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1. 发明授权

US07566710B2 Dual molecules containing a peroxide derivative, synthesis and therapeutic applications thereof 失效
标题翻译：含有过氧化物衍生物的双分子，其合成和治疗应用
公开(公告)号：US07566710B2
公开(公告)日：2009-07-28
申请号：US11196979
申请日：2005-08-04
申请人： Bernard Meunier , Anne Robert , Odile Dechy-Cabaret , Francoise Benoit-Vical
发明人： Bernard Meunier , Anne Robert , Odile Dechy-Cabaret , Francoise Benoit-Vical
IPC分类号： C07D215/38 , A61K31/4745 , A61K31/4709
CPC分类号： C07D405/12 , C07D323/04 , C07D471/04
摘要： The invention relates to dual molecules formed from coupling products complying with the formula wherein A represents a residue of molecule with anti-malarial activity, Y1 and Y2, represent a linear or branched alkylene chain at C1 to C5, or either Y1 or Y2 is absent, U is an amine, amide, sulphonamide, carboxyl, ether or thioether function, said function linking Y1 and Y2, Z1 and Z2, represent a linear arylene or alkylene, or either Z1 or Z2 is absent, or Z1+Z2 together represent a cyclic or polycyclic structure including the junction carbons Ci and Cj, R1 and R2, represent a hydrogen atom or a functional group capable of increasing the hydrosolubility of the dual molecule, Rx and Ry form a cyclic peroxide with 4 to 8 chain links, Cj being one of the peaks of said cyclic peroxide, or -Rx or Ry is a cyclic peroxide with 4 to 8 chain links, which may comprise 1 or 2 additional oxygen atoms in the cyclic structure, and one or more substituents R3, identical or different, at least one R3 representing a halogen atom, an —OH group, a —CF3 group, an aryl, an alkyl or alkoxy at C1 to C5, —NO2, the other substituent(s) having one of these correspondences or a hydrogen, and their addition salts with pharmacological acceptable acids.
摘要翻译：本发明涉及由符合下式的偶联产物形成的双分子：其中A代表具有抗疟疾活性的分子的残基，Y1和Y2代表C1至C5的直链或支链亚烷基链，或Y1或Y2不存在，U是胺，酰胺，磺酰胺，羧基，醚或硫醚的功能，所述连接Y1和Y2，Z1和Z2的功能代表线性亚芳基或亚烷基，或不存在Z1或Z2，或Z1 + Z2一起代表包括连接碳C 1和C 1的环状或多环结构，R 1和R 2表示氢原子或能够增加双分子的水溶性的官能团，Rx和Ry形成具有4至8个链键的环状过氧化物，C j为所述环状过氧化物的一个峰，或-Rx或Ry是具有4至8个链节的环状过氧化物，其可以在环状结构中包含1或2个另外的氧原子，以及一个或多个相同或不同的取代基R 3，至少一个R3 代表卤素原子，-OH基团，-CF 3基团，C 1 -C 5的芳基，烷基或烷氧基，-NO 2，具有这些对应关系的其它取代基或氢，以及它们与药理学可接受的酸。

2. 发明授权

US06949569B2 Dual molecules containing a peroxide derivative, synthesis and therapeutic applications thereof 失效
公开(公告)号：US06949569B2
公开(公告)日：2005-09-27
申请号：US10240929
申请日：2001-04-04
申请人： Bernard Meunier , Anne Robert , Odile Dechy-Cabaret , Francoise Benoit-Vical
发明人： Bernard Meunier , Anne Robert , Odile Dechy-Cabaret , Francoise Benoit-Vical
IPC分类号： A61K20060101 , A61K9/08 , A61K9/10 , A61K9/20 , A61K9/48 , A61K31/397 , A61K31/435 , A61K31/47 , A61K31/4709 , A61K31/4745 , A61K31/513 , A61P20060101 , A61P33/06 , C07D20060101 , C07D215/00 , C07D323/04 , C07D405/12 , C07D407/12 , C07D453/04 , C07D471/02 , C07D471/04
CPC分类号： C07D405/12 , C07D323/04 , C07D471/04
摘要： The invention relates to dual molecules formed from coupling products complying with the formula wherein A represents a residue of molecule with anti-malarial activity, Y1 and Y2, represent a linear or ramified alkylene chain at C1 to C5, with the possibility of either Y1 or Y2 being absent, U is an amine, amide, sulphonamide, carboxyl, ether or thioether function, said function linking Y1 and Y2, Z1 and Z2, represent a linear arylene or alkylene, with the possibility of either Z1 or Z2 being absent, or Z1+Z2 together represent a polycyclic structure including the junction carbons Ci and Cj, R1 and R2, represent a hydrogen atom or a functional group capable of increasing the hydrosolubility of the dual molecule, Rx and Ry form a cyclic peroxide with 4 to 8 chain links, Cj being one of the peaks of said cyclic peroxide, or Rx or Ry is a cyclic peroxide with 4 to 8 chain links, which may comprise 1 or 2 additional oxygen atoms in the cyclic structure, and one or more substituents R3, identical or different, at least one representing a halogen atom, an —OH group, a —CF3 group, an aryl, an alkyl or alkoxy at C1 to C5, —NO2, the other substituent(s) having one of these correspondences or a hydrogen, and their addition salts with pharmacological acceptable acids. Application as medicinal products with anti-malarial activity.

3. 发明申请

US20050288315A1 Dual molecules containing a peroxide derivative, synthesis and therapeutic applications thereof 失效
标题翻译：含有过氧化物衍生物的双分子，其合成和治疗应用
公开(公告)号：US20050288315A1
公开(公告)日：2005-12-29
申请号：US11196979
申请日：2005-08-04
申请人： Bernard Meunier , Anne Robert , Odile Dechy-Cabaret , Francoise Benoit-Vical
发明人： Bernard Meunier , Anne Robert , Odile Dechy-Cabaret , Francoise Benoit-Vical
IPC分类号： A61K20060101 , A61K9/08 , A61K9/10 , A61K9/20 , A61K9/48 , A61K31/397 , A61K31/435 , A61K31/47 , A61K31/4709 , A61K31/4745 , A61K31/513 , A61P20060101 , A61P33/06 , C07D20060101 , C07D215/00 , C07D323/04 , C07D405/12 , C07D407/12 , C07D453/04 , C07D471/02 , C07D471/04 , C07D43/02
CPC分类号： C07D405/12 , C07D323/04 , C07D471/04
摘要： The invention relates to dual molecules formed from coupling products complying with the formula wherein A represents a residue of molecule with anti-malarial activity, Y1 and Y2, represent a linear or ramified alkylene chain at C1 to C5, with the possibility of either Y1 or Y2 being absent, U is an amine, amide, sulphonamide, carboxyl, ether or thioether function, said function linking Y1 and Y2, Z1 and Z2, represent a linear arylene or alkylene, with the possibility of either Z1 or Z2 being absent, or Z1+Z2 together represent a polycyclic structure including the junction carbons Ci and Cj, R1 and R2, represent a hydrogen atom or a functional group capable of increasing the hydrosolubility of the dual molecule, Rx and Ry form a cyclic peroxide with 4 to 8 chain links, Cj being one of the peaks of said cyclic peroxide, or Rx or Ry is a cyclic peroxide with 4 to 8 chain links, which may comprise 1 or 2 additional oxygen atoms in the cyclic structure, and one or more substituents R3, identical or different, at least one representing a halogen atom, an —OH group, a —CF3 group, an aryl, an alkyl or alkoxy at C1 to C5, —NO2, the other substituent(s) having one of these correspondences or a hydrogen, and their addition salts with pharmacological acceptable acids. Application as medicinal products with anti-malarial activity.
摘要翻译：本发明涉及由符合下式的偶联产物形成的双分子：其中A表示具有抗疟疾活性的分子的残基Y 1和Y 2 2代表线性或在C1至C5处带有分支的亚烷基链，其中不存在Y 1或Y 2的可能性，U是胺，酰胺，磺酰胺，羧基，醚或硫醚功能，所述连接Y 1和Y 2，Z 1和Z 2的功能代表线性亚芳基或亚烷基，Z 1或Z 2 2个不存在的可能性，或Z 1 + Z 2 2一起表示包括连接碳C 1和C 1，R 1和R 2的多环结构表示氢原子或能够增加双分子的水溶性的官能团， R x和R y y形成具有4至8个链节的环状过氧化物，C j是所述环状过氧化物的峰之一氧化物或R x x或R y y是具有4至8个链节的环状过氧化物，其可以在环状结构中包含1或2个另外的氧原子，并且一个或更多的取代基R 3 3相同或不同，表示卤素原子，-OH基团，-CF 3 N 3基团，芳基，烷基或烷氧基中的至少一个 C 1〜C 5，-NO 2 2，其它取代基具有这些对应之一或氢，以及它们与药理学上可接受的酸的加成盐。作为具有抗疟活性的药用产品。

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