with aging or the progression of a disease.
摘要翻译：本公开提供了视网膜假体方法和装置，其模拟视网膜对广泛范围的刺激（包括天然刺激）的反应。响应于使用一组编码器，接口和换能器的刺激来产生神经节细胞发射模式，其中每个换能器靶向单个细胞或少量细胞。转换发生在与正常视网膜相同的时间尺度上。此外，本发明的方面可以与机器人或其他机械装置一起使用，其中需要视觉信息的处理。随着老化或疾病的进展，编码器可随时间而被调整。

9. 发明申请

US20130110236A1 RETINA PROSTHESIS 有权
公开(公告)号：US20130110236A1
公开(公告)日：2013-05-02
申请号：US13595812
申请日：2012-08-27
申请人： Sheila NIRENBERG
发明人： Sheila NIRENBERG
IPC分类号： A61F9/08
CPC分类号： A61N1/36046 , A61F9/08 , A61N1/0543 , G06N3/049
摘要： The invention provides a retinal prosthetic method and device that mimics the responses of the retina to a broad range of stimuli, including natural stimuli. Ganglion cell firing patterns are generated in response to a stimulus using a set of encoders, interfaces, and transducers, where each transducer targets a single cell or a small number of cells. The conversion occurs on the same time scale as that carried out by the normal retina. In addition, aspects of the invention may be used with robotic or other mechanical devices, where processing of visual information is required. The encoders may be adjusted over time with aging or the progression of a disease.
摘要翻译：本发明提供了视网膜假体方法和装置，其模拟视网膜对广泛范围的刺激（包括天然刺激）的反应。响应于使用一组编码器，接口和换能器的刺激来产生神经节细胞发射模式，其中每个换能器靶向单个细胞或少量细胞。转换发生在与正常视网膜相同的时间尺度上。此外，本发明的方面可以与机器人或其他机械装置一起使用，其中需要视觉信息的处理。随着老化或疾病的进展，编码器可随时间而被调整。

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