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1. 发明申请

US20110236904A1 DETECTION OF TUMOR STEM CELLS AND TUMOR CELLS IN EPITHELIAL-MESENCHYMAL TRANSITION IN BODY FLUIDS OF CANCER PATIENTS 有权
标题翻译：肿瘤患者体液转移中肿瘤干细胞和肿瘤细胞的检测
公开(公告)号：US20110236904A1
公开(公告)日：2011-09-29
申请号：US12678712
申请日：2007-09-17
申请人： Siegfried Hauch , Albert Winfried
发明人： Siegfried Hauch , Albert Winfried
IPC分类号： G01N33/574 , C12N5/095 , C12N5/09
CPC分类号： G01N33/574 , C12N2500/35 , G01N1/34 , G01N33/54393
摘要： The present invention relates to the detection of tumor stem cells and tumor cells in epithelial-mesenchymal transition and uses of such methods.According to the present invention said method comprises a selecting step for selection or enrichment of said predetermined cells from the sample wherein the sample is contacted with the solid surface for preferential binding of said predetermined cells to the solid surface and then the sample is removed from the solid surface in a washing step. The inventive method is characterized in that the sample contains a polyol at least during one of contacting the sample with the solid surface and the washing step and in a detection step detecting in said cells, preferentially selected or enriched by said selecting step, the presence or absence of expression of at least one marker associated with at least one of the group comprising tumor stem cells and tumor cells in epithelial-mesenchymal transition.
摘要翻译：本发明涉及上皮 - 间质转化中肿瘤干细胞和肿瘤细胞的检测及其应用。根据本发明，所述方法包括用于从样品中选择或富集所述预定细胞的选择步骤，其中样品与固体表面接触，以将所述预定细胞优先结合到固体表面，然后将样品从洗涤步骤中的固体表面。本发明的方法的特征在于，至少在使样品与固体表面和洗涤步骤接触的过程中，样品含有多元醇，并且在所述细胞中检测优选由所述选择步骤选择或富集的检测步骤中，存在或在上皮 - 间质转化中不存在与至少一个包含肿瘤干细胞和肿瘤细胞的组相关的标记物的表达。

2. 发明授权

US08557528B2 Detection of tumor stem cells and tumor cells in epithelial-mesenchymal transition in body fluids of cancer patients 有权
标题翻译：癌症患者体液中上皮 - 间质转化中肿瘤干细胞和肿瘤细胞的检测
公开(公告)号：US08557528B2
公开(公告)日：2013-10-15
申请号：US12678712
申请日：2008-09-17
申请人： Siegfried Hauch , Albert Winfried
发明人： Siegfried Hauch , Albert Winfried
IPC分类号： G01N33/53
CPC分类号： G01N33/574 , C12N2500/35 , G01N1/34 , G01N33/54393
摘要： The present invention relates to the detection of tumor stem cells and tumor cells in epithelial-mesenchymal transition and uses of such methods.According to the present invention said method comprises a selecting step for selection or enrichment of said predetermined cells from the sample wherein the sample is contacted with the solid surface for preferential binding of said predetermined cells to the solid surface and then the sample is removed from the solid surface in a washing step. The inventive method is characterized in that the sample contains a polyol at least during one of contacting the sample with the solid surface and the washing step and in a detection step detecting in said cells, preferentially selected or enriched by said selecting step, the presence or absence of expression of at least one marker associated with at least one of the group comprising tumor stem cells and tumor cells in epithelial-mesenchymal transition.
摘要翻译：本发明涉及上皮 - 间质转化中肿瘤干细胞和肿瘤细胞的检测及其应用。根据本发明，所述方法包括用于从样品中选择或富集所述预定细胞的选择步骤，其中样品与固体表面接触，以将所述预定细胞优先结合到固体表面，然后将样品从洗涤步骤中的固体表面。本发明的方法的特征在于，至少在使样品与固体表面和洗涤步骤接触的过程中，样品含有多元醇，并且在所述细胞中检测优选由所述选择步骤选择或富集的检测步骤中，存在或在上皮 - 间质转化中不存在与至少一个包含肿瘤干细胞和肿瘤细胞的组相关的标记物的表达。

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