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1. 发明申请

US20130344147A1 TABLET-FORMED PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译：用于口服给药的片剂形成的药物组合物及其生产方法
公开(公告)号：US20130344147A1
公开(公告)日：2013-12-26
申请号：US14002989
申请日：2012-03-05
申请人： Ayumi Kainose , Yohei Koya , Yoshiki Machi , Saichi Ono , Tadahiko Chiba
发明人： Ayumi Kainose , Yohei Koya , Yoshiki Machi , Saichi Ono , Tadahiko Chiba
IPC分类号： A61K9/20 , A61K33/44
CPC分类号： A61K9/20 , A61K9/205 , A61K9/2095 , A61K33/44
摘要： The object of the present invention is to provide an adsorbent for oral administration, which can: obviate sandy texture of granules-formed adsorbent for oral administration, reduce the volume administered compared to encapsulated adsorbent for oral administration, and be easy to take.The object of the present invention is solved by a tablet-formed pharmaceutical composition consisting of 65% or more by weight of particulate substance as an active ingredient and one or more additives, characterized in that: (a) the particulate substance does not exhibit water solubility and swelling property in water, has a distortion rate of 2% or less when subjected to a pressure of 2 MPa, and has a fracture strength of 5 MPa or more, (b) the tablet-formed pharmaceutical composition comprises one or more particle-formulating additives wherein the amount of the particle-formulating additives is 1% or more by weight in total with respect to the weight of the tablet-formed pharmaceutical composition, and a thin layer of the particle-formulating additive can be formed when 0.5 mL of solution or dispersion liquid of the particle-formulating additive of 1% by weight is dropped on a plane surface of fluorine resin and heat-dried.
摘要翻译：本发明的目的是提供一种用于口服给药的吸附剂，其可以：消除用于口服给药的颗粒形成的吸附剂的沙质质，与口服给药的封装吸附剂相比，减少施用的体积，并且容易服用。本发明的目的是通过由作为活性成分的颗粒物质的65重量％或更多的添加剂和一种或多种添加剂组成的片剂形式的药物组合物来解决，其特征在于：（a）颗粒物质不显示水在水中的溶解性和溶胀性在经受2MPa的压力时具有2％以下的变形率，断裂强度为5MPa以上，（b）片剂形成的药物组合物包含一种或多种颗粒制剂添加剂，相对于片剂形成的药物组合物的重量，配制粉剂的总量为1重量％以上，配方添加剂的薄层可以在0.5mL 的配方添加剂的1重量％的溶液或分散液滴在氟树脂的平面上并进行加热干燥。

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