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1. 发明授权

US5730720A Perfusion hyperthermia treatment system and method 失效
公开(公告)号：US5730720A
公开(公告)日：1998-03-24
申请号：US516580
申请日：1995-08-18
申请人： Jeffrey P. Sites , Philip R. Glassel , Michael D. Miller , Clark B. Norgaard , Thomas A. Roman , Dale J. Ziebarth
发明人： Jeffrey P. Sites , Philip R. Glassel , Michael D. Miller , Clark B. Norgaard , Thomas A. Roman , Dale J. Ziebarth
IPC分类号： A61M1/36 , A61M5/142 , A61M37/00
CPC分类号： A61M1/369 , A61M2205/12 , A61M2205/3606 , A61M2205/366 , A61M2205/505 , A61M2230/50 , A61M5/14232 , Y10S706/924
摘要： Method and apparatus to automatically monitor and control a perfusion hyperthermia treatment using a system including one or more programmed computers, and mechanical and sensor subsystems. The system includes a fluid path between a patient and an external fluid-treatment subsystem, wherein control of the external fluid-treatment subsystem includes feedback from sensors coupled to the patient. The resulting integrated system provides automated monitoring and control of the patient, the external fluid-treatment subsystem, and the treatment. In one embodiment, the fluid passing between the patient and the external fluid-treatment subsystem is blood. In one embodiment, an apparatus and method are provided for using a computerized system for a perfusion hyper/hypothermia treatment of a patient which obtains a body fluid having a temperature. A plurality of temperature signals representative of temperatures at each of a plurality of patient locations on or within the patient are coupled to the computer system. Measured temperatures are compared to a set of stored parameters in the computer system to generate a comparison value which controls a change in the temperature of the body fluid. The body fluid is then perfused into the patient to either warm, cool, or maintain the current temperature of the patient. In one such embodiment, the body fluid is blood withdrawn from the patient. In another such embodiment, the body fluid is saline.

2. 发明授权

US06413233B1 Perfusion hyperthermia treatment system and method 失效
标题翻译：灌注热疗治疗系统及方法
公开(公告)号：US06413233B1
公开(公告)日：2002-07-02
申请号：US09480088
申请日：2000-01-10
申请人： Jeffrey P. Sites , Philip R. Glassel , Michael D. Miller , Clark B. Norgaard , Thomas A. Roman , Dale J. Ziebarth
发明人： Jeffrey P. Sites , Philip R. Glassel , Michael D. Miller , Clark B. Norgaard , Thomas A. Roman , Dale J. Ziebarth
IPC分类号： A61M3700
CPC分类号： A61M1/369 , A61M5/14232 , A61M2205/12 , A61M2205/3606 , A61M2205/366 , A61M2205/505 , A61M2230/50 , Y10S706/924
摘要： Method and apparatus to automatically monitor and control a perfusion hyperthermia treatment using a system including one or more programmed computers, and mechanical and sensor subsystems. The system includes a fluid path between a patient and an external fluid-treatment subsystem, wherein control of the external fluid-treatment subsystem includes feedback from sensors coupled to the patient. The resulting integrated system provides automated monitoring and control of the patient, the external fluid-treatment subsystem, and the treatment. In one embodiment, the fluid passing between the patient and the external fluid-treatment subsystem is blood. In one embodiment, an apparatus and method are provided for using a computerized system for a perfusion hyper/hypothermia treatment of a patient which obtains a body fluid having a temperature. A plurality of temperature signals representative of temperatures at each of a plurality of patient locations on or within the patient are coupled to the computer system. Measured temperatures are compared to a set of stored parameters in the computer system to generate a comparison value which controls a change in the temperature of the body fluid. The body fluid is then perfused into the patient to either warm, cool, or maintain the current temperature of the patient. In one such embodiment, the body fluid is blood withdrawn from the patient. In another such embodiment, the body fluid is saline.
摘要翻译：使用包括一个或多个编程计算机的系统以及机械和传感器子系统来自动监测和控制灌注热疗的方法和装置。该系统包括患者和外部流体处理子系统之间的流体路径，其中外部流体处理子系统的控制包括耦合到患者的传感器的反馈。所得到的集成系统提供对患者，外部流体处理子系统和治疗的自动监测和控制。在一个实施例中，通过患者和外部流体处理子系统之间的流体是血液。在一个实施例中，提供了一种装置和方法，用于使用计算机化系统进行用于获得具有温度的体液的患者的灌注超/低温治疗。表示患者身上或患者内的多个患者位置中的每一个处的温度的多个温度信号被耦合到计算机系统。将测量的温度与计算机系统中的一组存储的参数进行比较，以产生控制体液温度变化的比较值。然后将体液灌注到患者中以加热，冷却或维持患者的当前温度。在一个这样的实施例中，体液是从患者抽出的血液。在另一个这样的实施方案中，体液是盐水。

3. 发明授权

US5692907A Interactive cardiac rhythm simulator 失效
标题翻译：交互式心律模拟器
公开(公告)号：US5692907A
公开(公告)日：1997-12-02
申请号：US515553
申请日：1995-08-16
申请人： Philip R. Glassel , Michael D. Miller
发明人： Philip R. Glassel , Michael D. Miller
IPC分类号： G06F17/00 , G09B23/28
CPC分类号： A61B5/04021 , G06F19/3437
摘要： A system for simulating the activity of the heart includes a computer controlled heart model for generating and displaying simulated electrogram signals. To accomplish this task, the simulation system includes various hardware components and software designed to realize a heart model and generate electrogram display data. Based on the recognition that groups of cells (tissue groups) of the heart can be selected such that the electrical characteristics of the tissue group, as a whole, resembles the simple electronic characteristics of an individual cell, the model is designed to simulate the electrical activities and interaction of multiple tissue groups. With this approach, each tissue group is associated with a software controlled state machine that changes states in response to stimulation signals from other tissue groups, internal or external sources, or timer expirations.
摘要翻译：用于模拟心脏活动的系统包括用于产生和显示模拟电描记信号的计算机控制的心脏模型。为了完成这个任务，仿真系统包括各种硬件组件和软件，设计用于实现心脏模型并生成电描记图显示数据。基于认识到可以选择心脏组的细胞（组织组），使得组织组的电特性总体上类似于单个细胞的简单电子特征，该模型被设计为模拟电活动和多组织组织的相互作用。利用这种方法，每个组织组与软件控制状态机相关联，该机器响应于来自其他组织组，内部或外部源或定时器到期的刺激信号而改变状态。

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