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1. 发明授权

US07447594B2 Molecular cardiotoxicology modeling 失效
标题翻译：分子心脏毒理学建模
公开(公告)号：US07447594B2
公开(公告)日：2008-11-04
申请号：US10338044
申请日：2003-01-08
申请人： Donna L. Mendrick , Mark W. Porter , Kory R. Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
发明人： Donna L. Mendrick , Mark W. Porter , Kory R. Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
IPC分类号： G06F19/00
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q2600/142 , C12Q2600/158 , G01N2500/00 , Y10S707/99945 , Y10S707/99948
摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
摘要翻译：本发明基于阐明基因表达的全面变化以及暴露于已知心脏毒素的组织或细胞中毒性标志物的鉴定。该基因可用作药物筛选和毒性测定中的毒性标记物。本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。

2. 发明申请

US20080215250A1 Molecular toxicology modeling 审中-公开
标题翻译：分子毒理学建模
公开(公告)号：US20080215250A1
公开(公告)日：2008-09-04
申请号：US11790979
申请日：2007-04-30
申请人： Donna L. Mendrick , Mark W. Porter , Kory R. Johnson , Arthur L. Castle , Michael R. Elashoff
发明人： Donna L. Mendrick , Mark W. Porter , Kory R. Johnson , Arthur L. Castle , Michael R. Elashoff
IPC分类号： G01N33/48
CPC分类号： C12Q1/6876 , C12Q1/6837 , C12Q1/6883 , C12Q2600/142 , C12Q2600/158 , G16B25/00 , G16B50/00
摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
摘要翻译：本发明基于阐明基因表达的全面变化以及暴露于已知毒素的组织或细胞中毒性标志物的鉴定。这些基因可用作药物筛选和毒性测定中的毒性标记。本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。

3. 发明授权

US07469185B2 Primary rat hepatocyte toxicity modeling 失效
标题翻译：原代大鼠肝细胞毒性建模
公开(公告)号：US07469185B2
公开(公告)日：2008-12-23
申请号：US10357507
申请日：2003-02-04
申请人： Donna L. Mendrick , Mark W. Porter , Kory R. Johnson , Brandon Higgs , Arthur L. Castle , Michael Orr , Michael R. Elashoff
发明人： Donna L. Mendrick , Mark W. Porter , Kory R. Johnson , Brandon Higgs , Arthur L. Castle , Michael Orr , Michael R. Elashoff
IPC分类号： G06F19/00
CPC分类号： G01N33/5014 , C12Q1/6876 , C12Q2600/158 , Y10S707/99945 , Y10S707/99948
摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
摘要翻译：本发明基于阐明基因表达的全面变化以及暴露于已知毒素的组织或细胞中毒性标志物的鉴定。这些基因可用作药物筛选和毒性测定中的毒性标记。本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。

4. 发明授权

US5042590A Tapered C-spring for a disk harrow 失效
标题翻译：锥形C弹簧用于磁盘耙
公开(公告)号：US5042590A
公开(公告)日：1991-08-27
申请号：US585770
申请日：1990-09-20
申请人： Bierl James F. , Warren L. Thompson , Terry L. Lowe , Mark W. Porter
发明人： Bierl James F. , Warren L. Thompson , Terry L. Lowe , Mark W. Porter
IPC分类号： A01B21/08
CPC分类号： A01B21/08
摘要： An improved disk harrow C-spring with a tapered cross section which reduces the compressive stresses in the inside radius and improves vertical and side-to-side flexibility. The curved portion of the C-spring has a constant cross section at the top and around three-fourths of the bend. At a location on the bend 45 degrees down from the horizontal, the thickness tapers to a location forward of the bearing hanger. The cross section is constant from the end of the taper to the end of the spring. The tapered cross section allows a thicker section to be used on the most highly stressed areas in the upper quadrant of the curved portion of the C-spring. The lower quadrant taper results in uniform stress distribution along the entire C-spring with the maximum compressive stress on the inside radius reduced substantially over a conventional C-spring. In addition, the tapered design provides an increase in both vertical and side-to-side flexibility for improved operation in rocky soil.
摘要翻译：一种改进的圆盘耙C型弹簧，具有锥形横截面，可减小内径的压缩应力，并提高垂直和侧对侧的灵活性。 C弹簧的弯曲部分在顶部和弯曲部的四分之三处具有恒定的横截面。在弯曲处的水平位置下降45度的位置，厚度逐渐变细到轴承架的前方位置。横截面从锥形的端部到弹簧的端部是恒定的。锥形横截面允许在C弹簧的弯曲部分的上象限中的最高应力区域上使用较厚的部分。下象限锥形导致沿着整个C形弹簧均匀的应力分布，内径半径上的最大压应力基本上大大降低了传统的C形弹簧。此外，锥形设计提高了纵向和侧向的灵活性，以改善岩土的运行。

5. 发明授权

US4255919A Cotton harvester with an offset head 失效
标题翻译：带偏移头的棉花收割机
公开(公告)号：US4255919A
公开(公告)日：1981-03-17
申请号：US54283
申请日：1979-07-02
申请人： Russell D. Copley , Francis E. Schlueter , Mark W. Porter
发明人： Russell D. Copley , Francis E. Schlueter , Mark W. Porter
IPC分类号： A01D46/08 , A01D45/18
CPC分类号： A01D46/08
摘要： A cotton harvester with an offset head having four row units positioned for harvesting cotton planted in uniformly spaced narrow rows. The frame of the harvester is supported near its forward end by a pair of drive wheels adapted to run between two pairs of rows of cotton. The head is offset so that three rows of cotton are accommodated between the wheels and one row of cotton is accommodated outside one of the wheels. The machine drive and guide wheels can therefore be positioned between the rows for ease in steering and driving. A cotton basket on the harvester can be dumped toward the side which is unobstructed by a harvesting unit so the receiving implement can be positioned closer to the harvester and so the head which is offset in the opposite direction can act as a counterweight to balance the harvester as the basket is extended transversely for dumping.
摘要翻译：具有偏移头的棉花收割机具有四排排，用于收获以均匀间隔狭窄的行排列的棉花。收割机的框架靠近其前端由一对适于在两排棉花之间运行的驱动轮支撑。头部被偏移，使得三排棉花容纳在轮子之间，并且一排棉花容纳在一个轮子之外。因此，机器驱动器和引导轮可以位于行之间以便于转向和驾驶。收割机上的棉筐可以倾倒到收拢单元不受阻挡的一侧，因此接收器具可以靠近收割机定位，因此相反方向偏移的头部可以作为配重来平衡收割机因为篮子横向延伸用于倾倒。

6. 发明申请

US20090197258A1 PRIMARY RAT HEPATOCYTE TOXICITY MODELING 审中-公开
标题翻译：原发性肝细胞毒性建模
公开(公告)号：US20090197258A1
公开(公告)日：2009-08-06
申请号：US12043666
申请日：2008-03-06
申请人： Donna L. Mendrick , Mark W. Porter , Kory R. Johnson , Brandon Higgs , Arthur L. Castle , Michael Orr , Michael R. Elashoff
发明人： Donna L. Mendrick , Mark W. Porter , Kory R. Johnson , Brandon Higgs , Arthur L. Castle , Michael Orr , Michael R. Elashoff
IPC分类号： C12Q1/68
CPC分类号： G01N33/5014 , C12Q1/6876 , C12Q2600/158 , Y10S707/99945 , Y10S707/99948
摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
摘要翻译：本发明基于阐明基因表达的全面变化以及暴露于已知毒素的组织或细胞中毒性标志物的鉴定。这些基因可用作药物筛选和毒性测定中的毒性标记。本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。

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