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1. 发明授权

US09006249B2 Substituted aminobutyric derivatives as neprilysin inhibitors 有权
标题翻译：取代的氨基丁酸衍生物作为内皮素抑制剂
公开(公告)号：US09006249B2
公开(公告)日：2015-04-14
申请号：US13490562
申请日：2012-06-07
申请人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号： A61K31/505 , A61K31/44 , A61K31/415 , A61K31/40 , A61K31/38 , A61K31/34 , A61K31/335 , A61K31/195 , C07D239/24 , C07D211/00 , C07D213/81 , C07D233/54 , C07D231/10 , C07D207/30 , C07D333/38 , C07D229/02 , C07C233/87 , C07C233/47 , C07C233/63 , C07C235/52 , C07C251/12 , C07C257/06 , C07C271/12 , C07C275/16 , C07C311/19 , C07C317/44 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/82 , C07D231/14 , C07D239/28 , C07D271/10 , C07D277/64 , C07D285/12 , C07D303/48 , C07D307/68 , C07D309/40 , C07D333/24 , C07D333/40 , C07D261/18
CPC分类号： A61K31/194 , A61K45/06 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C235/74 , C07C235/82 , C07C251/12 , C07C257/06 , C07C271/12 , C07C275/16 , C07C311/19 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/28 , C07D261/18 , C07D271/10 , C07D277/64 , C07D285/12 , C07D303/48 , C07D307/68 , C07D309/40 , C07D333/24 , C07D333/40
摘要： The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式I'化合物; 或其药学上可接受的盐，其中R1，R2，R3，X和n如本文所定义。本发明还涉及制备本发明化合物的方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

2. 发明授权

US08769278B2 Apparatus and method for efficiently and securely exchanging connection data 有权
标题翻译：用于有效和安全地交换连接数据的装置和方法
公开(公告)号：US08769278B2
公开(公告)日：2014-07-01
申请号：US12832017
申请日：2010-07-07
申请人： Joe S. Abuan , Berkat S. Tung , Robert Sun Quattlebaum , Barry A. Whitebook , Roberto Garcia, Jr.
发明人： Joe S. Abuan , Berkat S. Tung , Robert Sun Quattlebaum , Barry A. Whitebook , Roberto Garcia, Jr.
IPC分类号： H04L9/32 , G06F15/16
CPC分类号： H04L67/141 , H04L9/32 , H04L61/15 , H04L61/2571 , H04L61/2575 , H04L61/2578 , H04L61/2589 , H04L63/029 , H04L63/068 , H04L63/08 , H04L67/104
摘要： An apparatus, method, and machine-readable medium are described for securely and efficiently exchanging connection data for a peer-to-peer (“P2P”) session on a network comprising. For example, in one embodiment, a connection data exchange (“CDX”) service can perform the function of a central exchange point for connection data. In one embodiment, the CDX service can perform the operations of receiving a connection data structure, sometimes referred to herein as a “ticket,” created by a matchmaker or an invitation service in response to requests from a group of mobile computing devices attempting to establish peer-to-peer (“P2P”) connections. The ticket can identify each of the group of mobile computing devices and can include encrypted NAT hole punch data associated with each of the mobile computing devices. The CDX service can authenticate the ticket and decrypt the NAT hole punch data contained in the ticket using a CDX ticket key used by the matchmaker service or the invitation service to encrypt the ticket. Once the ticket is authenticated and the hole punch data retrieved, the CDX service can send connection data to each of the mobile computing devices residing behind NAT devices using the NAT hole punch data.
摘要翻译：描述了一种装置，方法和机器可读介质，用于安全且有效地交换包括网络上的对等（“P2P”）对话的连接数据。例如，在一个实施例中，连接数据交换（“CDX”）服务可以执行用于连接数据的中央交换点的功能。在一个实施例中，CDX服务可以响应于来自一组试图建立的移动计算设备的请求，执行接收由配对者或邀请服务创建的连接数据结构（这里有时称为“票证”）的操作对等（“P2P”）连接。票证可以识别移动计算设备中的每一个，并且可以包括与每个移动计算设备相关联的加密的NAT穿孔数据。 CDX服务可以使用配对服务或邀请服务使用的CDX票券密钥来对票据进行身份验证并解密包含在票据中的打孔数据，从而加密票据。一旦机票被认证并且检索到打孔数据，则CDX服务可以使用NAT打孔数据向驻留在NAT设备之后的每个移动计算设备发送连接数据。

3. 发明申请

US20120122764A1 SUBSTITUTED CARBAMOYLCYCLOALKYL ACETIC ACID DERIVATIVES AS NEP 有权
标题翻译：取代的碳水化合物乙酸衍生物作为NEP
公开(公告)号：US20120122764A1
公开(公告)日：2012-05-17
申请号：US13293560
申请日：2011-11-10
申请人： Rajeshri Ganesh KARKI , Toshio KAWANAMI , Gary Michael KSANDER , Qian LIU , Muneto MOGI , Nikolaus SCHIERING , Robert SUN
发明人： Rajeshri Ganesh KARKI , Toshio KAWANAMI , Gary Michael KSANDER , Qian LIU , Muneto MOGI , Nikolaus SCHIERING , Robert SUN
IPC分类号： A61K38/05 , C07D295/195 , C07C235/82 , C07D213/56 , C07D257/04 , C07D471/04 , A61K31/216 , A61K31/194 , A61K31/4418 , A61K31/41 , A61K31/437 , A61P9/12 , A61P3/10 , A61P3/04 , A61P9/04 , A61P9/00 , A61P9/10 , A61P13/12 , A61P1/16 , A61P9/06 , A61P5/42 , A61P27/06 , A61P15/00 , A61P11/06 , A61P29/00 , A61P35/02 , A61P25/08 , A61P25/24 , A61P25/18 , A61P1/00 , A61P3/00 , C07D207/16
CPC分类号： C07C233/52 , C07C233/63 , C07C237/22 , C07C2601/08 , C07D207/16 , C07D213/55 , C07D257/04 , C07D295/185 , C07D307/52 , C07D471/04
摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, B, X, m and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of compounds of the invention, and a combination of pharmacologically active agents and a compound of the invention.
摘要翻译：本发明提供式I化合物; 或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，B，X，m和n如本文所定义。本发明还涉及制备本发明化合物的方法及其治疗用途。本发明还提供了本发明化合物的药物组合物，以及药理活性剂和本发明化合物的组合。

4. 发明申请

US20110252238A1 Apparatus and Method for Efficiently and Securely Exchanging Connection Data 有权
标题翻译：用于有效和安全地交换连接数据的装置和方法
公开(公告)号：US20110252238A1
公开(公告)日：2011-10-13
申请号：US12832017
申请日：2010-07-07
申请人： Joe S. Abuan , Berkat S. Tung , Robert Sun Quanttlebaum , Barry A. Whitebook , Roberto Garcia, JR.
发明人： Joe S. Abuan , Berkat S. Tung , Robert Sun Quanttlebaum , Barry A. Whitebook , Roberto Garcia, JR.
IPC分类号： H04L9/32 , G06F15/16
CPC分类号： H04L67/141 , H04L9/32 , H04L61/15 , H04L61/2571 , H04L61/2575 , H04L61/2578 , H04L61/2589 , H04L63/029 , H04L63/068 , H04L63/08 , H04L67/104
摘要： An apparatus, method, and machine-readable medium are described for securely and efficiently exchanging connection data for a peer-to-peer (“P2P”) session on a network comprising. For example, in one embodiment, a connection data exchange (“CDX”) service can perform the function of a central exchange point for connection data. In one embodiment, the CDX service can perform the operations of receiving a connection data structure, sometimes referred to herein as a “ticket,” created by a matchmaker or an invitation service in response to requests from a group of mobile computing devices attempting to establish peer-to-peer (“P2P”) connections. The ticket can identify each of the group of mobile computing devices and can include encrypted NAT hole punch data associated with each of the mobile computing devices. The CDX service can authenticate the ticket and decrypt the NAT hole punch data contained in the ticket using a CDX ticket key used by the matchmaker service or the invitation service to encrypt the ticket. Once the ticket is authenticated and the hole punch data retrieved, the CDX service can send connection data to each of the mobile computing devices residing behind NAT devices using the NAT hole punch data.
摘要翻译：描述了一种装置，方法和机器可读介质，用于安全且有效地交换包括网络上的对等（“P2P”）对话的连接数据。例如，在一个实施例中，连接数据交换（“CDX”）服务可以执行用于连接数据的中央交换点的功能。在一个实施例中，CDX服务可以响应于来自一组试图建立的移动计算设备的请求，执行接收由配对者或邀请服务创建的连接数据结构（这里有时称为“票证”）的操作对等（“P2P”）连接。票证可以识别移动计算设备中的每一个，并且可以包括与每个移动计算设备相关联的加密的NAT穿孔数据。 CDX服务可以使用配对服务或邀请服务使用的CDX票券密钥来对票据进行身份验证并解密包含在票据中的打孔数据，从而加密票据。一旦机票被认证并且检索到打孔数据，则CDX服务可以使用NAT打孔数据向驻留在NAT设备之后的每个移动计算设备发送连接数据。

5. 发明授权

US08575160B2 Imidazole derivatives as aldosterone synthase inhibitors 失效
标题翻译：咪唑衍生物作为醛固酮合酶抑制剂
公开(公告)号：US08575160B2
公开(公告)日：2013-11-05
申请号：US13511581
申请日：2010-11-29
申请人： Robert Sun , Lauren G. Monovich , Sylvie Chamoin , John Westbrook
发明人： Robert Sun , Lauren G. Monovich , Sylvie Chamoin , John Westbrook
IPC分类号： C07D487/04 , A61K31/4188 , A61K31/428
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention provides a compound of formula (I) or pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, R7 and p are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，其中变量R1，R2，R3，R4，R5，R7和p在本文中定义。本发明还涉及制备本发明化合物的方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

6. 发明申请

US20130065893A1 IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS 失效
标题翻译：咪唑衍生物作为阿托品酮合成酶抑制剂
公开(公告)号：US20130065893A1
公开(公告)日：2013-03-14
申请号：US13511581
申请日：2010-11-29
申请人： Robert Sun , Lauren G. Monovich , Sylvie Chamoin , John Westbrook
发明人： Robert Sun , Lauren G. Monovich , Sylvie Chamoin , John Westbrook
IPC分类号： C07D487/04 , A61K31/4188 , A61K31/428 , A61K31/437 , A61K31/5377 , A61K31/4439 , A61K31/4725 , A61K31/4709 , A61P9/12 , A61P9/10 , A61P3/04 , A61P9/00 , A61P9/06 , A61P9/04 , A61P1/16 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention provides a compound of formula (I) or pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, R7 and p are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，其中变量R1，R2，R3，R4，R5，R7和p在本文中定义。本发明还涉及制备本发明化合物的方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

7. 发明授权

US08394853B2 Substituted aminopropionic derivatives as neprilysin inhibitors 有权
标题翻译：取代的氨基丙酸衍生物作为尿丙氨酸抑制剂
公开(公告)号：US08394853B2
公开(公告)日：2013-03-12
申请号：US12788766
申请日：2010-05-27
申请人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号： A61K31/235 , C07C229/34
CPC分类号： C07D317/34 , A61K31/197 , A61K31/216 , A61K31/325 , A61K31/351 , A61K31/357 , A61K31/41 , A61K31/421 , A61K31/44 , A61K31/505 , A61K31/5375 , A61K45/00 , A61K45/06 , C07B2200/05 , C07C233/47 , C07C233/49 , C07C233/51 , C07C233/56 , C07C233/63 , C07C235/12 , C07C235/78 , C07C237/16 , C07C237/22 , C07C255/60 , C07C271/22 , C07C275/24 , C07C311/08 , C07C311/51 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D213/82 , C07D239/28 , C07D239/34 , C07D239/36 , C07D257/04 , C07D261/18 , C07D263/32 , C07D265/30 , C07D271/06 , C07D295/15 , C07D309/32
摘要： The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式I'化合物; 或其药学上可接受的盐，其中R 1，R 2，R 3，R 5，B 1，X和n如本文所定义。本发明还涉及制备本发明化合物及其治疗用途的方法。本发明还提供药理活性剂和药物组合物的组合。

8. 外观设计

USD429007S Brick 失效
公开(公告)号：USD429007S
公开(公告)日：2000-08-01
申请号：US110482
申请日：1999-09-08
申请人： Robert Sun
设计人： Robert Sun

9. 发明授权

US08263629B2 Substituted aminobutyric derivatives as neprilysin inhibitors 有权
标题翻译：取代的氨基丁酸衍生物作为内皮素抑制剂
公开(公告)号：US08263629B2
公开(公告)日：2012-09-11
申请号：US12788794
申请日：2010-05-27
申请人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号： A61K31/42 , A61K31/4245 , A61K31/41 , C07D271/04 , C07D271/06 , C07D271/08 , C07D271/10 , C07D263/30 , C07D261/06 , C07D257/02
CPC分类号： A61K31/194 , A61K45/06 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C235/74 , C07C235/82 , C07C251/12 , C07C257/06 , C07C271/12 , C07C275/16 , C07C311/19 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/28 , C07D261/18 , C07D271/10 , C07D277/64 , C07D285/12 , C07D303/48 , C07D307/68 , C07D309/40 , C07D333/24 , C07D333/40
摘要： The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式I'化合物; 或其药学上可接受的盐，其中R1，R2，R3，X和n如本文所定义。本发明还涉及制备本发明化合物的方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

10. 发明申请

US20110038876A1 HETEROCYCLIC COMPOUNDS AND USE THEREOF AS ERK INHIBITORS 审中-公开
标题翻译：杂环化合物及其作为ERK抑制剂的用途
公开(公告)号：US20110038876A1
公开(公告)日：2011-02-17
申请号：US12601476
申请日：2008-06-17
申请人： Robert Sun , Alan B. Cooper , Yongqi Deng , Tong Wang , Yang Nan , Hugh Y. Zhu , Sobhana Babu Boga , Xiaolei Gao , Joseph M. Kelly , Sunil Paliwal , Hon-Chung Tsui , Ronald J. Doll , Neng-Yang Shih
发明人： Robert Sun , Alan B. Cooper , Yongqi Deng , Tong Wang , Yang Nan , Hugh Y. Zhu , Sobhana Babu Boga , Xiaolei Gao , Joseph M. Kelly , Sunil Paliwal , Hon-Chung Tsui , Ronald J. Doll , Neng-Yang Shih
IPC分类号： A61K31/519 , C07D487/04 , C07D487/08 , A61K31/496 , A61K39/395 , A61P35/00 , A61P35/02
CPC分类号： C07D487/04 , C07D519/00
摘要： Disclosed are the ERK inhibitors of formula 1.0: [Formula (1.0)] and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
摘要翻译：公开了式1.0的ERK抑制剂：[式（1.0）]及其药学上可接受的盐，酯和溶剂化物。 Q是可以具有桥或稠合环的哌啶或哌嗪环。哌啶环可以在环中具有双键。所有其他取代基如本文所定义。还公开了使用式1.0化合物治疗癌症的方法。

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