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1. 发明申请

US20120296204A1 Multi-Modality Ultrasound and Radio Frequency System for Imaging Tissue 审中-公开
标题翻译：用于成像组织的多模式超声和射频系统
公开(公告)号：US20120296204A1
公开(公告)日：2012-11-22
申请号：US13561047
申请日：2012-07-29
申请人： Aly M. Ismail , Francis Carr , Sai Kwok
发明人： Aly M. Ismail , Francis Carr , Sai Kwok
IPC分类号： A61B6/00 , A61N7/00
CPC分类号： A61B5/4312 , A61B5/0035 , A61B5/0051 , A61B5/05 , A61B8/085 , A61B8/4416 , A61B8/4477 , A61B8/485
摘要： This invention provides a dual-modality system for performing characterization and imaging of tissue, tumors, structures, lesions, and ablations under investigation. Specifically, the invention couples ultrasound technology comprising at least two focused ultrasound beams for vibrating target tissues located at the focal point of the ultrasound beams intersection with a radio frequency system for measuring the response of the target tissues. The ultrasound system vibrates the target tissues while the reflected radio frequency energy is transmitted into the target tissues. When reflected, the main carrier tone of the reflected radio frequency energy is cancelled and analysis is performed on the remaining sideband frequencies.
摘要翻译：本发明提供了一种用于进行正在研究的组织，肿瘤，结构，病变和消融的表征和成像的双重模态系统。具体地，本发明将包括至少两个聚焦超声波束的超声波技术耦合到位于与用于测量目标组织的响应的射频系统的超声波束交叉的焦点处的振动目标组织。超声系统使目标组织振动，同时将反射的射频能量传递到目标组织中。当反射时，反射的射频能量的主载波音调被消除，并且对剩余的边带频率进行分析。

2. 发明授权

US08135365B2 Phase-locked loop based controller for adjusting an adaptive continuous-time filter 有权
标题翻译：基于锁相环的控制器，用于调整自适应连续时间滤波器
公开(公告)号：US08135365B2
公开(公告)日：2012-03-13
申请号：US12960183
申请日：2010-12-03
申请人： Edward Youssoufian , David Yates , Aly M. Ismail , Geoffrey Hatcher
发明人： Edward Youssoufian , David Yates , Aly M. Ismail , Geoffrey Hatcher
IPC分类号： H04B1/10
CPC分类号： H03H21/0012 , H03H11/1291 , H03H2210/021 , H03H2210/043 , H03J2200/10
摘要： A direct conversion radio-frequency (RF) receiver includes a controller and an adaptive continuous-time filter. The adaptive continuous-time filter receives a multiple-bit control signal generated by the controller to adjust a characteristic of the continuous-time filter. The controller generates the multiple-bit control signal in response to process variation in the semiconductor material used to implement the controller and the adaptive continuous-time filter. A method for tuning an adaptive continuous-time filter comprises determining a RC time constant, converting the RC time constant to a digital word, comparing a select bit of the digital word to a respective bit of a predetermined reference word to generate a control bit, applying the control bit to an adjustable element to modify the RC time constant, repeating the determining, converting, comparing and applying steps until the control bits generate an output word and providing the output word to the adaptive continuous-time filter.
摘要翻译：直接转换射频（RF）接收机包括控制器和自适应连续时间滤波器。自适应连续时间滤波器接收由控制器产生的多位控制信号，以调整连续时间滤波器的特性。响应于用于实现控制器和自适应连续时间滤波器的半导体材料中的工艺变化，控制器产生多位控制信号。一种用于调整自适应连续时间滤波器的方法包括：确定RC时间常数，将RC时间常数转换为数字字，将数字字的选择位与预定参考字的相应位进行比较以产生控制位，将控制位应用到可调元件以修改RC时间常数，重复确定，转换，比较和应用步骤，直到控制位产生输出字并将输出字提供给自适应连续时间滤波器。

3. 发明申请

US20090281422A1 Multi-modality system for imaging in dense compressive media and method of use thereof 审中-公开
标题翻译：用于在致密压缩介质中成像的多模态系统及其使用方法
公开(公告)号：US20090281422A1
公开(公告)日：2009-11-12
申请号：US12151355
申请日：2008-05-06
申请人： Khaled N. Salama , Aly M. Ismail
发明人： Khaled N. Salama , Aly M. Ismail
IPC分类号： A61B6/00 , A61B5/00
CPC分类号： A61B5/05 , A61B5/0051 , A61B5/0097 , A61B5/0507 , A61B5/4312
摘要： A multi-modality system and method for performing detection, characterization and imaging of materials and objects in dense compressive media, such as in medical soft tissue applications, is disclosed. Medical tissue applications include but are not limited to the detection and diagnosis of breast tumors. Generally, an ultrasound subsystem is employed to excite a region in the dense compressive media and a microwave subsystem is employed to collect detection, characterization and imaging information from the excited region. In one preferred embodiment, multiple focused oscillating high-frequency ultrasound wave beams are transmitted into the media. The resultant low beat-frequency wave creates a force inducing motion in the materials and objects in the media. A radio-frequency microwave subsystem detects that motion and produces images based upon the Doppler effects of the excited materials and objects.
摘要翻译：公开了用于在诸如医用软组织应用的密集压缩介质中进行材料和物体的检测，表征和成像的多模态系统和方法。医疗组织应用包括但不限于乳腺肿瘤的检测和诊断。通常，使用超声子系统来激发密集压缩介质中的区域，并且使用微波子系统来收集来自激发区域的检测，表征和成像信息。在一个优选实施例中，多个聚焦的振荡高频超声波束被传送到介质中。所产生的低拍频波在介质中的材料和物体中产生一种力引起的运动。射频微波子系统基于被激发的材料和物体的多普勒效应来检测该运动并产生图像。

4. 发明授权

US07493097B2 High dynamic range compact mixer output stage for a wireless receiver 有权
标题翻译：用于无线接收器的高动态范围紧凑型混音器输出级
公开(公告)号：US07493097B2
公开(公告)日：2009-02-17
申请号：US11177102
申请日：2005-07-07
申请人： Aly M. Ismail , Geoffrey Hatcher , Edward Youssoufian , Dave Yates
发明人： Aly M. Ismail , Geoffrey Hatcher , Edward Youssoufian , Dave Yates
IPC分类号： H04B1/10 , H04B1/18
CPC分类号： H03D7/00 , H03D7/14
摘要： A mixer is disclosed having an output stage with an amplifier or gain device configured in a feedback loop to maintain a virtual ground at the input to the gain device. The gain device provides significant dynamic range, gain, and the appropriate impedance matching to insure a low noise output signal of a desired magnitude. Use of an amplifying output stage removes the dependence between mixer gain and mixer configuration, such as mixer bias resistor value, while concurrently overcome undesirable flicker noise that results from use of active devices in the mixer bias structure. A stable virtual ground at the mixer output and gain device input provides linearity over frequency. The gain device may comprises an operational amplifier or trans-resistance/trans-conductance device.
摘要翻译：公开了一种具有输出级的混频器，放大器或增益器件配置在反馈环路中，以在增益器件的输入端保持虚拟接地。增益器件提供了显着的动态范围，增益和适当的阻抗匹配，以确保具有所需幅度的低噪声输出信号。使用放大输出级除去混频器增益和混频器配置之间的相关性，例如混频器偏置电阻值，同时克服在混频器偏置结构中使用有源器件导致的不期望的闪烁噪声。混频器输出和增益器件输入端的稳定虚拟接地提供频率线性。增益装置可以包括运算放大器或反电阻/反电导装置。

5. 发明授权

US09236851B2 Phase-locked loop based controller for adjusting an adaptive continuous-time filter 有权
标题翻译：基于锁相环的控制器，用于调整自适应连续时间滤波器
公开(公告)号：US09236851B2
公开(公告)日：2016-01-12
申请号：US13366855
申请日：2012-02-06
申请人： Edward Youssoufian , Aly M. Ismail , Geoffrey Hatcher
发明人： Edward Youssoufian , David Yates , Aly M. Ismail , Geoffrey Hatcher
IPC分类号： H03H11/12
CPC分类号： H03H21/0012 , H03H11/1291 , H03H2210/021 , H03H2210/043 , H03J2200/10
摘要： A direct conversion radio-frequency (RF) receiver includes a controller and an adaptive continuous-time filter. The adaptive continuous-time filter receives a multiple-bit control signal generated by the controller to adjust a characteristic of the continuous-time filter. The controller generates the multiple-bit control signal in response to process variation in the semi-conductor material used to implement the controller and the adaptive continuous-time filter. A method for tuning an adaptive continuous-time filter comprises determining a RC time constant, converting the RC time constant to a digital word, comparing a select bit of the digital word to a respective bit of a predetermined reference word to generate a control bit, applying the control bit to an adjustable element to modify the RC time constant, repeating the determining, converting, comparing and applying steps until the control bits generate an output word and providing the output word to the adaptive continuous-time filter.
摘要翻译：直接转换射频（RF）接收机包括控制器和自适应连续时间滤波器。自适应连续时间滤波器接收由控制器产生的多位控制信号，以调整连续时间滤波器的特性。响应于用于实现控制器和自适应连续时间滤波器的半导体材料中的工艺变化，控制器产生多位控制信号。一种用于调整自适应连续时间滤波器的方法包括：确定RC时间常数，将RC时间常数转换为数字字，将数字字的选择位与预定参考字的相应位进行比较以产生控制位，将控制位应用到可调元件以修改RC时间常数，重复确定，转换，比较和应用步骤，直到控制位产生输出字并将输出字提供给自适应连续时间滤波器。

6. 发明申请

US20120289827A1 Multi-Modality Ultrasound and Radio Frequency Methodology for Imaging Tissue 审中-公开
标题翻译：成像组织的多模态超声和射频方法
公开(公告)号：US20120289827A1
公开(公告)日：2012-11-15
申请号：US13561048
申请日：2012-07-29
申请人： Aly M. Ismail , Francis Carr , Sai Kwok
发明人： Aly M. Ismail , Francis Carr , Sai Kwok
IPC分类号： A61B6/00 , A61N7/00
CPC分类号： A61B5/05 , A61B5/0035 , A61B5/0051 , A61B5/4312 , A61B5/7203 , A61B8/08 , A61B8/4416
摘要： This invention provides a dual-modality system for performing characterization and imaging of tissue, tumors, structures, lesions, and ablations under investigation. Specifically, the invention couples ultrasound technology comprising at least two focused ultrasound beams for vibrating target tissues located at the focal point of the ultrasound beams intersection with a radio frequency system for measuring the response of the target tissues. The ultrasound system vibrates the target tissues while the reflected radio frequency energy is transmitted into the target tissues. When reflected, the main carrier tone of the reflected radio frequency energy is cancelled and analysis is performed on the remaining sideband frequencies.
摘要翻译：本发明提供了一种用于进行正在研究的组织，肿瘤，结构，病变和消融的表征和成像的双重模态系统。具体地，本发明将包括至少两个聚焦超声波束的超声波技术耦合到位于与用于测量目标组织的响应的射频系统的超声波束交叉的焦点处的振动目标组织。超声系统使目标组织振动，同时将反射的射频能量传递到目标组织中。当反射时，反射的射频能量的主载波音调被消除，并且对剩余的边带频率进行分析。

7. 发明申请

US20100036240A1 Multi-modality system for imaging in dense compressive media and method of use thereof 审中-公开
标题翻译：用于在致密压缩介质中成像的多模态系统及其使用方法
公开(公告)号：US20100036240A1
公开(公告)日：2010-02-11
申请号：US12221868
申请日：2008-08-07
申请人： Aly M. Ismail , Kenneth Brian Cooper , Khaled N. Satama
发明人： Aly M. Ismail , Kenneth Brian Cooper , Khaled N. Satama
IPC分类号： A61B6/00 , A61B8/00
CPC分类号： A61B5/05 , A61B5/0035 , A61B5/0507 , A61B8/0825 , A61B8/4416
摘要： A multi-modality system and method for performing screening/detection, imaging and diagnosis/characterization of materials and objects in dense compressive media, such as in medical soft tissue applications, is disclosed. Medical tissue applications include but are not limited to the detection and diagnosis of breast tumors. Generally, the present invention involves coupling an ultrasound subsystem for exciting target tissues with a microwave subsystem for measuring the response, imaging and diagnosing the target tissues.
摘要翻译：公开了用于在诸如医用软组织应用中的密集压缩介质中进行材料和物体的筛选/检测，成像和诊断/表征的多模态系统和方法。医疗组织应用包括但不限于乳腺肿瘤的检测和诊断。通常，本发明涉及将用于激发目标组织的超声子系统与用于测量响应，成像和诊断目标组织的微波子系统相耦合。

8. 发明授权

US07088985B2 Low-noise filter for a wireless receiver 有权
标题翻译：无线接收机的低噪声滤波器
公开(公告)号：US07088985B2
公开(公告)日：2006-08-08
申请号：US10715631
申请日：2003-11-18
申请人： Aly M. Ismail
发明人： Aly M. Ismail
IPC分类号： H04B1/16
CPC分类号： H03H11/04 , H03H11/1291 , H03H11/40 , H03H11/525
摘要： A low-noise filter for a wireless receiver is disclosed. The low-noise filter comprises an amplifier and a filter comprising a frequency dependent negative resistance implemented using a general impedance converter to realize a bi-quad filter. The low-noise filter is implemented such that noise generated by the filter when an in-band signal is processed is prevented from appearing at the output of the amplifier stage.
摘要翻译：公开了一种用于无线接收机的低噪声滤波器。低噪声滤波器包括放大器和滤波器，该滤波器包括使用通用阻抗转换器来实现双二进制滤波器实现的频率相关负电阻。实现低噪声滤波器，使得当处理带内信号时由滤波器产生的噪声被防止出现在放大器级的输出端。

9. 发明授权

US07212073B2 Capacitive tuning network for low gain digitally controlled oscillator 有权
标题翻译：用于低增益数字控制振荡器的电容调谐网络
公开(公告)号：US07212073B2
公开(公告)日：2007-05-01
申请号：US11049560
申请日：2005-02-02
申请人： Edward Youssoufian , Aly M. Ismail
发明人： Edward Youssoufian , Aly M. Ismail
IPC分类号： H03L7/099
CPC分类号： H03L7/0991
摘要： According to one exemplary embodiment, a digitally controlled oscillator includes a capacitive tuning network, where the capacitive tuning network controls a frequency of an output signal of the digitally controlled oscillator. The capacitive tuning network includes a switched capacitor array, where a change of a first capacitance of the switched capacitor array causes the capacitive tuning network to change by a second capacitance, and where the first capacitance is larger than the second capacitance. According to this exemplary embodiment, the capacitive tuning network further includes a first capacitor coupled in parallel with the switched capacitor array. The first capacitor has a third capacitance, which is larger than the first capacitance. The capacitive tuning network further includes a second capacitor coupled in series with the first capacitor and the switched capacitor array. The second capacitor can have a fourth capacitance, where the third capacitance is larger than the fourth capacitance.
摘要翻译：根据一个示例性实施例，数字控制振荡器包括电容调谐网络，其中电容调谐网络控制数字控制振荡器的输出信号的频率。电容调谐网络包括开关电容器阵列，其中开关电容器阵列的第一电容的改变使得电容调谐网络改变第二电容，并且其中第一电容大于第二电容。根据该示例性实施例，电容调谐网络还包括与开关电容器阵列并联耦合的第一电容器。第一电容器具有比第一电容大的第三电容。电容调谐网络还包括与第一电容器和开关电容器阵列串联耦合的第二电容器。第二电容器可以具有第四电容，其中第三电容大于第四电容。

10. 发明申请

US20120133426A1 PHASE-LOCKED LOOP BASED CONTROLLER FOR ADJUSTING AN ADAPTIVE CONTINUOUS-TIME FILTER 审中-公开
标题翻译：用于调节自适应连续过滤器的相位锁定环路控制器
公开(公告)号：US20120133426A1
公开(公告)日：2012-05-31
申请号：US13366855
申请日：2012-02-06
申请人： Edward Youssoufian , David Yates , Aly M. Ismail , Geoffrey Hatcher
发明人： Edward Youssoufian , David Yates , Aly M. Ismail , Geoffrey Hatcher
IPC分类号： H03B1/00
CPC分类号： H03H21/0012 , H03H11/1291 , H03H2210/021 , H03H2210/043 , H03J2200/10
摘要： A direct conversion radio-frequency (RF) receiver includes a controller and an adaptive continuous-time filter. The adaptive continuous-time filter receives a multiple-bit control signal generated by the controller to adjust a characteristic of the continuous-time filter. The controller generates the multiple-bit control signal in response to process variation in the semi-conductor material used to implement the controller and the adaptive continuous-time filter. A method for tuning an adaptive continuous-time filter comprises determining a RC time constant, converting the RC time constant to a digital word, comparing a select bit of the digital word to a respective bit of a predetermined reference word to generate a control bit, applying the control bit to an adjustable element to modify the RC time constant, repeating the determining, converting, comparing and applying steps until the control bits generate an output word and providing the output word to the adaptive continuous-time filter.
摘要翻译：直接转换射频（RF）接收机包括控制器和自适应连续时间滤波器。自适应连续时间滤波器接收由控制器产生的多位控制信号，以调整连续时间滤波器的特性。响应于用于实现控制器和自适应连续时间滤波器的半导体材料中的工艺变化，控制器产生多位控制信号。一种用于调整自适应连续时间滤波器的方法包括：确定RC时间常数，将RC时间常数转换为数字字，将数字字的选择位与预定参考字的相应位进行比较以产生控制位，将控制位应用到可调元件以修改RC时间常数，重复确定，转换，比较和应用步骤，直到控制位产生输出字并将输出字提供给自适应连续时间滤波器。

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