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1. 外观设计

USD395523S Ladder top attachable toolbox 失效
公开(公告)号：USD395523S
公开(公告)日：1998-06-23
申请号：US66849
申请日：1997-02-21
申请人： Richard M. Fine , Alan D. Steigerwald
设计人： Richard M. Fine , Alan D. Steigerwald

2. 发明授权

US07196108B2 Bicyclic heterocycles for the treatment of diabetes and other diseases 失效
标题翻译：双环杂环用于治疗糖尿病和其他疾病
公开(公告)号：US07196108B2
公开(公告)日：2007-03-27
申请号：US10384391
申请日：2003-03-06
申请人： Magnus Pfahl , Catherine Tachdjian , Hussien A. Al-Shamma , Andrea Fanjul Giachino , Karine Jakubowicz-Jaillardon , Jianhua Guo , Richard M. Fine , Lyle W. Spruce , James W. Zapf
发明人： Magnus Pfahl , Catherine Tachdjian , Hussien A. Al-Shamma , Andrea Fanjul Giachino , Karine Jakubowicz-Jaillardon , Jianhua Guo , Richard M. Fine , Lyle W. Spruce , James W. Zapf
IPC分类号： A61K31/343 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/4166 , A61K31/427 , A61K31/4353 , A61K31/538 , A61K31/5415 , C07D277/34 , C07D265/36 , C07D243/10 , C07D241/36 , C07D233/72 , C07D223/14 , C07D221/02 , C07D209/04 , C07D335/04 , C07D333/50 , C07D319/14 , C07D311/04 , C07D307/77
CPC分类号： C07D277/20 , C07D417/06 , C07D417/10 , C07D417/14
摘要： The invention relates to certain bicyclic heterocycles havng the structure shown below which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, and atherosclerosis.
摘要翻译：本发明涉及某些具有下列结构的双环杂环，其可用于治疗与脂质和碳水化合物代谢相关的疾病，例如2型糖尿病和动脉粥样硬化。

3. 发明授权

US07390813B1 Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents 失效
标题翻译：吡啶基哌嗪和氨基烟酰胺及其作为治疗剂的用途
公开(公告)号：US07390813B1
公开(公告)日：2008-06-24
申请号：US10326210
申请日：2002-12-20
申请人： Mark P. Gray-Keller , Michael D. Winther , Richard M. Fine , Boris Klebansky , Heinz Gschwend , Daniel F. Harvey
发明人： Mark P. Gray-Keller , Michael D. Winther , Richard M. Fine , Boris Klebansky , Heinz Gschwend , Daniel F. Harvey
IPC分类号： A61K31/495 , C07D401/04
CPC分类号： A61K31/496 , A61K31/551
摘要： Novel compounds useful in the treatment of, prevention of or protection against diseases and/or conditions related to metabolic syndrome and lipid metabolism, especially diseases of fatty acid and cholesterol metabolism, such as those mediated by stearoyl-CoA desaturase, are disclosed along with methods of employing said compounds for such uses.
摘要翻译：可用于治疗，预防或保护与代谢综合征和脂质代谢相关的疾病和/或病症的新型化合物，特别是脂肪酸和胆固醇代谢疾病，例如由硬脂酰辅酶A去饱和酶介导的那些，以及方法使用所述化合物用于这种用途。

4. 发明申请

US20090197894A1 NICOTINAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS 审中-公开
标题翻译： NICOTINAMIDE衍生物及其作为治疗药物使用
公开(公告)号：US20090197894A1
公开(公告)日：2009-08-06
申请号：US12423432
申请日：2009-04-14
申请人： Jian-Min Fu , Vishnumurthy Kodumuru , Shaoyi Sun , Michael D. Winther , Richard M. Fine , Daniel F. Harvey , Boris Klebansky , Mark P. Gray-Keller , Heinz W. Gschwend , Wenbao Li
发明人： Jian-Min Fu , Vishnumurthy Kodumuru , Shaoyi Sun , Michael D. Winther , Richard M. Fine , Daniel F. Harvey , Boris Klebansky , Mark P. Gray-Keller , Heinz W. Gschwend , Wenbao Li
IPC分类号： A61K31/496 , C07D401/04 , A61P3/10
CPC分类号： A61K31/496 , A61K31/551 , Y02A50/387
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where m, n, p, V, R1, R2, R3, R4, R5 and R6 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译：公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中m，n，p，V，R ，R2，R3，R4，R5和R6如本文所定义。还公开了包含式（I）化合物的药物组合物。

5. 发明授权

US5566096A Integrated electrical signal switching and amplifying system 失效
标题翻译：集成电信号开关放大系统
公开(公告)号：US5566096A
公开(公告)日：1996-10-15
申请号：US219692
申请日：1994-03-29
申请人： Harold M. Wodlinger , Richard M. Fine
发明人： Harold M. Wodlinger , Richard M. Fine
IPC分类号： A61B5/04 , A61B5/0428 , G06F17/00 , G06F19/00 , G06F159/00
CPC分类号： A61B5/04288 , A61B5/04004 , A61B5/7475 , G06F19/3412 , A61B2562/226
摘要： A signal management system is disclosed which integrates a patient switching box and an amplification unit into a single compact enclosure sufficiently small to reside by the patient table in an operating unit set up for electrophysiology procedures. The system includes a front panel designed to accept standard ECG leads, a plurality of intracardiac leads, including leads available for stimulation and/or lesion generation, and a plurality of pressure channels. The front panel also includes a touch screen display to allow quick assignments of labels to each of the ECG or intracardiac leads and the pressure channels. The system includes an onboard microprocessor which allows any operation performed on the system to be automatically updated on a remote computer processing unit if attached, and vice-versa. Digital signal processors are used in the system to perform switching operations on the electrical signals received, and to perform gain, limiting and/or filtering processes thereon. The digital signal processors are automatically calibrated to adjust for varying gain and phase performance of the inputing front-end amplifiers which deliver the electrical signals from the intracardiac leads.
摘要翻译：公开了一种信号管理系统，其将患者切换盒和放大单元集成到足够小的单个紧凑型外壳中，以便由患者台驻留在为电生理过程设置的操作单元中。该系统包括设计用于接受标准ECG引线的前面板，包括可用于刺激和/或病变生成的引线的多个心内引线以及多个压力通道。前面板还包括一个触摸屏显示屏，可以快速分配每个心电图或心内线和压力通道的标签。该系统包括板载微处理器，其允许在系统上执行的任何操作在远程计算机处理单元（如果附加）上自动更新，反之亦然。系统中使用数字信号处理器来对所接收的电信号执行切换操作，并在其上执行增益，限制和/或滤波处理。数字信号处理器被自动校准，以调整输入前端放大器的变化的增益和相位性能，其输送来自心内引线的电信号。

6. 发明授权

US4908781A Computing device for calculating energy and pairwise central forces of particle interactions 失效
标题翻译：用于计算能量和颗粒相互作用的成对中心力的计算装置
公开(公告)号：US4908781A
公开(公告)日：1990-03-13
申请号：US796870
申请日：1985-11-12
申请人： Cyrus Levinthal , Richard M. Fine
发明人： Cyrus Levinthal , Richard M. Fine
IPC分类号： C07K1/00 , G06F17/50
CPC分类号： C07K1/00 , G06F19/701
摘要： This invention provides a computing device which calculates the total energy and total pairwise, central forces between selected pairs of interacting particles within a system. The device comprises (a) a means for generating both (i) a retrievable identifier for the spatial coordinates (x, y, z) of a particle i and (ii) retrievable identifiers of the type of pairwise, central interaction between i and a second particle j; (b) a means for determining r.sup.2, the square of the radius vector between i and j; (c) a means for determining r, the square root of r.sup.2 ; (d) a means for calculating energy and force/r values for each ij pair; (e) means for determining the force on each particle; and (f) means for accumulating energy and force/r values for each ij particle pair.
摘要翻译：本发明提供了一种计算装置，其计算系统内所选择的相互作用粒子对之间的总能量和总成对的中心力。该装置包括（a）用于产生（i）用于粒子i的空间坐标（x，y，z）的可检索标识符的装置，以及（ii）i和a之间成对的中心相互作用类型的可检索标识符第二粒子j; （b）确定r2的装置，i和j之间的半径向量的平方; （c）确定r的平均值r2的方法; （d）用于计算每个ij对的能量和力/ r值的手段; （e）用于确定每个颗粒上的力的装置; 和（f）用于累积每个ij粒子对的能量和力/ r值的装置。

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