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1. 发明授权

US07592148B1 Method for examining human kidney disease by detecting the fatty acid binding protein 有权
标题翻译：通过检测脂肪酸结合蛋白检测人肾脏疾病的方法
公开(公告)号：US07592148B1
公开(公告)日：2009-09-22
申请号：US09578693
申请日：2000-07-26
申请人： Masaya Yamanouchi , Akiko Honda , Hiromi Hase , Takeshi Sugaya , Kenjiro Kimura
发明人： Masaya Yamanouchi , Akiko Honda , Hiromi Hase , Takeshi Sugaya , Kenjiro Kimura
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/6893 , G01N2800/347
摘要： Method for examining kidney disease, which comprises detecting fatty acid binding protein derived from kidney tissues, which is present in specimen collected from mammal excluding Rodents. By the present method, it is possible to obtain test results, which may be very important information for diagnosis or prognosis of kidney disease that has been very difficult in the past. Based on test results obtained by the present method, it may be possible to select a suitable method for treatment of kidney disease with taking into consideration risks such as the prognosis, etc. Besides, the present method can be applied to, in addition to the kidney disease samples, urine samples as well, so that the examination procedure can be simple and efficient.
摘要翻译：用于检查肾脏疾病的方法，其包括检测来自肾组织的脂肪酸结合蛋白，其存在于不包括啮齿动物的哺乳动物收集的标本中。通过本方法，可以获得测试结果，这可能是过去非常困难的肾脏疾病的诊断或预后的非常重要的信息。根据本方法得到的检测结果，考虑到预后等风险，可以选择合适的肾脏疾病治疗方法。此外，本方法除了可以应用于肾脏疾病样本，尿液样本，使检查程序简单有效。

2. 发明申请

US20090079671A1 INPUT/OUTPUT-INTEGRATED DISPLAY DEVICE AND PROTECTIVE GLASS PLATE USED THEREIN 有权
标题翻译：输入/输出一体化显示设备及其使用的保护玻璃板
公开(公告)号：US20090079671A1
公开(公告)日：2009-03-26
申请号：US11917691
申请日：2006-07-04
申请人： Mizuki Nishi , Katsuto Tanaka , Hiroshi Honjo , Hiromi Hase
发明人： Mizuki Nishi , Katsuto Tanaka , Hiroshi Honjo , Hiromi Hase
IPC分类号： G09G3/20
CPC分类号： G06F3/0412 , C03C21/001 , G02F1/13338
摘要： The present invention herein provides an input/output-integrated display device which never causes, with ease, any contact between a protective glass plate and a part such as a display panel which is arranged in the device while facing the protective glass plate as well as a protective glass plate used in the display device. The input/output-integrated display device equipped with a means for inputting information through handwriting comprises a protective glass plate which is arranged as an outermost layer on the observation side of the device, while leaving a space between the protective glass plate and a part of the device facing the same. The protective glass plate is a chemically reinforced glass plate prepared by immersing, in a molten salt bath, a glass plate which is produced according to the floating technique and has a Young's modulus ranging from 71 to 74 GPa and a Poisson's ratio ranging from 0.22 to 0.24 to thus chemically reinforce the same; the protective glass plate has the side serving as the top face upon the production of the glass plate according to the floating technique and the bottom face side opposite to the top face side; the surface compression stress observed on the top face side ranges from 200 to 650 MPa; the protective glass plate is arranged in such a manner that the top face thereof faces the foregoing space; and the protective glass plate is deflected towards the bottom face side.
摘要翻译：本发明提供了一种输入/输出集成显示装置，其容易地不会在保护玻璃板和诸如布置在装置中的面对保护性玻璃板的显示面板的部分之间的任何接触以及在显示装置中使用的保护玻璃板。具有用于通过手写输入信息的装置的输入/输出集成显示装置包括保护玻璃板，其在装置的观察侧被布置为最外层，同时在保护玻璃板和保护玻璃板的一部分之间留有空间设备面对相同。保护玻璃板是通过在熔融盐浴中浸渍根据浮动技术制造的玻璃板，并且杨氏模量为71〜74GPa，泊松比为0.22〜 0.24，从而化学强化它们; 保护玻璃板根据浮动技术制造玻璃板并且与顶面侧相对的底面侧的一侧用作顶面; 在顶面观察到的表面压应力为200〜650MPa; 保护玻璃板以其顶面面向上述空间的方式配置; 并且保护玻璃板朝向底面侧偏转。

3. 发明授权

US06794154B1 Remedies for kidney diseases and method for screening the same 有权
标题翻译：肾脏疾病的治疗方法和筛查方法相同
公开(公告)号：US06794154B1
公开(公告)日：2004-09-21
申请号：US09979765
申请日：2001-11-27
申请人： Masaya Yamanouchi , Hiromi Hase , Akiko Honda , Takeshi Sugaya
发明人： Masaya Yamanouchi , Hiromi Hase , Akiko Honda , Takeshi Sugaya
IPC分类号： G01N3353
CPC分类号： C12N5/0686 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K31/00 , A61K31/336 , A61K31/41 , A61K31/425 , A61K31/4439 , A61K38/00 , C07K14/475 , C07K14/705 , C12N15/8509 , C12N2503/02 , C12N2510/04 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/92 , G01N2500/00 , G01N2500/10
摘要： The present invention provides a method for screening or identifying therapeutic or prophylactic agents for renal diseases, which comprises assaying a test substance for the activity of up-regulating the expression of fatty acid-binding protein (FABP), and novel mouse proximal renal tubular epithelial cell lines useful therein. The present invention also provides therapeutic or prophylactic agents for renal diseases comprising, as an active ingredient, an agent having activity of up-regulating FABP expression; agents for up-regulating the expression of FABP, and for treating or preventing renal diseases, which comprise a compound having activity of peroxisome proliferator-activated receptor (PPAR) agonist or carnitine palmitoyltransferase (CPT) inhibitor or the like.
摘要翻译：本发明提供了筛选或鉴定肾脏疾病的治疗或预防剂的方法，其包括测定测试物质以上调脂肪酸结合蛋白（FABP）表达的活性，以及新型小鼠近端肾小管上皮可用于其中的细胞系。本发明还提供了用于肾脏疾病的治疗剂或预防剂，其包含作为活性成分的具有上调FABP表达活性的药剂; 用于上调FABP表达的药物，以及用于治疗或预防肾脏疾病的药物，其包含具有过氧化物酶体增殖物激活受体（PPAR）激动剂或肉碱棕榈酰转移酶（CPT）抑制剂等的活性的化合物。

4. 发明授权

US08072431B2 Input/output-integrated display device and protective glass plate used therein 有权
标题翻译：输入/输出一体化显示装置及其中使用的保护玻璃板
公开(公告)号：US08072431B2
公开(公告)日：2011-12-06
申请号：US11917691
申请日：2006-07-04
申请人： Mizuki Nishi , Katsuto Tanaka , Hiroshi Honjo , Hiromi Hase
发明人： Mizuki Nishi , Katsuto Tanaka , Hiroshi Honjo , Hiromi Hase
IPC分类号： G06F3/03
CPC分类号： G06F3/0412 , C03C21/001 , G02F1/13338
摘要： The invention provides an input/output-integrated display device equipped with a means for inputting information through handwriting comprising a protective glass plate arranged as an outermost layer on the observation side of the device, leaving a space between the protective glass plate and a part of the device facing the same. The protective glass plate is a chemically reinforced glass plate prepared by immersing, in a molten salt bath, a glass plate produced according to the floating technique and has a Young's modulus of 71 to 74 GPa and a Poisson's ratio of 0.22 to 0.24 to thus chemically reinforce the same; the protective glass plate has the side serving as the top face upon the production of the glass plate according to the floating technique and the bottom face side opposite to the top face side; the surface compression stress on the top face side is 200 to 650 MPa; the protective glass plate is arranged such that the top face faces the space; and the protective glass plate is deflected towards the bottom face side at a warpage.
摘要翻译：本发明提供了一种输入/输出集成显示装置，其具有用于通过手写输入信息的装置，该装置包括在装置的观察侧布置为最外层的保护玻璃板，在保护玻璃板与保护玻璃板的一部分之间留有空间设备面对相同。保护性玻璃板是通过在熔盐浴中浸渍根据浮动技术制造的玻璃板并且具有71至74GPa的杨氏模量和0.22至0.24的泊松比而制备的化学增强玻璃板，从而化学加强; 保护玻璃板根据浮动技术制造玻璃板并且与顶面侧相对的底面侧的一侧用作顶面; 顶面侧的表面压缩应力为200〜650MPa; 保护玻璃板被布置成使得顶面面向空间; 并且保护性玻璃板在翘曲时向底面侧偏转。

5. 发明申请

US20070243560A1 Method for examining kidney diseases 审中-公开
标题翻译：检查肾脏疾病的方法
公开(公告)号：US20070243560A1
公开(公告)日：2007-10-18
申请号：US11812334
申请日：2007-06-18
申请人： Masaya Yamanouchi , Akiko Honda , Hiromi Hase , Takeshi Sugaya , Kenjiro Kimura
发明人： Masaya Yamanouchi , Akiko Honda , Hiromi Hase , Takeshi Sugaya , Kenjiro Kimura
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/347
摘要： Method for examining kidney disease, which comprises detecting fatty acid binding protein derived from kidney tissues, which is present in specimen collected from mammal excluding Rodents. By the present method, it is possible to obtain test results which may be very important information for diagnosis of prognosis of kidney disease, that has been very difficult in the past. Based on test results obtained by the present method, it may be possible to select a suitable method for treatment of kidney disease with taking into consideration risks as to the prognosis, etc. Besides, the present method can be applied to, in addition to the kidney tissue samples, urine samples as well, so that the examination procedure can be simple and efficient.
摘要翻译：用于检查肾脏疾病的方法，其包括检测来自肾组织的脂肪酸结合蛋白，其存在于不包括啮齿动物的哺乳动物收集的标本中。通过本方法，可以获得可能是诊断肾脏疾病预后的非常重要的信息的测试结果，这在过去是非常困难的。根据本方法得到的检测结果，考虑到预后的风险等，可以选择合适的肾病治疗方法。此外，本方法除了可以应用于肾组织样本，尿液样本，使检查程序简单有效。

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