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1. 发明申请

US20050130294A1 Methods and apparatus for blood separation and analysis using membranes on an optical bio-disc 失效
标题翻译：用于在光学生物盘上使用膜进行血液分离和分析的方法和装置
公开(公告)号：US20050130294A1
公开(公告)日：2005-06-16
申请号：US10891442
申请日：2004-07-13
申请人： Brandon Randall , Raveendra Pottathil , Shuguang Li
发明人： Brandon Randall , Raveendra Pottathil , Shuguang Li
IPC分类号： B01D20060101 , B01D11/04 , C12M1/34 , C12M3/00 , C12N1/00 , C12Q1/00 , G01N15/06 , G01N21/00 , G01N21/29 , G01N21/41 , G01N21/47 , G01N21/75 , G01N31/22 , G01N33/00 , G01N33/558 , G01N35/00
CPC分类号： G01N33/558 , G01N35/00069 , Y10S435/96 , Y10S435/97
摘要： Optical bio-discs for biochemical analysis, bio-disc analysis systems and biochemical analysis methods are described herein. In one embodiment, the bio-disc includes a sample analysis circuit that includes a separation membrane for separating an investigational feature of a sample. The bio-disc also includes a conjugate release pad, and an analysis membrane containing analysis zones that may be analyzed for the presence of analytes. An analysis method includes providing a sample to a separation membrane in a bio-disc, separating an investigational feature from the sample using a separation membrane, mixing reagents that include signal elements for detecting an analyte with the investigational feature so as to form a reagent-investigational feature mixture and capturing an analyte with a signal element bound thereto in an analysis zone on an analysis membrane. The method further includes determining the presence of an analyte by analyzing the signal elements present in the capture zone of the analysis membrane.
摘要翻译：用于生化分析的光学生物盘，生物盘分析系统和生化分析方法在本文中描述。在一个实施例中，生物盘包括样品分析电路，其包括用于分离样品的研究特征的分离膜。生物盘还包括缀合物释放垫，以及含有可分析存在分析物的分析区的分析膜。分析方法包括：将样品提供到生物盘中的分离膜，使用分离膜从样品中分离研究特征，将包括用于检测分析物的信号元件的试剂与研究特征混合，以形成试剂 - 研究特征混合物，并在分析膜上的分析区域中捕获结合有信号元素的分析物。该方法还包括通过分析存在于分析膜的捕获区域中的信号元素来确定分析物的存在。

2. 发明授权

US07077996B2 Methods and apparatus for blood separation and analysis using membranes on an optical bio-disc 失效
标题翻译：用于在光学生物盘上使用膜进行血液分离和分析的方法和装置
公开(公告)号：US07077996B2
公开(公告)日：2006-07-18
申请号：US10891442
申请日：2004-07-13
申请人： Brandon L. Randall , Raveendra Pottathil , Shuguang Li
发明人： Brandon L. Randall , Raveendra Pottathil , Shuguang Li
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： G01N33/558 , G01N35/00069 , Y10S435/96 , Y10S435/97
摘要： Optical bio-discs for biochemical analysis, bio-disc analysis systems and biochemical analysis methods are described herein. In one embodiment, the bio-disc includes a sample analysis circuit that includes a separation membrane for separating an investigational feature of a sample. The bio-disc also includes a conjugate release pad, and an analysis membrane containing analysis zones that may be analyzed for the presence of analytes. An analysis method includes providing a sample to a separation membrane in a bio-disc, separating an investigational feature from the sample using a separation membrane, mixing reagents that include signal elements for detecting an analyte with the investigational feature so as to form a reagent-investigational feature mixture and capturing an analyte with a signal element bound thereto in an analysis zone on an analysis membrane. The method further includes determining the presence of an analyte by analyzing the signal elements present in the capture zone of the analysis membrane.
摘要翻译：用于生化分析的光学生物盘，生物盘分析系统和生化分析方法在本文中描述。在一个实施例中，生物盘包括样品分析电路，其包括用于分离样品的研究特征的分离膜。生物盘还包括缀合物释放垫，以及含有可分析存在分析物的分析区的分析膜。分析方法包括：将样品提供到生物盘中的分离膜，使用分离膜从样品中分离研究特征，将包括用于检测分析物的信号元件的试剂与研究特征混合，以形成试剂 - 研究特征混合物，并在分析膜上的分析区域中捕获结合有信号元素的分析物。该方法还包括通过分析存在于分析膜的捕获区域中的信号元素来确定分析物的存在。

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