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    • 5. 发明授权
    • Anti-viral mushroom extracts
    • 抗病毒蘑菇提取物
    • US5714464A
    • 1998-02-03
    • US468274
    • 1995-08-09
    • Frank PirainoCurtis R. Brandt
    • Frank PirainoCurtis R. Brandt
    • A61K38/00C07K14/415C07K7/02
    • C07K14/415A61K38/00
    • A substantially pure compound extracted from the mushroom Rozites caperata is disclosed. The compound disclosed is SEQ ID NO:1, a twelve amino acid peptide, covalently linked by the epsilon amino group of a carboxy terminal lysine to the carboxyl terminus of SEQ ID NO:2, or a pharmaceutically acceptable nontoxic salt of the compound. The disclosed compound inhibits replication of viruses having lipid bilayer envelopes. Also disclosed is a method for inhibiting replication of viruses having lipid bilayer envelopes. According to the method, such viruses can be inhibited by administering an effective amount of a substantially pure compound, which is SEQ ID NO:1 covalently to SEQ ID NO:2, or a pharmaceutically acceptable nontoxic salt of the compound.
    • 公开了从蘑菇Rozites caperata提取的基本上纯的化合物。 所公开的化合物是SEQ ID NO:1,通过羧基末端赖氨酸的ε氨基与SEQ ID NO:2的羧基末端共价连接的12个氨基酸肽,或该化合物的药学上可接受的无毒性盐。 所公开的化合物抑制具有脂双层包膜的病毒的复制。 还公开了抑制具有脂双层包膜的病毒复制的方法。 根据该方法,通过向SEQ ID NO:2共价施用有效量的基本上纯的化合物,或该化合物的药学上可接受的无毒盐,可以抑制这些病毒。