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1. 发明授权

US06852547B2 Dynamically formed rotors for lock-in amplifier detection 失效
标题翻译：用于锁定放大器检测的动态转子
公开(公告)号：US06852547B2
公开(公告)日：2005-02-08
申请号：US10633352
申请日：2003-08-01
申请人： Antonio A. Garcia , Mark Hayes , Anil Vuppu , Karl Booksh
发明人： Antonio A. Garcia , Mark Hayes , Anil Vuppu , Karl Booksh
IPC分类号： B01D20060101 , B03C1/01 , G01N21/64 , G01N33/48 , G01N33/53 , G01N33/543 , G01N33/553 , G01N33/566 , G01N35/00
CPC分类号： G01N27/745 , B03C1/01 , B03C2201/18 , G01N21/6408 , G01N21/6428 , G01N21/645 , Y10T436/11
摘要： A method for measuring low levels of a substance in a sample includes the formation of a rotor from paramagnetic particles in a substantially uniform magnetic field. The rotor is rotated by rotating the substantially uniform magnetic field. A portion of the substance in a sample is bound to the paramagnetic particles, and a signal having a time-varying component is detected. The signal is then processed using a lock-in amplifier with a reference signal having a frequency twice that of the rotation of the magnetic field. This improves the signal-to-noise ratio of the time-varying component of the signal.
摘要翻译：用于测量样品中的低含量物质的方法包括在基本均匀的磁场中由顺磁性颗粒形成转子。通过旋转基本均匀的磁场来旋转转子。样品中物质的一部分与顺磁性粒子结合，检测出具有时变成分的信号。然后使用具有频率是磁场旋转频率的两倍的参考信号的锁定放大器来处理该信号。这提高了信号的时变分量的信噪比。

2. 发明申请

US20070058905A1 Polymer connectors for use in surface plasmon resonance sensor 失效
公开(公告)号：US20070058905A1
公开(公告)日：2007-03-15
申请号：US10558021
申请日：2004-05-28
申请人： Karl Booksh , Jean-Francois Masson
发明人： Karl Booksh , Jean-Francois Masson
IPC分类号： G02B6/36
CPC分类号： G02B6/3894 , G01N21/553 , G02B6/3816 , G02B6/3833 , G02B6/3861 , G02B6/4248
摘要： A device for connecting optical components of a fiber optic probe and a jumper in a Surface Plasmon Resonator (SPR) has two high-pressure-liquid-chromatography (HPLC) polyetheretherketone (PEEK) connectors, one containing the optical fibers from a probe and the other containing optical fibers which link to a detector and a light source. A method of joining a probe's distal end to a jumper, with at least two fibers or a multimode fiber connected to a light source and to a detection apparatus, has the steps of covering the distal end of the probe with a plastic sleeve, placing the sleeved distal end into a PEEK connector, trimming the distal end of the probe to be even with the edge of the PEEK connection, and connecting the PEEK connector with the jumper.

3. 发明申请

US20110201511A1 SYSTEM AND METHOD FOR AUTOMATED BIOPARTICLE RECOGNITION 有权
标题翻译：自动生物识别系统与方法
公开(公告)号：US20110201511A1
公开(公告)日：2011-08-18
申请号：US12667944
申请日：2008-07-07
申请人： Mark A. Hayes , Thomas J. Taylor , Karl Booksh , Neal Woodbury , Pierre Herckes
发明人： Mark A. Hayes , Thomas J. Taylor , Karl Booksh , Neal Woodbury , Pierre Herckes
IPC分类号： C40B30/04 , C40B60/12 , G01N27/447
CPC分类号： G01N27/44756 , B03C5/005 , B03C2201/26 , G01N21/553 , G01N2015/0088
摘要： The invention relates to a method for identifying the source of shed bioparticles and an apparatus that implements the method. The method involves collecting a sample of bioparticles from the environment, selecting from that sample the bioparticles most effective in identifying their source, and gathering data from those bioparticles to form bioparticle signatures. The bioparticle signatures are then processed into a multi-dimensional vector which is then compared to the multi-dimensional vector derived from a standard using a pattern recognition strategy that identifies the source. The apparatus has a particle collection device to collect the sample, a transfer device that selects information-rich bioparticles and a detector that restricts the movement of the information-rich bioparticles. The restricted movement is then translated into a bioparticle signature.
摘要翻译：本发明涉及一种用于鉴定脱落生物颗粒的来源的方法和一种实现该方法的装置。该方法包括从环境中收集生物颗粒样品，从该样品中选择生物颗粒最有效地鉴定其来源，并从这些生物颗粒收集数据以形成生物颗粒标记。然后将生物粒子标记处理成多维向量，然后将其与使用识别源的模式识别策略从标准导出的多维向量进行比较。该装置具有收集样品的颗粒收集装置，选择信息丰富的生物颗粒的转移装置和限制富含信息的生物颗粒的运动的检测器。受限制的运动然后被转换成生物特征。

4. 发明授权

US08821703B2 System and method for automated bioparticle recognition 有权
标题翻译：自动生物粒子识别的系统和方法
公开(公告)号：US08821703B2
公开(公告)日：2014-09-02
申请号：US12667944
申请日：2008-07-07
申请人： Mark A. Hayes , Thomas J. Taylor , Karl Booksh , Neal Woodbury , Pierre Herckes
发明人： Mark A. Hayes , Thomas J. Taylor , Karl Booksh , Neal Woodbury , Pierre Herckes
IPC分类号： B03C5/02 , C40B30/04 , C40B60/12
CPC分类号： G01N27/44756 , B03C5/005 , B03C2201/26 , G01N21/553 , G01N2015/0088
摘要： The invention relates to a method for identifying the source of shed bioparticles and an apparatus that implements the method. The method involves collecting a sample of bioparticles from the environment, selecting from that sample the bioparticles most effective in identifying their source, and gathering data from those bioparticles to form bioparticle signatures. The bioparticle signatures are then processed into a multi-dimensional vector which is then compared to the multi-dimensional vector derived from a standard using a pattern recognition strategy that identifies the source. The apparatus has a particle collection device to collect the sample, a transfer device that selects information-rich bioparticles and a detector that restricts the movement of the information-rich bioparticles. The restricted movement is then translated into a bioparticle signature.
摘要翻译：本发明涉及一种用于鉴定脱落生物颗粒的来源的方法和一种实现该方法的装置。该方法包括从环境中收集生物颗粒样品，从该样品中选择生物颗粒最有效地鉴定其来源，并从这些生物颗粒收集数据以形成生物颗粒标记。然后将生物粒子标记处理成多维向量，然后将其与使用识别源的模式识别策略从标准导出的多维向量进行比较。该装置具有收集样品的颗粒收集装置，选择信息丰富的生物颗粒的转移装置和限制富含信息的生物颗粒的运动的检测器。受限制的运动然后被转换成生物特征。

5. 发明申请

US20070286546A1 Surface Initiated Thin Polymeric Films for Chemical Sensors 审中-公开
标题翻译：用于化学传感器的表面起始的薄聚合物膜
公开(公告)号：US20070286546A1
公开(公告)日：2007-12-13
申请号：US10548621
申请日：2004-03-11
申请人： Jean-Francois Masson , Karl Booksh , Anna Prakash , Yoon Kim
发明人： Jean-Francois Masson , Karl Booksh , Anna Prakash , Yoon Kim
IPC分类号： G02B6/00
CPC分类号： B82Y30/00 , G01N21/553 , G01N21/7703 , G01N33/54373 , G01N33/548
摘要： Surface active sensors comprising imprinted functional polymer matrices tailor made to detect specific chemical species of interest, and a label free, surface initiated molecular imprinting technology for applications in surface active sensors are provided.
摘要翻译：提供了表面活性传感器，其包括定制的用于检测感兴趣的特定化学物种的印记的功能性聚合物基质，以及用于表面活性传感器中的无标记的表面起始的分子印迹技术。

6. 发明申请

US20060258021A1 Biocompatible linkers for surface plasmon resonance biosensors 审中-公开
标题翻译：表面等离子体共振生物传感器的生物相容性接头
公开(公告)号：US20060258021A1
公开(公告)日：2006-11-16
申请号：US10567059
申请日：2004-08-12
申请人： Karl Booksh , Jean-Francois Masson
发明人： Karl Booksh , Jean-Francois Masson
IPC分类号： G01N1/28 , G01N33/543
CPC分类号： G01N33/54393 , B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N33/54373
摘要： A method of coating an SPR biosensor specific for an analyte to reduce protein fouling, the method has the steps of providing an SPR biosensor, providing a solution of 11-mercaptoundecanol; incubating the SPR biosensor in the 11-mercaptoundecanol solution to form a self-assembling monolayer (SAM); incubating the SPR with SAM in a solution of epichlorohydrin and diglyme; next incubating the SPR in ethanolamine; preparing a solution of EDCNHS and a biocompatible polymer; incubating the SPR from ethanolamine in the EDC/NHS/polymer solution; providing a ligand specific for the analyte in a solution; incubating the polymer-coated SPR in the ligand solution to permit the ligand to react with the polymer-coated SPR; washing the ligand-coated SPR to remove unreacted ligand, thereby providing an SPR capable of reacting with the analyte. Another method replaces the solution for the SAM layer with a solution of MHA or NHS-MHA with HT, and attaches the ligand to the resulting SAM layer.
摘要翻译：一种涂覆专用于分析物的SPR生物传感器以减少蛋白质结垢的方法，该方法具有提供SPR生物传感器，提供11-巯基十一烷醇溶液的步骤; 将SPR生物传感器置于11-巯基十一烷醇溶液中以形成自组装单层（SAM）; 将SPR与SAM在表氯醇和二甘醇二甲醚溶液中孵育; 接着在乙醇胺中培养SPR; 制备EDCNHS和生物相容性聚合物的溶液; 在EDC / NHS /聚合物溶液中从乙醇胺中培养SPR; 提供溶液中分析物特异性的配体; 将配体溶液中的聚合物涂覆的SPR孵育以允许配体与聚合物涂覆的SPR反应; 洗涤配体涂覆的SPR以除去未反应的配体，从而提供能够与分析物反应的SPR。另一种方法用MHA或NHS-MHA与HT的溶液替代SAM层的溶液，并将配体连接到所得的SAM层。

7. 发明授权

US09207117B2 Apparatus and method for performing surface plasmon resonance (SPR) spectroscopy with an infrared (IR) spectrometer 有权
标题翻译：用红外（IR）光谱仪进行表面等离子体共振（SPR）光谱仪的装置和方法
公开(公告)号：US09207117B2
公开(公告)日：2015-12-08
申请号：US13812323
申请日：2011-07-28
申请人： Karl Booksh , Nicola Menegazzo , Yoon-Chang Kim , Derrick Allen , Lauren Kegel
发明人： Karl Booksh , Nicola Menegazzo , Yoon-Chang Kim , Derrick Allen , Lauren Kegel
IPC分类号： G02B5/20 , G01J3/42 , G01N21/35 , G01N21/552 , G01J3/02
CPC分类号： G01J3/0205 , G01J3/42 , G01N21/35 , G01N21/553 , G02B5/208
摘要： Methods of measuring a sample characteristic and accessories for infrared (IR) spectrometers are provided. An accessory includes an input port and an output port having an optical path therebetween, a surface plasmon resonance (SPR) structure for contacting a sample, a mirror system, and an optical element for producing collimated light. The SPR structure produces internally reflected light responsive to broadband IR light, modified by a SPR between the SPR structure and the sample. The mirror system directs the broadband IR light from the input port to the SPR structure and directs the internally reflected light from the SPR structure to the output port, producing output light indicative of a characteristic of the sample associated with the SPR. The optical element is disposed along the optical path between the input port and the output port.
摘要翻译：提供了测量红外（IR）光谱仪的样品特性和附件的方法。一个附件包括一个输入端口和一个具有光路的输出端口，用于接触样品的表面等离子体共振（SPR）结构，镜子系统和用于产生准直光的光学元件。 SPR结构产生内部反射光，响应宽带IR光，由SPR结构和样品之间的SPR进行修改。镜系统将宽带IR光从输入端口引导到SPR结构，并将内部反射光从SPR结构引导到输出端口，产生指示与SPR相关联的样本特征的输出光。光学元件沿着输入端口和输出端口之间的光路布置。

8. 发明申请

US20130240734A1 APPARATUS AND METHOD FOR PERFORMING SURFACE PLASMON RESONANCE (SPR) SPECTROSCOPY WITH AN INFRARED (IR) SPECTROMETER 有权
标题翻译：用红外（IR）光谱仪实现表面等离子体共振（SPR）光谱的装置和方法
公开(公告)号：US20130240734A1
公开(公告)日：2013-09-19
申请号：US13812323
申请日：2011-07-28
申请人： Karl Booksh , Nicola Menegazzo , Yoon-Chang Kim , Laurel Kegel , Derrick Allen
发明人： Karl Booksh , Nicola Menegazzo , Yoon-Chang Kim , Laurel Kegel , Derrick Allen
IPC分类号： G01J3/02 , G02B5/20 , G01J3/42
CPC分类号： G01J3/0205 , G01J3/42 , G01N21/35 , G01N21/553 , G02B5/208
摘要： Methods of measuring a sample characteristic and accessories for infrared (IR) spectrometers are provided. An accessory includes an input port and an output port having an optical path therebetween, a surface plasmon resonance (SPR) structure for contacting a sample, a mirror system, and an optical element for producing collimated light. The SPR structure produces internally reflected light responsive to broadband IR light, modified by a SPR between the SPR structure and the sample. The mirror system directs the broadband IR light from the input port to the SPR structure and directs the internally reflected light from the SPR structure to the output port, producing output light indicative of a characteristic of the sample associated with the SPR. The optical element is disposed along the optical path between the input port and the output port.
摘要翻译：提供了测量红外（IR）光谱仪的样品特性和附件的方法。一个附件包括一个输入端口和一个具有光路的输出端口，用于接触样品的表面等离子体共振（SPR）结构，镜子系统和用于产生准直光的光学元件。 SPR结构产生内部反射光，响应宽带IR光，由SPR结构和样品之间的SPR进行修改。镜系统将宽带IR光从输入端口引导到SPR结构，并将内部反射光从SPR结构引导到输出端口，产生指示与SPR相关联的样本特征的输出光。光学元件沿着输入端口和输出端口之间的光路布置。

9. 发明申请

US20070031292A1 Chemical sensors featuring dual-sensing motifs 审中-公开
标题翻译：化学传感器具有双重感应图案
公开(公告)号：US20070031292A1
公开(公告)日：2007-02-08
申请号：US10576578
申请日：2004-10-22
申请人： Karl Booksh , Anna Prakash
发明人： Karl Booksh , Anna Prakash
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N21/553 , G01N21/6428
摘要： Apparatus and methods featuring a sensor (10) having dual-sensing motifs. The sensor (10) includes an entrant medium (12), a thin metal film layer (14), sensing elements (16), and a fluorescent molecule (18) associated with the sensing elements (16). A target molecule (20) is captured by the sensing elements (16), and Surface Plasmon Resonance (SRP) and fluorescent detection are employed. The apparatus and methods were tested for the detection of Pinacolyl methylphosphanate (PMP), a simulant for nerve agent Soman.
摘要翻译：具有传感器（10）的装置和方法具有双重感测图案。传感器（10）包括入口介质（12），薄金属膜层（14），感测元件（16）和与感测元件（16）相关联的荧光分子（18）。靶分子（20）由感测元件（16）捕获，并且采用表面等离子体共振（SRP）和荧光检测。测试了该设备和方法检测苯甲酰甲基磷酸（PMP），神经毒素Soman的模拟物。

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