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1. 发明申请

US20110147251A1 PROSTHETIC HEART VALVE PACKAGING AND DEPLOYMENT SYSTEM 有权
标题翻译：前置心脏瓣膜包装和部署系统
公开(公告)号：US20110147251A1
公开(公告)日：2011-06-23
申请号：US12969238
申请日：2010-12-15
申请人： Fred Hodshon , Rafael Pintor , August Yambao , Abhishek Gautam , Louis A. Campbell , Lawrence Farhat , Tammy Huntley , Faisal Kalam , Travis Oba , Qinggang Zeng
发明人： Fred Hodshon , Rafael Pintor , August Yambao , Abhishek Gautam , Louis A. Campbell , Lawrence Farhat , Tammy Huntley , Faisal Kalam , Travis Oba , Qinggang Zeng
IPC分类号： B65D85/00
CPC分类号： A61F2/2427 , A61F2/0095 , A61F2/24 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2220/0075
摘要： Packaging for prosthetic heart valves including an assembly for securely retaining a heart valve within a jar and facilitating retrieval therefrom. The assembly includes a packaging sleeve that fits closely within the jar and has a clip structure for securing a valve holder. Contrary to previous designs, in one embodiment the valve holder is directed downward into the jar, and the valve is retained with an inflow end upward. The valve may have flexible leaflets, and a leaflet parting member on the end of the shaft extends through the leaflets and couples with the valve holder. The assembly of the packaging sleeve, valve, and holder can then be removed from the jar and a valve delivery tube connected with the holder, or to the leaflet parting member. The packaging sleeve may be bifurcated into two halves connected at a living hinge to facilitate removal from around the valve/holder subassembly. The packaging system facilitates attachment of the valve delivery tube for use in a quick-connect valve implant procedure.
摘要翻译：用于假体心脏瓣膜的包装，包括用于将心脏瓣膜牢固地保持在罐内并有助于从其中取出的组件。组件包括紧密地配合在罐内的包装套筒，并具有用于固定阀座的夹子结构。与以前的设计相反，在一个实施例中，阀保持器向下指向罐中，并且阀向上保持流入端。阀可以具有柔性小叶，并且在轴的端部上的小叶分离构件延伸穿过叶片并与阀座联接。然后可以将包装套筒，阀和保持器的组件从罐中移除，以及与保持器连接的阀输送管，或者与叶片分离构件相连。包装套筒可以分叉成在活动铰链处连接的两个半部，以便于从阀/支架子组件周围移除。该包装系统便于安装用于快速连接阀注入过程的阀输送管。

2. 发明授权

US09295539B2 Prosthetic heart valve packaging and deployment methods 有权
标题翻译：假体心脏瓣膜包装和部署方法
公开(公告)号：US09295539B2
公开(公告)日：2016-03-29
申请号：US13403537
申请日：2012-02-23
申请人： Fred Hodshon , Rafael Pintor , August Yambao , Abhishek Gautam , Louis A. Campbell , Lawrence Farhat , Tammy Huntley , Faisal Kalam , Travis Oba , Qinggang Zeng
发明人： Fred Hodshon , Rafael Pintor , August Yambao , Abhishek Gautam , Louis A. Campbell , Lawrence Farhat , Tammy Huntley , Faisal Kalam , Travis Oba , Qinggang Zeng
IPC分类号： A61F2/00 , A61F2/24
CPC分类号： A61F2/2427 , A61F2/0095 , A61F2/24 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2220/0075
摘要： Packaging for prosthetic heart valves including an assembly for securely retaining a heart valve within a jar and facilitating retrieval therefrom. The assembly includes a packaging sleeve that fits closely within the jar and has a clip structure for securing a valve holder. Contrary to previous designs, in one embodiment the valve holder is directed downward into the jar, and the valve is retained with an inflow end upward. The valve may have flexible leaflets, and a leaflet parting member on the end of the shaft extends through the leaflets and couples with the valve holder. The assembly of the packaging sleeve, valve, and holder can then be removed from the jar and a valve delivery tube connected with the holder, or to the leaflet parting member. The packaging sleeve may be bifurcated into two halves connected at a living hinge to facilitate removal from around the valve/holder subassembly.
摘要翻译：用于假体心脏瓣膜的包装，包括用于将心脏瓣膜牢固地保持在罐内并有助于从其中取出的组件。组件包括紧密地配合在罐内的包装套筒，并具有用于固定阀座的夹子结构。与以前的设计相反，在一个实施例中，阀保持器向下指向罐中，并且阀向上保持流入端。阀可以具有柔性小叶，并且在轴的端部上的小叶分离构件延伸穿过叶片并与阀座联接。然后可以将包装套筒，阀和保持器的组件从罐中移除，以及与保持器连接的阀输送管，或者与叶片分离构件相连。包装套筒可以分叉成在活动铰链处连接的两个半部，以便于从阀/支架子组件周围移除。

3. 发明授权

US5417969A Process for reducing the thrombogenicity of biomaterials 失效
标题翻译：降低生物材料血栓形成的方法
公开(公告)号：US5417969A
公开(公告)日：1995-05-23
申请号：US154654
申请日：1993-11-18
申请人： Li-Chien Hsu , David P. Balding , Lawrence Farhat
发明人： Li-Chien Hsu , David P. Balding , Lawrence Farhat
IPC分类号： A61L33/00 , A61L2/08 , A61L17/00 , A61L27/00
CPC分类号： A61L33/0017 , A61L33/0011
摘要： Processes for forming a uniform, continuous coating of heparin covalently bonded to blood-contacting polyvinylchloride surfaces of a medical device are disclosed. These processes include coating the polyvinylchloride surfaces with an organic solvent solution of heparin complexed with an organic cation, and then exposing the coated surfaces to ionizing radiation to covalently bind the heparin moiety to the polyvinylchloride. The complex of the coating is formed from a heparin moiety and at least one cationic moiety selected from the group consisting of dimethylstearylamine, polyethyleneimine, benzalkonium, stearylkonium, and tridodecylmethylammonium; the complex is soluble in organic solvents and forms continuous and uniform coatings on polyvinylchloride. Advantageously, the heparin moiety can be bonded to the polyvinylchloride surfaces simultaneously with sterilizing the medical devices using ionizing radiation.
摘要翻译：公开了用于形成均匀连续涂覆肝素的方法，其共价键合到医疗装置的与血液接触的聚氯乙烯表面。这些方法包括用与有机阳离子络合的肝素的有机溶剂溶液涂覆聚氯乙烯表面，然后将涂覆的表面暴露于电离辐射以将肝素部分共价结合到聚氯乙烯上。涂层的复合物由肝素部分和至少一种选自二甲基硬脂胺，聚乙烯亚胺，苯扎氯铵，硬脂基肟和十三烷基甲基铵的阳离子部分形成; 该复合物可溶于有机溶剂，并在聚氯乙烯上形成连续且均匀的涂层。有利地，肝素部分可以在使用电离辐射对医疗装置进行消毒的同时与聚氯乙烯表面结合。

4. 发明授权

US08869982B2 Prosthetic heart valve packaging and deployment system 有权
标题翻译：假心脏瓣膜包装和部署系统
公开(公告)号：US08869982B2
公开(公告)日：2014-10-28
申请号：US12969238
申请日：2010-12-15
申请人： Fred Hodshon , Rafael Pintor , August Yambao , Abhishek Gautam , Louis A. Campbell , Lawrence Farhat , Tammy Huntley , Faisal Kalam , Travis Oba , Qinggang Zeng
发明人： Fred Hodshon , Rafael Pintor , August Yambao , Abhishek Gautam , Louis A. Campbell , Lawrence Farhat , Tammy Huntley , Faisal Kalam , Travis Oba , Qinggang Zeng
IPC分类号： A61B17/06 , A61B19/02 , A61L15/00 , A61F2/00 , A61F2/24
CPC分类号： A61F2/2427 , A61F2/0095 , A61F2/24 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2220/0075
摘要： Packaging for prosthetic heart valves including an assembly for securely retaining a heart valve within a jar and facilitating retrieval therefrom. The assembly includes a packaging sleeve that fits closely within the jar and has a clip structure for securing a valve holder. Contrary to previous designs, in one embodiment the valve holder is directed downward into the jar, and the valve is retained with an inflow end upward. The valve may have flexible leaflets, and a leaflet parting member on the end of the shaft extends through the leaflets and couples with the valve holder. The assembly of the packaging sleeve, valve, and holder can then be removed from the jar and a valve delivery tube connected with the holder, or to the leaflet parting member. The packaging sleeve may be bifurcated into two halves connected at a living hinge to facilitate removal from around the valve/holder subassembly. The packaging system facilitates attachment of the valve delivery tube for use in a quick-connect valve implant procedure.
摘要翻译：用于假体心脏瓣膜的包装，包括用于将心脏瓣膜牢固地保持在罐内并有助于从其中取出的组件。组件包括紧密地配合在罐内的包装套筒，并具有用于固定阀座的夹子结构。与以前的设计相反，在一个实施例中，阀保持器向下指向罐中，并且阀向上保持流入端。阀可以具有柔性小叶，并且在轴的端部上的小叶分离构件延伸穿过叶片并与阀座联接。然后可以将包装套筒，阀和保持器的组件从罐中移除，以及与保持器连接的阀输送管，或者与叶片分离构件相连。包装套筒可以分叉成在活动铰链处连接的两个半部，以便于从阀/支架子组件周围移除。该包装系统便于安装用于快速连接阀注入过程的阀输送管。

5. 发明申请

US20130226278A1 METHODS AND APPARATUS FOR LUMINAL STENTING 审中-公开
公开(公告)号：US20130226278A1
公开(公告)日：2013-08-29
申请号：US13614349
申请日：2012-09-13
申请人： Gabriel NEWELL , Andy HUYNH , Lawrence FARHAT
发明人： Gabriel NEWELL , Andy HUYNH , Lawrence FARHAT
IPC分类号： A61F2/966
CPC分类号： A61F2/97 , A61F2/82 , A61F2/95 , A61F2/966 , A61F2002/9522 , A61F2002/9534 , A61F2002/9665
摘要： A stent delivery system, a core assembly, and methods of operating the same are provided. The delivery system can comprise a catheter and the core assembly. The core assembly can comprise a constraining member, protruding member, a core member, and a stent extending along the core member. The tubular constraining member can be spaced apart from the core member and define a capture area. The protruding member can be disposed along the core member at least partially distal of the capture area. The stent can have a first portion disposed within the capture area and a second portion, distal to the first portion, extending across or over an outer surface of the protruding member so that the protruding member and the constraining member cooperate to inhibit expansion of the first portion of the stent.

6. 发明申请

US20120150288A1 PROSTHETIC HEART VALVE PACKAGING AND DEPLOYMENT METHODS 有权
标题翻译：前置心脏瓣膜包装和部署方法
公开(公告)号：US20120150288A1
公开(公告)日：2012-06-14
申请号：US13403537
申请日：2012-02-23
申请人： Fred Hodshon , Rafael Pintor , August Yambao , Abhishek Gautam , Louis A. Campbell , Lawrence Farhat , Tammy Huntley , Faisal Kalam , Travis Oba , Qinggang Zeng
发明人： Fred Hodshon , Rafael Pintor , August Yambao , Abhishek Gautam , Louis A. Campbell , Lawrence Farhat , Tammy Huntley , Faisal Kalam , Travis Oba , Qinggang Zeng
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/0095 , A61F2/24 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2220/0075
摘要： Packaging for prosthetic heart valves including an assembly for securely retaining a heart valve within a jar and facilitating retrieval therefrom. The assembly includes a packaging sleeve that fits closely within the jar and has a clip structure for securing a valve holder. Contrary to previous designs, in one embodiment the valve holder is directed downward into the jar, and the valve is retained with an inflow end upward. The valve may have flexible leaflets, and a leaflet parting member on the end of the shaft extends through the leaflets and couples with the valve holder. The assembly of the packaging sleeve, valve, and holder can then be removed from the jar and a valve delivery tube connected with the holder, or to the leaflet parting member. The packaging sleeve may be bifurcated into two halves connected at a living hinge to facilitate removal from around the valve/holder subassembly.
摘要翻译：用于假体心脏瓣膜的包装，包括用于将心脏瓣膜牢固地保持在罐内并有助于从其中取出的组件。组件包括紧密地配合在罐内的包装套筒，并具有用于固定阀座的夹子结构。与以前的设计相反，在一个实施例中，阀保持器向下指向罐中，并且阀向上保持流入端。阀可以具有柔性小叶，并且在轴的端部上的小叶分离构件延伸穿过叶片并与阀座联接。然后可以将包装套筒，阀和保持器的组件从罐中移除，以及与保持器连接的阀输送管，或者与叶片分离构件相连。包装套筒可以分叉成在活动铰链处连接的两个半部，以便于从阀/支架子组件周围移除。

7. 发明授权

US5556408A Expandable and compressible atherectomy cutter 失效
标题翻译：可扩展和可压缩的粥样斑块切割刀
公开(公告)号：US5556408A
公开(公告)日：1996-09-17
申请号：US429939
申请日：1995-04-27
申请人： Lawrence Farhat
发明人： Lawrence Farhat
IPC分类号： A61B17/22 , A61B17/14
CPC分类号： A61B17/320725
摘要： An expandable and compressible atherectomy cutter for cutting plaque from a stenosis includes a distal hub and a proximal hub joined by a plurality of resilient blades. The blades are shaped to describe a cutting radius which may be compressed to allow the cutter to be inserted into a guide catheter during insertion and removal of the cutter from the patient. The proximal hub is attached to the distal end of a torque tube. A conically-shaped, flexible funnel extends distally from the distal end of the torque tube with the resilient blades located partially within the funnel. In use, the cutter is rotated and advanced to clear a stenosis in a vessel of a patient. At the same time, fluid is withdrawn from the torque tube causing debris to be gathered through the funnel and removed from the patient. Debris removal is enhanced by the channeling effect of the funnel.
摘要翻译：用于从狭窄切割斑块的可扩张和可压缩的粥样斑块切除刀具包括远端轮毂和由多个弹性叶片连接的近侧毂。叶片被成形为描述可以被压缩的切割半径，以允许切割器在插入并从患者移除切割器期间插入导向导管中。近端毂连接到扭矩管的远端。锥形的柔性漏斗从扭矩管的远端向远侧延伸，弹性刀片部分位于漏斗内。在使用中，切割器旋转并前进以清除患者血管中的狭窄。同时，流体从扭矩管中取出，导致碎屑通过漏斗收集并从患者身上移出。通过漏斗的通道效应增强了碎片去除。

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