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1. 发明申请

US20070133850A1 System for making a medical device 审中-公开
标题翻译：制造医疗器械的系统
公开(公告)号：US20070133850A1
公开(公告)日：2007-06-14
申请号：US11297769
申请日：2005-12-08
申请人： Juan Paez
发明人： Juan Paez
IPC分类号： G06K9/00
CPC分类号： G06T7/60 , A61F5/01 , G06T2207/30004
摘要： A castless system and method for sizing a medical device for use with limbs, joints, appendages, and other body members of a human or animal subject. The system uses at least two digital images to create a body member profile and extract measurements for the selection of a model template. The model template is used to manufacture a custom made orthosis, such as a brace.
摘要翻译：一种用于使人类或动物受试者的四肢，关节，附属物和其他身体成员使用的医疗装置的尺寸的无铸模系统和方法。该系统使用至少两个数字图像来创建主体成员简档并提取用于模型模板选择的测量。模型模板用于制造定制的矫形器，例如支架。

2. 发明申请

US20080105994A1 Method for creating a mold for a knee brace and a knee brace 失效
标题翻译：创建膝盖支架和膝盖支架模具的方法
公开(公告)号：US20080105994A1
公开(公告)日：2008-05-08
申请号：US12005079
申请日：2007-12-21
申请人： Jeffrey Stearns , Juan Paez
发明人： Jeffrey Stearns , Juan Paez
IPC分类号： B29C33/38
CPC分类号： B29C33/40 , A61F5/01 , A61F2002/5053 , Y10T29/49885
摘要： Disclosed is a method for producing a three-dimensional composite structure and a method for producing the mold for the three-dimensional composite structure. The mold is formed of at least one rigid die member and a second thermoplastic die member. The second thermoplastic die member is formed by coupling a rubber flexible pattern to a surface of the first die member. Vacuum or pressure is applied to a heated thermoplastic sheet to cause the heated thermoplastic sheet to deform about the flexible pattern, thereby forming the second die. Strips of reinforced polymer thermoset pre-preg material are then positioned within the cavities formed by the flexible pattern and are allowed to cure. Optionally, heat, pressure, and vacuum may be applied to the mold construction to facilitate the curing of the thermoset materials.
摘要翻译：公开了三维复合结构体的制造方法和三维复合结构体的制造方法。模具由至少一个刚性模具构件和第二热塑性模具构件形成。第二热塑性模具构件通过将橡胶柔性图案耦合到第一模具构件的表面而形成。将真空或压力施加到加热的热塑性片材上，使得加热的热塑性片材围绕柔性图案变形，从而形成第二模具。然后将增强的聚合物热固性预浸料材料条定位在由柔性图案形成的空腔内，并使其固化。任选地，可以将热，压力和真空施加到模具结构以便于热固性材料的固化。

3. 发明申请

US20070225629A1 ORTHOPEDIC BRACE 审中-公开
公开(公告)号：US20070225629A1
公开(公告)日：2007-09-27
申请号：US11685221
申请日：2007-03-13
申请人： James ISRAEL , Juan PAEZ
发明人： James ISRAEL , Juan PAEZ
IPC分类号： A61F5/00
CPC分类号： A61F5/0118
摘要： A brace for a patient appendage. The brace can include a first member and a second member. The first member is positioned proximate a first side of the patient appendage and includes a main body portion extending in a longitudinal direction. The first member additionally includes a circumferentially extending portion at least partially extending about the patient appendage. The second member is positioned proximate a second side of the patient appendage and includes a first end having an outer convexly curved portion.
摘要翻译：用于患者附属物的支架。支架可以包括第一构件和第二构件。第一构件位于患者附属物的第一侧附近，并且包括沿纵向方向延伸的主体部分。第一构件还包括围绕患者附件至少部分地延伸的周向延伸部分。第二构件位于患者附属物的第二侧附近，并且包括具有外部凸出弯曲部分的第一端。

4. 发明申请

US20080096212A1 Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments 有权
公开(公告)号：US20080096212A1
公开(公告)日：2008-04-24
申请号：US11894135
申请日：2007-08-20
申请人： Daphne Bell , Daniel Haber , Pasi Janne , Bruce Johnson , Thomas Lynch , Matthew Meyerson , Juan Paez , William Sellers , Jeffrey Settleman , Raffaella Sordella
发明人： Daphne Bell , Daniel Haber , Pasi Janne , Bruce Johnson , Thomas Lynch , Matthew Meyerson , Juan Paez , William Sellers , Jeffrey Settleman , Raffaella Sordella
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/485 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/574 , G01N33/74 , G01N2333/485 , G01N2800/52
摘要： The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.

5. 发明申请

US20060147959A1 Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments 有权
公开(公告)号：US20060147959A1
公开(公告)日：2006-07-06
申请号：US11294621
申请日：2005-12-05
申请人： Daphne Bell , Daniel Haber , Pasi Janne , Bruce Johnson , Thomas Lynch , Matthew Meyerson , Juan Paez , William Sellers , Jeffrey Settleman , Raffaella Sordella
发明人： Daphne Bell , Daniel Haber , Pasi Janne , Bruce Johnson , Thomas Lynch , Matthew Meyerson , Juan Paez , William Sellers , Jeffrey Settleman , Raffaella Sordella
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/485 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/574 , G01N33/74 , G01N2333/485 , G01N2800/52
摘要： The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.

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