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1. 发明申请

US20170128551A1 NOVEL USES OF RECOMBINANT CLOSTRIDIAL NEUROTOXINS WITH DECREASED DURATION OF EFFECT 审中-公开
公开(公告)号：US20170128551A1
公开(公告)日：2017-05-11
申请号：US15317105
申请日：2015-06-12
申请人： Klaus FINK , Susanne GRAFE , Imke SCHULTZ , Susanna ROLL
发明人： Klaus FINK , Susanne GRAFE , Imke SCHULTZ , Susanna ROLL
IPC分类号： A61K38/48
CPC分类号： A61K38/4893 , C12Y304/24069
摘要： This invention relates to novel uses of recombinant clostridial neurotoxins exhibiting decreased duration of effect, in particular uses for the treatment of patients suffering from a limited range of muscle extension, in particular from flexion contracture, in particular flexion contracture of the knee, and more particularly uses for the treatment of such patients having experienced a total knee arthroplasty.

2. 发明申请

US20140004541A1 METHOD FOR THE DETERMINATION OF BOTULINUM NEUROTOXIN BIOLOGICAL ACTIVITY 有权
标题翻译：测定嗜碱性粒细胞生物活性的方法
公开(公告)号：US20140004541A1
公开(公告)日：2014-01-02
申请号：US14004259
申请日：2012-03-09
申请人： Klaus Fink , Martin Vey
发明人： Klaus Fink , Martin Vey
IPC分类号： C12Q1/37 , C12N9/64
CPC分类号： C12N9/6472 , C12N9/6475 , C12Q1/37 , C12Y304/22055 , C12Y304/22056 , C12Y304/22059 , C12Y304/2206 , C12Y304/22061 , C12Y304/22062 , C12Y304/22063 , G01N33/5014 , G01N2333/33 , G01N2510/00
摘要： The present invention relates to means and methods for determining neurotoxin activity. Specifically, it relates to a polypeptide having caspase activity comprising a large subunit and a small subunit wherein the caspase further comprises a neurotoxin cleavage site which upon cleavage activates the caspase activity. Also encompassed are polynucleotides encoding the polypeptides as well as vectors or host cells comprising the polynucleotides. The present invention further relates to a method for determining neurotoxin activity in a sample based on the polypeptide of the invention as well as the use of the polypeptide for determining neurotoxin activity in a sample, in general.
摘要翻译：本发明涉及测定神经毒素活性的方法和方法。具体地说，本发明涉及一种具有半胱天冬酶活性的多肽，其包含大亚基和小亚基，其中半胱天冬酶还包含神经毒素切割位点，其在切割时激活半胱天冬酶活性。还包括编码多肽的多核苷酸以及包含多核苷酸的载体或宿主细胞。本发明还涉及基于本发明的多肽测定样品中的神经毒素活性的方法，以及通常用于测定样品中的神经毒素活性的多肽的用途。

3. 发明申请

US20080196313A1 Door and Door Frame Assembly 审中-公开
标题翻译：门和门框组件
公开(公告)号：US20080196313A1
公开(公告)日：2008-08-21
申请号：US12031790
申请日：2008-02-15
申请人： Klaus Fink , Michael Braun
发明人： Klaus Fink , Michael Braun
IPC分类号： E06B1/52
CPC分类号： E05B61/00 , E05B65/06 , E05F15/00 , E05F15/70 , E06B7/20
摘要： Door and frame assemblies are disclosed by the present application. In one exemplary embodiment, the a door is connected to a door frame, such that the door is moveable between an open position and a closed position. Activation of a trigger causes a door frame coupling arrangement to couple the door frame to the door in a closed position to thereby inhibit movement of the door relative to the frame. In another exemplary embodiment, a door is coupled to a door frame by a hinge. The hinge is configured to move the door in translation as the door is rotated from the open position to the closed position. For example, the hinge may move the door downward, toward the sill, when the door is moved from the open position to the closed position.
摘要翻译：门和框架组件由本申请公开。在一个示例性实施例中，门连接到门框，使得门能够在打开位置和关闭位置之间移动。触发器的激活导致门框联接装置在闭合位置将门框连接到门，从而阻止门相对于框架的移动。在另一个示例性实施例中，门通过铰链联接到门框。铰链构造成当门从打开位置旋转到关闭位置时平移移动门。例如，当门从打开位置移动到关闭位置时，铰链可以向下移动门，朝向门槛。

4. 发明授权

US06321824B1 Fabrication of zinc objects by dual phase casting 有权
标题翻译：通过双相铸造制造锌物体
公开(公告)号：US06321824B1
公开(公告)日：2001-11-27
申请号：US09201951
申请日：1998-12-01
申请人： Klaus Fink , Inho Song
发明人： Klaus Fink , Inho Song
IPC分类号： B22C900
CPC分类号： B22D17/007 , B22D21/027 , Y10S164/90
摘要： A plumbing product is made by a dual phase casting process with a zinc-aluminum alloy having between 0.5%-4% or 6%-22% aluminum by weight. The alloy is shredded into chips and heated to liquid state, processed to a dual phase state and then injection molded to form the part. The part can be plated using conventional plating techniques.
摘要翻译：管道产品通过双相铸造工艺制成，其中锌 - 铝合金的重量在0.5％-4％或6％-22％之间。将合金粉碎成芯片并加热至液态，加工成双相状态，然后注塑成型。该部件可以使用常规电镀技术进行电镀。

5. 发明授权

US5759677A Article of manufacture having at least in part the surface appearance of brass with a ceramic barrier coating 失效
标题翻译：具有至少部分具有陶瓷阻挡涂层的黄铜的表面外观的制品
公开(公告)号：US5759677A
公开(公告)日：1998-06-02
申请号：US664292
申请日：1996-06-11
申请人： Klaus Fink
发明人： Klaus Fink
IPC分类号： B32B15/00 , B32B15/04
CPC分类号： B32B15/00 , Y10T428/24975 , Y10T428/265 , Y10T428/31678
摘要： An article of manufacture having at least in part the surface appearance of brass includes a ceramic barrier coating applied to a base layer of Cu/Ni/Cr. The ceramic barrier coating includes an initial layer of ZrCn and an additional layer which is a nitrite, carbide or oxide of Zr, Ti, Si, Al or Hf.
摘要翻译：具有至少部分黄铜表面外观的制品具有涂敷在Cu / Ni / Cr基底层上的陶瓷阻挡涂层。陶瓷阻挡涂层包括ZrCn的初始层和作为Zr，Ti，Si，Al或Hf的亚硝酸盐，碳化物或氧化物的附加层。

6. 发明授权

US5752607A Process for distinguishing plumbing parts by the coatings applied thereto 失效
标题翻译：通过施加到其上的涂层区分管道部件的方法
公开(公告)号：US5752607A
公开(公告)日：1998-05-19
申请号：US617079
申请日：1996-03-18
申请人： Klaus Fink
发明人： Klaus Fink
IPC分类号： F16L1/00 , G01N21/35 , B07C5/00
CPC分类号： G01N21/3563
摘要： A process to distinguish plumbing parts, either individually or as combined into a plumbing product, in which one of two types of coatings have been applied to the parts, with the parts being visually indistinguishable by the type of coating. The parts are illuminated with a non-visible light operating at a frequency which will be absorbed by only one type of coating. The parts may be coated with an essentially organic coating or an essentially inorganic coating. Only one of these coatings will absorb the non-visible light and such absorption will be displayed so as to distinguish between parts having the different types of coatings.
摘要翻译：将管道部件单独地或组合成管道产品区分开的过程，其中两种类型的涂层中的一种已经被施加到部件上，其中部件在视觉上不能被涂层的类型区分开。部件以不可见光照射，频率将被仅一种类型的涂层吸收。这些部件可以涂覆有基本上有机的涂层或基本上无机的涂层。这些涂层中仅有一个将吸收不可见光，并且将显示这种吸收以便区分具有不同类型涂层的部件。

7. 发明授权

US09096886B2 Method for the determination of botulinum neurotoxin biological activity 有权
公开(公告)号：US09096886B2
公开(公告)日：2015-08-04
申请号：US14004259
申请日：2012-03-09
申请人： Klaus Fink , Martin Vey
发明人： Klaus Fink , Martin Vey
IPC分类号： A61K38/00 , A61K38/48 , C12Q1/37 , G01N33/50 , C12N9/64
CPC分类号： C12N9/6472 , C12N9/6475 , C12Q1/37 , C12Y304/22055 , C12Y304/22056 , C12Y304/22059 , C12Y304/2206 , C12Y304/22061 , C12Y304/22062 , C12Y304/22063 , G01N33/5014 , G01N2333/33 , G01N2510/00
摘要： The present invention relates to means and methods for determining neurotoxin activity. Specifically, it relates to a polypeptide having caspase activity comprising a large subunit and a small subunit wherein the caspase further comprises a neurotoxin cleavage site which upon cleavage activates the caspase activity. Also encompassed are polynucleotides encoding the polypeptides as well as vectors or host cells comprising the polynucleotides. The present invention further relates to a method for determining neurotoxin activity in a sample based on the polypeptide of the invention as well as the use of the polypeptide for determining neurotoxin activity in a sample, in general.

8. 发明授权

US5922102A Procedure for manufacturing zinc particles 失效
标题翻译：制造锌粒子的方法
公开(公告)号：US5922102A
公开(公告)日：1999-07-13
申请号：US990391
申请日：1997-12-15
申请人： Klaus Fink
发明人： Klaus Fink
IPC分类号： B22F9/08 , C22C1/04
CPC分类号： C22C1/04 , B22F9/08 , B22F2009/0808 , B22F2009/086 , B22F2998/10 , B22F2999/00
摘要： A procedure for making zinc particles of a size, shape and composition such that the particles can be subsequently used in a process for manufacturing zinc parts from such particles in either molten or powder form includes the initial step of heating zinc to a temperature at least as high as 720.degree. C. The molten zinc is passed through a screen having small openings, on the order of about 1/4".times.1/4" into a cooling region formed by a movable surface which is at a temperature of on the order of about -200.degree. C. The zinc forms small particles as it passes through the openings in the screen and essentially instantaneously solidifies as it contacts the movable surface. Thereafter, the solidified zinc particles are subjected to a grinding process to reduce their size to a powder having a surface area in the range of 2 mm.sup.2 to 20 mm.sup.2.
摘要翻译：制备尺寸，形状和组成的锌颗粒的方法，使得随后可以将颗粒用于从熔融或粉末形式的这种颗粒制造锌部件的方法中，包括将锌加热至至少等于高达720℃。熔融的锌通过具有大约+ E，fra 1/4 + EE“x + E，fra 1/4 + EE”的小开口的筛网进入冷却区域由可移动的表面形成，该可移动表面的温度约为-200℃左右。当锌通过屏幕中的开口时，形成小颗粒，并且当它接触可移动表面时基本上瞬间固化。此后，对固化的锌粒子进行研磨处理，以将其尺寸减小到表面积在2mm2至20mm2范围内的粉末。

9. 发明申请

US20130118080A1 DOOR AND DOOR FRAME ASSEMBLY 审中-公开
标题翻译：门和门框组装
公开(公告)号：US20130118080A1
公开(公告)日：2013-05-16
申请号：US13722289
申请日：2012-12-20
申请人： Klaus Fink , Michael Braun
发明人： Klaus Fink , Michael Braun
IPC分类号： E05F15/20 , E05B61/00 , E05F15/00 , E05B65/06
CPC分类号： E05B61/00 , E05B65/06 , E05F15/00 , E05F15/70 , E06B7/20
摘要： Door and frame assemblies are disclosed by the present application. In one exemplary embodiment, the a door is connected to a door frame, such that the door is moveable between an open position and a closed position. Activation of a trigger causes a door frame coupling arrangement to couple the door frame to the door in a closed position to thereby inhibit movement of the door relative to the frame. In another exemplary embodiment, a door is coupled to a door frame by a hinge. The hinge is configured to move the door in translation as the door is rotated from the open position to the closed position. For example, the hinge may move the door downward, toward the sill, when the door is moved from the open position to the closed position.
摘要翻译：门和框架组件由本申请公开。在一个示例性实施例中，门连接到门框，使得门能够在打开位置和关闭位置之间移动。触发器的激活导致门框联接装置在闭合位置将门框连接到门，从而阻止门相对于框架的移动。在另一个示例性实施例中，门通过铰链联接到门框。铰链构造成当门从打开位置旋转到关闭位置时平移移动门。例如，当门从打开位置移动到关闭位置时，铰链可以向下移动门，朝向门槛。

10. 发明申请

US20080289269A1 ROT RESISTANT DOOR 审中-公开
标题翻译：耐热门
公开(公告)号：US20080289269A1
公开(公告)日：2008-11-27
申请号：US12126515
申请日：2008-05-23
申请人： Tim J. O'Brien , Klaus Fink
发明人： Tim J. O'Brien , Klaus Fink
IPC分类号： E04H14/00
CPC分类号： E06B3/825 , E06B3/7015 , E06B2003/7071
摘要： The present application is directed to doors and door systems that are made from rot and/or swell resistant components. In one exemplary embodiment, every component of the door or door system is rot and/or swell resistant. In one exemplary embodiment, the door or door system remains rot and/or swell resistant after all hardware of the door or door system is installed.
摘要翻译：本申请涉及由腐烂和/或抗膨胀部件制成的门和门系统。在一个示例性实施例中，门或门系统的每个部件是腐烂和/或抗膨胀的。在一个示例性实施例中，在门或门系统的所有硬件安装之后，门或门系统保持腐烂和/或抗膨胀。

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